메뉴 건너뛰기




Volumn 8, Issue 8, 2011, Pages 467-472

From tissue turnover to the cell of origin for pancreatic cancer

Author keywords

[No Author keywords available]

Indexed keywords

CANCER INHIBITION; CANCER STEM CELL; CARCINOGENESIS; CELL ACTIVITY; CELL DIFFERENTIATION; CELL FUNCTION; CELL METABOLISM; CELL RENEWAL; CELL TRANSFORMATION; EPITHELIUM CELL; HUMAN; NONHUMAN; PANCREAS ADENOCARCINOMA; PANCREAS CANCER; PRIORITY JOURNAL; REVIEW; STEM CELL EXPANSION; TISSUE METABOLISM;

EID: 80051546790     PISSN: 17595045     EISSN: 17595053     Source Type: Journal    
DOI: 10.1038/nrgastro.2011.114     Document Type: Review
Times cited : (46)

References (61)
  • 4
    • 70350513347 scopus 로고    scopus 로고
    • Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras
    • Gidekel Friedlander, S. Y. et al. Context-dependent transformation of adult pancreatic cells by oncogenic K-Ras. Cancer Cell 16, 379-389 (2009).
    • (2009) Cancer Cell , vol.16 , pp. 379-389
    • Gidekel Friedlander, S.Y.1
  • 6
    • 57749113202 scopus 로고    scopus 로고
    • Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice
    • Habbe, N. et al. Spontaneous induction of murine pancreatic intraepithelial neoplasia (mPanIN) by acinar cell targeting of oncogenic Kras in adult mice. Proc. Natl Acad. Sci. USA 105, 18913-18918 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 18913-18918
    • Habbe, N.1
  • 7
    • 76649105065 scopus 로고    scopus 로고
    • Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice
    • Morris, J. P. T., Cano, D. A., Sekine, S., Wang, S. C. & Hebrok, M. Beta-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice. J. Clin. Invest. 120, 508-520 (2010).
    • (2010) J. Clin. Invest. , vol.120 , pp. 508-520
    • Morris, J.P.T.1    Cano, D.A.2    Sekine, S.3    Wang, S.C.4    Hebrok, M.5
  • 8
    • 78651228289 scopus 로고    scopus 로고
    • Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine
    • Furuyama, K. et al. Continuous cell supply from a Sox9-expressing progenitor zone in adult liver, exocrine pancreas and intestine. Nat. Genet. 43, 34-41 (2011).
    • (2011) Nat. Genet. , vol.43 , pp. 34-41
    • Furuyama, K.1
  • 9
    • 79951539242 scopus 로고    scopus 로고
    • Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas
    • Kopp, J. L. et al. Sox9+ ductal cells are multipotent progenitors throughout development but do not produce new endocrine cells in the normal or injured adult pancreas. Development 138, 653-665 (2011).
    • (2011) Development , vol.138 , pp. 653-665
    • Kopp, J.L.1
  • 10
    • 58149333204 scopus 로고    scopus 로고
    • Cancer induction by restriction of oncogene expression to the stem cell compartment
    • Perez-Caro, M. et al. Cancer induction by restriction of oncogene expression to the stem cell compartment. EMBO J. 28, 8-20 (2009).
    • (2009) EMBO J. , vol.28 , pp. 8-20
    • Perez-Caro, M.1
  • 11
    • 59049106578 scopus 로고    scopus 로고
    • Crypt stem cells as the cells-of-origin of intestinal cancer
    • Barker, N. et al. Crypt stem cells as the cells-of-origin of intestinal cancer. Nature 457, 608-611 (2009).
    • (2009) Nature , vol.457 , pp. 608-611
    • Barker, N.1
  • 12
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic β-cells are formed by self-duplication rather than stem-cell differentiation
    • DOI 10.1038/nature02520
    • Dor, Y., Brown, J., Martinez, O. I. & Melton, D. A. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 429, 41-46 (2004). (Pubitemid 38620543)
    • (2004) Nature , vol.429 , Issue.6987 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 13
    • 79953761842 scopus 로고    scopus 로고
    • Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression
