-
1
-
-
1442351728
-
The cellular pharmacology of nucleoside- and nucleotide-analogue reverse-transcriptase inhibitors and its relationship to clinical toxicities
-
P.L. Anderson T.N. Kakuda K.A. Lichtenstein The cellular pharmacology of nucleoside- and nucleotide-analogue reverse-transcriptase inhibitors and its relationship to clinical toxicities Clin. Infect. Dis. 38 2004 743 753
-
(2004)
Clin. Infect. Dis.
, vol.38
, pp. 743-753
-
-
Anderson, P.L.1
Kakuda, T.N.2
Lichtenstein, K.A.3
-
2
-
-
0032508491
-
Rat liver mitochondria can hydrolyse thiamine pyrophosphate to thiamine monophosphate which can cross the mitochondrial membrane in a carrier-mediated process
-
M. Barile D. Valenti C. Brizio E. Quagliariello S. Passarella Rat liver mitochondria can hydrolyse thiamine pyrophosphate to thiamine monophosphate which can cross the mitochondrial membrane in a carrier-mediated process FEBS Lett. 435 1998 6 10
-
(1998)
FEBS Lett.
, vol.435
, pp. 6-10
-
-
Barile, M.1
Valenti, D.2
Brizio, C.3
Quagliariello, E.4
Passarella, S.5
-
3
-
-
29144503030
-
A computational model of mitochondrial AZT metabolism
-
P.C. Bradshaw J.X. Li D.C. Samuels A computational model of mitochondrial AZT metabolism Biochem. J. 392 2005 363 373
-
(2005)
Biochem. J.
, vol.392
, pp. 363-373
-
-
Bradshaw, P.C.1
Li, J.X.2
Samuels, D.C.3
-
4
-
-
17644420382
-
A computational model of mitochondrial deoxynucleotide metabolism and DNA replication
-
P.C. Bradshaw D.C. Samuels A computational model of mitochondrial deoxynucleotide metabolism and DNA replication Am. J. Physiol. Cell Physiol. 288 2005 C989 C1002
-
(2005)
Am. J. Physiol. Cell Physiol.
, vol.288
, pp. C989-C1002
-
-
Bradshaw, P.C.1
Samuels, D.C.2
-
5
-
-
0033582514
-
Characterization of a dCTP transport activity reconstituted from human mitochondria
-
E.G. Bridges Z.L. Jiang Y.C. Cheng Characterization of a dCTP transport activity reconstituted from human mitochondria J. Biol. Chem. 274 1999 4620 4625
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 4620-4625
-
-
Bridges, E.G.1
Jiang, Z.L.2
Cheng, Y.C.3
-
6
-
-
0019978703
-
Replication of animal mitochondrial–DNA
-
D.A. Clayton Replication of animal mitochondrial–DNA Cell 28 1982 693 705
-
(1982)
Cell
, vol.28
, pp. 693-705
-
-
Clayton, D.A.1
-
7
-
-
85120255833
-
Inherited mitochondrial diseases of mtDNA replication
-
W.C. Copeland Inherited mitochondrial diseases of mtDNA replication Annu. Rev. Med. 51 2008 309 324
-
(2008)
Annu. Rev. Med.
, vol.51
, pp. 309-324
-
-
Copeland, W.C.1
-
10
-
-
0042171483
-
Inherited mitochondrial DNA depletion
-
O. Elpeleg Inherited mitochondrial DNA depletion Pediatr. Res. 54 2003 153 159
-
(2003)
Pediatr. Res.
