Are Age-Associated Diseases an Integral Part of Aging?

Handbook of the Biology of Aging

Volumn , Issue , 2005, Pages 43-62

  Masoro, Edward J ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 38149035226     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012088387-5/50005-4     Document Type: Chapter

References (137)

1. Abe J., Berk B.C. Reactive oxygen species as mediators of signal trnsduction and cardiovascular disease. Trends in Cardiovascular Medicine 1998, 8:59-64.
2. American Heritage Dictionary 1996, Houghton Mifflin, Boston. 3rd ed.
3. Ames B.N., Shigenaga M.K., Hagen T.M. Oxidants, antioxidants, and the degenerative diseases of aging. Proceedings of the National Academy of Sciences of the USA 1993, 90:7915-7922.
4. Amundson S.A., Myers T.G., Fornace A.J. Roles of p53 in growth arrest and apoptosis: putting on the brakes after genotoxic stress. Oncogene 1998, 17:3287-3299.
5. Anderson-Ranberg K., Schroll M., Jeune B Healthy centenarians do not exist, but autonomous centenarians do: a population-based study of morbidity among Danish centenarians. Journal of the American Geriatrics Society 2001, 49:900-908.
6. Babiak J., Gong E.L., Nichols A.V., Forte T.M., Kuehl T.J., McGill H.C. Characterization of HDL and lipoprotein intermediates to LDL and HDL in the serum of pedigreed baboons fed an atherogenic diet. Atherosclerosis 1984, 52:27-45.
7. Barja G. Endogenous oxidative stress: relationship to aging, longevity, and caloric restriction. Ageing Research Reviews 2002, 1:397-411.
8. Becker A.E., de Boer O.J., van der Wal A.C. The role of inflammation and infection in coronary artery disease. Annual Review of Medicine 2001, 52:289-297.
9. Bell D.R., Van Zant G. Stem cells, aging and cancer. Oncogene 2004, 23:7290-7296.
10. Bierman E.L. Arteriosclerosis and aging. Handbook of the biology of aging 1985, 842-858. Van Nostrand Reinhold, New York. 5th ed. C.E. Finch, E.L. Schneider (Eds.).
11. Bjorkbacka H., Kunjathoor V.V., Moore K.J., Koern S., Ordija C.M., Lee M.A., Means T., Halmen K., Luster A.D., Golenbock D.T., Freeman M. Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol to activation of innate immunity signaling pathways. Nature Medicine 2004, 10:416-421.
12. Blumenthal H.T. A view of aging-disease relationship from age 85. Journal of Gerontology: Biological Sciences 1999, 54A:B255-B259.
13. Blumenthal H.T. The aging-disease dichotomy: true or false. Journal of Gerontology 2003, 58A:138-145.
14. Borkan G.A., Norris A.H. Assessment of biological age using a profile of physical parameters. Journal of Gerontology 1980, 35:177-184.
15. Brody J.A., Schneider E.L. Diseases and disorders of aging: a hypothesis. Journal of Chronic Disease 1986, 39:871-876.
16. Bruunsgaard H., Skinhoj P., Pedersen A.N., Schroll M., Pedersen B.K. Ageing, tumour necrosis factor-alpha (TNFα) and atherosclerosis. Clinical Experimental Immunology 2000, 121:255-260.
17. Busse E.W. Theories of aging. Behavior and adaptation in adult life 1969, 11-32. Little Brown, Boston. E.W. Busse, E. Pfeiffer (Eds.).
18. Campisi J. Aging, tumor suppression and cancer: high-wire act. Mechanisms of Ageing and Development 2005, 126:51-58.
19. Casserly I., Torpol E. Convergence of atherosclerosis and Alzheimer's disease: inflammation, cholesterol, misfolded proteins. Lancet 2004, 363:1139-1146.
20. Chung H.Y., Kim H.J., Yu B.P. The inflammation hypothesis of aging: molecular modification by caloric restriction. Annals of the New York Academy of Sciences 2001, 928:327-335.
21. Cortopassi G.A. Fixation of deleterious alleles, evolution, and human aging. Mechanisms of Ageing and Development 2002, 123:851-855.
