Origin of pyrimidine deoxyribonucleotide pools in perfused rat heart: Implications for 3′-azido-3′-deoxythymidine-dependent cardiotoxicity

Biochemical Journal

Volumn 422, Issue 3, 2009, Pages 513-520

  Morris, Gerald W ^a,b   Iams, Tyler A ^a   Slepchenko, Kira G ^a   McKee, Edward E ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NOTRE DAME   (United States)

Author keywords

De novo pyrimidine synthesis; Deoxynucleoside salvage; Deoxynucleoside triphosphate pool; Nucleotide metabolism

Indexed keywords

CARDIOTOXICITY; CYTIDINE; DE NOVO PYRIMIDINE SYNTHESIS; DEOXYNUCLEOSIDE SALVAGE; DEOXYNUCLEOSIDE TRIPHOSPHATE POOL; DEOXYRIBONUCLEOSIDES; ISOTOPIC TRACING; MITOCHONDRIAL DNA; NUCLEAR DNA; NUCLEOSIDE ANALOGUES; NUCLEOTIDE METABOLISM; RAT HEART; RIBONUCLEOTIDES; SALVAGE PATHWAY; SYNTHESIS PATHWAYS; THYMIDINE KINASE;

BIOCHEMISTRY; DNA; GENES; LAKES; METABOLISM; NUCLEIC ACIDS; NUCLEOTIDES; PHOSPHORYLATION;

SYNTHESIS (CHEMICAL);

ADENOSINE TRIPHOSPHATE; CYTIDINE; DEOXYCYTIDINE; PYRIMIDINE DEOXYNUCLEOSIDE; PYRIMIDINE NUCLEOSIDE; RIBONUCLEOTIDE; THYMIDINE KINASE; THYMIDINE KINASE 2; UNCLASSIFIED DRUG; URACIL; URIDINE; ZIDOVUDINE; 2'-DEOXYCYTIDINE 5'-TRIPHOSPHATE; CYTIDINE TRIPHOSPHATE; DEOXYADENOSINE PHOSPHATE; DEOXYCYTIDINE PHOSPHATE; DEOXYCYTIDINE TRIPHOSPHATE; DEOXYGUANOSINE PHOSPHATE; DEOXYURIDINE; PYRIMIDINE NUCLEOTIDE; RNA DIRECTED DNA POLYMERASE INHIBITOR; THYMIDINE 5'-TRIPHOSPHATE; THYMIDINE TRIPHOSPHATE; URIDINE PHOSPHATE; URIDINE TRIPHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOTOXICITY; CONTROLLED STUDY; ENERGY CONSUMPTION; ENZYME PHOSPHORYLATION; HEART PERFUSION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; PYRIMIDINE SYNTHESIS; RAT; ANIMAL; DRUG EFFECT; HEART; IN VITRO STUDY; MALE; METABOLISM; PERFUSION; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTIDINE; CYTIDINE TRIPHOSPHATE; DEOXYADENINE NUCLEOTIDES; DEOXYCYTIDINE; DEOXYCYTOSINE NUCLEOTIDES; DEOXYGUANINE NUCLEOTIDES; DEOXYURIDINE; HEART; MALE; PERFUSION; PHOSPHORYLATION; PYRIMIDINE NUCLEOTIDES; RATS; RATS, SPRAGUE-DAWLEY; REVERSE TRANSCRIPTASE INHIBITORS; THYMINE NUCLEOTIDES; URACIL; URIDINE; URIDINE MONOPHOSPHATE; URIDINE TRIPHOSPHATE; ZIDOVUDINE;

EID: 70249142851     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20082427     Document Type: Article

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