Thiol depletion induces apoptosis in cultured lung fibroblasts

American Journal of Respiratory Cell and Molecular Biology

Volumn 21, Issue 1, 1999, Pages 54-64

  Aoshiba, Kazutetsu ^a   Yasui, Shuji ^a   Nishimura, Kazuyuki ^a   Nagai, Atsushi ^a,b  

^a TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^b Dept of Medicine   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARACHIDONATE 5 LIPOXYGENASE; CYSTEINE; GLUTATHIONE; LEUKOTRIENE; PROTEIN KINASE (CALCIUM,CALMODULIN); REACTIVE OXYGEN METABOLITE; THIOL DERIVATIVE;

APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; FIBROBLAST; HUMAN; LUNG; PHYSIOLOGY; TIME; WOUND HEALING;

APOPTOSIS; ARACHIDONATE 5-LIPOXYGENASE; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELLS, CULTURED; CYSTEINE; FIBROBLASTS; GLUTATHIONE; HUMANS; LEUKOTRIENES; LUNG; REACTIVE OXYGEN SPECIES; SULFHYDRYL COMPOUNDS; TIME FACTORS; WOUND HEALING;

EID: 0033161387     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/ajrcmb.21.1.3411     Document Type: Article

References (61)

1. Wolff, G., and R. G. Crystal. 1997. Biology of pulmonary fibrosis. In The Lung: Scientific Foundations. R. G. Crystal, J. B. West, E. R. Weibel, and P. J. Barnes, editors. Lippincott-Raven Publishers, Philadelphia. 2537-2554.
2. Polnovsky, V. A., B. Chen, C. Henke, D. Snover, C. Wendt, D. H. Ingbar, and P. B. Bitterman, 1993. Role of mesenchymal cell death in lung remodeling after injury. J. Clin. Invest. 92;388-397.
3. Martin, P. 1997. Wound healing: aiming for perfect skin regeneration. Science 276:75-81.
4. Grinnell, F. 1994. Fibroblasts, myofibroblasts, and wound contraction. J. Cell. Biol. 124:401-404.
5. Darby, I., O. Skalli, and G. Gabbiani. 1990, α-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing. Lab. Invest. 63:21-29.
6. Desmouliele, A., M. Redard, I. Darby, and G. Gabbiani. 1995. Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar. Am. J. Pathol. 145:56-66.
7. Cohen, J. J. 1994. Apoptosis: physiologic cell death. J. Lab. Clin. Med. 124: 761-765.
8. Gossens, V., J. Grooten, K. D. Vos, and W. Fiers. 1995. Direct evidence for Tumor necrosis factor-induced mitochondrial reactive oxygen intermediates and their involvement in cytotoxicity. Proc. Natl. Acad. Sci. USA 92;8115-8119.
9. Jacobson, M. D. 1996. Reactive oxygen species and programmed cell death. TIBS 21:83-86.
10. Forman, H. J., R. Liu, and L. Tian. 1997. Glutathione cycling in oxidative stress. In Oxygen, Gene Expression, and Cellular Function: Lung Biology in Health and Disease. Vol. 105. L. B. Clerch and D. J. Massaro, editors. Marcel Dekker, New York, 99-112.
11. Sato, N., S. Iwata, K. Nakamura, T. Hori, T. Mori, and J. Yodoi. 1995. Thiol-mediated redox regulation of apoptosis: possible roles of cellular thiols other than glutathione in T cell apoptosis. J. Immunol. 154:3194-3203.
12. Watson, R. W. G., O. D. Rotstein, A. B. Nathens, A. P. B. Dackiw, and J. C. Marshall. 1996. Thiol-mediated redox regulation of neutrophil apoptosis. Surgery 120:150-158.
13. Kane, D. J., T. A. Sarafian, R. Anton, H. Hahn, E. B. Gralla, J. S. Valentine, T. Ord, and D. F., Bredesen. 1993. Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species. Science 262:1274-1277.
14. Kanner, S. B., T.J. Kavanagh, A. Grossmann, S. Hu, J. B. Bolen, P. S. Rabinovitch, and J. A. Ledbetter. 1992. Sulfhydryl oxidation down-regulates T-cell signaling and inhibits tyrosine phosphorylation of phospholipase Cyl. Proc. Natl. Acad. Sci. USA 89:300-304.
15. lck in T cells. Oncogene 8:3133-3139.
16. Monterio, H. P., Y. Ivaschenko, R. Fischer, and A. Stern. 1991. Inhibition of protein tyrosine phosphatase activity by diamide is reversed by epidermal growth factor in fibroblasts. FEBS Lett. 295:146-148.
17. Kyriakis, J. M., and J. Avruch. 1996. Sounding the alarm: protein kinase cascades activated by stress and inflammation. J. Biol. Chem. 271:24313-24316.
