-
1
-
-
0028989769
-
Antiviral activities of isometric dideoxynucleosides of D- and L-related stereochemistry
-
Nair,V. and Jahnke,T.S. (1995) Antiviral activities of isometric dideoxynucleosides of D- and L-related stereochemistry. Antimicrob. Agents Chemother., 39, 1017-1029.
-
(1995)
Antimicrob. Agents Chemother
, vol.39
, pp. 1017-1029
-
-
Nair, V.1
Jahnke, T.S.2
-
2
-
-
0034026483
-
Enantioselectivity of the antiviral effects of nucleoside analogues
-
Zemlicka,J. (2000) Enantioselectivity of the antiviral effects of nucleoside analogues. Pharmacol. Ther., 85, 251-266.
-
(2000)
Pharmacol. Ther
, vol.85
, pp. 251-266
-
-
Zemlicka, J.1
-
3
-
-
0035139830
-
Potential use of antiviral L(-)nucleoside analogues for the prevention or treatment of viral associated cancers
-
Cheng,Y.C. (2001) Potential use of antiviral L(-)nucleoside analogues for the prevention or treatment of viral associated cancers. Cancer Lett., 162(Suppl.), S33-S37.
-
(2001)
Cancer Lett
, vol.162
, Issue.SUPPL.
-
-
Cheng, Y.C.1
-
4
-
-
33747158845
-
L-Nucleoside enantiomers as antivirals drugs: A mini-review
-
Mathe,C. and Gosselin,G. (2006) L-Nucleoside enantiomers as antivirals drugs: A mini-review. Antiviral Res., 71, 276-281.
-
(2006)
Antiviral Res
, vol.71
, pp. 276-281
-
-
Mathe, C.1
Gosselin, G.2
-
5
-
-
0017160519
-
Metabolism of pyrimidine L-nucleosides
-
Jurovcik,M. and Holy,A. (1976) Metabolism of pyrimidine L-nucleosides. Nucleic Acids Res., 3, 2143-2154.
-
(1976)
Nucleic Acids Res
, vol.3
, pp. 2143-2154
-
-
Jurovcik, M.1
Holy, A.2
-
6
-
-
0035172399
-
Antiviral L-nucleosides specific for hepatitis B virus infection
-
Bryant,M.L., Bridges,E.G., Placidi,L., Faraj,A., Loi,A.G., Pierra,C., Dukhan,D., Gosselin,G., Imbach,J.L. et al. (2001) Antiviral L-nucleosides specific for hepatitis B virus infection. Antimicrob. Agents Chemother., 45, 229-235.
-
(2001)
Antimicrob. Agents Chemother
, vol.45
, pp. 229-235
-
-
Bryant, M.L.1
Bridges, E.G.2
Placidi, L.3
Faraj, A.4
Loi, A.G.5
Pierra, C.6
Dukhan, D.7
Gosselin, G.8
Imbach, J.L.9
-
7
-
-
0033934998
-
The enantioselectivity of enzymes involved in current antiviral therapy using nucleoside analogues: A new strategy?
-
Maury,G. (2000) The enantioselectivity of enzymes involved in current antiviral therapy using nucleoside analogues: A new strategy? Antivir. Chem. Chemother., 11, 165-189.
-
(2000)
Antivir. Chem. Chemother
, vol.11
, pp. 165-189
-
-
Maury, G.1
-
8
-
-
0025916482
-
Diverging substrate specificity of pure human thymidine kinases 1 and 2 against antiviral dideoxynucleosides
-
Munch-Petersen,B., Cloos,L., Tyrsted,G. and Eriksson,S. (1991) Diverging substrate specificity of pure human thymidine kinases 1 and 2 against antiviral dideoxynucleosides. J. Biol. Chem., 266, 9032-9038.
-
(1991)
J. Biol. Chem
, vol.266
, pp. 9032-9038
-
-
Munch-Petersen, B.1
Cloos, L.2
Tyrsted, G.3
Eriksson, S.4
-
9
-
-
0033592879
-
Stereoisomeric selectivity of human deoxyribonucleoside kinases
-
Wang,J., Choudhury,D., Chattopadhyaya,J. and Eriksson,S. (1999) Stereoisomeric selectivity of human deoxyribonucleoside kinases. Biochemistry, 38, 16993-16999.
