-
1
-
-
33846641194
-
High EGFR expression predicts poor prognosis in patients with squamous cell carcinoma of the oral cavity and oropharynx: a TMA-based immunohistochemical analysis
-
Laimer K., et al. High EGFR expression predicts poor prognosis in patients with squamous cell carcinoma of the oral cavity and oropharynx: a TMA-based immunohistochemical analysis. Oral Oncol. 2007, 43:193-198.
-
(2007)
Oral Oncol.
, vol.43
, pp. 193-198
-
-
Laimer, K.1
-
2
-
-
34548803430
-
Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer
-
Franovic A., Gunaratnam L., Smith K., Robert I., Patten D., Lee S. Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer. Proc. Natl. Acad. Sci. USA 2007, 104:13092-13097.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 13092-13097
-
-
Franovic, A.1
Gunaratnam, L.2
Smith, K.3
Robert, I.4
Patten, D.5
Lee, S.6
-
3
-
-
34250345258
-
EGFR-targeted anti-cancer drugs in radiotherapy: preclinical evaluation of mechanisms
-
Baumann M., Krause M., Dikomey E., Dittmann K., Dorr W., Kasten-Pisula U., Rodemann H.P. EGFR-targeted anti-cancer drugs in radiotherapy: preclinical evaluation of mechanisms. Radiother. Oncol. 2007, 83:238-248.
-
(2007)
Radiother. Oncol.
, vol.83
, pp. 238-248
-
-
Baumann, M.1
Krause, M.2
Dikomey, E.3
Dittmann, K.4
Dorr, W.5
Kasten-Pisula, U.6
Rodemann, H.P.7
-
4
-
-
36849032852
-
Radiation-induced EGFR-signaling and control of DNA-damage repair
-
Rodemann H.P., Dittmann K., Toulany M. Radiation-induced EGFR-signaling and control of DNA-damage repair. Int. J. Radiat. Biol. 2007, 83:781-791.
-
(2007)
Int. J. Radiat. Biol.
, vol.83
, pp. 781-791
-
-
Rodemann, H.P.1
Dittmann, K.2
Toulany, M.3
-
5
-
-
36549072385
-
Validation of HB-EGF and amphiregulin as targets for human cancer therapy
-
Yotsumoto F., et al. Validation of HB-EGF and amphiregulin as targets for human cancer therapy. Biochem. Biophys. Res. Commun. 2008, 365:555-561.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.365
, pp. 555-561
-
-
Yotsumoto, F.1
-
6
-
-
34548066097
-
An update of the mechanisms of resistance to EGFR-tyrosine kinase inhibitors in breast cancer: Gefitinib (Iressa)-induced changes in the expression and nucleo-cytoplasmic trafficking of HER-ligands (review)
-
Ferrer-Soler L., Vazquez-Martin A., Brunet J., Menendez J.A., De Llorens R., Colomer R. An update of the mechanisms of resistance to EGFR-tyrosine kinase inhibitors in breast cancer: Gefitinib (Iressa)-induced changes in the expression and nucleo-cytoplasmic trafficking of HER-ligands (review). Int. J. Mol. Med. 2007, 20:3-10.
-
(2007)
Int. J. Mol. Med.
, vol.20
, pp. 3-10
-
-
Ferrer-Soler, L.1
Vazquez-Martin, A.2
Brunet, J.3
Menendez, J.A.4
De Llorens, R.5
Colomer, R.6
-
7
-
-
0029790979
-
Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents
-
Knebel A., Rahmsdorf H.J., Ullrich A., Herrlich P. Dephosphorylation of receptor tyrosine kinases as target of regulation by radiation, oxidants or alkylating agents. EMBO J. 1996, 15:5314-5325.
-
(1996)
EMBO J.
, vol.15
, pp. 5314-5325
-
-
Knebel, A.1
Rahmsdorf, H.J.2
Ullrich, A.3
Herrlich, P.4
-
8
-
-
33748742635
-
Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression
-
Peng X.H., Karna P., Cao Z., Jiang B.H., Zhou M., Yang L. Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression. J. Biol. Chem. 2006, 281:25903-25914.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 25903-25914
-
-
Peng, X.H.1
Karna, P.2
Cao, Z.3
Jiang, B.H.4
Zhou, M.5
Yang, L.6
-
9
-
-
37849185221
-
Extracellular heat shock protein 70 mediates heat stress-induced epidermal growth factor receptor transactivation in A431 carcinoma cells
-
Evdonin A.L., Guzhova I.V., Margulis B.A., Medvedeva N.D. Extracellular heat shock protein 70 mediates heat stress-induced epidermal growth factor receptor transactivation in A431 carcinoma cells. FEBS Lett. 2006, 580:6674-6678.
