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Volumn 584, Issue 18, 2010, Pages 3878-3884

Nuclear EGFR shuttling induced by ionizing radiation is regulated by phosphorylation at residue Thr654

Author keywords

Cell survival; DNA repair; Nuclear EGFR; Phosphorylation

Indexed keywords

DNA DEPENDENT PROTEIN KINASE; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUTAMINE; PEPTIDE; THREONINE; EGFR PROTEIN, HUMAN; NUCLEAR LOCALIZATION SIGNAL;

EID: 77956939857     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.febslet.2010.08.005     Document Type: Article
Times cited : (69)

References (42)
  • 1
    • 33846641194 scopus 로고    scopus 로고
    • High EGFR expression predicts poor prognosis in patients with squamous cell carcinoma of the oral cavity and oropharynx: a TMA-based immunohistochemical analysis
    • Laimer K., et al. High EGFR expression predicts poor prognosis in patients with squamous cell carcinoma of the oral cavity and oropharynx: a TMA-based immunohistochemical analysis. Oral Oncol. 2007, 43:193-198.
    • (2007) Oral Oncol. , vol.43 , pp. 193-198
    • Laimer, K.1
  • 2
    • 34548803430 scopus 로고    scopus 로고
    • Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer
    • Franovic A., Gunaratnam L., Smith K., Robert I., Patten D., Lee S. Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer. Proc. Natl. Acad. Sci. USA 2007, 104:13092-13097.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 13092-13097
    • Franovic, A.1    Gunaratnam, L.2    Smith, K.3    Robert, I.4    Patten, D.5    Lee, S.6
  • 4
    • 36849032852 scopus 로고    scopus 로고
    • Radiation-induced EGFR-signaling and control of DNA-damage repair
    • Rodemann H.P., Dittmann K., Toulany M. Radiation-induced EGFR-signaling and control of DNA-damage repair. Int. J. Radiat. Biol. 2007, 83:781-791.
    • (2007) Int. J. Radiat. Biol. , vol.83 , pp. 781-791
    • Rodemann, H.P.1    Dittmann, K.2    Toulany, M.3
  • 5
    • 36549072385 scopus 로고    scopus 로고
    • Validation of HB-EGF and amphiregulin as targets for human cancer therapy
    • Yotsumoto F., et al. Validation of HB-EGF and amphiregulin as targets for human cancer therapy. Biochem. Biophys. Res. Commun. 2008, 365:555-561.
    • (2008) Biochem. Biophys. Res. Commun. , vol.365 , pp. 555-561
    • Yotsumoto, F.1
  • 6
    • 34548066097 scopus 로고    scopus 로고
    • An update of the mechanisms of resistance to EGFR-tyrosine kinase inhibitors in breast cancer: Gefitinib (Iressa)-induced changes in the expression and nucleo-cytoplasmic trafficking of HER-ligands (review)
    • Ferrer-Soler L., Vazquez-Martin A., Brunet J., Menendez J.A., De Llorens R., Colomer R. An update of the mechanisms of resistance to EGFR-tyrosine kinase inhibitors in breast cancer: Gefitinib (Iressa)-induced changes in the expression and nucleo-cytoplasmic trafficking of HER-ligands (review). Int. J. Mol. Med. 2007, 20:3-10.
    • (2007) Int. J. Mol. Med. , vol.20 , pp. 3-10
    • Ferrer-Soler, L.1    Vazquez-Martin, A.2    Brunet, J.3    Menendez, J.A.4    De Llorens, R.5    Colomer, R.6
  • 7
    • 0029790979 scopus 로고    scopus 로고
    • Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents
    • Knebel A., Rahmsdorf H.J., Ullrich A., Herrlich P. Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents. EMBO J. 1996, 15:5314-5325.
    • (1996) EMBO J. , vol.15 , pp. 5314-5325
    • Knebel, A.1    Rahmsdorf, H.J.2    Ullrich, A.3    Herrlich, P.4
  • 8
    • 33748742635 scopus 로고    scopus 로고
    • Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression
    • Peng X.H., Karna P., Cao Z., Jiang B.H., Zhou M., Yang L. Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression. J. Biol. Chem. 2006, 281:25903-25914.