-
(1999)
Biochemistry
, vol.38
, pp. 16993-16999
-
-
Wang, J.1
Choudhury, D.2
Chattopadhyaya, J.3
Eriksson, S.4
-
10
-
-
0030664953
-
Relaxed enantioselectivity of human mitochondrial thymidine kinase and chemotherapeutic uses of L-nucleoside analogues
-
Verri,A., Priori,G., Spadari,S., Tondelli,L. and Focher,F. (1997) Relaxed enantioselectivity of human mitochondrial thymidine kinase and chemotherapeutic uses of L-nucleoside analogues. Biochem. J., 328(Pt 1), 317-320.
-
(1997)
Biochem. J
, vol.328
, Issue.PART 1
, pp. 317-320
-
-
Verri, A.1
Priori, G.2
Spadari, S.3
Tondelli, L.4
Focher, F.5
-
11
-
-
0031741750
-
A comparison of the enantioselectivities of human deoxycytidine kinase and human cytidine deaminase
-
Shafiee,M., Griffon,J.F., Gosselin,G., Cambi,A., Vincenzetti,S., Vita,A., Eriksson,S., Imbach,J.L. and Maury,G. (1998) A comparison of the enantioselectivities of human deoxycytidine kinase and human cytidine deaminase. Biochem. Pharmacol., 56, 1237-1242.
-
(1998)
Biochem. Pharmacol
, vol.56
, pp. 1237-1242
-
-
Shafiee, M.1
Griffon, J.F.2
Gosselin, G.3
Cambi, A.4
Vincenzetti, S.5
Vita, A.6
Eriksson, S.7
Imbach, J.L.8
Maury, G.9
-
12
-
-
0242552804
-
Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases
-
Van Rompay,A.R., Johansson,M. and Karlsson,A. (2003) Substrate specificity and phosphorylation of antiviral and anticancer nucleoside analogues by human deoxyribonucleoside kinases and ribonucleoside kinases. Pharmacol. Ther., 100, 119-139.
-
(2003)
Pharmacol. Ther
, vol.100
, pp. 119-139
-
-
Van Rompay, A.R.1
Johansson, M.2
Karlsson, A.3
-
13
-
-
17644435744
-
Nucleoside monophosphate kinases: Structure, mechanism, and substrate specificity
-
Yan,H. and Tsai,M.D. (1999) Nucleoside monophosphate kinases: Structure, mechanism, and substrate specificity. Adv. Enzymol. Relat. Areas Mol. Biol., 73, 103-134.
-
(1999)
Adv. Enzymol. Relat. Areas Mol. Biol
, vol.73
, pp. 103-134
-
-
Yan, H.1
Tsai, M.D.2
-
14
-
-
0037086275
-
Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates
-
Liou,J.Y., Dutschman,G.E., Lam,W., Jiang,Z. and Cheng,Y.C. (2002) Characterization of human UMP/CMP kinase and its phosphorylation of D- and L-form deoxycytidine analogue monophosphates. Cancer Res., 62, 1624-1631.
-
(2002)
Cancer Res
, vol.62
, pp. 1624-1631
-
-
Liou, J.Y.1
Dutschman, G.E.2
Lam, W.3
Jiang, Z.4
Cheng, Y.C.5
-
15
-
-
0038409001
-
Reaction of human UMP-CMP kinase with natural and analog substrates
-
Pasti,C., Gallois-Montbrun,S., Munier-Lehmann,H., Veron,M., Gilles,A.M. and Deville-Bonne,D. (2003) Reaction of human UMP-CMP kinase with natural and analog substrates. Eur. J. Biochem., 270, 1784-1790.
-
(2003)
Eur. J. Biochem
, vol.270
, pp. 1784-1790
-
-
Pasti, C.1
Gallois-Montbrun, S.2
Munier-Lehmann, H.3
Veron, M.4
Gilles, A.M.5
Deville-Bonne, D.6
-
16
-
-
0035031309
-
NDP kinase reactivity towards 3TC nucleotides
-
Kreimeyer,A., Schneider,B., Sarfati,R., Faraj,A., Sommadossi,J.P., Veron,M. and Deville-Bonne,D. (2001) NDP kinase reactivity towards 3TC nucleotides. Antiviral Res., 50, 147-156.