-
(2006)
FEBS Lett.
, vol.580
, pp. 6674-6678
-
-
Evdonin, A.L.1
Guzhova, I.V.2
Margulis, B.A.3
Medvedeva, N.D.4
-
10
-
-
33646141025
-
Epidermal growth factor receptor exposed to oxidative stress undergoes Src- and caveolin-1-dependent perinuclear trafficking
-
Khan E.M., Heidinger J.M., Levy M., Lisanti M.P., Ravid T., Goldkorn T. Epidermal growth factor receptor exposed to oxidative stress undergoes Src- and caveolin-1-dependent perinuclear trafficking. J. Biol. Chem. 2006, 281:14486-14493.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 14486-14493
-
-
Khan, E.M.1
Heidinger, J.M.2
Levy, M.3
Lisanti, M.P.4
Ravid, T.5
Goldkorn, T.6
-
11
-
-
38449087529
-
Crosstalk between G-protein-coupled receptors and epidermal growth factor receptor in cancer
-
Bhola N.E., Grandis J.R. Crosstalk between G-protein-coupled receptors and epidermal growth factor receptor in cancer. Front. Biosci. 2008, 13:1857-1865.
-
(2008)
Front. Biosci.
, vol.13
, pp. 1857-1865
-
-
Bhola, N.E.1
Grandis, J.R.2
-
12
-
-
34548037952
-
Identification of EGF receptor C-terminal sequences 1005-1017 and di-leucine motif 1010LL1011 as essential in EGF receptor endocytosis
-
Wang Q., Zhu F., Wang Z. Identification of EGF receptor C-terminal sequences 1005-1017 and di-leucine motif 1010LL1011 as essential in EGF receptor endocytosis. Exp. Cell Res. 2007, 313:3349-3363.
-
(2007)
Exp. Cell Res.
, vol.313
, pp. 3349-3363
-
-
Wang, Q.1
Zhu, F.2
Wang, Z.3
-
13
-
-
0034805908
-
Receptor heterodimerization: essential mechanism for platelet-derived growth factor-induced epidermal growth factor receptor transactivation
-
Saito Y., Haendeler J., Hojo Y., Yamamoto K., Berk B.C. Receptor heterodimerization: essential mechanism for platelet-derived growth factor-induced epidermal growth factor receptor transactivation. Mol. Cell. Biol. 2001, 21:6387-6394.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 6387-6394
-
-
Saito, Y.1
Haendeler, J.2
Hojo, Y.3
Yamamoto, K.4
Berk, B.C.5
-
14
-
-
24744449739
-
Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase
-
Dittmann K., et al. Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase. J. Biol. Chem. 2005, 280:31182-31189.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 31182-31189
-
-
Dittmann, K.1
-
15
-
-
33746088022
-
Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair
-
Toulany M., et al. Blockage of epidermal growth factor receptor-phosphatidylinositol 3-kinase-AKT signaling increases radiosensitivity of K-RAS mutated human tumor cells in vitro by affecting DNA repair. Clin. Cancer Res. 2006, 12:4119-4126.
-
(2006)
Clin. Cancer Res.
, vol.12
, pp. 4119-4126
-
-
Toulany, M.1
-
16
-
-
34548058584
-
Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity
-
Toulany M., Baumann M., Rodemann H.P. Stimulated PI3K-AKT signaling mediated through ligand or radiation-induced EGFR depends indirectly, but not directly, on constitutive K-Ras activity. Mol. Cancer Res. 2007, 5:863-872.
-
(2007)
Mol. Cancer Res.
, vol.5
, pp. 863-872
-
-
Toulany, M.1
Baumann, M.2
Rodemann, H.P.3
-
17
-
-
52749092194
-
Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK
-
Dittmann K., Mayer C., Kehlbach R., Rodemann H.P. Radiation-induced caveolin-1 associated EGFR internalization is linked with nuclear EGFR transport and activation of DNA-PK. Mol. Cancer. 2008, 7:69.
