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Volumn 5, Issue 3, 2011, Pages 168-176

Antiproliferative effects of molecular iodine in cancers

Author keywords

Antiproliferative; Apoptotic effects; Disruption of the mitochondrial transmembrane potential; Iodolactones; Malignant cell lines; Mitochondria mediated apoptosis; Molecular iodine

Indexed keywords

DELTA IODOLACTONE; IODINE; IODINE DERIVATIVE; THYROID HORMONE; UNCLASSIFIED DRUG;

EID: 80051721096     PISSN: None     EISSN: 18723136     Source Type: Journal    
DOI: 10.2174/187231311796764987     Document Type: Article
Times cited : (11)

References (111)
  • 1
    • 0021848195 scopus 로고
    • The origin of I in soil and the 129I problem
    • Cohen BL. The origin of I in soil and the 129I problem. Health Phys 1985; 49: 279-85.
    • (1985) Health Phys , vol.49 , pp. 279-285
    • Cohen, B.L.1
  • 2
    • 44349123591 scopus 로고    scopus 로고
    • Iodide accumulation provides kelp with an inorganic antioxidant impacting atmospheric chemistry
    • Küpper FC, Carpenter LJ, McFiggans GB, et al. Iodide accumulation provides kelp with an inorganic antioxidant impacting atmospheric chemistry. Proc Natl Acad Sci USA 2008; 105: 6954-8.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 6954-6958
    • Küpper, F.C.1    Carpenter, L.J.2    McFiggans, G.B.3
  • 3
    • 46349108585 scopus 로고    scopus 로고
    • The average of dietary iodine intake due to the ingestion of seaweeds is 1.2 mg/day in Japan
    • Nagataki S. The average of dietary iodine intake due to the ingestion of seaweeds is 1.2 mg/day in Japan. Thyroid 2008; 18: 667-68.
    • (2008) Thyroid , vol.18 , pp. 667-668
    • Nagataki, S.1
  • 4
    • 9044238841 scopus 로고    scopus 로고
    • Suppressive effect of iodine on DMBA-induced breast tumor growth in the rat
    • Funahashi H, Imai T, Tanaka Y, et al. Suppressive effect of iodine on DMBA-induced breast tumor growth in the rat. J Surg Oncol 1996; 61: 209-13.
    • (1996) J Surg Oncol , vol.61 , pp. 209-213
    • Funahashi, H.1    Imai, T.2    Tanaka, Y.3
  • 5
    • 19444386808 scopus 로고    scopus 로고
    • Inhibition of Nmethyl-N-nitrosourea-induced mammary carcinogenesis by molecular iodine (I2) but not by iodide (I-) treatment Evidence that I2 prevents cancer promotion
    • García-Solís P, Alfaro Y, Anguiano B, et al. Inhibition of Nmethyl-N-nitrosourea-induced mammary carcinogenesis by molecular iodine (I2) but not by iodide (I-) treatment Evidence that I2 prevents cancer promotion. Mol Cell Endocrinol 2005; 236: 49-57.
    • (2005) Mol Cell Endocrinol , vol.236 , pp. 49-57
    • García-Solís, P.1    Alfaro, Y.2    Anguiano, B.3
  • 6
    • 77952578951 scopus 로고    scopus 로고
    • A case-control study on seaweed consumption and the risk of breast cancer
    • Yang YJ, Nam SJ, Kong G, Kim MK. A case-control study on seaweed consumption and the risk of breast cancer. Br J Nutr 2010; 103: 1345-53.
    • (2010) Br J Nutr , vol.103 , pp. 1345-1353
    • Yang, Y.J.1    Nam, S.J.2    Kong, G.3    Kim, M.K.4
  • 7
    • 0033791189 scopus 로고    scopus 로고
    • Use of iodine for water disinfection: Iodine toxicity and maximum recommended dose
    • Backer H, Hollowell J. Use of iodine for water disinfection: iodine toxicity and maximum recommended dose. Environ Health Perspect 2000; 108: 679-84.
    • (2000) Environ Health Perspect , vol.108 , pp. 679-684
    • Backer, H.1    Hollowell, J.2
  • 9
    • 67649836744 scopus 로고    scopus 로고
    • Minireview: The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid
    • A, Kopp P. Minireview: The sodium-iodide symporter NIS and pendrin in iodide homeostasis of the thyroid. Endocrinology 2009; 150: 1084-90.
    • (2009) Endocrinology , vol.150 , pp. 1084-1090
  • 10
    • 35348944457 scopus 로고    scopus 로고
    • Roles of hydrogen peroxide in thyroid physiology and disease
    • Song Y, Driessens N, Costa M, et al. Roles of hydrogen peroxide in thyroid physiology and disease. J Clin Endocrinol Metab 2007; 92: 3764-73.
    • (2007) J Clin Endocrinol Metab , vol.92 , pp. 3764-3773
    • Song, Y.1    Driessens, N.2    Costa, M.3
  • 11
    • 0031835208 scopus 로고    scopus 로고
    • From iodine deficiency to goiter. Pathophysiology of iodine deficiency goiter
    • Gärtner R, Dugrillon A. From iodine deficiency to goiter. Pathophysiology of iodine deficiency goiter. Internist (Berl) 1998; 39: 566-73.
    • (1998) Internist (Berl) , vol.39 , pp. 566-573
    • Gärtner, R.1    Dugrillon, A.2
  • 12
    • 0025748578 scopus 로고
    • Formation of molecular iodine during oxidation of iodide by the peroxidase/H2O2 system. Implications for antithyroid therapy
    • Lagorce JF, Thomes JC, Catanzano G, Buxeraud J, Raby M, Raby C. Formation of molecular iodine during oxidation of iodide by the peroxidase/H2O2 system. Implications for antithyroid therapy. Biochem Pharmacol 1991; 42 Suppl: S89-92.
