Antineoplastic effect of iodine in mammary cancer: Participation of 6-iodolactone (6-IL) and peroxisome proliferator-activated receptors (PPAR)

Molecular Cancer

Volumn 8, Issue , 2009, Pages

  Aceves, Carmen ^a   García Solís, Pablo ^a   Arroyo Helguera, Omar ^a   Vega Riveroll, Laura ^a   Delgado, Guadalupe ^a   Anguiano, Brenda ^a  

^a CENTRO DE FÍSICA APLICADA Y TECNOLOGÍA AVANZADA   (Mexico)

Author keywords

[No Author keywords available]

Indexed keywords

6 IODOLACTONE; ARACHIDONIC ACID; CASPASE 3; CYCLINE; IODINE; LACTONE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; UNCLASSIFIED DRUG; UROKINASE; VASCULOTROPIN; 6 IODO 5 HYDROXY EICOSATRIENOIC ACID, DELTA LACTONE; 6-IODO-5-HYDROXY-EICOSATRIENOIC ACID, DELTA-LACTONE; ANTINEOPLASTIC AGENT; ARACHIDONIC ACID DERIVATIVE; VASCULOTROPIN A;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIANGIOGENIC ACTIVITY; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; SPRAGUE DAWLEY RAT; ANALYSIS OF VARIANCE; ANIMAL; CELL PROLIFERATION; DRUG EFFECT; EXPERIMENTAL NEOPLASM; IMMUNOHISTOCHEMISTRY; METABOLISM; METHODOLOGY;

RATTUS;

ANALYSIS OF VARIANCE; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; ARACHIDONIC ACID; ARACHIDONIC ACIDS; CASPASE 3; CELL PROLIFERATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FEMALE; IMMUNOHISTOCHEMISTRY; IODINE; MAMMARY NEOPLASMS, EXPERIMENTAL; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; RATS; RATS, SPRAGUE-DAWLEY; UROKINASE-TYPE PLASMINOGEN ACTIVATOR; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 65649110819     PISSN: None     EISSN: 14764598     Source Type: Journal    
DOI: 10.1186/1476-4598-8-33     Document Type: Article

References (33)

