메뉴 건너뛰기




Volumn 118, Issue 7, 2010, Pages 410-419

Antiproliferative/cytotoxic activity of molecular iodine and iodolactones in various human carcinoma cell lines. No interfering with EGF-signaling, but evidence for apoptosis

Author keywords

antiproliferative cytotoxic activity; human cancer cell lines; iodolactones; molecular iodine

Indexed keywords

ACETYLCYSTEINE; DELTA IODOLACTONE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; IODINE; IODOLACTONE DERIVATIVE; LACTONE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG; 6-IODO-5-HYDROXY-EICOSATRIENOIC ACID, DELTA-LACTONE; ANTINEOPLASTIC AGENT; ARACHIDONIC ACID DERIVATIVE; CYTOTOXIN; LACTONE;

EID: 77954876358     PISSN: 09477349     EISSN: 14393646     Source Type: Journal    
DOI: 10.1055/s-0029-1225615     Document Type: Article
Times cited : (31)

References (33)
  • 1
    • 19444377165 scopus 로고    scopus 로고
    • Is iodine a gatekeeper of the integrity of the mammary gland?
    • Aceves C, Anguiana B, Delgado G. Is iodine a gatekeeper of the integrity of the mammary gland? J Mammary Gland Biol Neopl 2005 10 189-196
    • (2005) J Mammary Gland Biol Neopl , vol.10 , pp. 189-196
    • Aceves, C.1    Anguiana, B.2    Delgado, G.3
  • 2
    • 0033161387 scopus 로고    scopus 로고
    • Thiol depletion induces apoptosis in cultured lung fibroblasts
    • Aoshiba K, Yasui S, Nishimura K, etal. Thiol depletion induces apoptosis in cultured lung fibroblasts. Am J Respir Cell Mol Biol 1999 21 54-64
    • (1999) Am J Respir Cell Mol Biol , vol.21 , pp. 54-64
    • Aoshiba, K.1    Yasui, S.2    Nishimura, K.3
  • 3
    • 33846819022 scopus 로고    scopus 로고
    • Uptake and antiproliferative effect of molecular iodine in the MCF-7 breast cancer cell line
    • Arroyo-Helguera O, Anguiano B, Delgado G, etal. Uptake and antiproliferative effect of molecular iodine in the MCF-7 breast cancer cell line. Endocr Relat Cancer 2006 13 1147-1158
    • (2006) Endocr Relat Cancer , vol.13 , pp. 1147-1158
    • Arroyo-Helguera, O.1    Anguiano, B.2    Delgado, G.3
  • 4
    • 58249112933 scopus 로고    scopus 로고
    • Signaling pathways involved in the antiproliferative effect of molecular iodine in normal and tumoral breast cells: Evidence that 6-iodolactone mediates apoptotic effects
    • Arroyo-Helguera O, Rojas E, Delgado G, etal. Signaling pathways involved in the antiproliferative effect of molecular iodine in normal and tumoral breast cells: evidence that 6-iodolactone mediates apoptotic effects. Endocr Rel Cancer 2008 15 1003-1011
    • (2008) Endocr Rel Cancer , vol.15 , pp. 1003-1011
    • Arroyo-Helguera, O.1    Rojas, E.2    Delgado, G.3
  • 5
    • 0019558717 scopus 로고
    • Lactoperoxidase-catalyzed iodination of arachidonic aicd: Formation of macrolipides
    • Boeynaems JM, Reagan D, Hubbard WC. Lactoperoxidase-catalyzed iodination of arachidonic aicd: formation of macrolipides. Lipids 1981 16 246-249
    • (1981) Lipids , vol.16 , pp. 246-249
    • Boeynaems, J.M.1    Reagan, D.2    Hubbard, W.C.3
  • 6
    • 0034663082 scopus 로고    scopus 로고
    • Intracellular thiol depletion causes mitochondrial permeability transition in Ebselen-induced apoptosis
    • Chen FY, Han MS, Choon NO. Intracellular thiol depletion causes mitochondrial permeability transition in Ebselen-induced apoptosis. Arch Biochem Biophys 2000 380 319-330