-
(2008)
Mol. Cancer.
, vol.7
, pp. 69
-
-
Dittmann, K.1
Mayer, C.2
Kehlbach, R.3
Rodemann, H.P.4
-
18
-
-
52049105154
-
PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro
-
Toulany M., Dittmann K., Fehrenbacher B., Schaller M., Baumann M., Rodemann H.P. PI3K-Akt signaling regulates basal, but MAP-kinase signaling regulates radiation-induced XRCC1 expression in human tumor cells in vitro. DNA Repair (Amst) 2008, 7:1746-1756.
-
(2008)
DNA Repair (Amst)
, vol.7
, pp. 1746-1756
-
-
Toulany, M.1
Dittmann, K.2
Fehrenbacher, B.3
Schaller, M.4
Baumann, M.5
Rodemann, H.P.6
-
19
-
-
33947118714
-
Role of the Sec61 translocon in EGF receptor trafficking to the nucleus and gene expression
-
Liao H.J., Carpenter G. Role of the Sec61 translocon in EGF receptor trafficking to the nucleus and gene expression. Mol. Biol. Cell 2007, 18:1064-1072.
-
(2007)
Mol. Biol. Cell
, vol.18
, pp. 1064-1072
-
-
Liao, H.J.1
Carpenter, G.2
-
20
-
-
33846058726
-
Repeat 18F-FDG PET for monitoring neoadjuvant chemotherapy in patients with stage III non-small cell lung cancer
-
Eschmann S.M., et al. Repeat 18F-FDG PET for monitoring neoadjuvant chemotherapy in patients with stage III non-small cell lung cancer. Lung Cancer 2007, 55:165-171.
-
(2007)
Lung Cancer
, vol.55
, pp. 165-171
-
-
Eschmann, S.M.1
-
21
-
-
0034855942
-
Nuclear localization of EGF receptor and its potential new role as a transcription factor
-
Lin S.Y., Makino K., Xia W., Matin A., Wen Y., Kwong K.Y., Bourguignon L., Hung M.C. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat. Cell Biol. 2001, 3:802-808.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 802-808
-
-
Lin, S.Y.1
Makino, K.2
Xia, W.3
Matin, A.4
Wen, Y.5
Kwong, K.Y.6
Bourguignon, L.7
Hung, M.C.8
-
22
-
-
40249109168
-
Activation of protein kinase Cepsilon stimulates DNA-repair via epidermal growth factor receptor nuclear accumulation
-
Wanner G., Mayer C., Kehlbach R., Rodemann H.P., Dittmann K. Activation of protein kinase Cepsilon stimulates DNA-repair via epidermal growth factor receptor nuclear accumulation. Radiother. Oncol. 2008, 86:383-390.
-
(2008)
Radiother. Oncol.
, vol.86
, pp. 383-390
-
-
Wanner, G.1
Mayer, C.2
Kehlbach, R.3
Rodemann, H.P.4
Dittmann, K.5
-
23
-
-
0034714277
-
Threonine phosphorylation diverts internalized epidermal growth factor receptors from a degradative pathway to the recycling endosome
-
Bao J., Alroy I., Waterman H., Schejter E.D., Brodie C., Gruenberg J., Yarden Y. Threonine phosphorylation diverts internalized epidermal growth factor receptors from a degradative pathway to the recycling endosome. J. Biol. Chem. 2000, 275:26178-26186.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 26178-26186
-
-
Bao, J.1
Alroy, I.2
Waterman, H.3
Schejter, E.D.4
Brodie, C.5
Gruenberg, J.6
Yarden, Y.7
-
24
-
-
0028302276
-
Expression of epidermal growth factor receptor in bladder cancer as related to established prognostic factors, oncoprotein (c-erbB-2, p53) expression and long-term prognosis
-
Lipponen P., Eskelinen M. Expression of epidermal growth factor receptor in bladder cancer as related to established prognostic factors, oncoprotein (c-erbB-2, p53) expression and long-term prognosis. Br. J. Cancer 1994, 69:1120-1125.