1. Cann S van Netten J van Netten C Hypothesis: Iodine, selenium and the development of breast cancer Cancer Causes Control 2000, 11(2):121-127. 10.1023/A:1008925301459 10710195
2. Venturi S Donati F Venturi A Venturi M Grossi L Guidi A Role of iodine in evolution and carcinogenesis of thyroid, breast and stomach Adv Clin Path 2000, 4(1):11-17. 10936894
3. Aceves C Anguiano B Delgado G Is iodine a gatekeeper of the integrity of the mammary gland? J Mammary Gland Biol Neoplasia 2005, 10(2):189-196. 10.1007/s10911-005-5401-5 16025225
4. Ghent W Eskin B Low D Hill L Iodine replacement in fibrocystic disease of the breast Can J Surg 1993, 36(5):453-460. 8221402
5. Funahashi H Imai T Tanaka Y Tobinaga J Wada M Morita T Yamada F Tsukamura K Oiwa M Kikumori T et al. Suppressive effect of iodine on DMBA-induced breast tumor growth in the rat J Surg Oncol 1996, 61(3):209-213. 10.1002/ (SICI)1096-9098(199603)61:3<209::AID-JSO9>3.0.CO;2-F 8637209
6. Kessler J The effect of supraphysiologic levels of iodine on patients with cyclic mastalgia Breast J 10, 4:328-336. 10.1111/ j.1075-122X.2004.21341.x 15239792
7. García-Solís P Alfaro Y Anguiano B Delgado G Guzman R Nandi S Díaz-Muñoz M Vázquez-Martínez O Aceves C Inhibition of N-methyl-N-nitrosourea-induced mammary carcinogenesis by molecular iodine (I2) but not by iodide (I-) treatment Evidence that I2 prevents cancer promotion Mol Cell Endocrinol 2005, 236(1-2):49-57. 10.1016/j.mce.2005.03.001 15922087
8. Dugrillon A Uedelhoven W Pisarev M Bechtner G Gärtner R Identification of delta-iodolactone in iodide treated human goiter and its inhibitory effect on proliferation of human thyroid follicles Horm Metab Res 1994, 26(10):465-469. 10.1055/s-2007-1001734 7851869
9. Pisarev M Krawiec L Juvenal G Bocanera L Pregliasco L Sartorio G Chester H Studies on the goiter inhibiting action of iodolactones Eur J Pharmacol 1994, 258(1-2):33-37. 10.1016/0014-2999(94)90054-X 7925597
10. Langer R Burzler C Bechtner G Gärtner R Influence of iodide and iodolactones on thyroid apoptosis. Evidence that apoptosis induced by iodide is mediated by iodolactones in intact porcine thyroid follicles Exp Clin Endocrinol Diabetes 2003, 111(6):325-329. 10.1055/s-2003-42721 14520597
11. Zhang L Sharma S Zhu L Kogai T Hershman J Brent G Dubinett S Huang M Nonradioactive iodide effectively induces apoptosis in genetically modified lung cancer cells Cancer Res 2003, 63(16):5065-5072. 12941836
12. Smyth P Role of iodine in antioxidant defence in thyroid and breast disease Biofactors 2003, 19(3-4):121-130. 10.1002/biof.5520190304 14757962
13. Anguiano B García-Solís P Delgado G Aceves Velasco C Uptake and gene expression with antitumoral doses of iodine in thyroid and mammary gland: Evidence that chronic administration has no harmful effects Thyroid 2007, 17(9):851-859. 10.1089/thy.2007.0122 17956159
14. Arroyo-Helguera O Anguiano B Delgado G Aceves C Uptake and antiproliferative effect of molecular iodine in the MCF-7 breast cancer cell line Endocr Relat Cancer 2006, 13(4):1147-1158. 10.1677/erc.1.01250 17158760
15. Arroyo-Helguera O Rojas E Delgado G Aceves C Signaling pathways involved in the antiproliferative effect of molecular iodine in normal and tumoral breast cells: Evidence that 6-iodolactone mediates apoptotic effects Endocr Relat Cancer 2008, 15(4):1003-1011. 10.1677/ERC-08-0125 18827038
16. Rillema J Mulder J Arachidonic acid distribution in lipids of mammary glands and DMBA-induced tumors of rats Prostaglandins Med 1978, 1(1):31-38. 10.1016/0161-4630(78)90074-5 102001
17. Razanamahefa L Prouff S Bardon S Stimulatory effect of arachidonic acid on T-47D human breast cancer cell growth is associated with enhancement of cyclin D1 mRNA expression Nutr Cancer 2000, 38(2):274-280. 10.1207/ S15327914NC382_17 11525606
18. Berger J Moller D The mechanisms of action of PPARs Annu Rev Med 2002, 53:409-435. 10.1146/annurev.med.53.082901.104018 11818483
19. Michalik L Desvergne B Wahli W Peroxisome-proliferator-activated receptors and cancers: Complex stories Nat Rev Cancer 2004, 4(1):61-70. 10.1038/nrc1254 14708026
20. Núñez-Anita RE Arroyo-Helguera O Cajero-Juárez M López-Bojorquez L Aceves C A complex between 6-iodolactone and the peroxisome proliferator-activated receptor type gamma may mediate the antineoplasic effect of iodine in mammary cancer Prostaglandins and Other Lipid Mediators 2009, 89:34-42. 10.1016/ j.prostaglandins.2009.04.001
21. Thompson HJ Methods for the induction of mammary carcinogenesis in the rat using either 7,12-dimethylbenz[a]antracene or 1-methyl-1-nitorosourea Methods in mammary gland biology and breast cancer research New York: Kluwer Academic/Plenum Publishers IMaA BB 2000:19-29
22. Russo J Russo I Atlas and histologic classification of tumors of the rat mammary gland J Mammary Gland Biol Neoplasia 2000, 5(2):187-200. 10.1023/ A:1026443305758 11149572
23. Aranda J Rivera J Jeziorski M Riesgo-Escovar J Nava G López-Barrera F Quiróz-Mercado H Berger P Martínez de la Escalera G Clapp C Prolactins are natural inhibitors of angiogenesis in the retina Invest Ophthalmol Vis Sci 2005, 46(8):2947-2953. 10.1167/iovs.05-0173 16043870
24. Suchanek K May F Robinson J Lee W Holman N Monteith G Roberts-Thomson S Peroxisome proliferator-activated receptor alpha in the human breast cancer cell lines MCF-7 and MDA-MB-231 Mol Carcinog 2002, 34(4):165-171. 10.1002/mc.10061 12203367
25. Suh N Wang Y Williams C Risingsong R Gilmer T Willson T Sporn M A new ligand for the peroxisome proliferator-activated receptor-gamma (PPAR-gamma), GW inhibits rat mammary carcinogenesis Cancer Res. 1999, 59(22):5671-5673. 10582681
26. Biscetti F Gaetani E Flex A Straface G Pecorini G Angelini F Stigliano E Aprahamian T Smith R Castellot J et al Peroxisome Proliferator-Activated Receptor Alpha Is Crucial for Iloprost-Induced in vivo Angiogenesis and Vascular Endothelial Growth Factor Upregulation J Vasc Res 2008, 46(2):103-108. 10.1159/000143793 18617751
27. Sawai H Liu J Reber H Hines O Eibl G Activation of peroxisome proliferator-activated receptor-gamma decreases pancreatic cancer cell invasion through modulation of the plasminogen activator system Mol Cancer Res 2006, 4(3):159-167. 10.1158/1541-7786.MCR-05-0257 16547153
28. Houck K Ferrara N Winer J Cachianes G Li B Leung D The vascular endothelial growth factor family: Identification of a fourth molecular species and characterization of alternative splicing of RNA Mol Endocrinol 1991, 5(12):1806-1814. 10.1210/mend-5-12-1806 1791831
29. Nakamura J Savinov A Lu Q Brodie A Estrogen regulates vascular endothelial growth/permeability factor expression in 7,12-dimethylbenz(a)anthracene-induced rat mammary tumors Endocrinology 1996, 137(12):5589-5596. 10.1210/en.137.12.5589 8940388
30. Stoddard FR Brooks A Eskin B Johannes G Iodine alters gene expression in the MCF7 breast cancer cell line: Evidence for an anti-estrogen effect of iodine Int J Med Sci 2008, 5(4):189-196. 2452979 18645607
31. Keller H Givel F Perroud M Wahli W Signaling cross-talk between peroxisome proliferator-activated receptor/retinoid × receptor and estrogen receptor through estrogen response elements Mol Endocrinol 1995, 9(7):794-804. 10.1210/me.9.7.794 7476963
32. Duffy M Urokinase plasminogen activator and its inhibitor, PAI-1, as prognostic markers in breast cancer: From pilot to level 1 evidence studies Clin Chem 2002, 48(8):1194-1197. 12142372
33. Duffy M Predictive markers in breast and other cancers: A review Clin Chem 2005, 51(3):494-503. 10.1373/clinchem.2004.046227 15637130