Human dendritic cells stimulated via TLR7 and/or TLR8 induce the sequential production of Il-10, IFN-γ, and IL-17A by naive CD4+ T cells

Journal of Immunology

Volumn 182, Issue 6, 2009, Pages 3372-3379

  Lombardi, Vincent ^a   Van Overtvelt, Laurence ^a   Horiot, Stéphane ^a   Moingeon, Philippe ^a  

^a Stallergenes SA   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 23; LIPOPOLYSACCHARIDE; MESSENGER RNA; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; AUTACOID; IL17A PROTEIN, HUMAN; IMIDAZOLE DERIVATIVE; RESIQUIMOD; TLR7 PROTEIN, HUMAN; TLR8 PROTEIN, HUMAN;

ARTICLE; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; GENE EXPRESSION; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; MONOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; BIOSYNTHESIS; CELL DIFFERENTIATION; CELL POLARITY; COCULTURE; DRUG EFFECT; DRUG POTENTIATION; IMMUNOLOGY; METABOLISM; PHYSIOLOGY; SECRETION;

CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL POLARITY; COCULTURE TECHNIQUES; DENDRITIC CELLS; HUMANS; IMIDAZOLES; INFLAMMATION MEDIATORS; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-17; LIPOPOLYSACCHARIDES; MONOCYTES; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8;

EID: 65449133935     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0801969     Document Type: Article

References (29)