    • Fukuda, A. et al. Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression. Cancer Cell 19, 441-455 (2011).
    • (2011) Cancer Cell , vol.19 , pp. 441-455
    • Fukuda, A.1
  • 14
    • 65849401051 scopus 로고    scopus 로고
    • The tortoise and the hair: Slow-cycling cells in the stem cell race
    • Fuchs, E. The tortoise and the hair: slow-cycling cells in the stem cell race. Cell 137, 811-819 (2009).
    • (2009) Cell , vol.137 , pp. 811-819
    • Fuchs, E.1
  • 16
    • 56549128268 scopus 로고    scopus 로고
    • Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair
    • Wilson, A. et al. Hematopoietic stem cells reversibly switch from dormancy to self-renewal during homeostasis and repair. Cell 135, 1118-1129 (2008).
    • (2008) Cell , vol.135 , pp. 1118-1129
    • Wilson, A.1
  • 17
    • 0035119871 scopus 로고    scopus 로고
    • Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes
    • Zulewski, H. et al. Multipotential nestin-positive stem cells isolated from adult pancreatic islets differentiate ex vivo into pancreatic endocrine, exocrine, and hepatic phenotypes. Diabetes 50, 521-533 (2001). (Pubitemid 32195216)
    • (2001) Diabetes , vol.50 , Issue.3 , pp. 521-533
    • Zulewski, H.1    Abraham, E.J.2    Gerlach, M.J.3    Daniel, P.B.4    Moritz, W.5    Muller, B.6    Vallejo, M.7    Thomas, M.K.8    Habener, J.F.9
  • 19
    • 79952119288 scopus 로고    scopus 로고
    • The adult mouse and human pancreas contain rare multipotent stem cells that express insulin
    • Smukler, S. R. et al. The adult mouse and human pancreas contain rare multipotent stem cells that express insulin. Cell Stem Cell 8, 281-293 (2011).
    • (2011) Cell Stem Cell , vol.8 , pp. 281-293
    • Smukler, S.R.1
  • 20
    • 76249094159 scopus 로고    scopus 로고
    • Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas
    • Rovira, M. et al. Isolation and characterization of centroacinar/terminal ductal progenitor cells in adult mouse pancreas. Proc. Natl Acad. Sci. USA 107, 75-80 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 75-80
    • Rovira, M.1
  • 21
    • 33847210675 scopus 로고    scopus 로고
    • Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver
    • Stanger, B. Z., Tanaka, A. J. & Melton, D. A. Organ size is limited by the number of embryonic progenitor cells in the pancreas but not the liver. Nature 445, 886-891 (2007).
    • (2007) Nature , vol.445 , pp. 886-891
    • Stanger, B.Z.1    Tanaka, A.J.2    Melton, D.A.3
  • 24
    • 79951644393 scopus 로고    scopus 로고
    • Facultative stem cells in liver and pancreas: Fact and fancy
    • Yanger, K. & Stanger, B. Z. Facultative stem cells in liver and pancreas: fact and fancy. Dev. Dyn. 240, 521-529 (2011).
    • (2011) Dev. Dyn. , vol.240 , pp. 521-529
    • Yanger, K.1    Stanger, B.Z.2
  • 25
    • 77951611220 scopus 로고    scopus 로고
    • Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss
    • Thorel, F. et al. Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss. Nature 464, 1149-1154 (2010).
    • (2010) Nature , vol.464 , pp. 1149-1154
    • Thorel, F.1
  • 28
    • 0037364517 scopus 로고    scopus 로고
    • In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion
    • DOI 10.1172/JCI200316502
    • Ianus, A., Holz, G. G., Theise, N. D. & Hussain, M. A. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J. Clin. Invest. 111, 843-850 (2003). (Pubitemid 37074959)
    • (2003) Journal of Clinical Investigation , vol.111 , Issue.6 , pp. 843-850
    • Ianus, A.1    Holz, G.G.2    Theise, N.D.3    Hussain, M.A.4
  • 29
    • 1442326000 scopus 로고    scopus 로고
    • No Evidence for Significant Transdifferentiation of Bone Marrow Into Pancreatic β-Cells in Vivo
    • DOI 10.2337/diabetes.53.3.616