    • (1991) Biochem Pharmacol , vol.42 , Issue.SUPPL
    • Lagorce, J.F.1    Thomes, J.C.2    Catanzano, G.3    Buxeraud, J.4    Raby, M.5    Raby, C.6
  • 13
    • 0034464961 scopus 로고    scopus 로고
    • Iodide excess induces apoptosis in thyroid cells through a p53-independent mechanism involving oxidative stress
    • Vitale M, Di Matola T, D'Ascoli F, et al. Iodide excess induces apoptosis in thyroid cells through a p53-independent mechanism involving oxidative stress. Endocrinology 2000; 141: 598-605.
    • (2000) Endocrinology , vol.141 , pp. 598-605
    • Vitale, M.1    di Matola, T.2    D'Ascoli, F.3
  • 14
    • 0028276145 scopus 로고
    • Studies on the goiter inhibiting action of iodolactones
    • Pisarev MA, Krawiec L, Juvenal GJ, et al. Studies on the goiter inhibiting action of iodolactones. Eur J Pharmacol 1994; 258: 33-37.
    • (1994) Eur J Pharmacol , vol.258 , pp. 33-37
    • Pisarev, M.A.1    Krawiec, L.2    Juvenal, G.J.3
  • 15
    • 77950436724 scopus 로고    scopus 로고
    • The role of iodine and delta-iodolactone in growth and apoptosis of malignant thyroid epithelial cells and breast cancer cells
    • Gärtner R, Rank P, Ander B. The role of iodine and delta-iodolactone in growth and apoptosis of malignant thyroid epithelial cells and breast cancer cells. Hormones (Athens) 2010; 9: 60-66.
    • (2010) Hormones (Athens) , vol.9 , pp. 60-66
    • Gärtner, R.1    Rank, P.2    Ander, B.3
  • 16
    • 77956511574 scopus 로고    scopus 로고
    • Biochemical changes during goiter induction by methylmercaptoimidazol and inhibition by delta-iodolactone in rat
    • Thomasz L, Oglio R, Randi AS, et al. Biochemical changes during goiter induction by methylmercaptoimidazol and inhibition by delta-iodolactone in rat. Thyroid 2010; 20: 1003-13.
    • (2010) Thyroid , vol.20 , pp. 1003-1013
    • Thomasz, L.1    Oglio, R.2    Randi, A.S.3
  • 17
    • 0021102118 scopus 로고
    • Iodination of arachidonic acid mediated by eosinophil peroxidase, myeloperoxidase and lactoperoxidase. Identification and comparison of products
    • Turk J, Henderson WR, Klebanoff SJ, Hubbard WC. Iodination of arachidonic acid mediated by eosinophil peroxidase, myeloperoxidase and lactoperoxidase. Identification and comparison of products. Biochim Biophys Acta 1983; 751: 189-200.
    • (1983) Biochim Biophys Acta , vol.751 , pp. 189-200
    • Turk, J.1    Henderson, W.R.2    Klebanoff, S.J.3    Hubbard, W.C.4
  • 18
    • 33344468233 scopus 로고    scopus 로고
    • Neutrophils and immunity: Challenges and opportunities
    • Nathan C. Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol 2006; 6: 173-82.
    • (2006) Nat Rev Immunol , vol.6 , pp. 173-182
    • Nathan, C.1
  • 20
    • 0021336552 scopus 로고
    • Toxic effect of the peroxidasehydrogen peroxide-halide antimicrobial system on Mycobacterium leprae
    • Klebanoff SJ, Shepard CC. Toxic effect of the peroxidasehydrogen peroxide-halide antimicrobial system on Mycobacterium leprae. Infect Immun 1984; 44: 534-36.
    • (1984) Infect Immun , vol.44 , pp. 534-536
    • Klebanoff, S.J.1    Shepard, C.C.2
  • 22
    • 0027436183 scopus 로고
    • Antitumor activity of an immobilized peroxidase system against murine Ehrlich ascites is mediated by the immune system
    • Combs SH, Morgan CD, Everse J. Antitumor activity of an immobilized peroxidase system against murine Ehrlich ascites is mediated by the immune system. Proc Soc Exp Biol Med 1993; 204: 306-11.
    • (1993) Proc Soc Exp Biol Med , vol.204 , pp. 306-311
    • Combs, S.H.1    Morgan, C.D.2    Everse, J.3
  • 23
    • 0018827927 scopus 로고
    • Eosinophil-mediated mammalian tumor cell cytotoxicity: Role of the peroxidase system
    • Jong EC, Klebanoff SJ. Eosinophil-mediated mammalian tumor cell cytotoxicity: role of the peroxidase system. J Immunol 1980; 124: 1949-53.
    • (1980) J Immunol , vol.124 , pp. 1949-1953
    • Jong, E.C.1    Klebanoff, S.J.2
  • 24
    • 18244390487 scopus 로고    scopus 로고
    • Myeloperoxidase: Friend and foe
    • Klebanoff SJ. Myeloperoxidase: friend and foe. J Leukoc Biol 2005; 77: 598-625.
    • (2005) J Leukoc Biol , vol.77 , pp. 598-625
    • Klebanoff, S.J.1
  • 27
    • 0031723728 scopus 로고    scopus 로고
    • Analysis of human sodium iodide symporter gene expression in extrathyroidal tissues and cloning of its complementary deoxyribonucleic acids from salivary gland, mammary gland, and gastric mucosa
    • Spitzweg C, Joba W, Eisenmenger W, Heufelder AE. Analysis of human sodium iodide symporter gene expression in extrathyroidal tissues and cloning of its complementary deoxyribonucleic acids from salivary gland, mammary gland, and gastric mucosa. J Clin Endocrinol Metab 1998; 83: 1746-51.
    • (1998) J Clin Endocrinol Metab , vol.83 , pp. 1746-1751
    • Spitzweg, C.1    Joba, W.2    Eisenmenger, W.3    Heufelder, A.E.4
  • 28
    • 3042811612 scopus 로고    scopus 로고
    • The Na+/I- symporter mediates iodide uptake in breast cancer metastases and can be selectively down-regulated in the thyroid
    • Wapnir IL, Goris M, Yudd A, et al. The Na+/I- symporter mediates iodide uptake in breast cancer metastases and can be selectively down-regulated in the thyroid. Clin Cancer Res 2004; 10: 4294-302.