-
(2001)
Antiviral Res
, vol.50
, pp. 147-156
-
-
Kreimeyer, A.1
Schneider, B.2
Sarfati, R.3
Faraj, A.4
Sommadossi, J.P.5
Veron, M.6
Deville-Bonne, D.7
-
17
-
-
0037200016
-
Phosphorylation of pyrimidine L-deoxynucleoside analog diphosphates. Kinetics of phosphorylation and dephosphorylation of nucleoside analog diphosphates and triphosphates by 3-phosphoglycerate kinase
-
Krishnan,P., Liou,J.Y. and Cheng,Y.C. (2002) Phosphorylation of pyrimidine L-deoxynucleoside analog diphosphates. Kinetics of phosphorylation and dephosphorylation of nucleoside analog diphosphates and triphosphates by 3-phosphoglycerate kinase. J. Biol. Chem., 277, 31593-31600.
-
(2002)
J. Biol. Chem
, vol.277
, pp. 31593-31600
-
-
Krishnan, P.1
Liou, J.Y.2
Cheng, Y.C.3
-
18
-
-
4644235485
-
Broad specificity of human phosphoglycerate kinase for antiviral nucleoside analogs
-
Gallois-Montbrun,S., Faraj,A., Seclaman,E., Sommadossi,J.P., Deville-Bonne,D. and Veron,M. (2004) Broad specificity of human phosphoglycerate kinase for antiviral nucleoside analogs. Biochem. Pharmacol., 68, 1749-1756.
-
(2004)
Biochem. Pharmacol
, vol.68
, pp. 1749-1756
-
-
Gallois-Montbrun, S.1
Faraj, A.2
Seclaman, E.3
Sommadossi, J.P.4
Deville-Bonne, D.5
Veron, M.6
-
19
-
-
0030480275
-
Identification of enzymes catalyzing two-step phosphorylation of cidofovir and the effect of cytomegalovirus infection on their activities in host oells
-
Cihlar,T. and Chen,M.S. (1996) Identification of enzymes catalyzing two-step phosphorylation of cidofovir and the effect of cytomegalovirus infection on their activities in host oells. Mol. Pharmacol., 50, 1502-1510.
-
(1996)
Mol. Pharmacol
, vol.50
, pp. 1502-1510
-
-
Cihlar, T.1
Chen, M.S.2
-
20
-
-
0033524447
-
Mechanistic studies comparing the incorporation of (+) and (-) isomers of 3TCTP by HIV-1 reverse transcriptase
-
Feng,J.Y. and Anderson,K.S. (1999) Mechanistic studies comparing the incorporation of (+) and (-) isomers of 3TCTP by HIV-1 reverse transcriptase. Biochemistry, 38, 55-63.
-
(1999)
Biochemistry
, vol.38
, pp. 55-63
-
-
Feng, J.Y.1
Anderson, K.S.2
-
21
-
-
1642420304
-
Relationship between antiviral activity and host toxicity: Comparison of the incorporation efficiencies of 2′,3′-dideoxy-5-fluoro-3′-thiacytidine- triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondrial DNA polymerase
-
Feng,J.Y., Murakami,E., Zorca,S.M., Johnson,A.A., Johnson,K.A., Schinazi,R.F., Furman,P.A. and Anderson,K.S. (2004) Relationship between antiviral activity and host toxicity: Comparison of the incorporation efficiencies of 2′,3′-dideoxy-5-fluoro-3′-thiacytidine- triphosphate analogs by human immunodeficiency virus type 1 reverse transcriptase and human mitochondrial DNA polymerase. Antimicrob. Agents Chemother., 48, 1300-1306.
-
(2004)
Antimicrob. Agents Chemother
, vol.48
, pp. 1300-1306
-
-
Feng, J.Y.1
Murakami, E.2
Zorca, S.M.3
Johnson, A.A.4
Johnson, K.A.5
Schinazi, R.F.6
Furman, P.A.7
Anderson, K.S.8
-
22
-
-
0037220313
-
Assessment of the effect of phosphorylated metabolites of anti-human immunodeficiency virus and anti-hepatitis B virus pyrimidine analogs on the behavior of human deoxycytidylate deaminase
-
Liou,J.Y., Krishnan,P., Hsieh,C.C., Dutschman,G.E. and Cheng,Y.C. (2003) Assessment of the effect of phosphorylated metabolites of anti-human immunodeficiency virus and anti-hepatitis B virus pyrimidine analogs on the behavior of human deoxycytidylate deaminase. Mol. Pharmacol., 63, 105-110.