    • Lechner, A. et al. No evidence for significant transdifferentiation of bone marrow into pancreatic beta-cells in vivo. Diabetes 53, 616-623 (2004). (Pubitemid 38270630)
    • (2004) Diabetes , vol.53 , Issue.3 , pp. 616-623
    • Lechner, A.1    Yang, Y.-G.2    Blacken, R.A.3    Wang, L.4    Nolan, A.L.5    Habener, J.F.6
  • 30
    • 9244224723 scopus 로고    scopus 로고
    • Intrinsic tumour suppression
    • DOI 10.1038/nature03098
    • Lowe, S. W., Cepero, E. & Evan, G. Intrinsic tumour suppression. Nature 432, 307-315 (2004). (Pubitemid 39551658)
    • (2004) Nature , vol.432 , Issue.7015 , pp. 307-315
    • Lowe, S.W.1    Cepero, E.2    Evan, G.3
  • 31
    • 77956233247 scopus 로고    scopus 로고
    • A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal
    • Milyavsky, M. et al. A distinctive DNA damage response in human hematopoietic stem cells reveals an apoptosis-independent role for p53 in self-renewal. Cell Stem Cell 7, 186-197 (2010).
    • (2010) Cell Stem Cell , vol.7 , pp. 186-197
    • Milyavsky, M.1
  • 32
    • 34447543913 scopus 로고    scopus 로고
    • Cellular senescence in cancer and aging
    • DOI 10.1016/j.cell.2007.07.003, PII S0092867407008902
    • Collado, M., Blasco, M. A. & Serrano, M. Cellular senescence in cancer and aging. Cell 130, 223-233 (2007). (Pubitemid 47081143)
    • (2007) Cell , vol.130 , Issue.2 , pp. 223-233
    • Collado, M.1    Blasco, M.A.2    Serrano, M.3
  • 33
    • 85047689866 scopus 로고    scopus 로고
    • Telomeres, stem cells, senescence, and cancer
    • DOI 10.1172/JCI200420761
    • Sharpless, N. E. & DePinho, R. A. Telomeres, stem cells, senescence, and cancer. J. Clin. Invest. 113, 160-168 (2004). (Pubitemid 38544198)
    • (2004) Journal of Clinical Investigation , vol.113 , Issue.2 , pp. 160-168
    • Sharpless, N.E.1    DePinho, R.A.2
  • 37
    • 76249108357 scopus 로고    scopus 로고
    • Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer
    • Morton, J. P. et al. Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer. Proc. Natl Acad. Sci. USA 107, 246-251 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , pp. 246-251
    • Morton, J.P.1
  • 38
    • 79954538151 scopus 로고    scopus 로고
    • P53-dependent regulation of growth, epithelial-mesenchymal transition and stemness in normal pancreatic epithelial cells
    • Pinho, A. V., Rooman, I. & Real, F. X. p53-dependent regulation of growth, epithelial-mesenchymal transition and stemness in normal pancreatic epithelial cells. Cell Cycle 10, 1312-1321 (2011).
    • (2011) Cell Cycle , vol.10 , pp. 1312-1321
    • Pinho, A.V.1    Rooman, I.2    Real, F.X.3
  • 40
    • 60149104597 scopus 로고    scopus 로고
    • Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells
    • Foudi, A. et al. Analysis of histone 2B-GFP retention reveals slowly cycling hematopoietic stem cells. Nat. Biotechnol. 27, 84-90 (2009).
    • (2009) Nat. Biotechnol. , vol.27 , pp. 84-90
    • Foudi, A.1
  • 41
    • 38349132624 scopus 로고    scopus 로고
    • Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation
    • Orford, K. W. & Scadden, D. T. Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation. Nat. Rev. Genet. 9, 115-128 (2008).
    • (2008) Nat. Rev. Genet. , vol.9 , pp. 115-128
    • Orford, K.W.1    Scadden, D.T.2
  • 42
    • 78649811793 scopus 로고    scopus 로고
    • Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells
    • Nakada, D., Saunders, T. L. & Morrison, S. J. Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature 468, 653-658 (2010).
    • (2010) Nature , vol.468 , pp. 653-658
    • Nakada, D.1    Saunders, T.L.2    Morrison, S.J.3
  • 43
    • 78649851511 scopus 로고    scopus 로고
    • The Lkb1 metabolic sensor maintains haematopoietic stem cell survival
    • Gurumurthy, S. et al. The Lkb1 metabolic sensor maintains haematopoietic stem cell survival. Nature 468, 659-663 (2010).