22. Costa P.T., McCrae R.R. Design and analysis of aging studies. Handbook of physiology 1995, 25-36. Oxford University Press, New York. E.J. Masoro (Ed.).
23. Cutler R.G., Semsei I. Development, cancer and aging: possible common mechanisms of action and regulation. Journal of Gerontology: Biological Sciences 1989, 44:25-34.
24. Del Monte U., Statuto M. Drop of connexins: a possible link between aging and cancer. Experimental Gerontology 2004, 39:273-275.
25. de Nigris F., Lerman A., Ignarro L.J., Williams-Ignarro S., Sica V., Baker A.H., Lerman A.O., Geng Y.J., Napoli C. Oxidative-sensitive mechanisms, vascular apoptosis, and atherosclerosis. Trends in Molecular Medicine 2003, 9:352-359.
26. De Pinho R.A. The age of cancer. Nature 2000, 408:248-254.
27. Dix D. The role of aging in cancer incidence: an epide miological study. Journal of Gerontology 1989, 44(Special Issue):10-18.
28. Donehower L.A. Does p53 affect organismal aging. Journal of Cellular Physiology 2002, 192:23-33.
29. Elby E.M., Parhad I.M., Hogan D.B., Fang T.S. Prevalence and types of dementia in the very old: results from the Canadian Study of Health and Aging. Neurology 1994, 44:1593-1600.
30. Ershler W.B., Longo D.L. Aging and cancer: issues of basic and clinical science. Journal of the National Cancer Institute 1997, 89:1489-1497.
31. Evans J.G. Aging and disease. Ciba Foundation Symposium No. 134 1988, 38-57. Wiley, Chichester, UK. D. Everid, J. Whalen (Eds.).
32. Evans W.J. Effects of exercise on body composition and functional capacity in the elderly. Journal of Gerontology 1995, 50A:147-150.
33. Evert J., Lawler E., Bogan H., Perls T. Morbidity profiles of centenarians: survivors, delayers, escapers. Journal of Gerontology: Medical Sciences 2003, 58A:232-237.
34. Faxon D.P., Fuster V., Libby P., Beckman J.A., Hiatt W.R., Thompson R.W., Topper J.N., Annex B.H., Rundback J.A., Fabunmi R.P., Robertson R.M., Loscalzo J. Atherosclerotic vascular disease conference group III: pathophysiology. Circulation 2004, 109:2617-2625.
35. Finch C.E., Crimmins E.M. Inflammatory exposure and historical changes in human life-spans. Science 2004, 305:1736-1739.
36. Finkel T., Holbrook N.J. Oxidants, oxidative stress, and the biology of aging. Nature 2000, 408:239-247.
37. Fries J.F. Aging natural death, and the compression of morbidity. New England Journal of Medicine 1980, 303:130-135.
38. Fontana L., Meyer T.E., Klein S., Holloszy J.O. Long-term calorie restriction is highly effective in reducing the risk of atherosclerosis in humans. Proceedings of the National Academy of Sciences of the USA 2004, 101:6659-6663.
39. Frontali M., Sabbadini G., Novelleto A., Jodice C., Naso F., Spadaro M., Gigcenti P., Jacopini A.G., Veneziano L., Mantuano E., Malaspina P., Ulizzi L., Brice A., Durr A., Terrenmato L. Genetic fitness in Huntington's disease and spinocerebellar ataxia: a population genetics model of CAG repe at expansions. Annals of Human Genetics 1996, 60:423-435.
40. Geiger H., Van Zant G. The aging of lympho-hematopoietic stem cells. Nature Immunology 2002, 3:329-333.
41. Gessert C.E., Elliott B.A., Haller I.V. Dying of old age: an examination of death certificates of Minnesota centenarians. Journal of the American Geriatrics Society 2002, 50:1561-1565.
42. Greaves D.R., Gordon S. Immunity atherosclerosis, and cardiovascular disease. Trends in Immunology 2001, 22:180-181.
43. Hasty P. The impact of DNA damage, genetic mutation and cellular responses on cancer prevention, longevity and aging: observations in humans and mice. Mechanisms of Ageing and Development 2005, 126:71-77.
44. Hasty P., Campisi J., Hoeijmakers J., van Steeg H., Vijg J. Aging and genome maintenance: lessons from the mouse. Science 2003, 299:1355-1359.
