Intracellular recognition of pathogens and autophagy as an innate immune host defence

Journal of Biochemistry

Volumn 150, Issue 2, 2011, Pages 143-149

  Yano, Tamaki ^a   Kurata, Shoichiro ^a,b  

^a TOHOKU UNIVERSITY   (Japan)

^b NONE   (Japan)

Author keywords

autophagy; inflammatory disease; innate immunity; intracellular pathogens; pattern recognition molecules

Indexed keywords

NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PEPTIDOGLYCAN RECOGNITION PROTEIN; TOLL LIKE RECEPTOR;

AUTOPHAGY; BACTERIAL VIRULENCE; CYTOSOL; DROSOPHILA; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; INNATE IMMUNITY; INTRACELLULAR SIGNALING; NONHUMAN; PARASITE VIRULENCE; PATHOGENESIS; REVIEW; VIRUS VIRULENCE;

BACTERIA (MICROORGANISMS); MAMMALIA;

EID: 79961055797     PISSN: 0021924X     EISSN: 17562651     Source Type: Journal    
DOI: 10.1093/jb/mvr083     Document Type: Review

References (57)

1. Akira, S., Uematsu, S., and Takeuchi, O. (2006) Pattern recognition and innate immunity. Cell 124, 783-801
2. Lemaitre, B. and Hoffmann, J. (2007) The host defense of Drosophila melanogaster. Ann. Rev. Immunol. 25, 697-743 (Pubitemid 46697922)
3. Lemaitre, B., Nicolas, E., Michaut, L., Reichhart, J. M., and Hoffmann, J.A. (1996) The dorsoventral regulatory gene cassette spätzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell 86, 973-983 (Pubitemid 26336801)
4. Kawai, T. and Akira, S. (2010) The role of pattern-recognition receptors in innate immunity: Update on Toll-loke receprotes. Nat. Immunol. 11, 373-384
5. Dziaeski, R. (2004) Peptidoglycan recognition proteins (PGRPs). Mol. Immnol. 40, 877-886
6. Kurata, S. (2010) Extracellular and intracellular pathogen recognition by Drosophila PGRP-LE and PGRP-LC. Int. Immunol. 22, 143-148
7. Kanneganti, T-D., Lamkanfi, M., and Núñez. (2007) Intracellular NOD-like receptors in host defense and disease. Immunity 27, 549-559 (Pubitemid 47615512)
8. Girardin, S.E., Tournebize, R., Mavris, M., Page, A.L., Li, X., Stark, G.R., Bertin, J., SiStefano, P.S., Yaniv, M., Sansonetti, P.J., and Philpott, D.J. (2001) CARD/Nod1 mediates NF-kappaB and JNK activation by invasive Shigella flexneri. EMBO Rep. 2, 736-742 (Pubitemid 32798718)
9. Bertin, J., Nir, W-J., Fischer, C.M., Tayber, O.V., Errada, P.R., Grant, J.R., Keilty, J.J., Gosselin, M.L., Robison, K.E., Wong, G.H.W., Glucksmann, M.A., and DiStefano, P.S. (1999) Human CARD4 protein is a novel CED-4/Apaf-1 cell death family member that activates NF-kB. J. Biol. Chem. 274, 12955-12958
10. Inohara, N., Koseki, T., del Peso, L., Hu, Y., Yee, C., Chen, S., Carrio, R., Merino, J., Liu, D., Ni, J., and Núñez, G. (1999) Nod1, an Apaf-1-like Activator of Caspase-9 and Nuclear Factor-kB. J. Biol. Chem. 274, 14560-14567
11. Nigro, G., Fazio, L.L., Martino, M.C., Rossi, G., Tattoli, I., Liparoti, V., De Castro, C., Molinaro, A., Philpott, D.J., and Bernardini, M.L. (2008) Muramylpeptide shedding modulates cell sending of Shigella flexneri. Cell. Microbiol. 10, 682-695 (Pubitemid 351194095)
12. Kobayashi, K.S., Chamaillard, M., Ogura, Y., Henegariu, O., Inohara, N., Núñez, G., and Flavell, R.A. (2005) Nod2-Dependent Regulation of Innate and Adaptive Immunity in the Intestinal Tract. Science 307, 731-734 (Pubitemid 40194644)
