Lesional dendritic cells in patients with chronic atopic dermatitis and psoriasis exhibit parallel ability to activate T-cell subsets

Journal of Allergy and Clinical Immunology

Volumn 128, Issue 3, 2011, Pages

  Fujita, Hideki ^a   Shemer, Avner ^b   Suárez Fariñas, Mayte ^a   Johnson Huang, Leanne M ^a   Tintle, Suzanne ^a   Cardinale, Irma ^a   Fuentes Duculan, Judilyn ^a   Novitskaya, Inna ^a   Carucci, John A ^c   Krueger, James G ^a   Guttman Yassky, Emma ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b SHEBA MEDICAL CENTER   (Israel)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Atopic dermatitis; chemokine; dendritic cells; psoriasis; skin; T cell polarity

Indexed keywords

CXCL1 CHEMOKINE; CXCL9 CHEMOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; INTERLEUKIN 18; MACROPHAGE DERIVED CHEMOKINE; MACROPHAGE INFLAMMATORY PROTEIN 3ALPHA; THYMUS AND ACTIVATION REGULATED CHEMOKINE;

ARTICLE; ATOPIC DERMATITIS; CELL EXPANSION; CELL ISOLATION; CELL POLARITY; CONTROLLED STUDY; DENDRITIC CELL; EPIDERMIS CELL; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HUMAN CELL; LANGERHANS CELL; MIXED LYMPHOCYTE REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSORIASIS; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; TH17 CELL; TH2 CELL;

EID: 80052259758     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2011.05.016     Document Type: Article

References (63)