    • (2004) Clin Cancer Res , vol.10 , pp. 4294-4302
    • Wapnir, I.L.1    Goris, M.2    Yudd, A.3
  • 29
    • 33751088303 scopus 로고    scopus 로고
    • Enhancement of sodium/iodide symporter expression in thyroid and breast cancer
    • Kogai T, Taki K, Brent GA. Enhancement of sodium/iodide symporter expression in thyroid and breast cancer. Endocr Relat Cancer 2006; 13: 797-826.
    • (2006) Endocr Relat Cancer , vol.13 , pp. 797-826
    • Kogai, T.1    Taki, K.2    Brent, G.A.3
  • 31
    • 0034813983 scopus 로고    scopus 로고
    • Iodide transport in lactating rat mammary tissue via a pathway independent from the Na+/I- cotransporter: Evidence for sulfate/iodide exchange
    • Shennan DB. Iodide transport in lactating rat mammary tissue via a pathway independent from the Na+/I- cotransporter: evidence for sulfate/iodide exchange. Biochem Biophys Res Commun 2001; 280: 1359-63.
    • (2001) Biochem Biophys Res Commun , vol.280 , pp. 1359-1363
    • Shennan, D.B.1
  • 32
    • 0141864361 scopus 로고    scopus 로고
    • Pendrin transporter carries out iodide uptake into MCF-7 human mammary cancer cells
    • Rillema JA, Hill MA. Pendrin transporter carries out iodide uptake into MCF-7 human mammary cancer cells. Exp Biol Med (Maywood) 2003; 228: 1078-82.
    • (2003) Exp Biol Med (Maywood) , vol.228 , pp. 1078-1082
    • Rillema, J.A.1    Hill, M.A.2
  • 33
    • 33846819022 scopus 로고    scopus 로고
    • Uptake and antiproliferative effect of molecular iodine in the MCF-7 breast cancer cell line
    • Arroyo-Helguera O, Anguiano B, Delgado G, Aceves C. Uptake and antiproliferative effect of molecular iodine in the MCF-7 breast cancer cell line. Endocr Relat Cancer 2006; 13: 1147-58.
    • (2006) Endocr Relat Cancer , vol.13 , pp. 1147-1158
    • Arroyo-Helguera, O.1    Anguiano, B.2    Delgado, G.3    Aceves, C.4
  • 34
    • 72449146430 scopus 로고    scopus 로고
    • Endogenous expression of the sodium iodide symporter mediates uptake of iodide in murine models of colorectal carcinoma
    • Gaertner FC, Rohde F, Mueller J, Blechert B, Janssen KP, Essler M. Endogenous expression of the sodium iodide symporter mediates uptake of iodide in murine models of colorectal carcinoma. Int J Cancer 2009; 125: 2783-91.
    • (2009) Int J Cancer , vol.125 , pp. 2783-2791
    • Gaertner, F.C.1    Rohde, F.2    Mueller, J.3    Blechert, B.4    Janssen, K.P.5    Essler, M.6
  • 36
    • 26044458588 scopus 로고    scopus 로고
    • Comparison of iodine contents in gastric cancer and surrounding normal tissues
    • Gulaboglu M, Yildiz L, Celebi F, Gul M, Peker K. Comparison of iodine contents in gastric cancer and surrounding normal tissues. Clin Chem Lab Med 2005; 43: 581-84.
    • (2005) Clin Chem Lab Med , vol.43 , pp. 581-584
    • Gulaboglu, M.1    Yildiz, L.2    Celebi, F.3    Gul, M.4    Peker, K.5
  • 37
    • 34347199036 scopus 로고
    • Der Metabolismus von Kohlehydraten, Calcium und Jod bei experimentellen bösartigen Geschwülsten
    • Goldfeder A. Der Metabolismus von Kohlehydraten, Calcium und Jod bei experimentellen bösartigen Geschwülsten. J Cancer Res Clin Oncol 1928; 27: 503-36.
    • (1928) J Cancer Res Clin Oncol , vol.27 , pp. 503-536
    • Goldfeder, A.1
  • 38
    • 0029049820 scopus 로고
    • Different tissue responses for iodine and iodide in rat thyroid and mammary glands
    • Eskin BA, Grotkowski CE, Connolly CP, Ghent WR. Different tissue responses for iodine and iodide in rat thyroid and mammary glands. Biol Trace Elem Res 1995; 49: 9-19.
    • (1995) Biol Trace Elem Res , vol.49 , pp. 9-19
    • Eskin, B.A.1    Grotkowski, C.E.2    Connolly, C.P.3    Ghent, W.R.4
  • 39
    • 0026035842 scopus 로고
    • The activity of locally applied cytotoxics to breast cancer cells in vitro
    • Park KG, Chetty U, Scott W, Miller W. The activity of locally applied cytotoxics to breast cancer cells in vitro. Ann R Coll Surg Engl 1991; 73: 96-69.
    • (1991) Ann R Coll Surg Engl , vol.73 , pp. 69-96
    • Park, K.G.1    Chetty, U.2    Scott, W.3    Miller, W.4
  • 40
    • 47349125602 scopus 로고    scopus 로고
    • Iodine alters gene expression in the MCF7 breast cancer cell line: Evidence for an anti-estrogen effect of iodine
    • Stoddard FR 2nd, Brooks AD, Eskin BA, Johannes GJ. Iodine alters gene expression in the MCF7 breast cancer cell line: evidence for an anti-estrogen effect of iodine. Int J Med Sci 2008; 5: 189-96.
    • (2008) Int J Med Sci , vol.5 , pp. 189-196
    • Stoddard 2nd, F.R.1    Brooks, A.D.2    Eskin, B.A.3    Johannes, G.J.4
  • 43
    • 0032895805 scopus 로고    scopus 로고
    • Influence of cytotoxic agents on intraperitoneal tumor implantation after laparoscopy
    • Neuhaus SJ, Watson DI, Ellis T, Rofe AM, Jamieson GG. Influence of cytotoxic agents on intraperitoneal tumor implantation after laparoscopy. Dis Colon Rectum 1999; 42: 10-15.