    • (2000) Arch Biochem Biophys , vol.380 , pp. 319-330
    • Chen, F.Y.1    Han, M.S.2    Choon, N.O.3
  • 7
    • 0025282495 scopus 로고
    • Evidence that a iodolactone mediates the inhibitory effect of iodide on thyroid cell proliferation but not on adenosine 3, 5 monophosphate formation
    • Dugrillon A, Bechtner G, Uedelhofen M, etal. Evidence that a iodolactone mediates the inhibitory effect of iodide on thyroid cell proliferation but not on adenosine 3, 5 monophosphate formation. Endocrinol 1990 127 337-343
    • (1990) Endocrinol , vol.127 , pp. 337-343
    • Dugrillon, A.1    Bechtner, G.2    Uedelhofen, M.3
  • 8
    • 0028989276 scopus 로고
    • Iodolactones decrease epidermal growth factor- induced proliferation of inositol 1, 4, 5 triphosphate generation in porcine thyroid follicles a possible mechanism of growth inhibition by iodide
    • Dugrillon A, Gärtner R. -Iodolactones decrease epidermal growth factor- induced proliferation of inositol 1, 4, 5 triphosphate generation in porcine thyroid follicles a possible mechanism of growth inhibition by iodide. Eur J Endocrin 1995 132 735-743
    • (1995) Eur J Endocrin , vol.132 , pp. 735-743
    • Dugrillon, A.1    Gärtner, R.2
  • 9
    • 0028172325 scopus 로고
    • Identification of -iodolactone in iodide treated human goiter and its inhibitory effect on proliferation of human thyroid follicles
    • etal
    • Dugrillon A, Uedelhofen M, Pisarev A, etal. Identification of -iodolactone in iodide treated human goiter and its inhibitory effect on proliferation of human thyroid follicles. Horm Metab Res 1994 26 465-469
    • (1994) Horm Metab Res , vol.26 , pp. 465-469
    • Dugrillon, A.1    Uedelhofen, M.2    Pisarev, A.3
  • 10
    • 0029049820 scopus 로고
    • Different tissue responses for iodine and iodide in rat thyroid and mammary glands
    • etal
    • Eskin BA, Grotowski CE, Conolly CP, etal. Different tissue responses for iodine and iodide in rat thyroid and mammary glands. Biol Trace Element Res 1995 49 9-19
    • (1995) Biol Trace Element Res , vol.49 , pp. 9-19
    • Eskin, B.A.1    Grotowski, C.E.2    Conolly, C.P.3
  • 11
    • 9044238841 scopus 로고    scopus 로고
    • Suppressive effect of iodine on DMBA-induced breast tumor growth in the rat
    • etal
    • Funahashi H, Imai F, Tanaka Y, etal. Suppressive effect of iodine on DMBA-induced breast tumor growth in the rat. J Surg Oncology 1996 61 209-213
    • (1996) J Surg Oncology , vol.61 , pp. 209-213
    • Funahashi, H.1    Imai, F.2    Tanaka, Y.3
  • 13
    • 0037271399 scopus 로고    scopus 로고
    • Glutathione disulfide induces apoptosis in U937 cells by a redox-mediated p38 MAP-kinase pathway
    • Filomeni G, Rotilio G, Ciriolo MR. Glutathione disulfide induces apoptosis in U937 cells by a redox-mediated p38 MAP-kinase pathway. The FASEB J 2003 17 64-66
    • (2003) The FASEB J , vol.17 , pp. 64-66
    • Filomeni, G.1    Rotilio, G.2    Ciriolo, M.R.3
  • 14
    • 0027449429 scopus 로고
    • Iodine replacement in fibrocystic desease of the breast
    • Ghent WR, Eskin BA, Low DA, etal. Iodine replacement in fibrocystic desease of the breast. Can J Surg 1993 36 453-460
    • (1993) Can J Surg , vol.36 , pp. 453-460
    • Ghent, W.R.1    Eskin, B.A.2    Low, D.A.3
  • 15
    • 0033088957 scopus 로고    scopus 로고
    • The role of gluthadione in the regulation of apoptosis
