Metformin sensitizes insulin signaling through AMPK-mediated pten down-regulation in preadipocyte 3T3-L1 cells

Journal of Cellular Biochemistry

Volumn 112, Issue 5, 2011, Pages 1259-1267

  Lee, Soo Kyung ^a   Lee, Jung Ok ^a   Kim, Ji Hae ^a   Kim, Su Jin ^a   You, Ga Young ^a   Moon, Ji Wook ^a   Jung, Jin Hee ^a   Park, Sun Hwa ^a   Uhm, Kyung Ok ^b   Park, Ji Man ^c   Suh, Pann Ghill ^c   Kim, Hyeon Soo ^a,d  

^a Korea University College of Medicine   (South Korea)

^b NATIONAL CENTER FOR GERIATRICS AND GERONTOLOGY   (Japan)

^c Ulsan National Institute of Science and Technology   (South Korea)

^d NONE   (South Korea)

Author keywords

adipocyte; AMPK; insulin; metformin; PTEN

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; APOPTOSIS SIGNAL REGULATING KINASE 1; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; METFORMIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFECT; DRUG SENSITIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENE INDUCTION; GENE SILENCING; IMMUNOBLOTTING; INSULIN SENSITIVITY; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROADIPOCYTE; PROMOTER REGION; SIGNAL TRANSDUCTION;

3T3-L1 CELLS; ADIPOCYTES; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; DIABETES MELLITUS, TYPE 2; DOWN-REGULATION; GLUCOSE; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; METFORMIN; MICE; PHOSPHORYLATION; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

MAMMALIA;

EID: 79953691133     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.23000     Document Type: Article

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