, vol.54
, pp. 153-159
-
-
Elpeleg, O.1
-
11
-
-
33845489103
-
Mitochondrial deoxynucleotide pool sizes in mouse liver and evidence for a transport mechanism for thymidine monophosphate
-
P. Ferraro L. Nicolosi P. Bernardi P. Reichard V. Bianchi Mitochondrial deoxynucleotide pool sizes in mouse liver and evidence for a transport mechanism for thymidine monophosphate Proc. Natl. Acad. Sci. USA 103 2006 18586 18591
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 18586-18591
-
-
Ferraro, P.1
Nicolosi, L.2
Bernardi, P.3
Reichard, P.4
Bianchi, V.5
-
12
-
-
34548503176
-
The insulin-like growth Factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth
-
S. Floyd C. Favre F.M. Lasorsa M. Leahy G. Trigiante P. Stroebel A. Marx G. Loughran K. O’Callaghan C.M.T. Marobbio D.J. Slotboom E.R.S. Kunji F. Palmieri R. O’Connor The insulin-like growth Factor-I-mTOR signaling pathway induces the mitochondrial pyrimidine nucleotide carrier to promote cell growth Mol. Biol. Cell 18 2007 3545 3555
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 3545-3555
-
-
Floyd, S.1
Favre, C.2
Lasorsa, F.M.3
Leahy, M.4
Trigiante, G.5
Stroebel, P.6
Marx, A.7
Loughran, G.8
O’Callaghan, K.9
Marobbio, C.M.T.10
Slotboom, D.J.11
Kunji, E.R.S.12
Palmieri, F.13
O’Connor, R.14
-
13
-
-
33750952513
-
Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system
-
T. Haitina J. Lindblom T. Renstrom R. Fredriksson Fourteen novel human members of mitochondrial solute carrier family 25 (SLC25) widely expressed in the central nervous system Genomics 88 2006 779 790
-
(2006)
Genomics
, vol.88
, pp. 779-790
-
-
Haitina, T.1
Lindblom, J.2
Renstrom, T.3
Fredriksson, R.4
-
14
-
-
0036837666
-
Amish lethal microcephaly: a new metabolic disorder with severe congenital microcephaly and 2-ketoglutaric aciduria
-
R.I. Kelley D. Robinson E.G. Puffenberger K.A. Strauss D.H. Morton Amish lethal microcephaly: a new metabolic disorder with severe congenital microcephaly and 2-ketoglutaric aciduria Am. J. Med. Genet. 112 2002 318 326
-
(2002)
Am. J. Med. Genet.
, vol.112
, pp. 318-326
-
-
Kelley, R.I.1
Robinson, D.2
Puffenberger, E.G.3
Strauss, K.A.4
Morton, D.H.5
-
15
-
-
1942468196
-
The role and structure of mitochondrial carriers
-
E.R.S. Kunji The role and structure of mitochondrial carriers FEBS Lett. 564 2004 239 244
-
(2004)
FEBS Lett.
, vol.564
, pp. 239-244
-
-
Kunji, E.R.S.1
-
16
-
-
33748964653
-
The conserved substrate binding site of mitochondrial carriers
-
E.R.S. Kunji A.J. Robinson The conserved substrate binding site of mitochondrial carriers Biochim. Biophys. Acta – Bioenerg. 1757 2006 1237 1248
-
(2006)
Biochim. Biophys. Acta – Bioenerg.
, vol.1757
, pp. 1237-1248
-
-
Kunji, E.R.S.1
Robinson, A.J.2
-
17
-
-
13444261490
-
Expression of deoxynucleotide carrier is not associated with the mitochondrial DNA depletion caused by anti-HIV dideoxynucleoside analogs and mitochondrial dNTP uptake
-
W. Lam C.S. Chen S.L. Ruan C.H. Leung Y.C. Cheng Expression of deoxynucleotide carrier is not associated with the mitochondrial DNA depletion caused by anti-HIV dideoxynucleoside analogs and mitochondrial dNTP uptake Mol. Pharmacol. 67 2005 408 416
-
(2005)
Mol. Pharmacol.
, vol.67
, pp. 408-416
-
-
Lam, W.1
Chen, C.S.2
Ruan, S.L.3
Leung, C.H.4
Cheng, Y.C.5
-
18
-
-
9244261979
-
Cardiomyopathy, nucleoside reverse transcriptase inhibitors and mitochondria are linked through AIDS and its therapy
-
W. Lewis Cardiomyopathy, nucleoside reverse transcriptase inhibitors and mitochondria are linked through AIDS and its therapy Mitochondrion 4 2004 141 152
-
(2004)
Mitochondrion
, vol.4
, pp. 141-152
-
-
Lewis, W.1
-
19
-
-
0242363266
-
Mitochondrial toxicity of NRTI antiviral drugs: an integrated cellular perspective
-
W. Lewis B.J. Day W.C. Copeland Mitochondrial toxicity of NRTI antiviral drugs: an integrated cellular perspective Nat. Rev. Drug Discov. 2 2003 812 822
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, pp. 812-822
-
-
Lewis, W.1
Day, B.J.2
Copeland, W.C.3
-
20
-
-
27144530639
-
Transgenic expression of the deoxynucleotide carrier causes mitochondrial damage that is enhanced by NRTIs for AIDS
-
W. Lewis C.P. Haase Y.K. Miller B. Ferguson T. Stuart T. Ludaway J. Mcnaught R. Russ J. Steltzer R. Santoianni R. Long G. Fiermonte F. Palmieri Transgenic expression of the deoxynucleotide carrier causes mitochondrial damage that is enhanced by NRTIs for AIDS Lab. Invest. 85 2005 972 981
-
(2005)
Lab. Invest.