    • (1999) Dis Colon Rectum , vol.42 , pp. 10-15
    • Neuhaus, S.J.1    Watson, D.I.2    Ellis, T.3    Rofe, A.M.4    Jamieson, G.G.5
  • 44
    • 0042014538 scopus 로고    scopus 로고
    • Nonradioactive iodide effectively induces apoptosis in genetically modified lung cancer cells
    • Zhang L, Sharma S, Zhu LX, et al. Nonradioactive iodide effectively induces apoptosis in genetically modified lung cancer cells. Cancer Res 2003; 63: 5065-72.
    • (2003) Cancer Res , vol.63 , pp. 5065-5072
    • Zhang, L.1    Sharma, S.2    Zhu, L.X.3
  • 45
    • 0036860425 scopus 로고    scopus 로고
    • Iodinated contrast media induce neutrophil apoptosis through a mitochondrial and caspase mediated pathway
    • Fanning NF, Manning BJ, Buckley J, Redmond HP. Iodinated contrast media induce neutrophil apoptosis through a mitochondrial and caspase mediated pathway. Br J Radiol 2002; 75: 861-73.
    • (2002) Br J Radiol , vol.75 , pp. 861-873
    • Fanning, N.F.1    Manning, B.J.2    Buckley, J.3    Redmond, H.P.4
  • 46
    • 0019558717 scopus 로고
    • Lactoperoxidasecatalyzed iodination of arachidonic acid: Formation of macrolides
    • Boeynaems JM, Reagan D, Hubbard WC. Lactoperoxidasecatalyzed iodination of arachidonic acid: formation of macrolides. Lipids 1981; 16: 246-49.
    • (1981) Lipids , vol.16 , pp. 246-249
    • Boeynaems, J.M.1    Reagan, D.2    Hubbard, W.C.3
  • 47
    • 77954876358 scopus 로고    scopus 로고
    • Antiproliferative/cytotoxic activity of molecular iodine and iodolactones in various human carcinoma cell lines. No interfering with EGFsignaling, but evidence for apoptosis
    • Rösner H, Torremante P, Möller W, Gärtner R. Antiproliferative/cytotoxic activity of molecular iodine and iodolactones in various human carcinoma cell lines. No interfering with EGFsignaling, but evidence for apoptosis. Exp Clin Endocrinol Diabetes 2010; 118: 410-19.
    • (2010) Exp Clin Endocrinol Diabetes , vol.118 , pp. 410-419
    • Rösner, H.1    Torremante, P.2    Möller, W.3    Gärtner, R.4
  • 48
    • 58249112933 scopus 로고    scopus 로고
    • Signaling pathways involved in the antiproliferative effect of molecular iodine in normal and tumoral breast cells: Evidence that 6- iodolactone mediates apoptotic effects
    • Arroyo-Helguera O, Rojas E, Delgado G, Aceves C. Signaling pathways involved in the antiproliferative effect of molecular iodine in normal and tumoral breast cells: evidence that 6- iodolactone mediates apoptotic effects. Endocr Relat Cancer 2008; 15: 1003-11.
    • (2008) Endocr Relat Cancer , vol.15 , pp. 1003-1011
    • Arroyo-Helguera, O.1    Rojas, E.2    Delgado, G.3    Aceves, C.4
  • 49
    • 35348996441 scopus 로고    scopus 로고
    • Uptake and gene expression with antitumoral doses of iodine in thyroid and mammary gland: Evidence that chronic administration has no harmful effects
    • Anguiano B, García-Solís P, Delgado G, Aceves Velasco C. Uptake and gene expression with antitumoral doses of iodine in thyroid and mammary gland: evidence that chronic administration has no harmful effects. Thyroid 2007; 17: 851-59.
    • (2007) Thyroid , vol.17 , pp. 851-859
    • Anguiano, B.1    García-Solís, P.2    Delgado, G.3    Aceves, V.C.4
  • 50
    • 0028989276 scopus 로고
    • Delta-Iodolactones decrease epidermal growth factor-induced proliferation and inositol-1,4,5-trisphosphate generation in porcine thyroid follicles--a possible mechanism of growth inhibition by iodide
    • Dugrillon A, Gärtner R. Delta-Iodolactones decrease epidermal growth factor-induced proliferation and inositol-1,4,5-trisphosphate generation in porcine thyroid follicles--a possible mechanism of growth inhibition by iodide. Eur J Endocrinol 1995; 132: 735-43.
    • (1995) Eur J Endocrinol , vol.132 , pp. 735-743
    • Dugrillon, A.1    Gärtner, R.2
  • 51
    • 77949568523 scopus 로고    scopus 로고
    • Iodine induces apoptosis via regulating MAPKs-related p53, p21, and BclxL in thyroid cancer cells
    • Liu XH, Chen GG, Vlantis AC, Tse GM, van Hasselt CA. Iodine induces apoptosis via regulating MAPKs-related p53, p21, and BclxL in thyroid cancer cells. Mol Cell Endocrinol 2010; 320: 128-35.
    • (2010) Mol Cell Endocrinol , vol.320 , pp. 128-135
    • Liu, X.H.1    Chen, G.G.2    Vlantis, A.C.3    Tse, G.M.4    van Hasselt, C.A.5
  • 53
    • 73649200741 scopus 로고
    • Action and metabolism of thyroid hormones and iodine-donating substances. I. Liver mitochondria
    • Rall JE, Michel R, Roche J, Michel O, Varrone S. Action and metabolism of thyroid hormones and iodine-donating substances. I. Liver mitochondria. J Biol Chem 1963; 238: 1848-54.
    • (1963) J Biol Chem , vol.238 , pp. 1848-1854
    • Rall, J.E.1    Michel, R.2    Roche, J.3    Michel, O.4    Varrone, S.5
  • 54
    • 0013860422 scopus 로고
    • Effect of inorganic iodine on oxidative phosphorylation in brain and kidney mitochondria of normal and hyperthyroid rabbits
    • Rachev RR. Effect of inorganic iodine on oxidative phosphorylation in brain and kidney mitochondria of normal and hyperthyroid rabbits. Bull Exp Biol Med 1966; 61: 53-55.