45. Hayflick L. Anarchy in gerontological terminology. Gerontologist 2002, 42:416-421.
46. Hebert K. Life expectancy in Great Britain rises-but later years are still spent in poor health. British Medical Journal 2004, 329:250.
47. Hill J.M., Zalos G., Halcox J.P.T., Schenke W.H., Waclawi W., Quyyumi A.A., Finkel T.C. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. New England Journal of Medicine 2003, 348:593-600.
48. Hitt R., Young-Xu Y., Silver M., Perls T. Centenarians: the older you get, the healthier you have been. Lancet 1999, 354:652.
49. Ho E., Boileau T., Bray T.M. Dietary influence in endocrine-inflammatory interactions in prostate cancer. Archives of Biochemistry and Biophysics 2004, 428:109-117.
50. Hofman A., Ott A., Breteler M.M., Bots M.L., Slooter A.J., van Harskamp E., van Duijin C.N., Van Broeckhoven C., Grobbee D.E. Atherosclerosis, apolipoprotein E, and prevalence of dementia and Alzheimer's disease in the Rotterdam study. Lancet 1997, 349:151-154.
51. Holehan A.M., Merry B.J. The experimental manipulation of ageing by diet. Biological Reviews 1986, 61:329-369.
52. Holliday R. The close relationship between biological aging and age-associated pathologies in humans. Journal of Gerontology: Biological Sciences 2004, 59A:543-546.
53. Horiuchi S., Finch C.E., Mesle F., Vallin J. Differential patterns of age-related mortality increase in middle age and old age. Journal of Gerontology: Biological Sciences 2003, 58A:495-507.
54. Hornsby P.J. Cellular senescence and tissue aging in vivo. Journal of Gerontology: Biological Sciences 2002, 57A:B251-B256.
55. Hughes K.A., Alipaz J.A., Drnevitch J.A., Reynolds R.M. A test of the evolutionary theories of aging. Proceedings of the National Academy of Sciences of the USA 2002, 99:14286-14291.
56. Irminger-Finger I. Geneva Workshop 2002. Cancer, apoptosis, and aging. Biochimia et Biophysica Acta 2003, 1653:41-45.
57. Jala V.R., Haribabu B. Leukotrienes and atherosclerosis: new roles for old mediators. Trends in Immunology 2004, 25:315-322.
58. Jones P.P., Christou C., Jordan J., Seals R. Baroreflex buffering is reduced with age in healthy men. Circulation 2003, 107:1770-1774.
59. Kalu D.N. Bone. Handbook of physiology 1995, 395-412. Oxford University Press, New York. E.J. Masoro (Ed.).
60. Khovidhunkit W., Kim M-S, Memon R.A., Shivenaga J.K., Moser A.H., Feingold K., Greenfeld C. The pathogenesis of atherosclerosis: effect of infection and inflammation on lipid and lipoprotein metabolism and consequences to the host. Journal of Lipid Research 2004, 45:1169-1196.
61. Kim S-h., Kominker P., Campisi J. Telomeres, aging and cancer: in search of a happy ending. Oncogene 2002, 21:503-511.
62. Kirkwood T.B.L. Evolution of ageing. Nature 1997, 270:301-304.
63. Klima M.P., Povysil C., Teasdale T.A. Causes of death in geriatric patients: a cross-cultural study. Journal Gerontology: Medical Sciences 1997, 52A:M247-M253.
64. Kohn R.R. Cause of death in very old people. Journal of the American Mecical Association 1982, 247:2793-2797.
65. Krabbe K.S., Pedersen M., Bruunsgaard H. Inflammatory mediators in the elderly. Experimental Gerontology 2004, 39:687-699.
66. Krtolica A., Parrinello S., Lockett S., Despres P-Y, Campisi J. Senescent fibroblasts promote epithelial cell growth and tumorigenesis; a link between cancer and aging. Proceedings of the National Academy of Sciences of the USA 2001, 98:12072-12077.
67. Lakatta E.G. Health, disease, and cardiovascular aging. America's aging-health in an older society 1985, 73-104. National Academy Press, Washington, DC. Committee on an Aging Society, Institute of Medicine and National Research Council (Ed.).