1. Kopp, E., and R. Medzhitov. 2003. Recognition of microbial infection by Tolllike receptors. Curr. Opin. Immunol. 15: 396-401.
2. Akira, S., S. Umetsu, and O. Takeuchi. 2006. Pathogen recognition and innate immunity. Cell 124: 783-801.
3. Mazzoni, A., and D. M. Segal. 2004. Controlling the Toll road to dendritic cell polarization. J. Leukocyte Biol. 75: 721-730.
4. Iwasaki, A., and R. Medzhitov. 2004. Toll-like receptor control of the adaptive immune responses. Nat. Immunol. 5: 987-995.
5. Acosta-Rodriguez, E. V., L. Rivino, J. Geginat, D. Larrossay, M. Gattorno, A. Lanzavecchia, F. Sallusto, and G. Napolitani. 2007. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nat. Immunol. 8: 639-646.
6. Acosta-Rodriguez, E. V., G. Napolitani, A. Lanzavecchia, and F. Sallusto. 2007. Interleukins 1β and 6 but not transforming growth factor-β are essential for the differentiation of interleukin 17-producing human T helper cells. Nat. Immunol. 8: 942-949.
7. Higgins, S. C., A. G. Jarnicki, E. C. Lavelle, and K. H. Mills. 2006. TLR4 mediates vaccine-induced protective cellular immunity to Bordetella pertussis: role of IL-17-producing T cells. J. Immunol. 177: 7980-7989.
8. Infante-Duarte, C., H. F. Horton, M. C. Byrne, and T. Kamradt. 2000. Microbial lipopeptides induce the production of IL-17 in Th cells. J. Immunol. 165: 6107-6115.
9. van Beelen, A. J., Z. Zelinkova, E. W. Taanman-Kueter, F. J. Muller, D. W. Hommes, S. A. Zaat, M. L. Kapsenberg, and E. C. de Jong. 2007. Stimulation of the intracellular bacterial sensor NOD2 programs dendritic cells to promote interleukin-17 production in human memory T cells. Immunity 27: 660-669.
10. Trinchieri, G. 2003. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. Immunol. 3: 133-146.
11. Abbas, A. K., K. M. Murphy, and A. Sher. 1996. Functional diversity of helper T lymphocytes. Nature 383: 787-793.
12. Sakaguchi, S., N. Sakaguchi, M. Asano, M. Itoh, and M. Toda. 1995. Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor α-chains (CD25). J. Immunol. 155: 1151-1164.
13. Cottrez, F., and H. Groux. 2004. Specialization in tolerance: innate CD(4+)CD(25+) versus acquired TR1 and TH3 regulatory T cells. Transplantation 77: 12-15.
14. Bacchetta, R., S. Gregori, and M. G. Roncarolo. 2005. CD4+ regulatory T cells: mechanisms of induction and effector function. Autoimmun. Rev. 4: 491-496.
15. Park, H., Z. Li, X. O. Yang, S. H. Chang, R. Nurieva, Y. H. Wang, Y. Wang, L. Hood, Z. Zhu, Q. Tian, and C. Dong. 2005. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat. Immunol. 6: 1133-1141.
16. Ivanov, I. I., B. S. McKenzie, L. Zhou, C. E. Tadokoro, A. Lepelley, J. J. Lafaille, D. J. Cua, and D. R. Littman. 2006. The orphan nuclear receptor RORγt directs the differentiation program of pro-inflammatory IL-17+T helper cells. Cell 126: 1121-1133.
17. Wilson, N. J., K. Boniface, J. R. Chan, B. S. McKenzie, W. M. Blumenschein, J. D. Mattson, B. Basham, K. Smith, T. Chen, F. Morel, et al. Development, cytokine profile and function of human interleukin 17-producing helper T cells. Nat. Immunol. 8: 950-957.
18. Veldhoen, M., R. J. Hocking, C. J. Atkins, R. M. Locksley, and B. Stockinger. 2006. TGFβ in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24: 179-189.
19. Langrish, C. L., Y. Chen, W. M. Blumenschein, J. Mattson, B. Basham, J. D. Sedgwick, T. McClanahan, R. A. Kastelein, and D. J. Cua. 2005. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201: 233-240.
20. Annunziato, F., L. Cosmi, V. Santarlasci, L. Maggi, F. Liotta, B. Mazzinghi, E. Parente, L. Filì, S. Ferri, F. Frosali, et al. 2007. Phenotypic and functional features of human Th17 cells. J. Exp. Med. 204: 1849-1861.
21. Jin, D., L. Zhang, J. Zheng, and Y. Zhao. 2008. The inflammatory Th 17 subset in immunity against self and non-self antigens. Autoimmunity 41: 154-162.
22. Iwanami, K., I. Matsumoto, Y. Tanaka-Watanabe, A. Inoue, M. Mihara, Y. Ohsugi, M. Mamura, D. Goto, S. Ito, A. Tsutsumi, T. Kishimoto, and T. Sumida. 2008. Crucial role of the interleukin-6/interleukin-17 cytokine axis in the induction of arthritis by glucose-6-phosphate isomerase. Arthritis Rheum. 58: 754-763.
23. Afzali, B., G. Lombardi, R. I. Lechler, and G. M. Lord. 2007. The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease. Clin. Exp. Immunol. 148: 32-46.
24. Napolitani, G., A. Rinaldi, F. Bertoni, F. Sallusto, and A. Lanzavecchia. 2005. Selected Toll-like receptor agonist combinations synergistically trigger a T helper type 1-polarizing program in dendritic cells. Nature Immunol. 6: 769-776.
25. Severa, M., M. E. Remoli, E. Giacomini, V. Annibali, V. Gafa, R. Lande, M. Tomai, M. Salvetti, and E. M. Coccia. 2007. Sensitization to TLR7 agonist in IFN-β-preactivated dendritic cells. J. Immunol. 178: 6208-6216.
26. Liu, B., Y. Yang, J. Dai, R. Medzhitov, M. A. Freudberg, P. L. Zhang, and Z. Li. 2006. TLR4 up-regulation at protein of gene level is pathogenic for lupus-like autoimmune disease. J. Immunol. 177: 6880-6888.
27. Vollmer, J., S. Tluk, C. Schmitz, S. Hamm, and M. Jurk. 2005. Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. J. Exp. Med. 202: 1575-1585.
28. Radstake, T. R., M. F. Roelofs, Y. M. Jenniskens, B. Oppers-Walgreen, P. L. van Riel, and P. Barrerra. 2004. Expression of Toll-like receptor 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-γ. Arthritis Rheum. 50: 3856-3865.
29. Roelofs, M. F., A. B. Joosten, S. Abdollahi-Roodsaz, A. W. T. van Lieshout, T. Sprong, F. H. van den Hoogen, W. B. van den Berg, and T. R. D. J Radstake. 2005. The expression of Toll-like receptors 3 and 7 in rheumatoid arthritis synovium is increased and costimulation of TLR3, 4 and 7/8 results in synergistic cytokine production by dendritic cells. J. Exp. Med. 52: 2313-2322.