The effects of acute multiple intraperitoneal injections of the GABAB receptor agonist baclofen on food intake in rats

European Journal of Pharmacology

Volumn 601, Issue 1-3, 2008, Pages 106-110

  Patel, Sunit M ^a   Ebenezer, Ivor S ^a  

^a UNIVERSITY OF PORTSMOUTH   (United Kingdom)

Author keywords

Baclofen; Diazepam; Food intake; GABAB receptors

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; BACLOFEN; DIAZEPAM; DRUG VEHICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG TOLERANCE; ENERGY BALANCE; FOOD INTAKE; HYPERPHAGIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPEATED DRUG DOSE; SEDATION;

ANIMALS; BACLOFEN; DIAZEPAM; DRUG ADMINISTRATION SCHEDULE; DRUG TOLERANCE; EATING; ENERGY METABOLISM; GABA AGONISTS; GABA MODULATORS; HOMEOSTASIS; INJECTIONS, INTRAPERITONEAL; MALE; RATS; RATS, WISTAR; RECEPTORS, GABA-B;

EID: 56949095727     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2008.10.059     Document Type: Article

References (26)

1. B receptor-immunoreactive neurones in hypothalamic regions regulating body weight. J. Neuroendocrinol. 15 (2003) 1-14
2. Baldwin B.A., Ebenezer I.S., and de la Riva C. Effects of intraventricular administration of muscimol or GABA on operant feeding in pigs. Physiol. Behav. 48 (1990) 417-421
3. B receptor: a site of therapeutic benefit. Curr. Opin. Pharmacol. 6 (2006) 37-43
4. Cooper S.J., and Higgs S. Benzodiazepine receptors and the determination of palatability. In: Cooper S.J., and Clifton P.G. (Eds). Drug Receptor Subtypes and Ingestive Behaviour (1996), Academic Press Ltd., Lond. 347-398
5. Cooper J.R., Bloom F.E., and Roth R.H. The Biochemical Basis of Neuropharmacology. eight ed. (2003), Oxford University Press, Oxford
6. Ebenezer I.S. The effect of intracerebroventricular administration of baclofen on food intake in rats. NeuroReport 1 (1990) 73-76
7. Ebenezer I.S. Intraperitoneal administration of baclofen increases consumption of both solid and liquid diets in rats. Eur. J. Pharmacol. 273 (1995) 183-185
8. Ebenezer I.S. The inhibitory effect of intraperitoneally administered cholecystokinin (CCK) on food intake in rats is attenuated by baclofen pretreatment. Brain Res. Bull. 41 (1996) 269-272
9. B agonist baclofen on operant food intake in satiated pigs. Br. J. Pharmacol. 101 (1990) 559-562
10. B receptor agonists baclofen and 3-aminopropylphosphinic acid (3-APA) on food intake in rats. Methods Find. Exp. Clin. Pharmacol. 26 (2004) 627-630
11. B receptor agonist baclofen on food intake in CFLP and C57BL/6 mice. Eur. J. Pharmacol. 569 (2007) 90-93
12. Ebenezer I.S., and Pringle A.K. The effects of systemic administration of baclofen on food intake in rats. Neuropharmacology 31 (1992) 39-42
13. Foltin R.W. Baclofen decreases food intake in non-human primates. Pharmacol. Biochem. Behav. 82 (2005) 608-614
14. Kasser T.R., Harris R.B.S., and Martin R.J. Level of satiety: GABA and pentose shunt activities in three brain sites associated with feeding. Am. J. Physiol. 248 (1985) 435-458
15. Kelley J., Rothstein J., and Grossman S.P. GABA and hypothalamic feeding systems: 1. Topographical analysis of the effects of microinjections of muscimol. Physiol. Behav. 23 (1979) 1123-1134
16. Kimura K., and Kuiriyama K. Distribution of gamma-aminobutyric acid (GABA) in the rat hypothalamus: functional correlates with activities of appetite controlling mechanisms. J. Neurochem. 24 (1975) 903-907
17. Naruse T. Effects of repeated intravenous administration of diazepam on food intake in rats. Fundam. Clin. Pharmacol. 8 (1994) 379-384
18. B receptor antagonist CGP 35348 on food intake in rats. Eur. J. Pharmacol. 503 (2004) 89-93
19. B receptor agonists on food intake in rats. Proc. Br. Pharmacol. Soc. (2004). http://pA2online.org/Vol2Issue1abst013.html @http://pA2online.org/Vol2Issue1abst013.html
20. B receptor agonist baclofen on food intake in rats. Eur. J. Pharmacol. 593 (2008) 68-72
21. Popova E.D., Puzin M.N., Kolyvanov G.B., and Levin A.A. Baclofen pharmacokinetics in rats. Eksp. Klin. Farmakol. 58 (1995) 53-54
22. B receptor agonist baclofen on liquid and solid gastric emptying in mice. Eur. J. Pharmacol. 470 (2003) 95-97
23. A-mediated transmission. Semin. Neurosci. 3 (1977) 211-218
24. Ward B.O., Somerville E.M., and Clifton P.G. Intraaccumbens baclofen selectively enhances feeding behaviour in the rats. Physiol. Behav. 68 (2000) 463-468
25. Winer B.J. Statistical Principles in Experimental Design (1971), McGraw-Hill, New York
26. B receptors in the median raphe nucleus. Behav. Brain Res. 59 (1993) 83-93