    • (2006) J. Biol. Chem. , vol.281 , pp. 25903-25914
    • Peng, X.H.1    Karna, P.2    Cao, Z.3    Jiang, B.H.4    Zhou, M.5    Yang, L.6
  • 9
    • 37849185221 scopus 로고    scopus 로고
    • Extracellular heat shock protein 70 mediates heat stress-induced epidermal growth factor receptor transactivation in A431 carcinoma cells
    • Evdonin A.L., Guzhova I.V., Margulis B.A., Medvedeva N.D. Extracellular heat shock protein 70 mediates heat stress-induced epidermal growth factor receptor transactivation in A431 carcinoma cells. FEBS Lett. 2006, 580:6674-6678.
    • (2006) FEBS Lett. , vol.580 , pp. 6674-6678
    • Evdonin, A.L.1    Guzhova, I.V.2    Margulis, B.A.3    Medvedeva, N.D.4
  • 10
    • 33646141025 scopus 로고    scopus 로고
    • Epidermal growth factor receptor exposed to oxidative stress undergoes Src- and caveolin-1-dependent perinuclear trafficking
    • Khan E.M., Heidinger J.M., Levy M., Lisanti M.P., Ravid T., Goldkorn T. Epidermal growth factor receptor exposed to oxidative stress undergoes Src- and caveolin-1-dependent perinuclear trafficking. J. Biol. Chem. 2006, 281:14486-14493.
    • (2006) J. Biol. Chem. , vol.281 , pp. 14486-14493
    • Khan, E.M.1    Heidinger, J.M.2    Levy, M.3    Lisanti, M.P.4    Ravid, T.5    Goldkorn, T.6
  • 11
    • 38449087529 scopus 로고    scopus 로고
    • Crosstalk between G-protein-coupled receptors and epidermal growth factor receptor in cancer
    • Bhola N.E., Grandis J.R. Crosstalk between G-protein-coupled receptors and epidermal growth factor receptor in cancer. Front. Biosci. 2008, 13:1857-1865.
    • (2008) Front. Biosci. , vol.13 , pp. 1857-1865
    • Bhola, N.E.1    Grandis, J.R.2
  • 12
    • 34548037952 scopus 로고    scopus 로고
    • Identification of EGF receptor C-terminal sequences 1005-1017 and di-leucine motif 1010LL1011 as essential in EGF receptor endocytosis
    • Wang Q., Zhu F., Wang Z. Identification of EGF receptor C-terminal sequences 1005-1017 and di-leucine motif 1010LL1011 as essential in EGF receptor endocytosis. Exp. Cell Res. 2007, 313:3349-3363.
    • (2007) Exp. Cell Res. , vol.313 , pp. 3349-3363
    • Wang, Q.1    Zhu, F.2    Wang, Z.3
  • 13
    • 0034805908 scopus 로고    scopus 로고
    • Receptor heterodimerization: essential mechanism for platelet-derived growth factor-induced epidermal growth factor receptor transactivation
    • Saito Y., Haendeler J., Hojo Y., Yamamoto K., Berk B.C. Receptor heterodimerization: essential mechanism for platelet-derived growth factor-induced epidermal growth factor receptor transactivation. Mol. Cell. Biol. 2001, 21:6387-6394.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 6387-6394
    • Saito, Y.1    Haendeler, J.2    Hojo, Y.3    Yamamoto, K.4    Berk, B.C.5
  • 14
    • 24744449739 scopus 로고    scopus 로고
    • Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase
    • Dittmann K., et al. Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase. J. Biol. Chem. 2005, 280:31182-31189.
    • (2005) J. Biol. Chem. , vol.280 , pp. 31182-31189
    • Dittmann, K.1
  • 15
    • 33746088022 scopus 로고    scopus 로고
    • Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair
    • Toulany M., et al. Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair. Clin. Cancer Res. 2006, 12:4119-4126.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 4119-4126
    • Toulany, M.1
  • 16
    • 34548058584 scopus 로고    scopus 로고
    • Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity
    • Toulany M., Baumann M., Rodemann H.P. Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity. Mol. Cancer Res. 2007, 5:863-872.
