Paclitaxel-loaded poly(N-vinylpyrrolidone)-b-poly(ε-caprolactone) nanoparticles: Preparation and antitumor activity in vivo

Journal of Controlled Release

Volumn 142, Issue 3, 2010, Pages 438-446

  Zhu, Zhenshu ^a   Li, Yuan ^a   Li, Xiaolin ^a   Li, Rutian ^a   Jia, Zhijun ^b   Liu, Baorui ^a   Guo, Wanhua ^b   Wu, Wei ^a   Jiang, Xiqun ^a  

^a NANJING UNIVERSITY   (China)

^b THE AFFILIATED DRUM TOWER HOSPITAL OF NANJING UNIVERSITY MEDICAL SCHOOL   (China)

Author keywords

Antitumor effect; Drug delivery; Poly(N vinylpyrrolidone); Polymeric nanoparticles

Indexed keywords

ANTI-TUMOR ACTIVITIES; ANTITUMOR EFFECT; BIODISTRIBUTIONS; CANCER CELL LINES; CAPROLACTONE; COMPUTED TOMOGRAPHY; DRUG LOADING; ENCAPSULATION EFFICIENCY; IN-VITRO; IN-VIVO; INTRAVENOUS ADMINISTRATION; MICE MODELS; N VINYLPYRROLIDONE; NEAR-INFRARED FLUORESCENCE; PACLITAXEL; POLYMERIC NANOPARTICLES; PRECIPITATION METHODS; SURVIVAL RATE; TEM; TUMOR VOLUMES;

ATOMIC FORCE MICROSCOPY; CELL CULTURE; COMPUTERIZED TOMOGRAPHY; DRUG DELIVERY; DYNAMIC LIGHT SCATTERING; ENCAPSULATION; LIGHT TRANSMISSION; NANOPARTICLES; POSITRON EMISSION TOMOGRAPHY; TRANSMISSION ELECTRON MICROSCOPY; TUMORS; ZETA POTENTIAL;

PRECIPITATION (CHEMICAL);

NANOPARTICLE; PACLITAXEL; POLYCAPROLACTONE; POLYMER; POVIDONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; ATOMIC FORCE MICROSCOPY; CANCER CELL CULTURE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; FLUORESCENCE IMAGING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIGHT SCATTERING; LIVER TUMOR; LOADING DRUG DOSE; MALE; MOUSE; NANOENCAPSULATION; NEAR INFRARED SPECTROSCOPY; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRECIPITATION; PRIORITY JOURNAL; SINGLE DRUG DOSE; SURVIVAL RATE; TRANSMISSION ELECTRON MICROSCOPY; TUMOR VOLUME; ZETA POTENTIAL;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL LINE, TUMOR; CELL SURVIVAL; DRUG CARRIERS; DRUG COMPOUNDING; LIGHT; MALE; MICE; MICE, INBRED ICR; MICROSCOPY, ATOMIC FORCE; MICROSCOPY, ELECTRON, TRANSMISSION; NANOPARTICLES; NEOPLASMS, EXPERIMENTAL; PACLITAXEL; PARTICLE SIZE; POLYESTERS; POSITRON-EMISSION TOMOGRAPHY; POVIDONE; SCATTERING, RADIATION; SPECTROSCOPY, NEAR-INFRARED; SURFACE PROPERTIES; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 77349116167     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.11.002     Document Type: Article

References (36)