13. Warren, S.E., Mao, D.P., Rodriguez, A.E., Miao, E.A., and Aderem, A. (2008) Multiple Nod-Like Receptors Activate Caspase 1 during Listeria monocytogenes Infection. J. Immunol. 180, 7558-7564
14. Kim, Y-G., Park, J-H., Shaw, M.H., Franchi, L., Inohara, N., and Núñez, G. (2008) The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to toll-like receptor ligands. Immunity 28, 246-257
15. Franchi, L., Amer, A., Body-Malapel, M., Kanneganti, T-D., Özören, N., Jagirdar, R., Inohara, N., Vandenabeele, P., Bertin, J., Coyle, A., Grant, E.P., and Núñez, G. (2006) Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1b in salmonella-infected macrophages. Nat. Immunol. 7, 576-582 (Pubitemid 43797338)
16. Wright, E.K., Goodart, S.A., Growney, J.D., Hadinoto, V., Endrizzi, M.G., Long, E.M., Sadigh, K., Abney, A.L., Bernstein-Hanley, I., and Dietrich, W.F. (2003) Naip5 Affects Host Susceptibility to the Intracellular Pathogen Legionella pneumophila. Curr. Biol. 13, 27-36 (Pubitemid 36080619)
17. Zamboni, D.S., Kobayashi, K.S., Kohlsdorf, T., Ogura, Y., Long, E.M., Vence, R.E., Kuida, K., Mariathasan, S., Dixit, V.M., Flavell, R.A., Dietrich, W.F., and Roy, C.R. (2006) The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Nat. Immunol. 7, 318-325
18. Fritz, J.H., Ferrero, R., Philpott, D.J., and Girardin, S.E. (2006) Nod-like proteins in immunity, inflammation and disease. Nat. Immunol. 7, 1250-1257 (Pubitemid 46111242)
19. Hsu, Y-M., Zhang, Y., You, Y., Wang, D., Li, H., Duramad, O., Qin, X-F., Dong, C., and Lin, X. (2007) The adaptor protein CARD9 is required for innate immune responses to intracellular pathogens. Nat. Immunol. 8, 198-205 (Pubitemid 46152651)
20. Gottar, M., Gobert, V., Michel, T., Belvin, M., Duyk, G., Hoffmann, J. A., Ferrandon, D., and Royet, J. (2002) The Drosophila immune response against Gram-negative bacteria is mediated by a peptidoglycan recognition protein. Nature 416, 640-644 (Pubitemid 34406765)
21. Gobert, V., Gottar, M., Matskevich, A.A., Rutschmann, S., Royet, J., Belvin, M., Hoffmann, J.A., and Ferrandon, D. (2003) Dual activation of the Drosophila toll pathway by two pattern recognition receptors. Science 302, 2126-2130 (Pubitemid 38017946)
22. Bischoff, V., Vignal, C., Boneca, I.G., Michel, T., Hoffmann, J.A., and Royet, J. (2004) Function of the drosophila pattern-recognition receptor PGRP-SD in the detection of Gram-positive bacteria. Nat. Immunol. 5, 1175-1180 (Pubitemid 39549632)
23. Gottar, M., Gobert, V., Matskevich, A.A., Reichhart, JM., Wang, C., Butt, T.M., Belvin, M., Hoffmann, J.A., and Ferrandon, D. (2006) Dual detection of fungal infections in Drosophila via recognition of glucans and sensing of virulence factors. Cell 127, 1425-1437 (Pubitemid 44960414)
24. Takehana, A., Yano, T., Mita, S., Kotani, A., Oshima, Y., and Kurata, S. (2004) Peptidoglycan recognition protein (PGRP)-LE and PGRP-LC act synergistically in Drosophila immunity. EMBO J. 23, 4690-4700 (Pubitemid 39657868)
25. Takehana, A., Katsuyama, T., Yano, T., Oshima, Y., Takada, H., Aigaki, T., and Kurata, S. (2002) Overexpression of a pattern-recognition receptor, peptidoglycanrecognition protein-LE, activates imd/ relish-mediated antibacterial defense and the prophenoloxidase cascade in Drosophila larvae. Proc. Natl Acad. Sci. USA 99, 13705-13710 (Pubitemid 35215445)
