Response to Therapy and Outcomes in Oropharyngeal Cancer Are Associated With Biomarkers Including Human Papillomavirus, Epidermal Growth Factor Receptor, Gender, and Smoking

International Journal of Radiation Oncology Biology Physics

Volumn 69, Issue 2 SUPPL., 2007, Pages

  Kumar, Bhavna ^a   Cordell, Kitrina G ^a,b   Lee, Julia S ^b   Prince, Mark E ^a   Tran, Huong H ^a   Wolf, Gregory T ^a   Urba, Susan G ^a   Worden, Francis P ^a   Chepeha, Douglas B ^a   Teknos, Theodoros N ^a   Eisbruch, Avraham ^b   Tsien, Christina I ^b   Taylor, Jeremy M G ^b   D'Silva, Nisha J ^a,b   Yang, Kun ^a   Kurnit, David M ^a   Bradford, Carol R ^a   Carey, Thomas E ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MICHIGAN   (United States)

Author keywords

Chemoradiation; Epidermal growth factor receptor; High risk human papillomavirus; Organ sparing clinical trial; Tonsil cancer

Indexed keywords

BIOLOGICAL ORGANS; BIOMARKERS; CHEMOTHERAPY; SURGERY; TUMORS; VIRUSES;

CHEMORADIATION; EPIDERMAL GROWTH FACTOR RECEPTORS; HUMAN PAPILLOMAVIRUS; ORGAN SPARING CLINICAL TRIALS; TONSIL CANCER;

ONCOLOGY;

BIOLOGICAL MARKER; EPIDERMAL GROWTH FACTOR RECEPTOR;

ADULT; ARTICLE; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CANCER SURGERY; CANCER SURVIVAL; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; GENDER; HEAD AND NECK CANCER; HIGH RISK PATIENT; HUMAN; HUMAN PAPILLOMAVIRUS TYPE 16; HUMAN TISSUE; LARYNX CARCINOMA; MAJOR CLINICAL STUDY; MALE; MULTIVARIATE ANALYSIS; OROPHARYNX CANCER; OROPHARYNX CARCINOMA; OUTCOME ASSESSMENT; PATIENT SELECTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; SMOKING; SMOKING CESSATION; SQUAMOUS CELL CARCINOMA; TONSIL CANCER; TREATMENT OUTCOME; TREATMENT RESPONSE; TUMOR BIOPSY; VIRUS TITRATION; WART VIRUS;

CARCINOMA, SQUAMOUS CELL; FEMALE; HUMAN PAPILLOMAVIRUS 16; HUMANS; MALE; MIDDLE AGED; NEOPLASM PROTEINS; OROPHARYNGEAL NEOPLASMS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SEX FACTORS; SMOKING; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 34548417668     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2007.05.072     Document Type: Article

References (11)

1. Bradford C.R., Wolf G.T., Carey T.E., et al. Predictive markers for response to chemotherapy, organ preservation, and survival in patients with advanced laryngeal carcinoma. Otolaryngol Head Neck Surg 121 (1999) 534-538
2. Urba S., Wolf G., Eisbruch A., et al. Single-cycle induction chemotherapy selects patients with advanced laryngeal cancer for combined chemoradiation: A new treatment paradigm. J Clin Oncol 24 (2006) 593-598
3. Worden F.P., Urba S., Bradford C., et al. One cycle of induction chemotherapy (IC) in advanced oropharyngeal cancer (SCOOP) to select patients for organ preservation (OP). [Abstract]. J Clin Oncol 23 Suppl (2005) 16S
4. Bauer J.A., Trask D.K., Kumar B., et al. Reversal of cisplatin resistance with a BH3 mimetic, (-)gossypol, in head and neck cancer cells: Role of wild-type p53 and Bcl-xL. Mol Cancer Ther 4 (2005) 1096-1104
5. Gillison M.L., Koch W.M., Capone R.B., et al. Evidence for a causal association between human papillomavirus and a subset of head and neck cancers. J Natl Cancer Inst 92 (2000) 709-720
6. Sisk E.A., Soltys S.G., Zhu S., et al. Human papillomavirus and p53 mutational status as prognostic factors in head and neck carcinoma. Head Neck 24 (2002) 841-849
7. Ritchie J.M., Smith E.M., Summersgill K.F., et al. Human papillomavirus infection as a prognostic factor in carcinomas of the oral cavity and oropharynx. Int J Cancer 104 (2003) 336-344
8. Weinberger P.M., Yu Z., Haffty B.G., et al. Molecular classification identifies a subset of human papillomavirus-associated oropharyngeal cancers with favorable prognosis. J Clin Oncol 24 (2006) 736-747
9. Psyrri A., Yu Z., Weinberger P.M., et al. Quantitative determination of nuclear and cytoplasmic epidermal growth factor receptor expression in oropharyngeal squamous cell cancer by using automated quantitative analysis. Clin Cancer Res 11 (2005) 5856-5862
10. Yang H., Yang K., Khafagi A., et al. Sensitive detection of human papillomavirus in cervical, head/neck, and schistosomiasis-associated bladder malignancies. Proc Natl Acad Sci U S A 102 (2005) 7683-7688
11. Fakhry C., and Gillison M.L. Clinical implications of human papillomavirus in head and neck cancers. J Clin Oncol 24 (2006) 2606-2611