, vol.85
, pp. 972-981
-
-
Lewis, W.1
Haase, C.P.2
Miller, Y.K.3
Ferguson, B.4
Stuart, T.5
Ludaway, T.6
Mcnaught, J.7
Russ, R.8
Steltzer, J.9
Santoianni, R.10
Long, R.11
Fiermonte, G.12
Palmieri, F.13
-
21
-
-
33745067485
-
Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol gamma hypothesis
-
W. Lewis J.J. Kohler S.H. Hosseini C.P. Haase W.C. Copeland R.J. Bienstock T. Ludaway J. McNaught R. Russ T. Stuart R. Santoianni Antiretroviral nucleosides, deoxynucleotide carrier and mitochondrial DNA: evidence supporting the DNA pol gamma hypothesis AIDS 20 2006 675 684
-
(2006)
AIDS
, vol.20
, pp. 675-684
-
-
Lewis, W.1
Kohler, J.J.2
Hosseini, S.H.3
Haase, C.P.4
Copeland, W.C.5
Bienstock, R.J.6
Ludaway, T.7
McNaught, J.8
Russ, R.9
Stuart, T.10
Santoianni, R.11
-
22
-
-
33750475923
-
Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia
-
M.J. Lindhurst G. Fiermonte S.W. Song E. Struys F. De Leonardis P.L. Schwartzberg A. Chen A. Castegna N. Verhoeven C.K. Mathews F. Palmieri L.G. Biesecker Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia Proc. Natl. Acad. Sci. USA 103 2006 15927 15932
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 15927-15932
-
-
Lindhurst, M.J.1
Fiermonte, G.2
Song, S.W.3
Struys, E.4
De Leonardis, F.5
Schwartzberg, P.L.6
Chen, A.7
Castegna, A.8
Verhoeven, N.9
Mathews, C.K.10
Palmieri, F.11
Biesecker, L.G.12
-
23
-
-
33645124958
-
3′-azido-3′-deoxythymidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: a possible mechanism of AZT hepatotoxicity
-
M.D. Lynx A.T. Bentley E.E. McKee 3′-azido-3′-deoxythymidine (AZT) inhibits thymidine phosphorylation in isolated rat liver mitochondria: a possible mechanism of AZT hepatotoxicity Biochem. Pharmacol. 71 2006 1342 1348
-
(2006)
Biochem. Pharmacol.
, vol.71
, pp. 1342-1348
-
-
Lynx, M.D.1
Bentley, A.T.2
McKee, E.E.3
-
24
-
-
30744433627
-
Identification of a mitochondrial transporter for pyrimidine nucleotides in Saccharomyces cerevisiae: bacterial expression, reconstitution and functional characterization
-
C.M.T. Marobbio M.A. Di Noia F. Palmieri Identification of a mitochondrial transporter for pyrimidine nucleotides in Saccharomyces cerevisiae : bacterial expression, reconstitution and functional characterization Biochem. J. 393 2006 441 446
-
(2006)
Biochem. J.
, vol.393
, pp. 441-446
-
-
Marobbio, C.M.T.1
Di Noia, M.A.2
Palmieri, F.3
-
25
-
-
0036845261
-
Identification and reconstitution of the yeast mitochondrial transporter for thiamine pyrophosphate
-
C.M.T. Marobbio A. Vozza M. Harding F. Bisaccia F. Palmieri J.E. Walker Identification and reconstitution of the yeast mitochondrial transporter for thiamine pyrophosphate EMBO J. 21 2002 5653 5661
-
(2002)
EMBO J.
, vol.21
, pp. 5653-5661
-
-
Marobbio, C.M.T.1
Vozza, A.2
Harding, M.3
Bisaccia, F.4
Palmieri, F.5
Walker, J.E.6
-
26
-
-
0042474390
-
Alteration of nucleotide metabolism: a new mechanism for mitochondrial disorders
-
R. Marti Y. Nishigaki M.R. Vila M. Hirano Alteration of nucleotide metabolism: a new mechanism for mitochondrial disorders Clin. Chem. Lab. Med. 41 2003 845 851
-
(2003)
Clin. Chem. Lab. Med.
, vol.41
, pp. 845-851
-
-
Marti, R.1
Nishigaki, Y.2
Vila, M.R.3
Hirano, M.4
-
27
-
-
33746539166
-
DNA precursor metabolism and genomic stability
-
C.K. Mathews DNA precursor metabolism and genomic stability FASEB J. 20 2006 1300 1314
-
(2006)
FASEB J.
, vol.20
, pp. 1300-1314
-
-
Mathews, C.K.1
-
28
-
-
1242317666
-
The mitochondrial transporter family (SLC25): physiological and pathological implications
-
F. Palmieri The mitochondrial transporter family (SLC25): physiological and pathological implications Pflugers Arch. 447 2004 689 709
-
(2004)
Pflugers Arch.