1. Peer D., Karp J.M., Hong S., Farokhzad O.C., Margalit R., and Langer R. Nanocarriers as an emerging platform for cancer therapy. Nat. Nanotechnol. 2 12 (2007) 751
2. Zhang L., Yang M., Wang Q., Li Y., Guo R., Jiang X., Yang C., and Liu B. 10-Hydroxycamptothecin loaded nanoparticles: preparation and antitumor activity in mice. J. Control. Release 119 2 (2007) 153-162
3. Fonseca C., Simoes S., and Gaspar R. Paclitaxel-loaded PLGA nanoparticles: preparation, physicochemical characterization and in vitro anti-tumoral activity. J. Control. Release 83 2 (2002) 273-286
4. Kwon G., Suwa S., Yokoyama M., Okano T., Sakurai Y., and Kataoka K. Enhanced tumor accumulation and prolonged circulation times of micelle-forming poly (ethylene oxide-aspartate) block copolymer-adriamycin conjugates. J. Control. Release 29 1-2 (1994) 17-23
5. Cabral H., Nishlyama N., and Kataoka K. Optimization of (1, 2-diamino-cyclohexane)platinum(II)-loaded polymeric micelles directed to improved tumor targeting and enhanced antitumor activity. J. Control. Release 121 3 (2007) 146-155
6. Owens D.E., and Peppas N.A. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int. J. Pharm. 307 1 (2006) 93-102
7. Li S.D., and Huang L. Pharmacokinetics and biodistribution of nanoparticles. Mol. Pharmacol. 5 4 (2008) 496-504
8. Kataoka K., Harada A., and Nagasaki Y. Block copolymer micelles for drug delivery: design, characterization and biological significance. Adv. Drug Deliv. Rev. 47 1 (2001) 113-131
9. Yamamoto Y., Nagasaki Y., Kato Y., Sugiyama Y., and Kataoka K. Long-circulating poly (ethylene glycol)-poly (d, l-lactide) block copolymer micelles with modulated surface charge. J. Control. Release 77 1-2 (2001) 27-38
10. Madani F., Bessodes M., Lakrouf A., Vauthier C., Scherman D., and Chaumeil J.C. PEGylation of microspheres for therapeutic embolization: preparation, characterization and biological performance evaluation. Biomaterials 28 (2007) 1198-1208
11. Wang X., Ishida T., and Kiwada H. J. Control. Release 119 (2007) 236-244
12. Burt H.M., Zhang X., Toleikis P., Embree L., and Hunter W.L. Development of copolymers of poly (d, l-lactide) and methoxypolyethylene glycol as micellar carriers of paclitaxel. Colloids Surf. B Biointerfaces 16 1-4 (1999) 161-171
13. Ishida T., Harada M., Wang X.Y., Ichihara M., Irimura K., and Kiwada H. Accelerated blood clearance of PEGylated liposomes following preceding liposome injection: effects of lipid dose and PEG surface-density and chain length of the first-dose liposomes. J. Control. Release 105 3 (2005) 305-317
14. Ishida T., Ichihara M., Wang X.Y., Yamamoto K., Kimura J., Majima E., and Kiwada H. Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes. J. Control. Release 112 1 (2006) 15-25
15. Wang X.Y., Ishida T., and Kiwada H. Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes. J. Control. Release 119 2 (2007) 236-244
16. Kaneda Y., Tsutsumi Y., Yoshioka Y., Kamada H., Yamamoto Y., Kodaira H., Tsunoda S., Okamoto T., Mukai Y., Shibata H., Nakagawa S., and Mayumi T. The use of PVP as a polymeric carrier to improve the plasma half-life of drugs. Biomaterials 25 16 (2004) 3259-3266
17. Kamada H., Tsutsumi Y., Sato-Kamada K., Yamamoto Y., Yoshioka Y., Okamoto T., Nakagawa S., Nagata S., and Mayumi T. Synthesis of a poly (vinylpyrrolidone-co-dimethyl maleic anhydride) co-polymer and its application for renal drug targeting. Nat. Biotechnol. 21 (2003) 399-404
18. Torchilin V.P. Polymer-coated long-circulating microparticulate pharmaceuticals. J. Microencapsul. 15 1 (1998) 1-19
19. Pound G., McKenzie J.M., Lange R.F.M., and Klumperman B. Polymer-protein conjugates from aldehyde endfunctional poly (N-vinylpyrrolidone) synthesised via xanthate-mediated living radical polymerisation. Chem. Commun. 2008 27 (2008) 3193-3195
