Human TSLP promotes CD40 ligand-induced IL-12 production by myeloid dendritic cells but maintains their Th2 priming potential

Blood

Volumn 105, Issue 12, 2005, Pages 4749-4751

  Watanabe, Norihiko ^a   Hanabuchi, Shino ^a   Marloie Provost, Marie Annick ^a   Antonenko, Svetlana ^a   Liu, Yong Jun ^a   Soumelis, Vassili ^a,b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b INSTITUT CURIE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 LIGAND; CYTOKINE; INTERLEUKIN 12; INTERLEUKIN 4; THYMIC STROMAL LYMPHOPOIETIN; UNCLASSIFIED DRUG;

ARTICLE; ATOPIC DERMATITIS; BONE MARROW CELL; CELL DIFFERENTIATION; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; INFLAMMATION; KERATINOCYTE; NEGATIVE FEEDBACK; PRIORITY JOURNAL; T LYMPHOCYTE; TH1 CELL; TH2 CELL;

EID: 20444415309     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2004-09-3622     Document Type: Article

References (16)

1. Busse WW, Rosenwasser LJ. Mechanisms of asthma. J Allergy Clin Immunol. 2003;111(suppl):S799-S804.
2. O'Garra A. Cytokines induce the development of functionally heterogeneous T helper cell subsets. Immunity. 1998;8:275-283.
3. D'Andrea A, Ma X, Aste-Amezaga M, Paganin C, Trinchieri G. Stimulatory and inhibitory effects of interleukin (IL)-4 and IL-13 on the production of cytokines by human peripheral blood mononuclear cells: priming for IL-12 and tumor necrosis factor alpha production. J Exp Med. 1995;181:537-546.
4. Hochrein H, O'Keeffe M, Luft T, et al. Interleukin (IL)-4 is a major regulatory cytokine governing bioactive IL-12 production by mouse and human dendritic cells. J Exp Med. 2000;192:823-833.
5. van der Pouw Kraan TC, Boeije LC, de Groot ER, et al. Reduced production of IL-12 and IL-12-dependent IFN-gamma release in patients with allergic asthma. J Immunol. 1997;158:5560-5565.
6. Renzi PM, Xu L, Yang XX, Powell WS, Martin JG. IL-2 enhances allergic airway responses in rats by increased inflammation but not through increased synthesis of cysteinyl leukotrienes. J Allergy Clin Immunol. 1999;104:145-152.
7. Snijders A, Van der Pouw Kraan TC, Engel M, et al. Enhanced prostaglandin E2 production by monocytes in atopic dermatitis (AD) is not accompanied by enhanced production of IL-6, IL-10 or IL-12. Clin Exp Immunol. 1998;111:472-476.
8. Morahan G, Huang D, Wu M, et al. Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children. Lancet. 2002;360:455-459.
9. Reche PA, Soumelis V, Gorman DM, et al. Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. J Immunol. 2001;167:336-343.
10. Quentmeier H, Drexler HG, Fleckenstein D, et al. Cloning of human thymic stromal lymphopoietin (TSLP) and signaling mechanisms leading to proliferation. Leukemia. 2001;15:1286-1292.
11. Soumelis V, Reche PA, Kanzler H, et al. Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat Immunol. 2002;3:673-680.
12. Gilliet M, Soumelis V, Watanabe N, et al. Human dendritic cells activated by TSLP and CD40L induce proallergic cytotoxic T cells. J Exp Med. 2003;197:1059-1063.
13. + T cell homeostatic expansion. Nat Immunol. 2004;5:426-434.
14. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol. 2003;3:133-146.
15. Grewe M, Bruijnzeel-Koomen CA, Schopt E, et al. A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis. Immunol Today. 1998;19:359-361.
16. Thepen T, Langeveld-Wildschut EG, Bihari IC, et al. Biphasic response against aeroallergen in atopic dermatitis showing a switch from an initial TH2 response to a TH1 response in situ: an Immunocytochemical study. J Allergy Clin Immunol. 1996;97:828-837.