    • (1966) Bull Exp Biol Med , vol.61 , pp. 53-55
    • Rachev, R.R.1
  • 55
    • 0001763130 scopus 로고
    • Physical and chemical studies of a limited reaction of iodine with proteins
    • Cunningham LW, Nuenke BJ. Physical and chemical studies of a limited reaction of iodine with proteins. J Biol Chem 1959; 234: 1447-51.
    • (1959) J Biol Chem , vol.234 , pp. 1447-1451
    • Cunningham, L.W.1    Nuenke, B.J.2
  • 56
    • 0014766547 scopus 로고
    • The nature of inhibition of mitochondrial malate dehydrogenase by thyroxine, iodine cyanide and molecular iodine
    • Varrone S, Consiglio E, Covelli I. The nature of inhibition of mitochondrial malate dehydrogenase by thyroxine, iodine cyanide and molecular iodine. Eur J Biochem 1970; 13: 305-12.
    • (1970) Eur J Biochem , vol.13 , pp. 305-312
    • Varrone, S.1    Consiglio, E.2    Covelli, I.3
  • 57
    • 33745950626 scopus 로고    scopus 로고
    • Mitochondrial outer membrane permeabilization during apoptosis: The innocent bystander scenario
    • Chipuk JE, Bouchier-Hayes L, Green DR. Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenario. Cell Death Differ 2006; 13: 1396-402.
    • (2006) Cell Death Differ , vol.13 , pp. 1396-1402
    • Chipuk, J.E.1    Bouchier-Hayes, L.2    Green, D.R.3
  • 58
    • 33745827711 scopus 로고    scopus 로고
    • Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving the mitochondria-mediated pathway
    • Shrivastava A, Tiwari M, Sinha RA, et al. Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving the mitochondria-mediated pathway. J Biol Chem 2006; 281: 19762-71.
    • (2006) J Biol Chem , vol.281 , pp. 19762-19771
    • Shrivastava, A.1    Tiwari, M.2    Sinha, R.A.3
  • 59
    • 0034663082 scopus 로고    scopus 로고
    • Intracellular thiol depletion causes mitochondrial permeability transition in Ebselen-induced apoptosis
    • Chen FY, Han MS, Choon NO. Intracellular thiol depletion causes mitochondrial permeability transition in Ebselen-induced apoptosis. Arch Biochem Biophys 2000; 380: 319-30.
    • (2000) Arch Biochem Biophys , vol.380 , pp. 319-330
    • Chen, F.Y.1    Han, M.S.2    Choon, N.O.3
  • 60
    • 0033088957 scopus 로고    scopus 로고
    • The role of gluthadione in the regulation of apoptosis
    • Hall AG. The role of gluthadione in the regulation of apoptosis. Eur J Clin Invest 1999; 29: 238-45.
    • (1999) Eur J Clin Invest , vol.29 , pp. 238-245
    • Hall, A.G.1
  • 63
    • 0037271399 scopus 로고    scopus 로고
    • Glutathione disulfide induces apoptosis in U937 cells by a redox-mediated p38 MAP-kinase pathway
    • Filomeni G, Rotilio G, Ciriolo MR. Glutathione disulfide induces apoptosis in U937 cells by a redox-mediated p38 MAP-kinase pathway. The FASEB J 2003; 17: 64-66.
    • (2003) The FASEB J , vol.17 , pp. 64-66
    • Filomeni, G.1    Rotilio, G.2    Ciriolo, M.R.3
  • 65
    • 0032080283 scopus 로고    scopus 로고
    • Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
    • Saitoh M, Nishitoh H, Fujii M, et al. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. EMBO J 1998; 17: 2596-606.
    • (1998) EMBO J , vol.17 , pp. 2596-2606
    • Saitoh, M.1    Nishitoh, H.2    Fujii, M.3
  • 66
    • 2942696470 scopus 로고    scopus 로고
    • Thioredoxin-2 inhibits mitochondria- located ASK1-mediated apoptosis in a JNK-independent manner
    • Zhang R, Al-Lamki R, Bai L, et al. Thioredoxin-2 inhibits mitochondria- located ASK1-mediated apoptosis in a JNK-independent manner. Circ Res 2004; 94: 1483-91.
    • (2004) Circ Res , vol.94 , pp. 1483-1491
    • Zhang, R.1    Al-Lamki, R.2    Bai, L.3
  • 67
    • 49249115751 scopus 로고    scopus 로고
    • Identification of thioredoxin-2 as a regulator of the mitochondrial permeability transition
    • He M, Cai J, Go YM, et al. Identification of thioredoxin-2 as a regulator of the mitochondrial permeability transition. Toxicol Sci 2008; 105: 44-50.
    • (2008) Toxicol Sci , vol.105 , pp. 44-50
    • He, M.1    Cai, J.2    Go, Y.M.3
  • 68
    • 65649110819 scopus 로고    scopus 로고
    • Antineoplastic effect of iodine in mammary cancer: Participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR)
    • Aceves C, García-Solís P, Arroyo-Helguera O, Vega-Riveroll L, Delgado G, Anguiano B. Antineoplastic effect of iodine in mammary cancer: participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR). Mol Cancer 2009; 8: 33.
    • (2009) Mol Cancer , vol.8 , pp. 33
    • Aceves, C.1    García-Solís, P.2    Arroyo-Helguera, O.3    Vega-Riveroll, L.4    Delgado, G.5    Anguiano, B.6
  • 69
    • 0032555196 scopus 로고    scopus 로고
    • Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice
    • Elstner E, Müller C, Koshizuka K, et al. Ligands for peroxisome proliferator-activated receptorgamma and retinoic acid receptor inhibit growth and induce apoptosis of human breast cancer cells in vitro and in BNX mice. Proc Natl Acad Sci USA 1998; 95: 8806-11.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8806-8811
    • Elstner, E.1    Müller, C.2    Koshizuka, K.3
  • 70
    • 17644398431 scopus 로고    scopus 로고
    • Differential susceptibility of nonmalignant human breast epithelial cells and breast cancer cells to thiol antioxidant-induced G(1)- delay
    • Menon SG, Coleman MC, Walsh SA, Spitz DR, Goswami PC. Differential susceptibility of nonmalignant human breast epithelial cells and breast cancer cells to thiol antioxidant-induced G(1)- delay. Antioxid Redox Signal 2005; 7: 711-18.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 711-718
    • Menon, S.G.1    Coleman, M.C.2    Walsh, S.A.3    Spitz, D.R.4    Goswami, P.C.5
  • 71
    • 34447250844 scopus 로고    scopus 로고
    • Peroxiredoxin I and II inhibit H2O2-induced cell death in MCF-7 cell lines
    • Bae JY, Ahn SJ, Han W, Noh DY. Peroxiredoxin I and II inhibit H2O2-induced cell death in MCF-7 cell lines. J Cell Biochem 2007; 101: 1038-45.