-
(1994)
Br. J. Cancer
, vol.69
, pp. 1120-1125
-
-
Lipponen, P.1
Eskelinen, M.2
-
25
-
-
0034069067
-
The nuclear accumulation of a variant epidermal growth factor receptor (EGFR) lacking the transmembrane domain requires coexpression of a full-length EGFR
-
Marti U., Wells A. The nuclear accumulation of a variant epidermal growth factor receptor (EGFR) lacking the transmembrane domain requires coexpression of a full-length EGFR. Mol. Cell Biol. Res. Commun. 2000, 3:8-14.
-
(2000)
Mol. Cell Biol. Res. Commun.
, vol.3
, pp. 8-14
-
-
Marti, U.1
Wells, A.2
-
26
-
-
11244280137
-
Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer [erratum appears in Cancer Res. 2005 Mar 1;65(5):2045]
-
Lo H.W., Xia W., Wei Y., Ali-Seyed M., Huang S.F., Hung M.C. Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer [erratum appears in Cancer Res. 2005 Mar 1;65(5):2045]. Cancer Res. 2005, 65:338-348.
-
(2005)
Cancer Res.
, vol.65
, pp. 338-348
-
-
Lo, H.W.1
Xia, W.2
Wei, Y.3
Ali-Seyed, M.4
Huang, S.F.5
Hung, M.C.6
-
27
-
-
23844442173
-
Quantitative determination of nuclear and cytoplasmic epidermal growth factor receptor expression in oropharyngeal squamous cell cancer by using automated quantitative analysis
-
Psyrri A., Yu Z., Weinberger P.M., Sasaki C., Haffty B., Camp R., Rimm D., Burtness B.A. Quantitative determination of nuclear and cytoplasmic epidermal growth factor receptor expression in oropharyngeal squamous cell cancer by using automated quantitative analysis. Clin. Cancer Res. 2005, 11:5856-5862.
-
(2005)
Clin. Cancer Res.
, vol.11
, pp. 5856-5862
-
-
Psyrri, A.1
Yu, Z.2
Weinberger, P.M.3
Sasaki, C.4
Haffty, B.5
Camp, R.6
Rimm, D.7
Burtness, B.A.8
-
28
-
-
0035496541
-
The role of c-erbB-2/HER2/neu in breast cancer progression and metastasis
-
Eccles S.A. The role of c-erbB-2/HER2/neu in breast cancer progression and metastasis. J Mammary Gland Biol. Neoplasia. 2001, 6:393-406.
-
(2001)
J Mammary Gland Biol. Neoplasia.
, vol.6
, pp. 393-406
-
-
Eccles, S.A.1
-
29
-
-
31044450992
-
Co-regulation of B-Myb expression by E2F1 and EGF receptor
-
Hanada N., Lo H.W., Day C.P., Pan Y., Nakajima Y., Hung M.C. Co-regulation of B-Myb expression by E2F1 and EGF receptor. Mol. Carcinog. 2006, 45:10-17.
-
(2006)
Mol. Carcinog.
, vol.45
, pp. 10-17
-
-
Hanada, N.1
Lo, H.W.2
Day, C.P.3
Pan, Y.4
Nakajima, Y.5
Hung, M.C.6
-
30
-
-
12344299675
-
Growth of intestinal epithelium in organ culture is dependent on EGF signalling
-
Abud H.E., Watson N., Heath J.K. Growth of intestinal epithelium in organ culture is dependent on EGF signalling. Exp. Cell Res. 2005, 303:252-262.
-
(2005)
Exp. Cell Res.
, vol.303
, pp. 252-262
-
-
Abud, H.E.1
Watson, N.2
Heath, J.K.3
-
31
-
-
31444440292
-
Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival
-
Lo H.W., Hung M.C. Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival. Br. J. Cancer 2006, 94:184-188.
-
(2006)
Br. J. Cancer
, vol.94
, pp. 184-188
-
-
Lo, H.W.1
Hung, M.C.2
-
32
-
-
0031891006
-
Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells
-
Bandyopadhyay D., Mandal M., Adam L., Mendelsohn J., Kumar R. Physical interaction between epidermal growth factor receptor and DNA-dependent protein kinase in mammalian cells. J. Biol. Chem. 1998, 273:1568-1573.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 1568-1573
-
-
Bandyopadhyay, D.1
Mandal, M.2
Adam, L.3
Mendelsohn, J.4
Kumar, R.5
-
33
-
-
34248358971
-
Nuclear expression of phosphorylated EGFR is associated with poor prognosis of patients with esophageal squamous cell carcinoma
-
Hoshino M., et al. Nuclear expression of phosphorylated EGFR is associated with poor prognosis of patients with esophageal squamous cell carcinoma. Pathobiology 2007, 74:15-21.