1. T. Bieber, and N. Novak Pathogenesis of atopic dermatitis: new developments Curr Allergy Asthma Rep 9 2009 291 294
2. A. Di Cesare, P. Di Meglio, and F.O. Nestle The IL-23/Th17 axis in the immunopathogenesis of psoriasis J Invest Dermatol 129 2009 1339 1350
3. K.E. Nograles, L.C. Zaba, A. Shemer, J. Fuentes-Duculan, I. Cardinale, and T. Kikuchi IL-22-producing "T22" T cells account for upregulated IL-22 in atopic dermatitis despite reduced IL-17-producing TH17 T cells J Allergy Clin Immunol 123 2009 1244 1252 e2
4. B. Homey, M. Steinhoff, T. Ruzicka, and D.Y. Leung Cytokines and chemokines orchestrate atopic skin inflammation J Allergy Clin Immunol 118 2006 178 189 (Pubitemid 43946487)
5. P.Y. Ong, and D.Y. Leung Immune dysregulation in atopic dermatitis Curr Allergy Asthma Rep 6 2006 384 389 (Pubitemid 44340170)
6. E. Guttman-Yassky, M.A. Lowes, J. Fuentes-Duculan, J. Whynot, I. Novitskaya, and I. Cardinale Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis J Allergy Clin Immunol 119 2007 1210 1217 (Pubitemid 46654193)
7. E. Guttman-Yassky, K.E. Nograles, and J.G. Krueger Contrasting pathogenesis of atopic dermatitis and psoriasis - part II: immune cell subsets and therapeutic concepts J Allergy Clin Immunol 127 2011 1420 1432
8. E. Guttman-Yassky, M.A. Lowes, J. Fuentes-Duculan, L.C. Zaba, I. Cardinale, and K.E. Nograles Low expression of the IL-23/Th17 pathway in atopic dermatitis compared to psoriasis J Immunol 181 2008 7420 7427
9. E. Guttman-Yassky, M. Suarez-Farinas, A. Chiricozzi, K.E. Nograles, A. Shemer, and J. Fuentes-Duculan Broad defects in epidermal cornification in atopic dermatitis identified through genomic analysis J Allergy Clin Immunol 124 2009 1235 1244 e58
10. I. Nomura, B. Gao, M. Boguniewicz, M.A. Darst, J.B. Travers, and D.Y. Leung Distinct patterns of gene expression in the skin lesions of atopic dermatitis and psoriasis: a gene microarray analysis J Allergy Clin Immunol 112 2003 1195 1202 (Pubitemid 37550015)
11. I. Nomura, E. Goleva, M.D. Howell, Q.A. Hamid, P.Y. Ong, and C.F. Hall Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes J Immunol 171 2003 3262 3269 (Pubitemid 37093553)
12. N. Novak, and T. Bieber The role of dendritic cell subtypes in the pathophysiology of atopic dermatitis J Am Acad Dermatol 53 suppl 2005 S171 S176
13. R.M. Steinman, and J. Banchereau Taking dendritic cells into medicine Nature 449 2007 419 426 (Pubitemid 47509552)
14. L.C. Zaba, J.G. Krueger, and M.A. Lowes Resident and " inflammatory" dendritic cells in human skin J Invest Dermatol 129 2009 302 308
15. R.A. Clark Skin-resident T cells: the ups and downs of onsite immunity J Invest Dermatol 130 2010 362 370
16. E. Guttman-Yassky, and J.G. Krueger Psoriasis: evolution of pathogenic concepts and new therapies through phases of translational research Br J Dermatol 157 2007 1103 1115 (Pubitemid 350115667)
17. L.C. Zaba, J. Fuentes-Duculan, N.J. Eungdamrong, M.V. Abello, I. Novitskaya, and K.C. Pierson Psoriasis is characterized by accumulation of immunostimulatory and Th1/Th17 cell-polarizing myeloid dendritic cells J Invest Dermatol 129 2009 79 88
18. L.C. Zaba, J. Fuentes-Duculan, N.J. Eungdamrong, L.M. Johnson-Huang, K.E. Nograles, and T.R. White Identification of TNF-related apoptosis-inducing ligand and other molecules that distinguish inflammatory from resident dendritic cells in patients with psoriasis J Allergy Clin Immunol 125 2010 1261 1268 e9
19. S.P. Jariwala The role of dendritic cells in the immunopathogenesis of psoriasis Arch Dermatol Res 299 2007 359 366 (Pubitemid 47383849)
20. L.M. Johnson-Huang, N.S. McNutt, J.G. Krueger, and M.A. Lowes Cytokine-producing dendritic cells in the pathogenesis of inflammatory skin diseases J Clin Immunol 29 2009 247 256
21. M.A. Lowes, F. Chamian, M.V. Abello, J. Fuentes-Duculan, S.L. Lin, and R. Nussbaum Increase in TNF-alpha and inducible nitric oxide synthase-expressing dendritic cells in psoriasis and reduction with efalizumab (anti-CD11a) Proc Natl Acad Sci U S A 102 2005 19057 19062 (Pubitemid 43049565)