68. Lakatta E.G. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprise; part III: cellular and molecular clues to heart and arterial aging. Circulaton 2003, 107:490-497.
69. Lakatta E.G., Levy D. Arterial and cardiac aging: major shareholders in cardiovascular disease enterprise: prt I: aging arteries: a "set up" for vascular disease. Circulation 2003, 107:139-146.
70. Landmesser U., Hornig B., Drexler H. Endothelial function: a critical determinant in atherosclerosis. Circulation 2004, 109(Suppl. II):II.
71. Lee R.D. Rethinking the evolutionary theory of aging. Transfers, not births, shape senescence in social species. Proceedings of the National Acadey of Sciences of the USA 2003, 100:9367-9642.
72. Libby P., Ridker P.M., Maseri A. Inflammation and atherosclerosis. Circulation 2003, 105:1135-1143.
73. Lindeman R.D., Tobin J.D., Shock N.W. Longitudianal studies on the rate of decline in renal function with age. Journal of the American Geriatrics Society 1985, 33:278-285.
74. Lipman R., Dallal G.E., Bronson R.T. Lesion biomarkers of aging in B6C3F1 hybrid mice. Journal of Gerontology: Biological Sciences 1999, 54A:B466-B477.
75. Lipman R., Galecki A., Burke D.T., Miller R.A. Genetic loci that influence cause of death in a heterogeneous mouse stock. Journal of Gerontology: Biological Sciences 2004, 59A:977-983.
76. Liu L., Wylie R.C., Andrews L.G., Tollefsbol T.O. Aging, cancer, and nutrition: the DNA methylation connection. Mechanisms of Ageing and Development 2003, 124:989-998.
77. Longo V.D., Finch C.E. Genetics of aging and diseases: from rare mutations and model systems to disease prevention. Archives of Neurology 2002, 59:1706-1708.
78. Lusis A.J. Atherosclerosis. Nature 2000, 407:233-241.
79. Maeda H., Gleiser C.A., Masoro E.J., Murata I., McMahan C., Yu B.P. Nutritional influences of aging of Fischer 344 rats: II. pathology. Journal of Gerontology 1985, 40:671-688.
80. Maier B., Gluba W., Bernier B., Turner I., Mohammad K., Guise T., Sutherland A., Thomer M., Scrable H. Modulation of mammalian life span by the short isoform of p53. Genes and Development 2004, 18:306-319.
81. Martin G.M. The evolutionary substrate of aging. Archives of Neurology 2002, 59:1702-1705.
82. Marx J. Inflammation and cancer: the link grows stronger. Science 2004, 306:966-968.
83. Handbook of physiology, Section 11, Aging 1995, Oxford University Press, New York. E.J. Masoro (Ed.).
84. Masoro E.J. Biomarkers of age and aging. Experimental Gerontology 1997, 32:87-94.
85. McCullough K.D., Coleman W.B., Smith G.J., Grisham J.W. Age-dependent induction of hepatic tumor regression by the tissue microenvironment after transplantation of neoplastically transformed rat liver epithelial cells into the liver. Cancer Research 1997, 57:1807-1813.
86. Medewar P.B. An unsolved problem of biology 1952, Oxford University Press, Oxford.
87. Miller R.A. Gerontology as oncology. Cancer 1991, 68:2496-2501.
88. Miyaishi O., Ando F., Matsuzawa R., Isobe K-I. Cancer incidence in old age. Mechanisms of Ageing and Development 2000, 117:47-55.
89. Navab M., Ananthramaiah G.M., Reddy S.T., Van Lenten B.J., Ansell B.J., Fonarow G.C., Vahabzadeh K., Hama S., Hough G., Kamranpour N., Berliner J.A., Lusis A., Fogelman A.M. The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL. Journal of Lipid Research 2004, 45:993-1007.
90. Nelson W.G., De Marzo A.M., DeWeese T.L., Isaacs W.B. The role of inflammation in the pathogenesis of prostate cancer. Journal of Urology 2004, 172:S6-S12.