    • (2007) J Cell Biochem , vol.101 , pp. 1038-1045
    • Bae, J.Y.1    Ahn, S.J.2    Han, W.3    Noh, D.Y.4
  • 72
    • 0036889940 scopus 로고    scopus 로고
    • Differential action of iodine on mitochondria from human tumoraland extra-tumoral tissue in inducing the release of apoptogenic proteins
    • Upadhyay G, Singh R, Sharma R, Balapure AK, Godbole MM. Differential action of iodine on mitochondria from human tumoraland extra-tumoral tissue in inducing the release of apoptogenic proteins. Mitochondrion 2002; 2: 199-210.
    • (2002) Mitochondrion , vol.2 , pp. 199-210
    • Upadhyay, G.1    Singh, R.2    Sharma, R.3    Balapure, A.K.4    Godbole, M.M.5
  • 73
    • 0035200658 scopus 로고    scopus 로고
    • Cellular thiols and reactive oxygen species in drug-induced apoptosis
    • Davis W Jr, Ronai Z, Tew KD. Cellular thiols and reactive oxygen species in drug-induced apoptosis. J Pharmacol Exp Ther 2001; 296: 1-6
    • (2001) J Pharmacol Exp Ther , vol.296 , pp. 1-6
    • Davis Jr., W.1    Ronai, Z.2    Tew, K.D.3
  • 74
    • 28844503390 scopus 로고    scopus 로고
    • Structural studies on a mitochondrial glyoxalase II
    • Marasinghe GP, Sander IM, Bennett B, et al. Structural studies on a mitochondrial glyoxalase II. J Biol Chem 2005; 280: 40668-75.
    • (2005) J Biol Chem , vol.280 , pp. 40668-40675
    • Marasinghe, G.P.1    Sander, I.M.2    Bennett, B.3
  • 76
    • 0035038825 scopus 로고    scopus 로고
    • Expression of glyoxalase I and II in normal and breast cancer tissues
    • Rulli A, Carli L, Romani R, et al. Expression of glyoxalase I and II in normal and breast cancer tissues. Breast Cancer Res Treat 2001; 66: 67-72.
    • (2001) Breast Cancer Res Treat , vol.66 , pp. 67-72
    • Rulli, A.1    Carli, L.2    Romani, R.3
  • 77
    • 0026040383 scopus 로고
    • Cellular glutathione and thiol measurements from surgically resected human lung tumor and normal lung tissue
    • Cook JA, Pass HI, Iype SN, et al. Cellular glutathione and thiol measurements from surgically resected human lung tumor and normal lung tissue. Cancer Res 1991; 51: 4287-94.
    • (1991) Cancer Res , vol.51 , pp. 4287-4294
    • Cook, J.A.1    Pass, H.I.2    Iype, S.N.3
  • 78
    • 0032562519 scopus 로고    scopus 로고
    • Thioredoxin redox control of cell growth and death and the effects of inhibitors
    • Powis G, Kirkpatrick DL, Angulo M, Baker A. Thioredoxin redox control of cell growth and death and the effects of inhibitors. Chem Biol Interact 1998; 111-12: 23-34.
    • (1998) Chem Biol Interact , vol.111-112 , pp. 23-34
    • Powis, G.1    Kirkpatrick, D.L.2    Angulo, M.3    Baker, A.4
  • 79
    • 0036949216 scopus 로고    scopus 로고
    • Costunolide triggers apoptosis in human leukemia U937 cells by depleting intracellular thiols
    • Choi JH, Ha J, Park JH, et al. Costunolide triggers apoptosis in human leukemia U937 cells by depleting intracellular thiols. Jpn J Cancer Res 2002; 93: 1327-33.
    • (2002) Jpn J Cancer Res , vol.93 , pp. 1327-1333
    • Choi, J.H.1    Ha, J.2    Park, J.H.3
  • 80
    • 34548303581 scopus 로고    scopus 로고
    • Cellular thiol status-dependent inhibition of tumor cell growth via modulation of p27(kip1) translocation and retinoblastoma protein phosphorylation by 1'-acetoxychavicol acetate
    • Unahara Y, Kojima-Yuasa A, Higashida M, et al. Cellular thiol status-dependent inhibition of tumor cell growth via modulation of p27(kip1) translocation and retinoblastoma protein phosphorylation by 1'-acetoxychavicol acetate. Amino Acids 2007; 33: 469-76.
    • (2007) Amino Acids , vol.33 , pp. 469-476
    • Unahara, Y.1    Kojima-Yuasa, A.2    Higashida, M.3
  • 81
    • 0035853767 scopus 로고    scopus 로고
    • Arachidonic acid causes cell death through the mitochondrial permeability transition. Implications for tumor necrosis factor-alpha aopototic signaling
    • Scorrano L, Penzo D, Petronilli V, Pagano F, Bernardi P. Arachidonic acid causes cell death through the mitochondrial permeability transition. Implications for tumor necrosis factor-alpha aopototic signaling. J Biol Chem 2001; 276: 12035-40.
