Long-term lowering of tumour interstitial fluid pressure reduces Ki-67 expression

Journal of Biomechanics

Volumn 40, Issue 10, 2007, Pages 2324-2329

  Hofmann, Matthias ^a   Schultz, Maike ^a   Bernd, August ^a   Bereiter Hahn, Jürgen ^a   Kaufmann, Roland ^a   Kippenberger, Stefan ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Ki 67; Mechanical stretch; Tumour cell proliferation; Tumour interstitial fluid pressure

Indexed keywords

BIOMARKERS; DATA ACQUISITION; TUMORS;

CATHETERIZATION; HIGH TUMOR INTERSTITIAL FLUID PRESSURE (TIFP); MECHANICAL STRETCH;

BODY FLUIDS;

KI 67 ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CATHETERIZATION; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; HIGH TUMOR INTERSTITIAL FLUID PRESSURE; LEYDIG CELL; MOUSE; NONHUMAN; PRESSURE MEASUREMENT; PRIORITY JOURNAL; SOLID TUMOR; STAINING;

ANIMALS; CATHETERIZATION; CELL LINE, TUMOR; CELL PROLIFERATION; EXTRACELLULAR FLUID; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; KI-67 ANTIGEN; MICE; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; PRESSURE;

EID: 34250885728     PISSN: 00219290     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2006.10.039     Document Type: Article

References (25)

1. Boucher Y., and Jain R.K. Microvascular pressure is the principal driving force for interstitial hypertension in solid tumors: implications for vascular collapse. Cancer Research 52 (1992) 5110-5114
2. Carmeliet P., and Jain R.K. Angiogenesis in cancer and other diseases. Nature 407 (2000) 249-257
3. Chen C.S., Mrksich M., Huang S., Whitesides G.M., and Ingber D.E. Geometric control of cell life and death. Science 276 (1997) 1425-1428
4. Fadnes H.O., Reed R.K., and Aukland K. Interstitial fluid pressure in rats measured with a modified wick technique. Microvascular Research 14 (1977) 27-36
5. Gerdes J., Schwab U., Lemke H., and Stein H. Production of a mouse monoclonal antibody reactive with a human nuclear antigen associated with cell proliferation. International Journal of Cancer 31 1 (1983) 13-20
6. Heldin C.-H., Rubin K., Pietras K., and Östman A. High interstitial fluid pressure-an obstacle in cancer therapy. Nature Reviews Cancer 4 (2004) 806-813
7. Hofmann M., Žaper J., Bernd A., Bereiter-Hahn J., Kaufmann R., and Kippenberger S. Mechanical-pressure induced phosphorylation of p38 mitogen-activated protein kinase in epithelial cells via Src and protein kinase C. Biochemical and Biophysical Research Communications 316 (2004) 673-679
8. Hofmann M., Guschel M., Bernd A., Bereiter-Hahn J., Kaufmann R., Tandi C., Wiig H., and Kippenberger S. Lowering of tumor interstital fluid pressure reduces tumor cell proliferation in a xenograft tumor model. Neoplasia 8 2 (2006) 89-95
9. Jain R.K. Barriers to drug delivery in solid tumors. Scientific American 271 (1994) 58-65
10. Jain R.K. The next frontier of molecular medicine: delivery of therapeutics. Nature Medicine 4 (1998) 655-657
11. Jain R.K. Delivery of molecular medicine to solid tumors: lessons from in vivo imaging of gene expression and function. Journal of Controlled Release 74 (2001) 7-25
12. Kauhanen S., von Boguslawsky K., Michelsson J.E., and Leivo I. Satellite cell proliferation in rabbit hindlimb muscle following immobilization and remobilization: an immunohistochemical study using MIB 1 antibody. Acta Neuropathologica 95 2 (1998) 165-170
13. Kawabe J., Okumura S., Lee M.C., Sadoshima J., and Ishikawa Y. Translocation of caveolin regulates stretch-induced ERK activity in vascular smooth muscle cells. American Journal of Physiology: Heart and Circulatory Physiology 286 5 (2004) H1845-H1852
14. Kippenberger S., Bernd A., Loitsch S.M., Guschel M., Müller J., Bereiter-Hahn J., and Kaufmann R. Signaling of mechanical stretch in human keratinocytes via MAP kinases. Journal of Investigative Dermatology 114 (2000) 408-412
15. Kippenberger S., Loitsch S., Guschel M., Müller J., Knies Y., Kaufmann R., and Bernd A. Mechanical stretch stimulates protein kinase B/Akt phosphorylation in epidermal cells via angiotensin II type 1 receptor and epidermal growth factor receptor. Journal of Biological Chemistry 280 4 (2005) 3060-3067
16. Lee I., Boucher Y., Demhartner T.J., and Jain R.K. Changes in tumour blood flow, oxygenation and interstitial fluid pressure induced by pentoxifylline. British Journal of Cancer 69 3 (1994) 492-496
17. Leu A.J., Berk D.A., Lymboussaki A., Alitalo K., and Jain R.K. Absence of functional lymphatics within a murine sarcoma: a molecular and functional evaluation. Cancer Research 60 (2000) 4324-4327
18. Li Y.S., Haga J.H., and Chien S. Molecular basis of the effects of shear stress on vascular endothelial cells. Journal of Biomechanics 38 10 (2005) 1949-1971
19. Netti P.A., Berk D.A., Swartz M.A., Grodzinsky A.J., and Jain R.K. Role of extracellular matrix assembly in interstitial transport in solid tumors. Cancer Research 60 (2000) 2497-2503
20. Padera T.P., Stoll B.R., Tooredman J.B., Capen D., di Thomaso E., and Jain R.K. Pathology: cancer cells compress intratumour vessels. Nature 427 (2004) 695
21. Salnikov A., Iversen V.V., Koisti M., Sundberg C., Johansson L., Stuhr L.B., Sjöquist M., Ahlström H., Reed R.K., and Rubin K. Lowering of tumor interstitial fluid pressure specifically augments efficacy of chemotherapy. Faseb Journal 17 (2003) 1756-1758
22. Scholzen T., and Gerdes J. The Ki-67 protein: from the known and the unknown. Journal of Cellular Physiology 182 (2000) 311-322
23. Takei T., Rivas-Gotz C., Delling C.A., Koo J.T., Mills I., McCarthy T.L., Centrella M., and Sumpio B.E. Effect of strain on human keratinocytes in vitro. Journal of Cellular Physiology 173 (1997) 64-72
24. Wang J.H.C., and Thampatty B.P. An introductory review of cell mechanobiology. Biomechanics and Modeling in Mechanobiology 5 (2006) 1-16
25. i data. Critical Reviews in Biomedical Engineering 18 1 (1990) 27-54