Activation of the PDK-1/Akt/eNOS pathway involved in aortic endothelial function differs between hyperinsulinemic and insulin-deficient diabetic rats

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 297, Issue 5, 2009, Pages

  Kobayashi, Tsuneo ^a   Taguchi, Kumiko ^a   Nemoto, Shingo ^a   Nogami, Takagoro ^a   Matsumoto, Takayuki ^a   Kamata, Katsuo ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

3 Phosphoinositide dependent; Diabetes; Hyperinsulinemia; Nitric oxide

Indexed keywords

ACETYLCHOLINE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INSULIN; NITRIC OXIDE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; PROTEIN KINASE B INHIBITOR; SERINE; THREONINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA DISEASE; ARTICLE; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVITY; GLUCOSE BLOOD LEVEL; HYPERGLYCEMIA; HYPERINSULINEMIA; HYPOINSULINEMIA; INSULIN BLOOD LEVEL; INSULIN DEFICIENCY; MALE; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; STREPTOZOCIN DIABETES; SYSTOLIC BLOOD PRESSURE; VASODILATATION;

ACETYLCHOLINE; ANIMALS; AORTA; BLOOD GLUCOSE; BLOOD PRESSURE; DIABETES MELLITUS, EXPERIMENTAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIUM, VASCULAR; ENZYME ACTIVATION; HYPERINSULINISM; INOSITOL; INSULIN; MALE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; NITROPRUSSIDE; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, WISTAR; SERINE; SIGNAL TRANSDUCTION; THREONINE; VASODILATION; VASODILATOR AGENTS;

EID: 70350452174     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00536.2009     Document Type: Article

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