20. Kamada H., Tsutsumi Y., Yamamoto Y., Kihira T., Kaneda Y., Mu Y., Kodaira H., Tsunoda S., Nakagawa S., and Mayumi T. Antitumor activity of tumor necrosis factor-alpha conjugated with polyvinylpyrrolidone on solid tumors in mice. Cancer Res. 60 22 (2000) 6416-6420
21. Lukyanov A.N., and Torchilin V.P. Micelles from lipid derivatives of water-soluble polymers as delivery systems for poorly soluble drugs. Adv. Drug Deliv. Rev. 56 9 (2004) 1273-1289
22. Chung T.W., Cho K.Y., Lee H.C., Nah J.W., Yeo J.H., Akaike T., and Cho C.S. Novel micelle-forming block copolymer composed of poly (e-caprolactone) and poly (vinyl-pyrrolidone). Polymer 45 5 (2004) 1591-1597
23. Le Garrec D., Gori S., Luo L., Lessard D., Smith D.C., Yessine M.A., Ranger M., and Leroux J.C. Poly(N-vinylpyrrolidone)-block-poly(d, l-lactide) as a new polymeric solubilizer for hydrophobic anticancer drugs: in vitro and in vivo evaluation. J. Control. Release 99 1 (2004) 83-101
24. Wu Z., Chen H., Liu X., Zhang Y., Li D., and Huang H. Protein adsorption on poly (N-vinylpyrrolidone)-modified silicon surfaces prepared by surface-initiated atom transfer radical polymerization. Langmuir 25 5 (2009) 2900-2906
25. Gaucher G., Asahina K., Wang J., and Leroux J.C. Effect of poly (N-vinyl-pyrrolidone)-block-poly (d, l-lactide) as coating agent on the opsonization, phagocytosis, and pharmacokinetics of biodegradable nanoparticles. Biomacromolecules 10 2 (2009) 408-416
26. Luo L.B., Ranger M., Lessard D.G., Le Garrec D., Gori S., Leroux J.C., Rimmer S., and Smith D. Novel amphiphilic diblock copolymer of low molecular weight poly(N-vinylpyrrolidone)-block-poly(d, l-lactide): synthesis, characterization, and micellization. Macromolecules 37 11 (2004) 4008-4013
27. Zhang L., Hu Y., Jiang X., Yang C., Lu W., and Yang Y.H. Camptothecin derivative-loaded poly (caprolactone-co-lactide)-b-PEG-b-poly(caprolactone-co-lactide) nanoparticles and their biodistribution in mice. J. Control. Release 96 1 (2004) 135-148
28. Zhang C., Qineng P., and Zhang H. Self-assembly and characterization of paclitaxel-loaded N-octyl-O-sulfate chitosan micellar system. Colloids Surf. B Biointerfaces 39 1-2 (2004) 69-75
29. Kim S., Kim J.Y., Huh K.M., Acharya G., and Park K. Hydrotropic polymer micelles containing acrylic acid moieties for oral delivery of paclitaxel. J. Control. Release 132 3 (2008) 222-229
30. Cho Y.W., Lee J., Lee S.C., Huh K.M., and Park K. Hydrotropic agents for study of in vitro paclitaxel release from polymeric micelles. J. Control. Release 97 2 (2004) 249-257
31. Davis M.E., and Shin D.M. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat. Rev. Drug Discov. 7 9 (2008) 771-782
32. Chen H., Kim S., Li L., Wang S., Park K., and Cheng J. Release of hydrophobic molecules from polymer micelles into cell membranes revealed by Foster resonance energy transfer imaging. PNAS 105 18 (2008) 6596-6601
33. Hwang H.Y., Kim I.S., Kwon I.C., and Kim Y.H. Tumor targetability and antitumor effect of docetaxel-loaded hydrophobically modified glycol chitosan nanoparticles. J. Control. Release 128 2 (2008) 23-31
34. Liu Z., Davis C., Cai W., He L., Chen X., and Dai H. Circulation and long term fate of functionalized biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy. PNAS 105 5 (2008) 1410-1415
35. Alexis F., Pridgen E., Molnar L.K., and Farokhzad O.C. Factors affecting the clearance and biodistribution of polymeric nanoparticles. Mol. Pharmacol. 5 4 (2008) 505-515
36. Tatsumi M., Nakamoto Y., Traughber B., Marshall L.T., Geschwind J.F.H., and Wahl R.L. Initial experience in small animal tumor imaging with a clinical positron emission tomography/computed tomography scanner using 2-[F-18] Fluoro-2-deoxy-d-glucose. Cancer Res. 63 19 (2003) 6252-6257