22. S.F. Ziegler, and D. Artis Sensing the outside world: TSLP regulates barrier immunity Nat Immunol 11 2010 289 293
23. T. Ito, Y.H. Wang, O. Duramad, T. Hori, G.J. Delespesse, and N. Watanabe TSLP-activated dendritic cells induce an inflammatory T helper type 2 cell response through OX40 ligand J Exp Med 202 2005 1213 1223 (Pubitemid 41586952)
24. V. Soumelis, P.A. Reche, H. Kanzler, W. Yuan, G. Edward, and B. Homey Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP Nat Immunol 3 2002 673 680 (Pubitemid 34752477)
25. Y.H. Wang, and Y.J. Liu Thymic stromal lymphopoietin, OX40-ligand, and interleukin-25 in allergic responses Clin Exp Allergy 39 2009 798 806
26. N. Watanabe, S. Hanabuchi, M.A. Marloie-Provost, S. Antonenko, Y.J. Liu, and V. Soumelis Human TSLP promotes CD40 ligand-induced IL-12 production by myeloid dendritic cells but maintains their Th2 priming potential Blood 105 2005 4749 4751 (Pubitemid 40807299)
27. H. Fujita, K.E. Nograles, T. Kikuchi, J. Gonzalez, J.A. Carucci, and J.G. Krueger Human Langerhans cells induce distinct IL-22-producing CD4+ T cells lacking IL-17 production Proc Natl Acad Sci U S A 106 2009 21795 21800
28. E. Klechevsky, R. Morita, M. Liu, Y. Cao, S. Coquery, and L. Thompson-Snipes Functional specializations of human epidermal Langerhans cells and CD14+ dermal dendritic cells Immunity 29 2008 497 510
29. M. Suarez-Farinas, M. Pellegrino, K.M. Wittkowski, and M.O. Magnasco Harshlight: a "corrective make-up" program for microarray chips BMC Bioinformatics 6 2005 294
30. M. Suarez-Farinas, M.A. Lowes, L.C. Zaba, and J.G. Krueger Evaluation of the psoriasis transcriptome across different studies by gene set enrichment analysis (GSEA) PLoS One 5 2010 e10247
31. R.A. Irizarry, C. Wang, Y. Zhou, and T.P. Speed Gene set enrichment analysis made simple Stat Methods Med Res 18 2009 565 575
32. L.C. Zaba, J. Fuentes-Duculan, R.M. Steinman, J.G. Krueger, and M.A. Lowes Normal human dermis contains distinct populations of CD11c+BDCA-1+ dendritic cells and CD163+FXIIIA+ macrophages J Clin Invest 117 2007 2517 2525 (Pubitemid 47494353)
33. A. Wollenberg, S. Wen, and T. Bieber Phenotyping of epidermal dendritic cells: clinical applications of a flow cytometric micromethod Cytometry 37 1999 147 155 (Pubitemid 29463484)
34. A. Wollenberg, S. Kraft, D. Hanau, and T. Bieber Immunomorphological and ultrastructural characterization of Langerhans cells and a novel, inflammatory dendritic epidermal cell (IDEC) population in lesional skin of atopic eczema J Invest Dermatol 106 1996 446 453 (Pubitemid 26117582)
35. A.S. Lonsdorf, S.T. Hwang, and A.H. Enk Chemokine receptors in T-cell-mediated diseases of the skin J Invest Dermatol 129 2009 2552 2566
36. E.V. Acosta-Rodriguez, L. Rivino, J. Geginat, D. Jarrossay, M. Gattorno, and A. Lanzavecchia Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells Nat Immunol 8 2007 639 646 (Pubitemid 46785128)
37. F. Annunziato, L. Cosmi, V. Santarlasci, L. Maggi, F. Liotta, and B. Mazzinghi Phenotypic and functional features of human Th17 cells J Exp Med 204 2007 1849 1861 (Pubitemid 47240944)
38. S.P. Singh, H.H. Zhang, J.F. Foley, M.N. Hedrick, and J.M. Farber Human T cells that are able to produce IL-17 express the chemokine receptor CCR6 J Immunol 180 2008 214 221
39. M.C. Lebre, T. Burwell, P.L. Vieira, J. Lora, A.J. Coyle, and M.L. Kapsenberg Differential expression of inflammatory chemokines by Th1- and Th2-cell promoting dendritic cells: a role for different mature dendritic cell populations in attracting appropriate effector cells to peripheral sites of inflammation Immunol Cell Biol 83 2005 525 535 (Pubitemid 41805755)
40. M.K. Oyoshi, R. He, L. Kumar, J. Yoon, and R.S. Geha Cellular and molecular mechanisms in atopic dermatitis Adv Immunol 102 2009 135 226
41. A.M. Bowcock, and J.G. Krueger Getting under the skin: the immunogenetics of psoriasis Nat Rev Immunol 5 2005 699 711 (Pubitemid 43090738)
42. A. Pivarcsi, M. Gombert, M.C. Dieu-Nosjean, A. Lauerma, R. Kubitza, and S. Meller CC chemokine ligand 18, an atopic dermatitis-associated and dendritic cell-derived chemokine, is regulated by staphylococcal products and allergen exposure J Immunol 173 2004 5810 5817 (Pubitemid 39392171)
