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Volumn 27, Issue 3-4, 2011, Pages 233-242

Deltonin, a steroidal saponin, inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis and antiangiogenesis

Author keywords

Anti tumor; Antiangiogenesis; Apoptosis; Colorectal Cancer; Deltonin; Steroidal saponin

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 9; DELTONIN; FLUOROURACIL; MITOGEN ACTIVATED PROTEIN KINASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROCASPASE 8; PROCASPASE 9; PROTEIN BAX; PROTEIN BCL 2; SAPONIN; UNCLASSIFIED DRUG;

EID: 79953782992     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000327949     Document Type: Article
Times cited : (33)

References (44)
  • 2
    • 67449086490 scopus 로고    scopus 로고
    • Mass screening for colorectal cancer is not justified in most developing countries
    • Lambert R, Sauvaget C, Sankaranarayanan R: Mass screening for colorectal cancer is not justified in most developing countries. Int J Cancer 2009;125:253-256.
    • (2009) Int J Cancer , vol.125 , pp. 253-256
    • Lambert, R.1    Sauvaget, C.2    Sankaranarayanan, R.3
  • 3
    • 0038052092 scopus 로고    scopus 로고
    • Metastatic colorectal cancer: Systemic treatment in the new millennium
    • Coutinho AK, RochaLima CM: Metastatic colorectal cancer: systemic treatment in the new millennium. Cancer Control 2003;10:224-238. (Pubitemid 36665845)
    • (2003) Cancer Control , vol.10 , Issue.3 , pp. 224-238
    • Coutinho, A.K.1    Rocha, L.C.M.S.2
  • 6
    • 77954861340 scopus 로고    scopus 로고
    • Characterization of steroidal saponins in crude extracts from Dioscoream zingiberensis C.H.Wright by ultraperformance liquid chromatography/electrospray ionization quadrupole time-of-fighttandem mass spectrometry
    • Zhu J, Guo X, Fu S, Zhang X, Liang X: Characterization of steroidal saponins in crude extracts from Dioscoream zingiberensis C.H.Wright by ultraperformance liquid chromatography/electrospray ionization quadrupole time-of-fighttandem mass spectrometry. J Pharm Biomed Anal 2010;53:462-474.
    • (2010) J Pharm Biomed Anal , vol.53 , pp. 462-474
    • Zhu, J.1    Guo, X.2    Fu, S.3    Zhang, X.4    Liang, X.5
  • 7
    • 77950301041 scopus 로고    scopus 로고
    • Three-liquid-phase extraction of diosgenin and steroidal saponins from fermentation of Dioscorea zingibernsis C. H. Wright
    • Liu L, Dong YS, Xiu ZL: Three-liquid-phase extraction of diosgenin and steroidal saponins from fermentation of Dioscorea zingibernsis C. H. Wright. Process Biochem 2010;45:752-756.
    • (2010) Process Biochem , vol.45 , pp. 752-756
    • Liu, L.1    Dong, Y.S.2    Xiu, Z.L.3
  • 8
    • 76649087318 scopus 로고    scopus 로고
    • Biotransformation of steriodal saponins in Dioscorea zingiberensis Wright to diosgenin by Trichoderma harzianum
    • Liu L, Dong YS, Qi SS, Wang H, Xiu ZL: Biotransformation of steriodal saponins in Dioscorea zingiberensis Wright to diosgenin by Trichoderma harzianum. Appl Microbiol Biotechnol 2010;85:933-940
    • (2010) Appl Microbiol Biotechnol , vol.85 , pp. 933-940
    • Liu, L.1    Dong, Y.S.2    Qi, S.S.3    Wang, H.4    Xiu, Z.L.5
  • 9
    • 78549287083 scopus 로고    scopus 로고
    • Anti-thrombotic activity and chemical characterization of steroidal saponins from Dioscorea zingiberensis C.H.Wrigh
    • Li H, Huang W, Wen YQ, Gong GH, Zhao QB, Yu G: Anti-thrombotic activity and chemical characterization of steroidal saponins from Dioscorea zingiberensis C.H.Wrigh. Fitoterapia 2010;81:1147-1156.
    • (2010) Fitoterapia , vol.81 , pp. 1147-1156
    • Li, H.1    Huang, W.2    Wen, Y.Q.3    Gong, G.H.4    Zhao, Q.B.5    Yu, G.6
  • 10
    • 67349243470 scopus 로고    scopus 로고
    • Qualitative and quantitative analysis of microbial transformation of steroidal saponins in Dioscorea Zingiberensis
    • Qi SS, Dong YS, Zhao YK, Xiu ZL: Qualitative and quantitative analysis of microbial transformation of steroidal saponins in Dioscorea Zingiberensis. Chromatographia 2008;69:865-870.