-
(2003)
Mol. Pharmacol
, vol.63
, pp. 105-110
-
-
Liou, J.Y.1
Krishnan, P.2
Hsieh, C.C.3
Dutschman, G.E.4
Cheng, Y.C.5
-
23
-
-
0043198520
-
Cytosolic and mitochondrial deoxyribonucleotidases: Activity with substrate analogs, inhibitors and implications for therapy
-
Mazzon,C., Rampazzo,C., Scaini,M.C., Gallinaro,L., Karlsson,A., Meier,C., Balzarini,J., Reichard,P. and Bianchi,V. (2003) Cytosolic and mitochondrial deoxyribonucleotidases: Activity with substrate analogs, inhibitors and implications for therapy. Biochem. Pharmacol., 66, 471-479.
-
(2003)
Biochem. Pharmacol
, vol.66
, pp. 471-479
-
-
Mazzon, C.1
Rampazzo, C.2
Scaini, M.C.3
Gallinaro, L.4
Karlsson, A.5
Meier, C.6
Balzarini, J.7
Reichard, P.8
Bianchi, V.9
-
24
-
-
0017239363
-
Active site of ribonucleoside diphosphate reductase from Escherichia coli. Inactivation of the enzyme by 2′-substituted ribonucleoside diphosphates
-
Thelander,L. and Larsson,B. (1976) Active site of ribonucleoside diphosphate reductase from Escherichia coli. Inactivation of the enzyme by 2′-substituted ribonucleoside diphosphates. J. Biol. Chem., 251, 1398-1405.
-
(1976)
J. Biol. Chem
, vol.251
, pp. 1398-1405
-
-
Thelander, L.1
Larsson, B.2
-
25
-
-
0027143180
-
Alternative model for mechanism-based inhibition of Escherichia coli ribonucleotide reductase by 2′-azido-2′-deoxyuridine 5′-diphosphate
-
Salowe,S., Bollinger,J.M.Jr, Ator,M., Stubbe,J., McCraken,J., Peisach,J., Samano,M.C. and Robins,M.J. (1993) Alternative model for mechanism-based inhibition of Escherichia coli ribonucleotide reductase by 2′-azido-2′-deoxyuridine 5′-diphosphate. Biochemistry, 32, 12749-12760.
-
(1993)
Biochemistry
, vol.32
, pp. 12749-12760
-
-
Salowe, S.1
Bollinger Jr, J.M.2
Ator, M.3
Stubbe, J.4
McCraken, J.5
Peisach, J.6
Samano, M.C.7
Robins, M.J.8
-
26
-
-
3242668813
-
Enantioselectivity of ribonucleotide reductase: A first study using stereoisomers of pyrimidine 2′-azido-2′-deoxynucleosides
-
Roy,B., Verri,A., Lossani,A., Spadari,S., Focher,F., Aubertin,A.M., Gosselin,G., Mathe,C. and Perigaud,C. (2004) Enantioselectivity of ribonucleotide reductase: A first study using stereoisomers of pyrimidine 2′-azido-2′-deoxynucleosides. Biochem. Pharmacol., 68, 711-718.
-
(2004)
Biochem. Pharmacol
, vol.68
, pp. 711-718
-
-
Roy, B.1
Verri, A.2
Lossani, A.3
Spadari, S.4
Focher, F.5
Aubertin, A.M.6
Gosselin, G.7
Mathe, C.8
Perigaud, C.9
-
27
-
-
14644404369
-
The enantioselectivities of the active and allosteric sites of mammalian ribonucleotide reductase
-
He,J., Roy,B., Perigaud,C., Kashlan,O.B. and Cooperman,B.S. (2005) The enantioselectivities of the active and allosteric sites of mammalian ribonucleotide reductase. FEBS J., 272, 1236-1242.
-
(2005)
FEBS J
, vol.272
, pp. 1236-1242
-
-
He, J.1
Roy, B.2
Perigaud, C.3
Kashlan, O.B.4
Cooperman, B.S.5
-
28
-
-
29144473268
-
Substrate specificity of vaccinia virus thymidylate kinase
-
Topalis,D., Collinet,B., Gasse,C., Dugue,L., Balzarini,J., Pochet,S. and Deville-Bonne,D. (2005) Substrate specificity of vaccinia virus thymidylate kinase. FEBS J., 272, 6254-6265.