43. M.J. Toebak, S. Gibbs, D.P. Bruynzeel, R.J. Scheper, and T. Rustemeyer Dendritic cells: biology of the skin Contact Dermatitis 60 2009 2 20
44. U. Brand, I. Bellinghausen, A.H. Enk, H. Jonuleit, D. Becker, and J. Knop Allergen-specific immune deviation from a TH2 to a TH1 response induced by dendritic cells and collagen type I J Allergy Clin Immunol 104 1999 1052 1059 (Pubitemid 29532128)
45. S. Dubrac, M. Schmuth, and S. Ebner Atopic dermatitis: the role of Langerhans cells in disease pathogenesis Immunol Cell Biol 88 2010 400 409
46. G.C. Mudde, F.C. Van Reijsen, G.J. Boland, G.C. de Gast, P.L. Bruijnzeel, and C.A. Bruijnzeel-Koomen Allergen presentation by epidermal Langerhans' cells from patients with atopic dermatitis is mediated by IgE Immunology 69 1990 335 341 (Pubitemid 20076508)
47. G. Stingl, and D. Maurer IgE-mediated allergen presentation via Fc epsilon RI on antigen-presenting cells Int Arch Allergy Immunol 113 1997 24 29 (Pubitemid 27160711)
48. S.S. Duraisingham, J. Hornig, F. Gotch, and S. Patterson TLR-stimulated CD34 stem cell-derived human skin-like and monocyte-derived dendritic cells fail to induce Th17 polarization of naive T cells but do stimulate Th1 and Th17 memory responses J Immunol 183 2009 2242 2251
49. V. Lombardi, L. Van Overtvelt, S. Horiot, and P. Moingeon Human dendritic cells stimulated via TLR7 and/or TLR8 induce the sequential production of Il-10, IFN-gamma, and IL-17A by naive CD4+ T cells J Immunol 182 2009 3372 3379
50. A. Akhavan, and D. Rudikoff Atopic dermatitis: systemic immunosuppressive therapy Semin Cutan Med Surg 27 2008 151 155 (Pubitemid 351938751)
51. K.T. Amor, C. Ryan, and A. Menter The use of cyclosporine in dermatology: part I J Am Acad Dermatol 63 2010 925 948
52. M. Chacko, and J.M. Weinberg Efalizumab Dermatol Ther 20 2007 265 269 (Pubitemid 350029315)
53. R. Takiguchi, S. Tofte, B. Simpson, E. Harper, A. Blauvelt, and J. Hanifin Efalizumab for severe atopic dermatitis: a pilot study in adults J Am Acad Dermatol 56 2007 222 227 (Pubitemid 46074243)
54. V. Di Lernia Progressive multifocal leukoencephalopathy and antipsoriatic drugs: assessing the risk of immunosuppressive treatments Int J Dermatol 49 2010 631 635
55. C. Ryan, K.T. Amor, and A. Menter The use of cyclosporine in dermatology: part II J Am Acad Dermatol 63 2010 949 974
56. F.O. Nestle, C. Conrad, A. Tun-Kyi, B. Homey, M. Gombert, and O. Boyman Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production J Exp Med 202 2005 135 143 (Pubitemid 41002916)
57. E. Guttman-Yassky, M.A. Lowes, J. Fuentes-Duculan, J. Whynot, I. Novitskaya, and I. Cardinale Major differences in inflammatory dendritic cells and their products distinguish atopic dermatitis from psoriasis J Allergy Clin Immunol 119 2007 1210 1217 (Pubitemid 46654193)
58. H. Fujita, K.E. Nograles, T. Kikuchi, J. Gonzalez, J.A. Carucci, and J.G. Krueger Human Langerhans cells induce distinct IL-22-producing CD4+ T cells lacking IL-17 production Proc Natl Acad Sci U S A 106 2009 21795 21800
59. D.M. Kube, C.D. Savci-Heijink, A.F. Lamblin, F. Kosari, G. Vasmatzis, and J.C. Cheville Optimization of laser capture microdissection and RNA amplification for gene expression profiling of prostate cancer BMC Mol Biol 8 2007 25
60. M. Suarez-Farinas, M. Pellegrino, K.M. Wittkowski, and M.O. Magnasco Harshlight: a "corrective make-up" program for microarray chips BMC Bioinformatics 6 2005 294
61. M. Suarez-Farinas, M.A. Lowes, L.C. Zaba, and J.G. Krueger Evaluation of the psoriasis transcriptome across different studies by gene set enrichment analysis (GSEA) PLoS One 5 2010 e10247
62. R.A. Irizarry, C. Wang, Y. Zhou, and T.P. Speed Gene set enrichment analysis made simple Stat Methods Med Res 18 2009 565 575
63. E. Guttman-Yassky, M. Suarez-Farinas, A. Chiricozzi, K.E. Nograles, A. Shemer, and J. Fuentes-Duculan Broad defects in epidermal cornification in atopic dermatitis identified through genomic analysis J Allergy Clin Immunol 124 2009 1235 1244 e58