    • (2008) Chromatographia , vol.69 , pp. 865-870
    • Qi, S.S.1    Dong, Y.S.2    Zhao, Y.K.3    Xiu, Z.L.4
  • 11
    • 78449308202 scopus 로고    scopus 로고
    • Anthelmintic activity of steroidal saponins from Dioscorea zingiberensis Wright against Dactylogyrus intermedius (Monogenea) in goldfish (Carassiusauratus)
    • Wang GX, Jiang DX, Li J, Han J, Liu YT, Liu XL: Anthelmintic activity of steroidal saponins from Dioscorea zingiberensis Wright against Dactylogyrus intermedius (Monogenea) in goldfish (Carassiusauratus). Parasitol Res 2010;107:1365-1371.
    • (2010) Parasitol Res , vol.107 , pp. 1365-1371
    • Wang, G.X.1    Jiang, D.X.2    Li, J.3    Han, J.4    Liu, Y.T.5    Liu, X.L.6
  • 13
    • 79953801766 scopus 로고    scopus 로고
    • Methods and compositions for promoting activity of anti-cancer therapies
    • US patent 20090263504A1
    • Story MJ, Wayte KM: Methods and compositions for promoting activity of anti-cancer therapies. US patent 20090263504A1, 2009;10-22.
    • (2009) , pp. 10-22
    • Story, M.J.1    Wayte, K.M.2
  • 15
    • 39449092456 scopus 로고    scopus 로고
    • SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis
    • DOI 10.1038/sj.bjc.6604193, PII 6604193
    • Otsubo T, Akiyama Y, Yanagihara K, Yuasa Y: SOX2 is frequently downregulated in gastric cancers and inhibits cell growth through cell-cycle arrest and apoptosis. Br J Cancer 2008;98:824-831. (Pubitemid 351272602)
    • (2008) British Journal of Cancer , vol.98 , Issue.4 , pp. 824-831
    • Otsubo, T.1    Akiyama, Y.2    Yanagihara, K.3    Yuasa, Y.4
  • 16
    • 19944411156 scopus 로고    scopus 로고
    • Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth
    • DOI 10.1038/sj.onc.1208427
    • Edwards LA, Thiessen B, Dragowska WH, Daynard T, Bally MB, Dedhar S: Inhibition of ILK in PTEN-mutant human glioblastomas inhibits PKB/Akt activation, induces apoptosis, and delays tumor growth. Oncogene 2005;24:3596-3605. (Pubitemid 40756229)
    • (2005) Oncogene , vol.24 , Issue.22 , pp. 3596-3605
    • Edwards, L.A.1    Thiessen, B.2    Dragowska, W.H.3    Daynard, T.4    Bally, M.B.5    Dedhar, S.6
  • 17
    • 63349086921 scopus 로고    scopus 로고
    • Chloroquine inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis
    • Zheng Y, Zhao YL, Deng X, Yang S, Mao Y, Li Z, Jiang P, Zhao X, Wei Y: Chloroquine inhibits colon cancer cell growth in vitro and tumor growth in vivo via induction of apoptosis. Cancer Invest 2009;27:286-292,
    • (2009) Cancer Invest , vol.27 , pp. 286-292
    • Zheng, Y.1    Zhao, Y.L.2    Deng, X.3    Yang, S.4    Mao, Y.5    Li, Z.6    Jiang, P.7    Zhao, X.8    Wei, Y.9
  • 21
    • 0030865849 scopus 로고    scopus 로고
    • A highly sensitive model for quantification of in vivo tumor angiogenesis induced by alginateen-capsulated tumor cells
    • Hoffmann J, Schirner M, Menrad A, Schneider MR: A highly sensitive model for quantification of in vivo tumor angiogenesis induced by alginateen- capsulated tumor cells. Cancer Res 1997;57:3847-3851.