    • Hall AG. The role of gluthadione in the regulation of apoptosis. Eur J Clin Invest 1999 29 238-245
    • (1999) Eur J Clin Invest , vol.29 , pp. 238-245
    • Hall, A.G.1
  • 16
    • 49249115751 scopus 로고    scopus 로고
    • Identification of Thioredoxin-2 as a Regulator of the Mitochondrial Permeability Transition
    • He M, Cai J, Go YM, etal. Identification of Thioredoxin-2 as a Regulator of the Mitochondrial Permeability Transition. Tox Sci 2008 105 44-50
    • (2008) Tox Sci , vol.105 , pp. 44-50
    • He, M.1    Cai, J.2    Go, Y.M.3
  • 17
    • 9444272026 scopus 로고    scopus 로고
    • GSH depletion enhances adenoviral bax-induced apoptosis in lung cancer cells
    • Honda T, S Coppola L, Ghibelli S, etal. GSH depletion enhances adenoviral bax-induced apoptosis in lung cancer cells. Canc Gene Ther 2004 11 249-255
    • (2004) Canc Gene Ther , vol.11 , pp. 249-255
    • Honda, T.1    Coppola L, S.2    Ghibelli, S.3
  • 19
    • 0037147634 scopus 로고    scopus 로고
    • RAC1-dependent regulation of cholinergically induced lamellar protrusive activity is independent of MAP-kinase and attenuated by active p-JNK
    • Jung A, Rösner H. RAC1-dependent regulation of cholinergically induced lamellar protrusive activity is independent of MAP-kinase and attenuated by active p-JNK. Dev Neurosci 2002 13 2443-2446
    • (2002) Dev Neurosci , vol.13 , pp. 2443-2446
    • Jung, A.1    Rösner, H.2
  • 20
    • 0028323292 scopus 로고
    • Suppressive effect of iodine preparation on proliferation of DMBA-induced cancer in rat
    • Katoh N, Funahashi H, Vendoh K. Suppressive effect of iodine preparation on proliferation of DMBA-induced cancer in rat. J Jpn Soc Cancer 1994 29 30-36
    • (1994) J Jpn Soc Cancer , vol.29 , pp. 30-36
    • Katoh, N.1    Funahashi, H.2    Vendoh, K.3
  • 21
    • 3142764631 scopus 로고    scopus 로고
    • The effect of supraphysiologic levels of iodine on patients with cyclic mastalgia
    • Kessler JH. The effect of supraphysiologic levels of iodine on patients with cyclic mastalgia. Breast J 2004 10 328-336
    • (2004) Breast J , vol.10 , pp. 328-336
    • Kessler, J.H.1
  • 22
    • 36448955389 scopus 로고    scopus 로고
    • A mild and environmentally benign oxidation of thiols to disulfides
    • Kirihari M, Asai Y, Ogawa S, etal. A mild and environmentally benign oxidation of thiols to disulfides. Synthesis 2007 21 3286-3289
    • (2007) Synthesis , vol.21 , pp. 3286-3289
    • Kirihari, M.1    Asai, Y.2    Ogawa, S.3
  • 23
  • 25
    • 0030606321 scopus 로고    scopus 로고
    • In growth cones of rat cerebral neurons and human neuroblastoma cells, activation of protein kinase C causes a shift from filopodial to lamellipodial actin dynamics
    • Rösner H, Fischer H. In growth cones of rat cerebral neurons and human neuroblastoma cells, activation of protein kinase C causes a shift from filopodial to lamellipodial actin dynamics. Neurosci Lett 1996 219 175-178
    • (1996) Neurosci Lett , vol.219 , pp. 175-178
    • Rösner, H.1    Fischer, H.2
  • 26
    • 0028905886 scopus 로고
    • Muscarinic receptor-mediated induction of actin-driven lamellar protrusions in neuroblastoma cell somata and growth cones. Involvement of protein kinase C