    • (2007) Mol. Cancer Res. , vol.5 , pp. 863-872
    • Toulany, M.1    Baumann, M.2    Rodemann, H.P.3
  • 17
    • 52749092194 scopus 로고    scopus 로고
    • Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK
    • Dittmann K., Mayer C., Kehlbach R., Rodemann H.P. Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK. Mol. Cancer. 2008, 7:69.
    • (2008) Mol. Cancer. , vol.7 , pp. 69
    • Dittmann, K.1    Mayer, C.2    Kehlbach, R.3    Rodemann, H.P.4
  • 18
    • 52049105154 scopus 로고    scopus 로고
    • PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro
    • Toulany M., Dittmann K., Fehrenbacher B., Schaller M., Baumann M., Rodemann H.P. PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro. DNA Repair (Amst) 2008, 7:1746-1756.
    • (2008) DNA Repair (Amst) , vol.7 , pp. 1746-1756
    • Toulany, M.1    Dittmann, K.2    Fehrenbacher, B.3    Schaller, M.4    Baumann, M.5    Rodemann, H.P.6
  • 19
    • 33947118714 scopus 로고    scopus 로고
    • Role of the Sec61 translocon in EGF receptor trafficking to the nucleus and gene expression
    • Liao H.J., Carpenter G. Role of the Sec61 translocon in EGF receptor trafficking to the nucleus and gene expression. Mol. Biol. Cell 2007, 18:1064-1072.
    • (2007) Mol. Biol. Cell , vol.18 , pp. 1064-1072
    • Liao, H.J.1    Carpenter, G.2
  • 20
    • 33846058726 scopus 로고    scopus 로고
    • Repeat 18F-FDG PET for monitoring neoadjuvant chemotherapy in patients with stage III non-small cell lung cancer
    • Eschmann S.M., et al. Repeat 18F-FDG PET for monitoring neoadjuvant chemotherapy in patients with stage III non-small cell lung cancer. Lung Cancer 2007, 55:165-171.
    • (2007) Lung Cancer , vol.55 , pp. 165-171
    • Eschmann, S.M.1
  • 22
    • 40249109168 scopus 로고    scopus 로고
    • Activation of protein kinase Cepsilon stimulates DNA-repair via epidermal growth factor receptor nuclear accumulation
    • Wanner G., Mayer C., Kehlbach R., Rodemann H.P., Dittmann K. Activation of protein kinase Cepsilon stimulates DNA-repair via epidermal growth factor receptor nuclear accumulation. Radiother. Oncol. 2008, 86:383-390.
    • (2008) Radiother. Oncol. , vol.86 , pp. 383-390
    • Wanner, G.1    Mayer, C.2    Kehlbach, R.3    Rodemann, H.P.4    Dittmann, K.5
  • 23
    • 0034714277 scopus 로고    scopus 로고
    • Threonine phosphorylation diverts internalized epidermal growth factor receptors from a degradative pathway to the recycling endosome
    • Bao J., Alroy I., Waterman H., Schejter E.D., Brodie C., Gruenberg J., Yarden Y. Threonine phosphorylation diverts internalized epidermal growth factor receptors from a degradative pathway to the recycling endosome. J. Biol. Chem. 2000, 275:26178-26186.
    • (2000) J. Biol. Chem. , vol.275 , pp. 26178-26186
    • Bao, J.1    Alroy, I.2    Waterman, H.3    Schejter, E.D.4    Brodie, C.5    Gruenberg, J.6    Yarden, Y.7
  • 24
    • 0028302276 scopus 로고
    • Expression of epidermal growth factor receptor in bladder cancer as related to established prognostic factors, oncoprotein (c-erbB-2, p53) expression and long-term prognosis
    • Lipponen P., Eskelinen M. Expression of epidermal growth factor receptor in bladder cancer as related to established prognostic factors, oncoprotein (c-erbB-2, p53) expression and long-term prognosis. Br. J. Cancer 1994, 69:1120-1125.
