Deltonin isolated from Dioscorea zingiberensis inhibits cancer cell growth through inducing mitochondrial apoptosis and suppressing akt and mitogen activated protein kinase signals

Biological and Pharmaceutical Bulletin

Volumn 34, Issue 8, 2011, Pages 1231-1239

  Shu, Dan ^a   Qing, Yong ^a   Tong, Qingyi ^a   He, Yang ^a   Xing, Zhihua ^a   Zhao, Yinglan ^a   Li, Yi ^a   Wei, Yuquan ^a   Huang, Wen ^a   Wu, Xiaohua ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Akt; Apoptosis; Deltonin; Mitochondria; Mitogen activated protein kinase; Reactive oxygen species

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; CYTOCHROME C; DELTONIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SAPONIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIOSCOREA ZINGIBERENSIS; DIOSCOREACEAE; DNA FRAGMENTATION; DRUG EFFECT; DRUG MECHANISM; DRUG SCREENING; DRUG STRUCTURE; EMBRYO; ENZYME ACTIVATION; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN CELL; IC 50; MALE; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; RHIZOME; SIGNAL TRANSDUCTION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; CASPASES; CELL LINE, TUMOR; CELL PROLIFERATION; DIOSCOREA; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASMS; PHYTOTHERAPY; PLANT EXTRACTS; POLY(ADP-RIBOSE) POLYMERASES; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RHIZOME; SIGNAL TRANSDUCTION; SPIROSTANS;

EID: 80051542008     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.34.1231     Document Type: Article

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