18. O'Donnell, V. B., S. Spycher, and A. Azzi. 1995. Involvement of oxidants and oxidant-generating enzyme(s) in tumor necrosis factor α-mediated apoptosis: role for lipoxygenase pathway but not mitochondrial respiratory chain. Biochem. J. 310:133-141.
19. Korystov, Y. N., O. R. Dobrovinskaya, V. V. Shaposhnikova, and L. K. Eidus. 1996. Role of arachidonic acid metabolism in thymocyte apoptosis after irradiation. FEBS Lett. 388:238-241.
20. Rees, R. S., D. J. Smith, Jr., B. Adamson, M. Im, and D. Hinshaw. 1995. Oxidative stress; the role of the glutathione redox cycle in skin preconditioning. J. Surg. Res. 58:395-400.
21. Adamson, B., D. Schwarz, P. Klugston, R. Gilmont, I.. Perry, J. Fisher, W. Lindblad, and R. Rees. 1996. Delayed repair: the role of glutathione in rat incisional wound model. J. Surg. Res. 62:159-164.
22. Takcuchi, K., M. Okada, K. Ueshima, T. Ohuchi, and S. Okabe, 1993. Endogenous sulfhydryls in healing gastric mucosal injury induced by HCI in the rat. Digestion 54:91-97.
23. Frank, S., B. Munz, und S. Werner. 1997. The human homologue of a bovine no-selenium glutathione peroxidase is a novel keratinocyte growth factor-regulated gene. Oncogene 14:915-922.
24. Rees, R. S., D. Smith, T. D. Li, B. Cashmer, W. Garner, J. Punch, and D. J. Smith, Jr. 1994. The role of xanthine oxidase and xanthine dehydrogenasc in skin ischemia. J. Surg. Res. 56:162-167.
25. Bannai, S., J. Tsukeda, and J. Okumura. 1997. Effect of antioxidants on cultured human diploid fibroblasts exposed to cystine-free medium. Biochem. Biophys. Res. Commun. 74:15282-15288.
26. Oshima, R. G., W. J. Rhead, J. G. Thoene, and J. A. Schneider. 1997. Cystine metabolism in human fibroblasts. J. Biol. Chem. 251:4287-4293.
27. Chiba T., S. Takahashi, N. Sato, S. Ishii, and K. Kikuchi. 1996. Fas-mediated apoptosis is modulated by intracellular glutathione in human T cells. Eur. J. Immunol. 26:1164-1169.
28. Tietze, F. 1996. Enzymatic method for quantitative determination of nanogram amounts of total and oxidized glutathione. Anal. Biochem. 27:502-522.
29. Haugland, R. P. 1996. Handbook of Flourescent Probes and Research Chemicals, 6th edition. Molecular Probes, Eugene, OR.
30. Plumb, J. A., R. Milroy, and S. B. Kaye. 1989. Effects of the pH dependence of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-tetrazolium bromide-formazan on chemosensitivity determined by a novel tetrazolium-based assay. Cancer Res. 49:4435-4440.
31. Kerr, J. F. R., A. H. Wyllie, and A. R. Currie. 1972. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26:239-257.
32. Starke, P. E., and J. L. Farber. 1985. Endogenous defences against the cytotoxicity of hydrogen peroxide in cultured rat hepatocytes. J. Biol. Chem. 260:86-92.
33. Chance, B., H. Sies, and A. Boveris. 1979. Hydroperoxide metabolism in mammalian organs. Physiol. Rev. 59:527-605.
34. Okuda, S., N. Nishiyama, H. Saito, and H. Katsuki. 1996. Hydrogen peroxide-mediated neuronal cell death induced by an endogenous neurotoxin, 3-hydroxykynurenine. Proc. Natl. Acad. Sci. USA 93:12553-12588.
35. Coyle, J. T., and P. Puttfarcken. 1993. Oxidative stress, glutathione, and neurodegenerative disorders. Science 262:689-695.
36. Derijard. B., J. Raingeaud, T. Barrett, I. Wu, J. Han, R. J. Ulevitch, and R. J. Davis. 1995. Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms. Science 267:682-685.
37. Raingeaud, J., S. Gupta, J. S. Rogers, M. Dickens, J. Han, R. J. Ulevitch, and R. J. Davis, 1995. Pro-inflammatory cytokines and environmental stress cause p38-mitogen-activated protein kinase activation by dual phosphorylation on tyrosine and threonine. J. Biol. Chem. 270:7420-7426.
38. Cuenda, A., J. Rouse, Y. N. Doza, R. Meier, P. Cohen, T. F. Gallagher, P. R. Young, and J. C. Lee. 1995. SB203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-I. FEBS Lett. 364:229-233.
39. Aoshiba, K., S. I. Rennard, and J. S. Spurzem. 1997. Cell-matrix and cell-cell interactions modulate apoptosis of bronchial epithelial cells. Am. J. Physiol. 272:L28-L37.