26. Kaneko, T., Yano, T., Aggarwal, K., Lim, J-H., Ueda, K., Oshima, Y., Peach, C., Erturk-Hasdemir, D., Goldman, W.E., Oh, B-H., Kurata, S., and Silverman, N. (2006) PGRP-LC and PGRP-LE have essential yet distinct functions in the drosophila immune response to monomeric DAP-type peptidoglycan. Nat. Immunol. 7, 715-723 (Pubitemid 43905870)
27. Yano, T., Mita, S., Ohmori, H., Oshima, Y., Fujimoto, Y., Ueda, R., Takada, H., Goldman, W.E., Fukase, K., Silverman, N., Yoshimori, T., and Kurata, S. (2008) Autophagic control of Listeria though intracellular innate immune recognition in drosophila. Nat. Immunol. 9, 908-916
28. Goto, A., Yano, T., Terashima, J., Iwashita, S., Oshima, Y., and Kurata, S. (2010) Cooperative Regulation of the Induction of the Novel Antibacterial Listericin by Peptidoglycan Recognition Protein LE and the JAK-STST Pathway. J. Biol. Chem. 285, 15731-15738
29. Nakagawa, I., Amano, A., Mizushima, N., Yamamoto, A., Yamaguxhi, H., Kamimoto, T., Nara, A., Funao, J., Nakata, M., Tsuda, K., Hamada, S., and Yoshimori, T. (2004) Autophagy defends cells against invading Group A Streptococcus. Science 306, 1037-1040 (Pubitemid 39482907)
30. Yang, Z. and Klionsky, D. (2010) Eaten alive: A history of macroautophagy. Nat. Cell Biol. 12, 814-822
31. Nakatogawa, H., Suzuki, K., Kamada, Y., and Ohsumi, Y. (2009) Dynamics and diversity in autophagy mechanisms: Lessons from yeast. Nat. Rev. Mol. Cell Biol. 10, 458-467
32. Mizushima, N. and Levine, B. (2010) Autophagy in mammalian development and differentiation. Nat. Cell Biol. 12, 823-830
33. Chang, Y-Y. and Neufeld, T.P. (2010) Autophagy takes flight in Drosophila. FEBS Lett. 584, 1342-1349
34. Levine, B. and Deretic, V. (2007) Unveiling the roles of autophagy in innate and adaptive immunity. Nat. Rev. Immunol. 7, 767-777 (Pubitemid 47480305)
35. Travasso, L.H., Carneiro, L.M., Ramjeet, M., Hussey, S., Kim, Y-G, Magalhães, J., Yuan, L., Soares, F., Chea, E., Bourhis, L.L., Boneca, I.G., Allaoui, A., Jones, N.L., Nuñez, G., Girardin, S.E., and Philpott, D.J. (2009) Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat. Immunol. 11, 55-62
36. Xu, Y., Jagannath, C., Liu, X-D., Sharafkhaneh, A., Kolodziejska, K.E., and Eissa, T. (2007) Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Immunity 27, 135-144 (Pubitemid 47089027)
37. Delgado, M.A., Elmaoued, R.A., Davis, A.S., Kyei, G., and Deretic, V. (2008) Toll-like receptors control autophagy. EMBO J. 27, 1110-1121 (Pubitemid 351508141)
38. Deretic, V. and Levine, B. (2009) Autophagy, Immunity, and Microbial Adaptations. Cell Host Micro. 5, 527-549
39. Shelly, S., Lukinova, N., Bambina, S., Berman, A., and Cherry, S. (2009) Autophagy is an essential component of drosophila immunity against vesicular stomatitis virus. Immunity 30, 588-598
40. Orvrdahl, A., MacPherson, S., Sumpter, R., Tallóczy, Z., Zou, Z., and Levine, B. (2010) autophagy protects against Sindbis virus infection of the central nervous system. Cell Host Micro. 7, 115-127
41. Zhao, Z., Fux, B., Goodwin, M., Dunay, I.R., Strong, D., Miller, B.C., Cadwell, K., Delgado, M.A., Ponpuak, M., Green, K.G., Schmidt, R.E., Mizushima, N., Deretic, V., Sibley, L.D., and Virgin, H.W. (2008) Autophagosome-independent essential function for the autophagy protein Atg5 in cellular immunity to intracellular pathogens. Cell Host Micro. 4, 458-469
42. Virgin, H.W. and Levine, B. (2009) Autophagy genes in immunity. Nat. Immunol. 10, 461-470