    • (2001) J Biol Chem , vol.276 , pp. 12035-12040
    • Scorrano, L.1    Penzo, D.2    Petronilli, V.3    Pagano, F.4    Bernardi, P.5
  • 82
    • 77950436724 scopus 로고    scopus 로고
    • The role of iodine and deltaiodolactone in growth and apoptosis of malignant thyroid epithelial cells and breast cancer cells
    • Gärtner R, Rank P, Ander B. The role of iodine and deltaiodolactone in growth and apoptosis of malignant thyroid epithelial cells and breast cancer cells. Hormones (Athens) 2010; 9: 60-6.
    • (2010) Hormones (Athens) , vol.9 , pp. 60-66
    • Gärtner, R.1    Rank, P.2    Ander, B.3
  • 83
    • 17744387757 scopus 로고    scopus 로고
    • Reactions of indole derivatives with oxiranes and aziridines on silica. Synthesis of betacarbolin- 1-one mimic of pancratistatin
    • Hudlicky T, Rinner U, Finn KJ, Ghiviriga I. Reactions of indole derivatives with oxiranes and aziridines on silica. Synthesis of betacarbolin- 1-one mimic of pancratistatin. J Org Chem 2005; 70: 3490-99.
    • (2005) J Org Chem , vol.70 , pp. 3490-3499
    • Hudlicky, T.1    Rinner, U.2    Finn, K.J.3    Ghiviriga, I.4
  • 84
    • 0025028927 scopus 로고
    • Differences in the distribution of iodine and iodide in the Sprague-Dawley rat
    • Thrall KD, Bull RJ. Differences in the distribution of iodine and iodide in the Sprague-Dawley rat. Fundam Appl Toxicol 1990; 15: 75-81.
    • (1990) Fundam Appl Toxicol , vol.15 , pp. 75-81
    • Thrall, K.D.1    Bull, R.J.2
  • 85
    • 0026469364 scopus 로고
    • Distribution of iodine into blood components of the Sprague-Dawley rat differs with the chemical form administered
    • Thrall KD, Bull RJ, Sauer RL. Distribution of iodine into blood components of the Sprague-Dawley rat differs with the chemical form administered. J Toxicol Environ Health 1992; 37: 443-9.
    • (1992) J Toxicol Environ Health , vol.37 , pp. 443-449
    • Thrall, K.D.1    Bull, R.J.2    Sauer, R.L.3
  • 86
    • 0027096366 scopus 로고
    • Evidence of thyroxine formation following iodine administration in Sprague-Dawley rats
    • Thrall KD, Sauer RL, Bull RJ. Evidence of thyroxine formation following iodine administration in Sprague-Dawley rats. J Toxicol Environ Health 1992; 37: 535-48.
    • (1992) J Toxicol Environ Health , vol.37 , pp. 535-548
    • Thrall, K.D.1    Sauer, R.L.2    Bull, R.J.3
  • 87
    • 0026078797 scopus 로고
    • Comparison of toxicity induced by iodine and iodide in male and female rats
    • Sherer TT, Thrall KD, Bull RJ. Comparison of toxicity induced by iodine and iodide in male and female rats. J Toxicol Environ Health 1991; 32: 89-101.
    • (1991) J Toxicol Environ Health , vol.32 , pp. 89-101
    • Sherer, T.T.1    Thrall, K.D.2    Bull, R.J.3
  • 89
    • 0032429022 scopus 로고    scopus 로고
    • Expression of extracellular glutathione peroxidase in human and mouse gastrointestinal tract
    • Tham DM, Whitin JC, Kim KK, Zhu SX, Cohen HJ. Expression of extracellular glutathione peroxidase in human and mouse gastrointestinal tract. Am J Physiol 1998; 275: G1463-71.
    • (1998) Am J Physiol , vol.275
    • Tham, D.M.1    Whitin, J.C.2    Kim, K.K.3    Zhu, S.X.4    Cohen, H.J.5
  • 90
    • 0027406097 scopus 로고
    • Glutathione content of the small intestine: Regulation and function
    • Kelly FJ. Glutathione content of the small intestine: regulation and function. Br J Nutr 1993; 69: 589-96.
    • (1993) Br J Nutr , vol.69 , pp. 589-596
    • Kelly, F.J.1
  • 92
    • 84888451297 scopus 로고
    • Studies on the glutathione content of the blood in nutritional anemia
    • Schultze MO, Elvehjem CA. Studies on the glutathione content of the blood in nutritional anemia. J Biol Chem 1936; 116: 711-6.
    • (1936) J Biol Chem , vol.116 , pp. 711-716
    • Schultze, M.O.1    Elvehjem, C.A.2
  • 93
    • 70449169186 scopus 로고
    • Iodine metabolism and physiological aspects of endemic goitre
    • Stanbury JB. Iodine metabolism and physiological aspects of endemic goitre. Bull World Health Organ 1958; 18: 201-15.
    • (1958) Bull World Health Organ , vol.18 , pp. 201-215
    • Stanbury, J.B.1
  • 94
    • 0014028021 scopus 로고
    • Conversion of iodate to iodide in vivo and in vitro
    • Taurog A, Howells EM, Nachimson HI. Conversion of iodate to iodide in vivo and in vitro. J Biol Chem 1966; 241: 4686-93.
    • (1966) J Biol Chem , vol.241 , pp. 4686-4693
    • Taurog, A.1    Howells, E.M.2    Nachimson, H.I.3
  • 95
    • 84888457545 scopus 로고
    • PATENTSCOPE ® WO/1994/006289, Available from
    • Shanbrom E. Iodine-iodide treatment of red blood cells. PATENTSCOPE ® WO/1994/006289 1994; Available from: http://www.wipo.int/pctdb/en/wo.jsp?IA=WO1993004731&wo=1993004731&DISPLAY=DESC
    • (1994) Iodine-iodide Treatment of Red Blood Cells
    • Shanbrom, E.1
  • 97
    • 0014891123 scopus 로고
    • Ueber die preoperative Vorbehandlung hyperthyreoter Strumen mit Endojodin
    • Matthaes P. Ueber die preoperative Vorbehandlung hyperthyreoter Strumen mit Endojodin. Langenbecks Arch Chir 1970; 328: 78-90.