, vol.447
, pp. 689-709
-
-
Palmieri, F.1
-
30
-
-
23144439258
-
Intracellular interactions between nucleos(t)ide inhibitors of HIV reverse transcriptase
-
A.S. Ray Intracellular interactions between nucleos(t)ide inhibitors of HIV reverse transcriptase AIDS Rev. 7 2005 113 125
-
(2005)
AIDS Rev.
, vol.7
, pp. 113-125
-
-
Ray, A.S.1
-
31
-
-
18544382852
-
Mutant deoxynucleotide carrier is associated with congenital microcephaly
-
M.J. Rosenberg R. Agarwala G. Bouffard J. Davis G. Fiermonte M.S. Hilliard T. Koch L.M. Kalikin I. Makalowska D.H. Morton E.M. Petty J.L. Weber F. Palmieri R.I. Kelley A.A. Schaffer L.G. Biesecker Mutant deoxynucleotide carrier is associated with congenital microcephaly Nat. Genet. 32 2002 175 179
-
(2002)
Nat. Genet.
, vol.32
, pp. 175-179
-
-
Rosenberg, M.J.1
Agarwala, R.2
Bouffard, G.3
Davis, J.4
Fiermonte, G.5
Hilliard, M.S.6
Koch, T.7
Kalikin, L.M.8
Makalowska, I.9
Morton, D.H.10
Petty, E.M.11
Weber, J.L.12
Palmieri, F.13
Kelley, R.I.14
Schaffer, A.A.15
Biesecker, L.G.16
-
32
-
-
10344253295
-
Deoxyribonucleotides and disorders of mitochondrial DNA integrity
-
A. Saada Deoxyribonucleotides and disorders of mitochondrial DNA integrity DNA Cell Biol. 23 2004 797 806
-
(2004)
DNA Cell Biol.
, vol.23
, pp. 797-806
-
-
Saada, A.1
-
33
-
-
0038183839
-
mtDNA depletion myopathy: elucidation of the tissue specificity in the mitochondrial thymidine kinase (TK2) deficiency
-
A. Saada A. Shaag O. Elpeleg mtDNA depletion myopathy: elucidation of the tissue specificity in the mitochondrial thymidine kinase (TK2) deficiency Mol. Genet. Metab. 79 2003 1 5
-
(2003)
Mol. Genet. Metab.
, vol.79
, pp. 1-5
-
-
Saada, A.1
Shaag, A.2
Elpeleg, O.3
-
35
-
-
33745698359
-
Mitochondrial AZT metabolism
-
D.C. Samuels Mitochondrial AZT metabolism IUBMB Life 58 2006 403–408
-
(2006)
IUBMB Life
, vol.58
, pp. 403–408
-
-
Samuels, D.C.1
-
36
-
-
18744389159
-
Mitochondria from cultured cells derived from normal and thiamine-responsive megaloblastic anemia individuals efficiently import thiamine diphosphate
-
Q. Song C.K. Singleton Mitochondria from cultured cells derived from normal and thiamine-responsive megaloblastic anemia individuals efficiently import thiamine diphosphate BMC Biochem. 3 2002 8
-
(2002)
BMC Biochem.
, vol.3
, pp. 8
-
-
Song, Q.1
Singleton, C.K.2
-
37
-
-
0042632468
-
Mitochondrial DNA depletion can be prevented by dGMP and dAMP supplementation in a resting culture of deoxyguanosine kinase-deficient fibroblasts
-
J.W. Taanman J.R. Muddle A.C. Muntau Mitochondrial DNA depletion can be prevented by dGMP and dAMP supplementation in a resting culture of deoxyguanosine kinase-deficient fibroblasts Hum. Mol. Genet. 12 2003 1839 1845
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 1839-1845
-
-
Taanman, J.W.1
Muddle, J.R.2
Muntau, A.C.3
-
38
-
-
0028143584
-
Physiological concentrations of purines and pyrimidines
-
T.W. Traut Physiological concentrations of purines and pyrimidines Mol. Cell. Biochem. 140 1994 1 22
-
(1994)
Mol. Cell. Biochem.
, vol.140
, pp. 1-22
-
-
Traut, T.W.1
-
39
-
-
4944260285
-
Mitochondrial disorders
-
M. Zeviani S. Di Donato Mitochondrial disorders Brain 127 2004 2153 2172
-
(2004)
Brain
, vol.127
, pp. 2153-2172
-
-
Zeviani, M.1
Di Donato, S.2
|