43. Yano, T. and Kurata, S. (2009) An unexpected twist for autophagy in Crohn's disease. Nat. Immunol. 10, 134-135
44. Cadwell, K., Liu, J.Y., Broun, S.L., Miyoshi, H., Loh, J., Lennerz, J.K., Kishi, C., Kc, W., Carrero, J.A., Hunt, S., Stone, C.D., Brunt, E.M., Xavier, R.J., Sleckman, B.P., Li, E., Mizushima, N., Stappenbeck, T., and Virgin, H.W. (2008) A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells. Nature 456, 259-263
45. Saitoh, T., Fujita, N., Jang, M.H., Uematsu, S., Yang, B.G., Satoh, T., Omori, H., Noda, T., Yamamoto, N., Komatsu, M., Tanaka, K., Kawai, T., Tsujimura, T., Takeuchi, O., Yoshimori, T., and Akira, S (2008) Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 456, 264-269
46. Yoshikawa, Y., Ogawa, M., Hain, T., Yoshida, M., Fukumatsu, M., Kim, M., Mimuro, H., Nakagawa, I., Yanagawa, T., Ishii, T., Kakizuka, A., Sztul, E., Chakraborty, T., and Sasakawa, C. (2009) Listeria monocytogenes ActA-mediated escape from autophagic recognition. Nat. Cell Biol. 11, 1233-1240
47. Thurston, T.L., Ryzhakov, G., Bloor, S., von Muhlinen, N., and Randow, F. (2009) The TBK1 adaptor and autophagy receptor NDP52 restricts the proliferation of ubiquitin-coated bacteria. Nat. Immunol. 10, 1215-1221
48. Amano, A., Nakagawa, I., and Yoshimori, T. (2006) Autophagy in Innate Immunity against Intracellular Bacteria. J. Biochem. 140, 161-166 (Pubitemid 44618901)
49. Py, B., Lipinsky, M.M., and Yuan, J. (2007) Autophagy Limits Listeria monocytogenes Intracellular Growth in the Early Phase of Primary Infection. Autophagy 3, 117-125 (Pubitemid 46449099)
50. Ogawa, M., Yoshimori, T., Suzuki, T., Sagara, H., Mizushima, N., and Sasakawa, C. (2005) Escape of Intracellular Shigella from Autophagy. Science 307, 727-731 (Pubitemid 40194643)
51. Brimingham, C.L., Smith, A.C., Bakowski, M.A., Yoshimori, T., and Brumell, J.H. (2006) Autophagy Controls Salmonella Infection in Response to Damage to the Salmonella-containing Vacuole. J. Biol. Chem. 281, 11374-11383 (Pubitemid 43855562)
52. Gutierrez, M.G., Master, S.S., Singh, S.B., Taylor, G.A., Colombo, M.I., and Deretic, V. (2004) Autophagy Is a Defense Mechanism Inhibiting BCG and Mycobacterium tuberculosis Survival in Infected Macrophages. Cell 119, 753-766 (Pubitemid 40017683)
53. Singh, S.B., Davis, A.S., Taylor, G.A., and Deretic, V. (2006) Human IRGM induces autophagy to eliminate intracellular Mycobacteria. Science 313, 1438-1441 (Pubitemid 44360272)
54. Ling, Y.M., Shaw, M.H., Ayala, C., Coppens, I., Taylor, G.A., Ferguson, D.J.P., and Yap, G.S. (2006) Vacuolar and plasma membrane stripping and autophagic elimination of Toxoplasma gondii in primed effector macrophages. J. Exp. Med. 203, 2063-2071
55. Wang, Y., Weiss, L.M., and Orlofsky, A. (2009) Host cell autophagy is induced by Toxoplasma gondii and contributes to parasite growth. J. Biol. Chem. 284, 1694-1701
56. Liang, X.H., Kleeman, L.K., Jiang, H.H., Gordon, G., Goldman, J.E., Berry, G., Herman, B., and Levine, B. (1998) Protection against fatal Sindbis virus encephalitis by Beclin, a novel Bcl-2-interacting protein. J. Virol. 72, 8586-8596 (Pubitemid 28471796)
57. Liu, Y.L., Schiff, M., Czymmek, K., Tallóczy, Z., Levine, B., and Dinesh-Kumar, S.P. (2005) Autophagy regulates programmed cell death during the plant innate immune response. Cell 121, 567-577 (Pubitemid 40720010)