    • (1997) Cancer Res , vol.57 , pp. 3847-3851
    • Hoffmann, J.1    Schirner, M.2    Menrad, A.3    Schneider, M.R.4
  • 22
    • 0028057613 scopus 로고
    • Disruption of epithelial cell-matrix interactions induces apoptosis
    • Frisch SM, Francis H: Disruption of epithelial cell-matrix interactions induces apoptosis. J Cell Biol 1994;124:619-626. (Pubitemid 24064472)
    • (1994) Journal of Cell Biology , vol.124 , Issue.4 , pp. 619-626
    • Frisch, S.M.1    Francis, H.2
  • 23
    • 2442623486 scopus 로고    scopus 로고
    • The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells
    • DOI 10.1093/carcin/bgh052
    • Nguyen TT, Tran E, Nguyen TH, Do PT, Huynh TH, Huynh H: The role of activated MEK-ERK pathway in quercetin-induced growth inhibition and apoptosis in A549 lung cancer cells. Carcinogenesis 2004;25:647-659. (Pubitemid 38618516)
    • (2004) Carcinogenesis , vol.25 , Issue.5 , pp. 647-659
    • Nguyen, T.T.T.1    Tran, E.2    Nguyen, T.H.3    Do, P.T.4    Huynh, T.H.5    Huynh, H.6
  • 24
    • 42549167500 scopus 로고    scopus 로고
    • Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway
    • Cusimano A, Foderà D, D'Alessandro N, Lampiasi N, Azzolina A, Montalto G, Cervello M: Potentiation of the antitumor effects of both selective cyclooxygenase-1 and cyclooxygenase-2 inhibitors in human hepatic cancer cells by inhibition of the MEK/ERK pathway. Cancer Biol Ther 2007;6:1461-1468. (Pubitemid 351590359)
    • (2007) Cancer Biology and Therapy , vol.6 , Issue.9 , pp. 1461-1468
    • Cusimano, A.1    Fodera, D.2    D'Alessandro, N.3    Lampiasi, N.4    Azzolina, A.5    Montalto, G.6    Cervello, M.7
  • 25
    • 70450222919 scopus 로고    scopus 로고
    • Acute toxicity and subchronic toxicity of steroidal saponins from Dioscorea zingiberensis C.H.Wright in rodents
    • Qin Y, Wu X, Huang W, Gong G, Li D, He Y, Zhao Y: Acute toxicity and subchronic toxicity of steroidal saponins from Dioscorea zingiberensis C.H.Wright in rodents. J Ethnopharmacol 2009;126:543-550.
    • (2009) J Ethnopharmacol , vol.126 , pp. 543-550
    • Qin, Y.1    Wu, X.2    Huang, W.3    Gong, G.4    Li, D.5    He, Y.6    Zhao, Y.7
  • 26
    • 33845626635 scopus 로고    scopus 로고
    • Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002
    • Kunnimalaiyaan M, Ndiaye M, Chen H: Apoptosis-mediated medullary thyroid cancer growth suppression by the PI3K inhibitor LY294002. Surgery 2006;140:1009-1014.
    • (2006) Surgery , vol.140 , pp. 1009-1014
    • Kunnimalaiyaan, M.1    Ndiaye, M.2    Chen, H.3
  • 27
    • 77949912798 scopus 로고    scopus 로고
    • Protective effects of diosgenin in the hyperlipidemic rat model and in human vascular endothelial cells against hydrogen peroxide-induced apoptosis
    • Gong GH, Qin Y, Huang W, Zhou S, Wu XH, Yang XH: Protective effects of diosgenin in the hyperlipidemic rat model and in human vascular endothelial cells against hydrogen peroxide-induced apoptosis. Chemic Biol Interact 2010;184:366-375.
    • (2010) Chemic Biol Interact , vol.184 , pp. 366-375
    • Gong, G.H.1    Qin, Y.2    Huang, W.3    Zhou, S.4    Wu, X.H.5    Yang, X.H.6
  • 29
    • 0032774382 scopus 로고    scopus 로고
    • The role of radiation-induced apoptosis as a determinant of tumor responses to radiation therapy
    • DOI 10.1023/A:1009675028784
    • Rupnow BA, Knox SJ: The role of radiation-induced apoptosis as a determinant of tumor responses to radiation therapy. Apoptosis 1999;4:115-143. (Pubitemid 29378795)
    • (1999) Apoptosis , vol.4 , Issue.2 , pp. 115-143
    • Rupnow, B.A.1    Knox, S.J.2
  • 31
    • 0036594890 scopus 로고    scopus 로고
    • The role of the cyclin-dependent kinase inhibitor p21 in apoptosis
    • Gartel AL, Tyner AL: The role of the cyclin-dependent kinase inhibitor p21 in apoptosis. Mol Cancer Ther 2002;1:639-649.