-
(2007)
Pathobiology
, vol.74
, pp. 15-21
-
-
Hoshino, M.1
-
34
-
-
65649138288
-
Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer
-
Xia W., et al. Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer. Mol. Carcinog. 2008.
-
(2008)
Mol. Carcinog.
-
-
Xia, W.1
-
35
-
-
0030772168
-
Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation
-
Schmidt-Ullrich R.K., et al. Radiation-induced proliferation of the human A431 squamous carcinoma cells is dependent on EGFR tyrosine phosphorylation. Oncogene 1997, 15:1191-1197.
-
(1997)
Oncogene
, vol.15
, pp. 1191-1197
-
-
Schmidt-Ullrich, R.K.1
-
36
-
-
0036315395
-
The UV (Ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular signal-regulated kinase signaling cascade from the activated epidermal growth factor receptor
-
Iordanov M.S., Choi R.J., Ryabinina O.P., Dinh T.H., Bright R.K., Magun B.E. The UV (Ribotoxic) stress response of human keratinocytes involves the unexpected uncoupling of the Ras-extracellular signal-regulated kinase signaling cascade from the activated epidermal growth factor receptor. Mol. Cell. Biol. 2002, 22:5380-5394.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 5380-5394
-
-
Iordanov, M.S.1
Choi, R.J.2
Ryabinina, O.P.3
Dinh, T.H.4
Bright, R.K.5
Magun, B.E.6
-
37
-
-
37649013040
-
Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation
-
Thiel K.W., Carpenter G. Epidermal growth factor receptor juxtamembrane region regulates allosteric tyrosine kinase activation. Proc. Natl. Acad. Sci. USA 2007, 104:19238-19243.
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 19238-19243
-
-
Thiel, K.W.1
Carpenter, G.2
-
38
-
-
34247135913
-
Classical nuclear localization signals: definition, function, and interaction with importin alpha
-
Lange A., Mills R.E., Lange C.J., Stewart M., Devine S.E., Corbett A.H. Classical nuclear localization signals: definition, function, and interaction with importin alpha. J. Biol. Chem. 2007, 282:5101-5105.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 5101-5105
-
-
Lange, A.1
Mills, R.E.2
Lange, C.J.3
Stewart, M.4
Devine, S.E.5
Corbett, A.H.6
-
39
-
-
0029797971
-
Regulation of protein transport to the nucleus: central role of phosphorylation
-
Jans D.A., Hubner S. Regulation of protein transport to the nucleus: central role of phosphorylation. Physiol. Rev. 1996, 76:651-685.
-
(1996)
Physiol. Rev.
, vol.76
, pp. 651-685
-
-
Jans, D.A.1
Hubner, S.2
-
40
-
-
33748089029
-
DNA-PK autophosphorylation facilitates Artemis endonuclease activity
-
Goodarzi A.A., et al. DNA-PK autophosphorylation facilitates Artemis endonuclease activity. EMBO J. 2006, 25:3880-3889.
-
(2006)
EMBO J.
, vol.25
, pp. 3880-3889
-
-
Goodarzi, A.A.1
-
41
-
-
51049105757
-
Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair
-
Toulany M., Kehlbach R., Florczak U., Sak A., Wang S., Chen J., Lobrich M., Rodemann H.P. Targeting of AKT1 enhances radiation toxicity of human tumor cells by inhibiting DNA-PKcs-dependent DNA double-strand break repair. Mol. Cancer Ther. 2008, 7:1772-1781.
-
(2008)
Mol. Cancer Ther.
, vol.7
, pp. 1772-1781
-
-
Toulany, M.1
Kehlbach, R.2
Florczak, U.3
Sak, A.4
Wang, S.5
Chen, J.6
Lobrich, M.7
Rodemann, H.P.8
-
42
-
-
0042632901
-
Pathways of DNA double-strand break repair during the mammalian cell cycle
-
Rothkamm K., Kruger I., Thompson L.H., Lobrich M. Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol. Cell. Biol. 2003, 23:5706-5715.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 5706-5715
-
-
Rothkamm, K.1
Kruger, I.2
Thompson, L.H.3
Lobrich, M.4
|