-
(2005)
FEBS J
, vol.272
, pp. 6254-6265
-
-
Topalis, D.1
Collinet, B.2
Gasse, C.3
Dugue, L.4
Balzarini, J.5
Pochet, S.6
Deville-Bonne, D.7
-
29
-
-
0014186966
-
A novel method for phosphorylation of nucleosides to 5′-nucleotides
-
Yoshikawa,M., Kato,T. and Takenishi,T. (1967) A novel method for phosphorylation of nucleosides to 5′-nucleotides. Tetrahedron Lett. 50, 5065-5068.
-
(1967)
Tetrahedron Lett
, vol.50
, pp. 5065-5068
-
-
Yoshikawa, M.1
Kato, T.2
Takenishi, T.3
-
30
-
-
3142753383
-
Liquid chromatographic analysis of nucleosides and their mono-, di- and triphosphates using porous graphitic carbon stationary phase coupled with electrospray mass spectrometry
-
Xing,J., Apedo,A., Tymiak,A. and Zhao,N. (2004) Liquid chromatographic analysis of nucleosides and their mono-, di- and triphosphates using porous graphitic carbon stationary phase coupled with electrospray mass spectrometry. Rapid Commun. Mass Spectrom., 18, 1599-1606.
-
(2004)
Rapid Commun. Mass Spectrom
, vol.18
, pp. 1599-1606
-
-
Xing, J.1
Apedo, A.2
Tymiak, A.3
Zhao, N.4
-
31
-
-
0042970469
-
Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans
-
Pochet,S., Dugue,L., Labesse,G., Delepierre,M. and Munier-Lehmann,H. (2003) Comparative study of purine and pyrimidine nucleoside analogues acting on the thymidylate kinases of Mycobacterium tuberculosis and of humans. Chembiochem, 4, 742-747.
-
(2003)
Chembiochem
, vol.4
, pp. 742-747
-
-
Pochet, S.1
Dugue, L.2
Labesse, G.3
Delepierre, M.4
Munier-Lehmann, H.5
-
32
-
-
0028291887
-
Improved spectrophotometric assay of nucleoside monophosphate kinase activity using the pyruvate kinase/lactate dehydrogenase coupling system
-
Blondin,C., Serina,L., Wiesmuller,L., Gilles,A.M. and Barzu,O. (1994) Improved spectrophotometric assay of nucleoside monophosphate kinase activity using the pyruvate kinase/lactate dehydrogenase coupling system. Anal. Biochem., 220, 219-221.
-
(1994)
Anal. Biochem
, vol.220
, pp. 219-221
-
-
Blondin, C.1
Serina, L.2
Wiesmuller, L.3
Gilles, A.M.4
Barzu, O.5
-
33
-
-
0041825376
-
Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases
-
Chen,Y., Gallois-Montbrun,S., Schneider,B., Veron,M., Morera,S., Deville-Bonne,D. and Janin,J. (2003) Nucleotide binding to nucleoside diphosphate kinases: X-ray structure of human NDPK-A in complex with ADP and comparison to protein kinases. J. Mol. Biol., 332, 915-926.
-
(2003)
J. Mol. Biol
, vol.332
, pp. 915-926
-
-
Chen, Y.1
Gallois-Montbrun, S.2
Schneider, B.3
Veron, M.4
Morera, S.5
Deville-Bonne, D.6
Janin, J.7
-
36
-
-
0035881487
-
Structure and expression of human mitochondrial adenylate kinase targeted to the mitochondrial matrix
-
Noma,J., Fujisawa,K., Yamashiro,Y., Shinohara,M., Nakazawa,A., Gondo,T., Ishihara,J. and Yoshinobu,K. (2001) Structure and expression of human mitochondrial adenylate kinase targeted to the mitochondrial matrix. Biochem. J., 358, 225-232.
-
(2001)
Biochem. J
, vol.358
, pp. 225-232
-
-
Noma, J.1
Fujisawa, K.2
Yamashiro, Y.3
Shinohara, M.4
Nakazawa, A.5
Gondo, T.6
Ishihara, J.7
Yoshinobu, K.8
-
37
-
-
19944428454
-
The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus
-
Ren,H., Wang,L., Bennett,M., Liang,Y., Zheng,X., Lu,F., Li,L., Nan,J, Luo,M. et al. (2005) The crystal structure of human adenylate kinase 6: An adenylate kinase localized to the cell nucleus. Proc. Natl Acad. Sci. USA, 102, 303-308.