91. Nissen S.E., Tsunoda T., Turzae R.M., Schoenhagen P., Cooper C.J., Yasin M., Eaton G.M., Halpern S., Crowe T., Blankenship J.C., Kerensky R. Effect of recombinant apoA-I Milano on coronary atherosclerosis in patients with acute coronary syndromes. Journal of the American Medical Association 2003, 290:2292-2300.
92. Papciak S.M., Song L., Nagel J.E., Adler W.H. Immune system. Encyclopedia of gerontology 1996, Vol. 1:753-759. Academic Press, San Diego. J.E. Birren (Ed.).
93. Park I-K, Morrison S.J., Clarke M.I. Bmi 1, stem cells, and senescence. Journal of Clinical Investigation 2004, 113:175-179.
94. Pedersen M., Bruunsgaard H., Weis N., Hendel H.W., Andreassen B.U., Eldrup E., Dela F., Pedersen B.K. Circulating levels of TNF-alpha and Il-6-relation to truncal fat mass and muscle mass in healthy elderly individuals and in patients with type-2 diabetes. Mechanisms of Aging, and Development 2003, 124:495-502.
95. Perlman R.M. The aging syndrome. Journal of the American Geriatrics Society 1954, 2:123-129.
96. Perls T. Dementia-free centenarians. Experimental. Gerontology 2004, 39:1587-1593.
97. Rattan S.I.S. Ageing and disease: proteins as the molecular link. Perspectives in Biology and Medicine 1991, 34:526-533.
98. Rauscher F., Goldschmidt-Clermont P., Davis B.H., Wang T., Gregg D., Ramaswami P., Pippen A., Annex B.H., Dong E., Taylor D.A. Aging, progenitor cell exhaustion, and atherosclerosis. Circulation 2003, 108:457-463.
99. Reape T.J., Groot P.H.E. Chemokines, and atherosclerosis. Atherosclerosis 1999, 147:213-225.
100. Robbie L., Libby P. Inflammation and atherosclerosis. Annalas of the New York Academy of Sciences 2001, 947:167-180.
101. Rose M.R. Evolutionary biology of aging 1991, Oxford University Press, New York.
102. Ross R. The pathogenesis of atherosclerosis. New England Journal of Medicine 1986, 314:488-500.
103. Ross R. The pathogenesis of atherosclerosis. Nature 1993, 801-809.
104. Ross R. Atherosclerosis: an inflammatory disease. New England Journal of Medicine 1999, 340:115-126.
105. Rowe J.W., Kahn R.W. Successful aging 1998, Pantheon Books, New York.
106. Rowe J.W., Andres R., Tobin J.D., Norris A.H., Shock N.W. The effect of age on creatinine clearance in men: a cross-sectional and longitudinal study. Journal of Gerontology 1976, 31:155-163.
107. Rowe J.W., Wang S.Y., Elahi D. Design, conduct, and analysis of human aging research. Handbook of the biology of aging 1990, 63-71. Academic Press, San Diego. 3rd ed. E.L. Schneider, J.W. Rowe (Eds.).
108. Schwartsburd P.M. Age-promoted creation of a pro-cancer microenvironment: pathogenesis of dyscoordinate feedback control. Mechanisms of Ageing and Development 2004, 125:581-590.
109. Scott D.L. Arthritis in the elderly. Brocklehurst's textbook of geriatric medicine and gerontology 2003, 887-904. Churchill Livingstone, London. 6th ed. R. Tallis, H. Fillit (Eds.).
110. Scott J. Pathophysiology and biochemistry of cardiovascular disease. Current Opinion in Genetics and Development 2004, 14:271-279.
111. Scully J.L. What is a disease?. EMBO Report 2004, 7:650-653.
112. Seddon J.M., Gensler G., Klein M.L., Rifai N. Association between C-reactive protein and age-related macular degeneration. Journal of the American Medical Association 2004, 291:704-710.
113. Semsei I. On the nature of aging. Mechanisms of Ageing, and Development 2000, 117:93-108.
114. Sharpless N.E., DePinho R.A. Telomeres, stem cells, senescence and cancer. Journal of Clinical Investigation 2004, 113:160-168.