    • Rösner H, Vacun G, Rebhan M. Muscarinic receptor-mediated induction of actin-driven lamellar protrusions in neuroblastoma cell somata and growth cones. Involvement of protein kinase C. Eur J Cell Biol 1995 66 324-334
    • (1995) Eur J Cell Biol , vol.66 , pp. 324-334
    • Rösner, H.1    Vacun, G.2    Rebhan, M.3
  • 27
    • 0035934309 scopus 로고    scopus 로고
    • Disassembly of microtubules and inhibition of neurite outgrowth, neuroblastoma cell proliferation, and MAP-kinase tyrosine dephoisphorylation by dibenzyl-trisulphide
    • etal
    • Rösner H, Williams LAD, Jung A, etal. Disassembly of microtubules and inhibition of neurite outgrowth, neuroblastoma cell proliferation, and MAP-kinase tyrosine dephoisphorylation by dibenzyl-trisulphide. Biochim Biophys Acta 2001 1540 166-177
    • (2001) Biochim Biophys Acta , vol.1540 , pp. 166-177
    • Rösner, H.1    Williams, L.A.D.2    Jung, A.3
  • 28
    • 0032080283 scopus 로고    scopus 로고
    • Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1
    • etal
    • Saitoh M, Nishitoh H, Fujii M, etal. Mammalian thioredoxin is a direct inhibitor of apoptosis signal-regulating kinase (ASK) 1. The EMBO J 1998 17 2596-2606
    • (1998) The EMBO J , vol.17 , pp. 2596-2606
    • Saitoh, M.1    Nishitoh, H.2    Fujii, M.3
  • 29
    • 33745827711 scopus 로고    scopus 로고
    • Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving mitochonria-mediated pathway
    • Shrivastava A, Tiwari M, Sinha RA, etal. Molecular iodine induces caspase-independent apoptosis in human breast carcinoma cells involving mitochonria-mediated pathway. J Biol Chem 2006 281 19762-19771
    • (2006) J Biol Chem , vol.281
    • Shrivastava, A.1    Tiwari, M.2    Sinha, R.A.3
  • 30
    • 47349125602 scopus 로고    scopus 로고
    • Iodine alters gene expression in the MCF-7 breast cancer cell line: Evidence for an anti-estrogen effect of iodine
    • Stoddard FR, Brooks AD, Eskin BA, etal. Iodine alters gene expression in the MCF-7 breast cancer cell line: Evidence for an anti-estrogen effect of iodine. Int J Med Sci 2008 5 189-196
    • (2008) Int J Med Sci , vol.5 , pp. 189-196
    • Stoddard, F.R.1    Brooks, A.D.2    Eskin, B.A.3
  • 31
    • 1642325525 scopus 로고    scopus 로고
    • Mastopathie, Mammkarzinom und Jodlactone
    • Torremante P. Mastopathie, Mammkarzinom und Jodlactone. Dtsch Med Wochenschr 2004 129 641-646
    • (2004) Dtsch Med Wochenschr , vol.129 , pp. 641-646
    • Torremante, P.1
  • 32
    • 0036889940 scopus 로고    scopus 로고
    • Differential action of iodine on mitochondria from human tumoral- and extra-tumoral tissue in inducing the release of apoptogenic proteins
    • Upadhyay G, Singh R, Sharma R, etal. Differential action of iodine on mitochondria from human tumoral- and extra-tumoral tissue in inducing the release of apoptogenic proteins. Mitochondrion 2002 2 199-210
    • (2002) Mitochondrion , vol.2 , pp. 199-210
    • Upadhyay, G.1    Singh, R.2    Sharma, R.3
  • 33
    • 2942696470 scopus 로고    scopus 로고
    • Thioredoxin-2 Inhibits Mitochondria-Located ASK1-Mediated Apoptosis in a JNK-Independent Manner
    • Zhang R, Al-Lamki L, Bai JW, etal. Thioredoxin-2 Inhibits Mitochondria-Located ASK1-Mediated Apoptosis in a JNK-Independent Manner. Circ Res 2004 94 1483-1490
    • (2004) Circ Res , vol.94 , pp. 1483-1490
    • Zhang, R.1    Al-Lamki, L.2    Bai, J.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.