-
(2005)
Proc. Natl Acad. Sci. USA
, vol.102
, pp. 303-308
-
-
Ren, H.1
Wang, L.2
Bennett, M.3
Liang, Y.4
Zheng, X.5
Lu, F.6
Li, L.7
Nan, J.8
Luo, M.9
-
38
-
-
0017740850
-
Characterization of pyrimidine nucleoside monophosphokinase in normal and malignant tissues
-
Arima,T., Akiyoshi,H. and Fujii,S. (1977) Characterization of pyrimidine nucleoside monophosphokinase in normal and malignant tissues. Cancer Res., 37, 1593-1597.
-
(1977)
Cancer Res
, vol.37
, pp. 1593-1597
-
-
Arima, T.1
Akiyoshi, H.2
Fujii, S.3
-
39
-
-
0022869412
-
Structural relationships in the adenylate kinase family
-
Schulz,G.E., Schiltz,E., Tomaselli,A.G., Frank,R., Brune,M., Wittinghofer,A. and Schirmer,R.H. (1986) Structural relationships in the adenylate kinase family. FEBS J., 161, 127-132.
-
(1986)
FEBS J
, vol.161
, pp. 127-132
-
-
Schulz, G.E.1
Schiltz, E.2
Tomaselli, A.G.3
Frank, R.4
Brune, M.5
Wittinghofer, A.6
Schirmer, R.H.7
-
40
-
-
0029644728
-
Movie of the structural changes during a catalytic cycle of nucleoside monophosphate kinases
-
Vonrheim,C., Schlauderer,G.J. and Schulz,G.E. (1995) Movie of the structural changes during a catalytic cycle of nucleoside monophosphate kinases. Structure, 3, 483-490.
-
(1995)
Structure
, vol.3
, pp. 483-490
-
-
Vonrheim, C.1
Schlauderer, G.J.2
Schulz, G.E.3
-
41
-
-
34547913146
-
-
Filippakopoulos,P., Bunkoczi,G., Jansson,A., Schreurs,A., Knapp,S., Edwards,A., Von Delft,F. and Sundstrom.M. (2005) Crystal structure of human AK1A in complex with AP5A. Structural Genomics Consortium Oxford, PDB code 1Z83.
-
Filippakopoulos,P., Bunkoczi,G., Jansson,A., Schreurs,A., Knapp,S., Edwards,A., Von Delft,F. and Sundstrom.M. (2005) Crystal structure of human AK1A in complex with AP5A. Structural Genomics Consortium Oxford, PDB code 1Z83.
-
-
-
-
42
-
-
0242500963
-
Structures of human thymidylate kinase in complex with prodrugs: Implications for the structure-based design of novel compounds
-
Ostermann,N., Segura-Pena,D., Meier,C., Veit,T., Monnerjahn,C., Konrad,M. and Lavie,A. (2003) Structures of human thymidylate kinase in complex with prodrugs: Implications for the structure-based design of novel compounds. Biochemistry, 42, 2568-2577.
-
(2003)
Biochemistry
, vol.42
, pp. 2568-2577
-
-
Ostermann, N.1
Segura-Pena, D.2
Meier, C.3
Veit, T.4
Monnerjahn, C.5
Konrad, M.6
Lavie, A.7
-
43
-
-
4043166269
-
Substrate-induced conformational changes in human UMP/CMP kinase
-
Segura-Pena,D., Sekulic,N., Ort,S., Konrad,M. and Lavie,A. (2004) Substrate-induced conformational changes in human UMP/CMP kinase. J. Biol. Chem., 279, 33882-33889.
-
(2004)
J. Biol. Chem
, vol.279
, pp. 33882-33889
-
-
Segura-Pena, D.1
Sekulic, N.2
Ort, S.3
Konrad, M.4
Lavie, A.5
-
44
-
-
0029785130
-
Crystal structure of the complex of UMP/CMP kinase from Dictyostelium discoideum and the bisubstrate inhibitor P1-(5′-adenosyl) P5-(5′-uridyl) pentaphosphate (UP5A) and Mg2 + at 2.2A: Implications for water-mediated specificity
-
Scheffzek,K., Kliche,W., Wiesmuller,L. and Reinstein,J. (1996) Crystal structure of the complex of UMP/CMP kinase from Dictyostelium discoideum and the bisubstrate inhibitor P1-(5′-adenosyl) P5-(5′-uridyl) pentaphosphate (UP5A) and Mg2 + at 2.2A: Implications for water-mediated specificity. Biochemistry, 35, 9716-9727.