115. Shock N.W. Physiological aspects of aging. Annual Review of Physiology 1961, 23:97-122.
116. Shock N.W. Physical activity and the "rate of aging" Journal of the Canadian Medical Association 1967, 96:836-840.
117. Normal human aging: the Baltimore longitudinal study of aging. NIH Publ. 84-2450 1984, U.S. Government Printing Office, Washington, DC. N.W. Shock (Ed.).
118. Sinclair A.J., Croxon S.C.M. Diabetes mellitus. Brocklehurst's textbook of geriatric medicine and gerontology 2003, 1193-1218. Churchill Livingstone, London. 6th ed. R. Tallis, H. Fillit (Eds.).
119. Skoog I., Blennow K., Marcusson J. Dementia. Encyclopedia of gerontology 1996, Vol. 1:383-413. Academic Press, San Diego. J.E. Birren (Ed.).
120. Smith D.W.E. Cancer mortality at very old ages. Cancer 1996, 77:1367-1372.
121. Steinberg D. Low density lipoprotein oxidation and its pathobiological significance. Journal of Biological Chemistry 1997, 272:20963-20966.
122. Stout R.W. Atherosclerosis and lipid metabolism. Brocklehurst's textbook of geriatric medicine and gerontology 2003, 355-370. Churchill Livingstone, London. 6th ed. R. Tallis, H. Fillit (Eds.).
123. Strehler B.L. Time, cells and aging 1977, Academic Press, New York. 2nd ed.
124. Tyner S.D., Venkatachalam S., Choi J., Jones S., Ghebranious N., Ingelmann S., Lu X., Soron G., Cooper B., Brayton C., Park S.H., Thompson T., Karsenty G., Bradley A., Donehower L. p53 mutant mice that display early aging-associated phenotypes. Nature 2002, 415:45-53.
125. Urban L., Bessenyei B., Marka M., Semsei M. On the role of aging in the etiology of autoimmunity. Gerontology 2002, 179-184.
126. Van Zant G., Liang Y. The role of stem cells in aging. Experimental Hematology 2004, 31:659-672.
127. Viera C., Pasyukova E.G., Zeng Z.B., Hackett J.B., Lyman R.F., Mackay T. Genotype-environment interaction for quantitative trait loci affecting life span in Drosophila melanogaster. Genetics 2000, 154:213-227.
128. Vijg J., Dolle M.E.T. Instability of the nuclear genome and the role of DNA repair. Handbook of the biology of aging 2001, 84-113. Academic Press, San Diego. 5th ed. E.J. Masoro, S.N. Austad (Eds.).
129. Vijg J., Dolle M.E. Large genome rearrangements as a primary cause of aging. Mechanisms of Ageing and Development 2002, 123:907-915.
130. Von Straus E., Fratiglioni L., Viitanen M., Forsell Y., Winblad B. Morbidity and comorbidity in relation to functional status: a community-based study of the oldest old (90+years). Journal of the American Geriatrics Society 2000, 48:1462-1469.
131. Wick G., Berger P., Jansen-Durr P., Grubeck-Loebenstein B. A Darwinian-evoltuionary concept, of agerelated diseases. Experimental Gerontology 2003, 38:13-25.
132. Wick G., Jansen-Dürr, Berger P., Blasko I., Grubeck-Loebenstein B. Diseases of aging. Vaccine 2000, 18:1567-1583.
133. Williams G.C. Pleiotropy, natural selection, and the evolution of senescence. Evolution 1957, 11:398-411.
134. Witzum J.L. The oxidation hypothesis of atherosclerosis. Lancet 1994, 344:793-795.
135. Yaffe K., Lindquist K., Pennix B.W., Simonsick E.M., Pahor M., Kritchevsky S., Launer L., Kuller L., Rubin S., Harris T. Inflammatory markers and cognition in well-functioning African American and white elders. Neurology 2003, 61:76-80.
136. Zhang Q., Powers E.T., Nieva J., Huff M.E., Dendle M.A., Bieschke J., Glabe C.G., Eschenmoser A., Wentworth P., Lerner R.A., Kelly J.W. Metabolite-initiated, misfolding may trigger Alzheimer's disease. Proceedings of the National Academy of Sciences of the USA 2004, 101:4752-4757.
137. Zhang Y., Herman B. Ageing and apoptosis. Mechanisms of Ageing and Development 2002, 123:245-260.