40. Savani, R. C., C. Wang, B. Yang, S. Zhang, M. G. Kinsella, T. N. Wight, R. Stern, D. M. Nance, and E. A. Turley. 1995. Migration of bovine aortic smooth muscle cells after wound injury: the role of hyaluronan and RHAMM. J. Clin. Invest. 95:1158-1168.
41. Faber-Elman, A., A. Solomon, J. A. Abraham, M. Marikovsky, and M. Schwartz. 1996. Involvement of wound-associated factors in rat brain astrocyte migratory response to axonal injury: in vitro simulation. J. Clin. Invest. 97:162-171.
42. Buttke, T. M., and P. A. Sandstrom. 1994. Oxidative stress as a mediator of apoptosis. Immunol. Today 15:7-10.
43. Behl, C., J. B. Davis, R. Lesley, and D. Schubert. 1994. Hydrogen peroxide mediates amyloid β protein cytotoxicity. Cell 77:817-827.
44. Talley, A. K., S. Dewhurst, S. W. Perry, S. C. Dollard, S. Gummuluru, S. M. Fine, D. New, L. G. Epstein, H. E. Gendelman, and H. A. Gelbard. 1995. Tumor necrosis factor alpha-induced apoptosis in human neuronal cells: protection by the antioxidant N-acetylcysteine and the genes bcl-2 and crmA. Mol. Cell. Biol. 15:2359-2360.
45. Nobel, C. S. I., M. Kimland, B. Lind, S. Orrenius, and A. F. G. Slater. 1995. Dithiocarbamates induce apoptosis in thymus by raising the intracellular level of redox-active copper. J. Biol. Chem. 270:26202-26208.
46. Lin, K., S. Lee, K. Narayanan, J. M. Baraban, J. M. Hardwick, and R. R. Ratan. 1995. Thiol agents and Bcl-2 identify an alphavirus-induced apoptotic pathway that requires activation of the transcription factor NF-kappa B. J. Cell Biol. 131:1149-1161.
47. Weltin, D., K. Aupeix, C. Iltis, J. M. Cuillerot, P. Dufour, J. Marchal, and P. Bischoff 1996. N-acetylcysteine protects lymphocytes from nitrogen mustard-induced apoptosis. Biochem. Pharmacol. 51:1123-1129.
48. Martensson, J., A. Jain, W. Frayer, and A. Meister. 1989. Glutathione metabolism in the lung: inhibition of its synthesis loads to lammellar body and mitochondrial defects. Proc, Natl. Acad. Sci. USA 86:5296-5300.
49. Meister, A. 1995. Mitochondrial changes associated with glutathione deficiency. BBA 1271:35-42.
50. Green, D. G., and J. C. Reed. 1998, Mitochodria and apoptosis. Science 281: 1309-1312.
51. Rao, G. N., M. S. Rung, and R. W. Alexander. 1995. Hydrogen peroxide activation of cytosolic phospholipase A2 in vascular smooth muscle cells. BBA 1265:67-72.
52. Boyer, C. S., G. L. Bannenberg, E. P. A. Neve, A. Ryrfeldt, and P. Moldeus. 1995. Evidence for the activation of the signal-responsive phospholipase A2 by endogenous hydrogen peroxide. Biochem. Pharmacol. 50:753-761.
53. Chen, X., A. Gresham, A. Mottison, and A. P. Pentland. 1996. Oxidative stress mediates synthesis of phospholipase A2 after UVB injury. BBA 1299:23-33.
54. Yu, M., G. A. Jamiesin, Jr., G. D. Leikauf, and D. W. Nebert. 1998. Phospholipase A2 activation and increase in specific prostaglandins in the oxidatively stressed 14Cos/14Cos mouse hepatocyte line. Biochem. Pharmacol. 55:193-200.
55. Strek, M. F.. 1996. Leukotriene receptor antagonists and synthesis inhibitors in asthma. In Pulmonary and Critical Care Pharmacology and Therapeutics. A. R. Leff, editor. McGraw-Hill, New York. 663-668.
56. Cui, X., and J, G. Douglas. 1997, Arachidonic acid activates c-jun N-terminal kinase through NADPII oxidase in rabbit proximal tubular epithelial cells. Proc. Natl. Acad. Sci. USA 94:3771-3776.
57. Hermeking, H., and D. Eick. 1994. Mediation of c-Myc-induced apoptosis by p53. Science 265:2091-2093.
58. Shi, L., W. K. Nishioka, J. Th'ng, E. M. Bradbury, D. W. Litchfield, and A. H. Greenberg. 1994. Premature p34ced2 activation required for apoptosis. Science 263:1143-1145.
59. Evan, G., and T. Littlewood. 1998. A matter of life and cell death. Science 281:1317-1322.
60. Simon, A. R., B. L. Fanburg, and B. H. Cochran. 1997. Oxidative stress and cell proliferation. In Oxygen, Gene Expression, and Cellular Function. Lung Biology in Health and Disease. Vol. 105. L. B. Clerch and D. J. Massaro, editors. Marcel Dekker, New York. 123-138.
61. 2 for platelet-derived growth factor signal transduction. Science 270:296-299.