    • (1970) Langenbecks Arch Chir , vol.328 , pp. 78-90
    • Matthaes, P.1
  • 98
    • 34250930873 scopus 로고
    • Anorganisches Jod zur Behandlung thyreotoxischer Krisen
    • Westermann HH. Anorganisches Jod zur Behandlung thyreotoxischer Krisen. Klinische Wochenschrift 1941; 20: 1124-1127.
    • (1941) Klinische Wochenschrift , vol.20 , pp. 1124-1127
    • Westermann, H.H.1
  • 99
    • 84888474962 scopus 로고    scopus 로고
    • ® Solution (10% povidone iodine), Available from
    • ® Solution (10% povidone iodine) 2005; Available from: http://www.safety.vanderbilt.edu/-pdf/hcs_msds/betadine_solution%207_05.pdf
    • (2005)
  • 100
    • 0013911076 scopus 로고
    • Untersuchungen zum Stoffwechselverhalten von J131-Polyvinylpyrrolidon im menschlichen Körper
    • Heinrich HC, Gabbe EE, Nass WP, Becker K. Untersuchungen zum Stoffwechselverhalten von J131-Polyvinylpyrrolidon im menschlichen Körper. Klinische Wochenschrift 1966;44: 488-493.
    • (1966) Klinische Wochenschrift , vol.44 , pp. 488-493
    • Heinrich, H.C.1    Gabbe, E.E.2    Nass, W.P.3    Becker, K.4
  • 101
    • 77349116167 scopus 로고    scopus 로고
    • Paclitaxel-loaded poly(N-vinylpyrrolidone)- b-poly(epsilon-caprolactone) nanoparticles: Preparation and antitumor activity in vivo
    • Zhu Z, Li Y, Li X, et al. Paclitaxel-loaded poly(N-vinylpyrrolidone)- b-poly(epsilon-caprolactone) nanoparticles: preparation and antitumor activity in vivo. J Control Release 2010; 142: 438-46.
    • (2010) J Control Release , vol.142 , pp. 438-446
    • Zhu, Z.1    Li, Y.2    Li, X.3
  • 102
    • 55049137346 scopus 로고    scopus 로고
    • Superior antitumor efficiency of cisplatin- loaded nanoparticles by intratumoral delivery with decreased tumor metabolism rate
    • Li X, Li R, Qian X, et al. Superior antitumor efficiency of cisplatin- loaded nanoparticles by intratumoral delivery with decreased tumor metabolism rate. Eur J Pharm Biopharm 2008; 70: 726-34.
    • (2008) Eur J Pharm Biopharm , vol.70 , pp. 726-734
    • Li, X.1    Li, R.2    Qian, X.3
  • 103
    • 3342875557 scopus 로고    scopus 로고
    • Effective accumulation of poly(vinylpyrrolidone-co-vinyl laurate) into the spleen
    • Yoshioka Y, Tsutsumi Y, Mukai Y, et al. Effective accumulation of poly(vinylpyrrolidone-co-vinyl laurate) into the spleen. J Biomed Mater Res A 2004; 70: 219-23.
    • (2004) J Biomed Mater Res A , vol.70 , pp. 219-223
    • Yoshioka, Y.1    Tsutsumi, Y.2    Mukai, Y.3
  • 104
    • 23844465250 scopus 로고    scopus 로고
    • Preparation, characterization, and drug-release properties of poly(N- isopropylacrylamide) microspheres having poly(itaconic acid) graft chains
    • Taşdelen B, Kayaman-Apohan N, Misirli Z, Güven O, Baysal BM. Preparation, characterization, and drug-release properties of poly(N- isopropylacrylamide) microspheres having poly(itaconic acid) graft chains. J Appl Polym Sci 2005; 97: 1115-1124.
    • (2005) J Appl Polym Sci , vol.97 , pp. 1115-1124
    • Taşdelen, B.1    Kayaman-Apohan, N.2    Misirli, Z.3    Güven, O.4    Baysal, B.M.5
  • 105
    • 33845296551 scopus 로고    scopus 로고
    • The in vitro effective antiviral action of povidone-iodine (PVP-I) may also have therapeutic potential by its intravenous administration diluted with Ringer's solution
    • Sabracos L, Romanou S, Dontas I, Coulocheri S, Ploumidou K, Perrea D. The in vitro effective antiviral action of povidone-iodine (PVP-I) may also have therapeutic potential by its intravenous administration diluted with Ringer's solution. Med Hypotheses 2007; 68: 272-4.
    • (2007) Med Hypotheses , vol.68 , pp. 272-274
    • Sabracos, L.1    Romanou, S.2    Dontas, I.3    Coulocheri, S.4    Ploumidou, K.5    Perrea, D.6
  • 108
    • 63149119372 scopus 로고    scopus 로고
    • Population-based cancer survival trends in England and Wales up to 2007: An assessment of the NHS cancer plan for England
    • Rachet B, Maringe C, Nur U, et al. Population-based cancer survival trends in England and Wales up to 2007: an assessment of the NHS cancer plan for England. Lancet Oncol 2009; 10: 35-69.
    • (2009) Lancet Oncol , vol.10 , pp. 35-69
    • Rachet, B.1    Maringe, C.2    Nur, U.3
  • 109
    • 84984767910 scopus 로고    scopus 로고
    • Trends and inequalities in survival for 20 cancers in England and Wales 1986-2001: Population-based analyses and clinical commentaries
    • Richards MA. Trends and inequalities in survival for 20 cancers in England and Wales 1986-2001: population-based analyses and clinical commentaries. Foreword. Br J Cancer 2008; 99 Suppl 1: S1.
    • (2008) Foreword. Br J Cancer , vol.99 , Issue.SUPPL. 1
    • Richards, M.A.1
  • 110
    • 84888456729 scopus 로고    scopus 로고
    • Note
    • Office for National Statistics (ONS), Survival Rates in England, patients diagnosed 2001-2006 followed up to 2007.
  • 111
    • 84888461212 scopus 로고    scopus 로고
    • American Cancer Society 2011. Available from
    • American Cancer Society 2011. Available from: http://www.-cancer.org/cancer/pancreaticcancer/detailedguide/pancreaticcancer-survival-rates


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