    • (2010) Nature , vol.468 , pp. 659-663
    • Gurumurthy, S.1
  • 44
    • 78649874959 scopus 로고    scopus 로고
    • Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells
    • Gan, B. et al. Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cells. Nature 468, 701-704 (2010).
    • (2010) Nature , vol.468 , pp. 701-704
    • Gan, B.1
  • 47
    • 0035824387 scopus 로고    scopus 로고
    • Stem cells: PTEN - Coupling tumor suppression to stem cells?
    • DOI 10.1126/science.1067931
    • Penninger, J. M. & Woodgett, J. Stem cells. PTEN-coupling tumor suppression to stem cells? Science 294, 2116-2118 (2001). (Pubitemid 33150660)
    • (2001) Science , vol.294 , Issue.5549 , pp. 2116-2118
    • Penninger, J.M.1    Woodgett, J.2
  • 50
    • 0031787342 scopus 로고    scopus 로고
    • Malignant transformation of duct-like cells originating from acini in transforming growth factor transgenic mice
    • DOI 10.1016/S0016-5085(98)70098-8
    • Wagner, M., Luhrs, H., Kloppel, G., Adler, G. & Schmid, R. M. Malignant transformation of duct-like cells originating from acini in transforming growth factor transgenic mice. Gastroenterology 115, 1254-1262 (1998). (Pubitemid 28485618)
    • (1998) Gastroenterology , vol.115 , Issue.5 , pp. 1254-1262
    • Wagner, M.1    Luhrs, H.2    Kloppel, G.3    Adler, G.4    Schmid, R.M.5
  • 53
    • 77956925475 scopus 로고    scopus 로고
    • PTEN loss accelerates KrasG12D-induced pancreatic cancer development
    • Hill, R. et al. PTEN loss accelerates KrasG12D-induced pancreatic cancer development. Cancer Res. 70, 7114-7124 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 7114-7124
    • Hill, R.1
  • 54
    • 76349101165 scopus 로고    scopus 로고
    • Synergistic action of Smad4 and Pten in suppressing pancreatic ductal adenocarcinoma formation in mice
    • Xu, X., Ehdaie, B., Ohara, N., Yoshino, T. & Deng, C. X. Synergistic action of Smad4 and Pten in suppressing pancreatic ductal adenocarcinoma formation in mice. Oncogene 29, 674-686 (2010).
    • (2010) Oncogene , vol.29 , pp. 674-686
    • Xu, X.1    Ehdaie, B.2    Ohara, N.3    Yoshino, T.4    Deng, C.X.5
  • 55
    • 79952279828 scopus 로고    scopus 로고
    • DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors
    • Jiao, Y. et al. DAXX/ATRX, MEN1, and mTOR pathway genes are frequently altered in pancreatic neuroendocrine tumors. Science 331, 1199-1203 (2011).
    • (2011) Science , vol.331 , pp. 1199-1203
    • Jiao, Y.1
  • 58
    • 77955488036 scopus 로고    scopus 로고
    • LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest
    • Morton, J. P. et al. LKB1 haploinsufficiency cooperates with Kras to promote pancreatic cancer through suppression of p21-dependent growth arrest. Gastroenterology 139, 586-597 (2010).
    • (2010) Gastroenterology , vol.139 , pp. 586-597
    • Morton, J.P.1
  • 60
    • 79953691133 scopus 로고    scopus 로고
    • Metformin sensitizes insulin signaling through AMPK-mediated PTEN down-regulation in preadipocyte 3T3-L1 cells
    • Lee, S. K. et al. Metformin sensitizes insulin signaling through AMPK-mediated PTEN down-regulation in preadipocyte 3T3-L1 cells. J. Cell Biochem. 112, 1259-1267 (2011).
    • (2011) J. Cell Biochem. , vol.112 , pp. 1259-1267
    • Lee, S.K.1
  • 61
    • 62549089788 scopus 로고    scopus 로고
    • Inflammation and mitochondrial fatty acid beta-oxidation link obesity to early tumor promotion
    • Khasawneh, J. et al. Inflammation and mitochondrial fatty acid beta-oxidation link obesity to early tumor promotion. Proc. Natl Acad. Sci. USA 106, 3354-3359 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 3354-3359
    • Khasawneh, J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.