-
(1996)
Biochemistry
, vol.35
, pp. 9716-9727
-
-
Scheffzek, K.1
Kliche, W.2
Wiesmuller, L.3
Reinstein, J.4
-
45
-
-
4744343045
-
Linkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pair
-
Wolf-Watz,M., Thai,V., Henzler-Wildman,K., Hadjipavlou,G., Eisenmesser,E.Z. and Kern,D. (2004) Linkage between dynamics and catalysis in a thermophilic-mesophilic enzyme pair. Nat. Struct. Mol. Biol., 11, 945-949.
-
(2004)
Nat. Struct. Mol. Biol
, vol.11
, pp. 945-949
-
-
Wolf-Watz, M.1
Thai, V.2
Henzler-Wildman, K.3
Hadjipavlou, G.4
Eisenmesser, E.Z.5
Kern, D.6
-
46
-
-
33144487234
-
Roles of static and dynamic domains in stability and catalysis of adenylate kinase
-
Bae,E. and Phillips,G.N.Jr (2006) Roles of static and dynamic domains in stability and catalysis of adenylate kinase. Proc. Natl. Acad. Sci. USA, 103, 2132-2137.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 2132-2137
-
-
Bae, E.1
Phillips Jr, G.N.2
-
47
-
-
18244402627
-
Behavior of thymidylate kinase toward monophosphate metabolites and its role in the metabolism of 1-(2′-deoxy-2′-fluoro-beta-L-arabinofuranosyl)-5-methyluracil (Clevudine) and 2′,3′-didehydro-2′,3′-dideoxythymidine in cells
-
Hu,R., Li,L., Degreve,B., Dutschman,G.E., Lam,W. and Cheng,Y.C. (2005) Behavior of thymidylate kinase toward monophosphate metabolites and its role in the metabolism of 1-(2′-deoxy-2′-fluoro-beta-L-arabinofuranosyl)-5-methyluracil (Clevudine) and 2′,3′-didehydro-2′,3′-dideoxythymidine in cells. Antimicrob. Agents Chemother., 49, 2044-2049.
-
(2005)
Antimicrob. Agents Chemother
, vol.49
, pp. 2044-2049
-
-
Hu, R.1
Li, L.2
Degreve, B.3
Dutschman, G.E.4
Lam, W.5
Cheng, Y.C.6
-
48
-
-
0036096201
-
Pharmacology of beta-L-thymidine and beta-L-2′-deoxycytidine in HepG2 cells and primary human hepatocytes: Relevance to chemotherapeutic efficacy against hepatitis B virus
-
Hernandez-Santiago,B., Placidi,L., Cretton-Scott,E., Faraj,A., Bridges,E.G., Bryant,M.L., Rodriguez-Orengo,J., Imbach,J.L., Gosselin,G. et al. (2002) Pharmacology of beta-L-thymidine and beta-L-2′-deoxycytidine in HepG2 cells and primary human hepatocytes: relevance to chemotherapeutic efficacy against hepatitis B virus. Antimicrob. Agents Chemother., 46, 1728-1733.
-
(2002)
Antimicrob. Agents Chemother
, vol.46
, pp. 1728-1733
-
-
Hernandez-Santiago, B.1
Placidi, L.2
Cretton-Scott, E.3
Faraj, A.4
Bridges, E.G.5
Bryant, M.L.6
Rodriguez-Orengo, J.7
Imbach, J.L.8
Gosselin, G.9
-
49
-
-
33846661140
-
Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase
-
Sabini,E., Hazra,S., Konrad,M., Burley,S.K. and Lavie,A. (2007) Structural basis for activation of the therapeutic L-nucleoside analogs 3TC and troxacitabine by human deoxycytidine kinase. Nucleic Acids Res., 35, 186-192.
-
(2007)
Nucleic Acids Res
, vol.35
, pp. 186-192
-
-
Sabini, E.1
Hazra, S.2
Konrad, M.3
Burley, S.K.4
Lavie, A.5
|