    • (1994) Br. J. Cancer , vol.69 , pp. 1120-1125
    • Lipponen, P.1    Eskelinen, M.2
  • 25
    • 0034069067 scopus 로고    scopus 로고
    • The nuclear accumulation of a variant epidermal growth factor receptor (EGFR) lacking the transmembrane domain requires coexpression of a full-length EGFR
    • Marti U., Wells A. The nuclear accumulation of a variant epidermal growth factor receptor (EGFR) lacking the transmembrane domain requires coexpression of a full-length EGFR. Mol. Cell Biol. Res. Commun. 2000, 3:8-14.
    • (2000) Mol. Cell Biol. Res. Commun. , vol.3 , pp. 8-14
    • Marti, U.1    Wells, A.2
  • 26
    • 11244280137 scopus 로고    scopus 로고
    • Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer [erratum appears in Cancer Res. 2005 Mar 1;65(5):2045]
    • Lo H.W., Xia W., Wei Y., Ali-Seyed M., Huang S.F., Hung M.C. Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer [erratum appears in Cancer Res. 2005 Mar 1;65(5):2045]. Cancer Res. 2005, 65:338-348.
    • (2005) Cancer Res. , vol.65 , pp. 338-348
    • Lo, H.W.1    Xia, W.2    Wei, Y.3    Ali-Seyed, M.4    Huang, S.F.5    Hung, M.C.6
  • 27
    • 23844442173 scopus 로고    scopus 로고
    • Quantitative determination of nuclear and cytoplasmic epidermal growth factor receptor expression in oropharyngeal squamous cell cancer by using automated quantitative analysis
    • Psyrri A., Yu Z., Weinberger P.M., Sasaki C., Haffty B., Camp R., Rimm D., Burtness B.A. Quantitative determination of nuclear and cytoplasmic epidermal growth factor receptor expression in oropharyngeal squamous cell cancer by using automated quantitative analysis. Clin. Cancer Res. 2005, 11:5856-5862.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 5856-5862
    • Psyrri, A.1    Yu, Z.2    Weinberger, P.M.3    Sasaki, C.4    Haffty, B.5    Camp, R.6    Rimm, D.7    Burtness, B.A.8
  • 28
    • 0035496541 scopus 로고    scopus 로고
    • The role of c-erbB-2/HER2/neu in breast cancer progression and metastasis
    • Eccles S.A. The role of c-erbB-2/HER2/neu in breast cancer progression and metastasis. J Mammary Gland Biol. Neoplasia. 2001, 6:393-406.
    • (2001) J Mammary Gland Biol. Neoplasia. , vol.6 , pp. 393-406
    • Eccles, S.A.1
  • 30
    • 12344299675 scopus 로고    scopus 로고
    • Growth of intestinal epithelium in organ culture is dependent on EGF signalling
    • Abud H.E., Watson N., Heath J.K. Growth of intestinal epithelium in organ culture is dependent on EGF signalling. Exp. Cell Res. 2005, 303:252-262.
    • (2005) Exp. Cell Res. , vol.303 , pp. 252-262
    • Abud, H.E.1    Watson, N.2    Heath, J.K.3
  • 31
    • 31444440292 scopus 로고    scopus 로고
    • Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival
    • Lo H.W., Hung M.C. Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival. Br. J. Cancer 2006, 94:184-188.
    • (2006) Br. J. Cancer , vol.94 , pp. 184-188
    • Lo, H.W.1    Hung, M.C.2
  • 32
    • 0031891006 scopus 로고    scopus 로고
    • Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells
    • Bandyopadhyay D., Mandal M., Adam L., Mendelsohn J., Kumar R. Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells. J. Biol. Chem. 1998, 273:1568-1573.
    • (1998) J. Biol. Chem. , vol.273 , pp. 1568-1573
    • Bandyopadhyay, D.1    Mandal, M.2    Adam, L.3    Mendelsohn, J.4    Kumar, R.5
  • 33
    • 34248358971 scopus 로고    scopus 로고
    • Nuclear expression of phosphorylated EGFR is associated with poor prognosis of patients with esophageal squamous cell carcinoma
    • Hoshino M., et al. Nuclear expression of phosphorylated EGFR is associated with poor prognosis of patients with esophageal squamous cell carcinoma. Pathobiology 2007, 74:15-21.