    • (2002) Mol Cancer Ther , vol.1 , pp. 639-649
    • Gartel, A.L.1    Tyner, A.L.2
  • 32
    • 44849106825 scopus 로고    scopus 로고
    • TRAIL inactivates the mitotic checkpoint and potentiates death induced by microtubule-targeting agents in human cancer cells
    • Kim M, Liao J, Dowling ML, Voong KR, Parker SE, Wang S, El-Deiry WS, Kao GD: TRAIL inactivates the mitotic checkpoint and potentiates death induced by microtubule-targeting agents in human cancer cells. Cancer Res 2008;68:3440-3449.
    • (2008) Cancer Res , vol.68 , pp. 3440-3449
    • Kim, M.1    Liao, J.2    Dowling, M.L.3    Voong, K.R.4    Parker, S.E.5    Wang, S.6    El-Deiry, W.S.7    Kao, G.D.8
  • 33
    • 0842281645 scopus 로고    scopus 로고
    • Cell Death: Critical Control Points
    • DOI 10.1016/S0092-8674(04)00046-7
    • Danial NN, Korsmeyer SJ: Cell death: critical control points. Cell 2004;116:205-219. (Pubitemid 38167313)
    • (2004) Cell , vol.116 , Issue.2 , pp. 205-219
    • Danial, N.N.1    Korsmeyer, S.J.2
  • 34
    • 0035282334 scopus 로고    scopus 로고
    • Mammalian MAP kinase signalling cascades
    • DOI 10.1038/35065000
    • Chang L, Karin M: Mammalian MAP kinase signalling cascades. Nature 2001;410:37-40. (Pubitemid 32225829)
    • (2001) Nature , vol.410 , Issue.6824 , pp. 37-40
    • Chang, L.1    Karin, M.2
  • 35
    • 0038726089 scopus 로고    scopus 로고
    • Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK
    • DOI 10.1038/ncb1005
    • Allan LA, Morrice N, Brady S, Magee G, Pathak S, Clarke PR: Inhibition of caspase-9 through phosphorylation at Thr 125 by ERK MAPK. Nat Cell Biol 2003;5:647-654. (Pubitemid 36818087)
    • (2003) Nature Cell Biology , vol.5 , Issue.7 , pp. 647-654
    • Allan, L.A.1    Morrice, N.2    Brady, S.3    Magee, G.4    Pathak, S.5    Clarke, P.R.6
  • 36
    • 0028912119 scopus 로고
    • Controlling the vasculature: Angiogenesis, antiangiogenesis and vascular targeting of gene therapy
    • Fan TP, Jaggar R, Bicknell R: Controlling the vasculature: angiogenesis, antiangiogenesis and vascular targeting of gene therapy. Trends Pharmacol Sci 1995;16:57-66.
    • (1995) Trends Pharmacol Sci , vol.16 , pp. 57-66
    • Fan, T.P.1    Jaggar, R.2    Bicknell, R.3
  • 37
  • 38
    • 69749102520 scopus 로고    scopus 로고
    • Antiangiogenic Drugs: Insights into Drug Development from Endostatin, Avastin and Thalidomide
    • Holaday JW, Berkowitz BA: Antiangiogenic Drugs: Insights into Drug Development from Endostatin, Avastin and Thalidomide. Mol Interven 2009;9:157-166.
    • (2009) Mol Interven , vol.9 , pp. 157-166
    • Holaday, J.W.1    Berkowitz, B.A.2
  • 39
    • 0032421377 scopus 로고    scopus 로고
    • Natural products as angiogenesis inhibitors
    • Paper DH: Natural products as angiogenesis inhibitors. Planta Med 1998;64:686-695.
    • (1998) Planta Med , vol.64 , pp. 686-695
    • Paper, D.H.1
  • 40
    • 0038555375 scopus 로고    scopus 로고
    • Tumor angiogenesis: A potential target in cancer control by phytochemicals
    • DOI 10.2174/1568009033481985
    • Singh RP, Agarwal R: Tumor angiogenesis: a potential target in cancer control by phytochemicals. Curr Cancer Drug Targets 2003;3:205-217. (Pubitemid 36565762)
    • (2003) Current Cancer Drug Targets , vol.3 , Issue.3 , pp. 205-217
    • Singh, R.P.1    Agarwal, R.2
  • 41
    • 79953801766 scopus 로고    scopus 로고
    • Methods and compositions for inhibiting angiogenesis
    • US20090263349A1
    • Story MJ, Wayte KM: Methods and compositions for inhibiting angiogenesis. US20090263349A1 2009;10-22.
    • (2009) , pp. 10-22
    • Story, M.J.1    Wayte, K.M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.