Subtype-selective positive cooperative interactions between brucine analogs and acetylcholine at muscarinic receptors: Functional studies

Molecular Pharmacology

Volumn 55, Issue 4, 1999, Pages 778-786

  Birdsall, Nigel J M ^b   Farries, Tim ^a,c   Gharagozloo, Parviz ^c   Kobayashi, Shinsaku ^d   Lazareno, Sebastian ^c   Sugimoto, Masahiko ^e  

^a Imutran Ltd   (United Kingdom)

^b NATIONAL INSTITUTE FOR MEDICAL RESEARCH   (United Kingdom)

^c Med Res Cncl Collaborative Centre   (United Kingdom)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^e DAIICHI SANKYO CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; BRUCINE; BRUCINE N OXIDE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC RECEPTOR; N CHLOROMETHYLBRUCINE; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ACETYLCHOLINE RELEASE; ALZHEIMER DISEASE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHO CELL; CHOLINERGIC SYSTEM; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG POTENCY; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; RAT; RECEPTOR AFFINITY;

EID: 0032890816     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Birdsall NJM, Cohen F, Lazareno S and Matsui H (1995) Allosteric regulation of G protein-linked receptors. Biochem Soc Trans 23:108-111.
2. Birdsall NJM, Farries T, Gharagozloo P, Kobayashi S, Kuonen D, Lazareno S, Popham A and Sugimoto M (1997) Selective allosteric enhancement of the binding and actions of acetylcholine at muscarinic receptor subtypes. Life Sci 60:1047-1052.
3. Bruns RF and Fergus JH (1990) Allosteric enhancement of adenosine A1 receptor binding and function by 2-amino-3-benzoylthiophenes. Mol Pharmacol 38:939-949.
4. Caulfield MP and Birdsall NJM (1998) International Union of Pharmacology XVII. Classification of muscarinic acetylcholine receptors. Pharmacol Rev 50:279-290.
5. Christopoulos A, Lanzafame A and Mitchelson F (1998) Allosteric interactions at muscarinic cholinoceptors. Clin Exp Pharmacol Physiol 25:189-194.
6. Clark AL and Mitchelson F (1976) The inhibitory effect of gallamine on muscarinic receptors. Br J Pharmacol 58:323-331.
7. 1 receptor. Br J Pharmacol 117:1521-1529.
8. Costa E and Guidotti A (1996) Benzodiazepines on trial: A research strategy for their rehabilitation. Trends Pharmacol Sci 17:192-200.
9. Ehlert FJ (1988) Gallamine allosterically antagonizes muscarinic receptor-mediated inhibition of adenylate cyclase activity in the rat myocardium. J Pharmacol Exp Ther 247:596-602.
10. Ellis J (1997) Allosteric binding sites on muscarinic receptors. Drug Dev Res 40:193-204.
11. Ellis J, Huyler J and Brann MR (1991) Allosteric regulation of cloned m1-m5 muscarinic receptor subtypes. Biochem Pharmacol 42:1927-1932.
12. Ellis J and Seidenberg M (1992) Two allosteric modulators interact at a common site on cardiac muscarinic receptors. Mol Pharmacol 42:638-641.
13. Ellman GL, Courtney KD, Andres V and Featherstone MR (1961) A rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol 7:88-95.
14. Gharagozloo P, Lazareno S, Popham A and Birdsall NJM (1999) Allosteric interactions of quaternary strychnine and brucine derivatives with muscarinic acetylcholine receptors. J Med Chem 42:438-445.
15. 3H]acetylcholine to m2 muscarinic receptors. Biochem Pharmacol 52:1767-1775.
16. 2 dopamine receptors by amiloride and amiloride analogs. Mol Pharmacol 50:1295-1308.
17. Holzgrabe U and Mohr K (1998) Allosteric modulators of ligand binding to muscarinic acetylcholine receptors. DDT 3:214-222.
18. Jakubik J, Bacakova L, El-Fakahany EE and Tucek S (1997) Positive cooperativity of acetylcholine and other agonists with allosteric ligands on muscarinic acetylcholine receptors. Mol Pharmacol 52:172-179.
19. Jakubik J, Bacakova L, Lisa V, El-Fakahany EE and Tucek S (1996) Activation of muscarinic acetylcholine receptors via their allosteric binding sites. Proc Natl Acad Sci USA 93:8705-8709.
20. Kollias-Baker C, Ruble J, Dennis D, Bruns RF, Linden J and Belardinelli L (1994) Allosteric enhancer PD 81,723 acts by novel mechanism to potentiate cardiac actions of adenosine. Circ Res 75:961-971.
21. 35S]GTPγS binding to cell membranes, in Methods in Molecular Biology 83: Receptor Signal Transduction Protocols (Challis RAJ ed) pp 107-116. Humana Press, Totowa, NJ.
22. Lazareno S and Birdsall NJM (1993) Estimation of competitive antagonist affinity from functional inhibition curves using the Gaddum, Schild and Cheng-Prusoff equations. Br J Pharmacol 109:1110-1119.
23. Lazareno S and Birdsall NJM (1995) Detection, quantitation, and verification of allosteric interactions of agents with labeled and unlabeled ligands at G protein-coupled receptors: Interactions of strychnine and acetylcholine at muscarinic receptors. Mol Pharmacol 48:362-378.
24. Lazareno S, Farries T and Birdsall NJM (1993) Pharmacological characterization of guanine nucleotide exchange reactions in membranes from CHO cells stably transfected human muscarinic receptors m1-m4. Life Sci 52:449-456.
25. Lazareno S, Gharagozloo P, Kuonen D, Popham A and Birdsall NJM (1998) Subtype-selective positive cooperative interactions between brucine analogues and acetylcholine at muscarinic receptors: Radioligand binding studies. Mol Pharmacol 53:573-589.
26. Lee NH and El-Fakahany EE (1991) Allosteric antagonists of the muscarinic acetylcholine receptor. Biochem Pharmacol 42:199-205.
27. 2A-adrenergic receptor. Mol Pharmacol 53:916-925.
28. A receptor channels. Annu Rev Neurosci 17:569-602.
29. q/11. Mol Pharmacol 45:890-898.
30. Proska J and Tucek S (1995) Competition between positive and negative allosteric effectors on muscarinic receptors. Mol Pharmacol 48:696-702.
31. Stockton JM, Birdsall NJM, Burgen ASV and Hulme EC (1983) Modification of the binding properties of muscarinic receptors by gallamine. Mol Pharmacol 23:551-557.
32. Tucek S, Musilkova J, Nedoma J, Proska J, Shelkovnikov S and Vorlicek J (1990) Positive cooperativity in the binding of alcuronium and N-methylscopolamine to muscarinic acetylcholine receptors. Mol Pharmacol 38:674-680.
33. Tucek S and Proska J (1995) Allosteric modulation of muscarinic acetylcholine receptors. Trends Pharmacol Sci 18:205-212.