    • (2007) Pathobiology , vol.74 , pp. 15-21
    • Hoshino, M.1
  • 34
    • 65649138288 scopus 로고    scopus 로고
    • Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer
    • Xia W., et al. Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer. Mol. Carcinog. 2008.
    • (2008) Mol. Carcinog.
    • Xia, W.1
  • 35
    • 0030772168 scopus 로고    scopus 로고
    • Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation
    • Schmidt-Ullrich R.K., et al. Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation. Oncogene 1997, 15:1191-1197.
    • (1997) Oncogene , vol.15 , pp. 1191-1197
    • Schmidt-Ullrich, R.K.1
  • 36
    • 0036315395 scopus 로고    scopus 로고
    • The UV (Ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular signal-regulated kinase signaling cascade from the activated epidermal growth factor receptor
    • Iordanov M.S., Choi R.J., Ryabinina O.P., Dinh T.H., Bright R.K., Magun B.E. The UV (Ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular signal-regulated kinase signaling cascade from the activated epidermal growth factor receptor. Mol. Cell. Biol. 2002, 22:5380-5394.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 5380-5394
    • Iordanov, M.S.1    Choi, R.J.2    Ryabinina, O.P.3    Dinh, T.H.4    Bright, R.K.5    Magun, B.E.6
  • 37
    • 37649013040 scopus 로고    scopus 로고
    • Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation
    • Thiel K.W., Carpenter G. Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation. Proc. Natl. Acad. Sci. USA 2007, 104:19238-19243.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 19238-19243
    • Thiel, K.W.1    Carpenter, G.2
  • 38
    • 34247135913 scopus 로고    scopus 로고
    • Classical nuclear localization signals: definition, function, and interaction with importin alpha
    • Lange A., Mills R.E., Lange C.J., Stewart M., Devine S.E., Corbett A.H. Classical nuclear localization signals: definition, function, and interaction with importin alpha. J. Biol. Chem. 2007, 282:5101-5105.
    • (2007) J. Biol. Chem. , vol.282 , pp. 5101-5105
    • Lange, A.1    Mills, R.E.2    Lange, C.J.3    Stewart, M.4    Devine, S.E.5    Corbett, A.H.6
  • 39
    • 0029797971 scopus 로고    scopus 로고
    • Regulation of protein transport to the nucleus: central role of phosphorylation
    • Jans D.A., Hubner S. Regulation of protein transport to the nucleus: central role of phosphorylation. Physiol. Rev. 1996, 76:651-685.
    • (1996) Physiol. Rev. , vol.76 , pp. 651-685
    • Jans, D.A.1    Hubner, S.2
  • 40
    • 33748089029 scopus 로고    scopus 로고
    • DNA-PK autophosphorylation facilitates Artemis endonuclease activity
    • Goodarzi A.A., et al. DNA-PK autophosphorylation facilitates Artemis endonuclease activity. EMBO J. 2006, 25:3880-3889.
    • (2006) EMBO J. , vol.25 , pp. 3880-3889
    • Goodarzi, A.A.1
  • 41
    • 51049105757 scopus 로고    scopus 로고
    • Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair
    • Toulany M., Kehlbach R., Florczak U., Sak A., Wang S., Chen J., Lobrich M., Rodemann H.P. Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair. Mol. Cancer Ther. 2008, 7:1772-1781.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 1772-1781
    • Toulany, M.1    Kehlbach, R.2    Florczak, U.3    Sak, A.4    Wang, S.5    Chen, J.6    Lobrich, M.7    Rodemann, H.P.8
  • 42
    • 0042632901 scopus 로고    scopus 로고
    • Pathways of DNA double-strand break repair during the mammalian cell cycle
    • Rothkamm K., Kruger I., Thompson L.H., Lobrich M. Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol. Cell. Biol. 2003, 23:5706-5715.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 5706-5715
    • Rothkamm, K.1    Kruger, I.2    Thompson, L.H.3    Lobrich, M.4


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