Role of nitric oxide in diabetic complications

American Journal of Therapeutics

Volumn 12, Issue 6, 2005, Pages 499-502

  Cohen, Richard A ^a,b  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Vascular Biology Unit X704   (United States)

Author keywords

Endothelium; Nitric oxide; Oxidant stress; Prostacyclin; Smooth muscle

Indexed keywords

CYSTEINE; FREE RADICAL; ICOSANOID; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; OXIDIZING AGENT; OXYGEN; PEROXYNITRITE; PROSTACYCLIN SYNTHASE; REACTIVE OXYGEN METABOLITE; SCAVENGER; SUPEROXIDE; THIOL DERIVATIVE; THROMBOXANE RECEPTOR;

CONFERENCE PAPER; DIABETIC ANGIOPATHY; ENDOTHELIUM; ENDOTHELIUM CELL; ENZYME ACTIVATION; HUMAN; HYPERGLYCEMIA; HYPERLIPIDEMIA; NONHUMAN; OXIDATION; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SMOOTH MUSCLE; VASCULAR DISEASE; VASODILATATION;

DIABETES COMPLICATIONS; HUMANS; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; OXIDATIVE STRESS; VASODILATION;

EID: 28044432087     PISSN: 10752765     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mjt.0000178776.77267.19     Document Type: Conference Paper

References (12)

1. Zou MH, Shi C, Cohen RA. High glucose via peroxynitrite causes tyrosine nitration and inactivation of prostacyclin synthase that is associated with thromboxane/prostaglandin H2 receptor-mediated apoptosis and adhesion molecule expression in cultured human aortic endothelial cells. Diabetes. 2002;51:198-203.
2. Zou MH, Shi C, Cohen RA. Oxidation of the zinc-thiolate complex and uncoupling of endothelial nitric oxide synthase by peroxynitrite. J Clin Invest. 2002;109:817-826.
3. Cayatte AJ, Du Y, Oliver-Krasinski J, et al. The thromboxane receptor antagonist S18886 but not aspirin inhibits atherogenesis in apo E-deficient mice evidence that eicosanoids other than thromboxane contribute to atherosclerosis. Arterioscler Thromb Vasc Biol. 2000;20:1724-1728.
4. Cohen RA, Xu S, Maitland K, et al. The TP receptor antagonist, S18886, prevents the enhancement of atherogenesis by diabetes mellitus in apolipoprotein E deficient mice. Circulation. 2001;104:II-118.
5. Williams SB, Cusco JA, Roddy MA, et al. Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus. J Am Coll Cardiol. 1996;27:567-574.
6. Adachi T, Matsui R, Xu S, et al. Antioxidant improves smooth muscle sarco/endoplasmic reticulum Ca(2+)-AT-Pase function and lowers tyrosine nitration in hypercholesterolemia and improves nitric oxide-induced relaxation. Circ Res. 2002;90:1114-1121.
7. Adachi T, Matsui R, Weisbrod RM, et al. Reduced sarco/endoplasmic reticulum Ca2+ uptake activity can account for the reduced response to NO, but not sodium nitroprusside, in hypercholesterolemic rabbit aorta. Circulation. 2001;104:1040-1045.
8. 2. Am J Physiol. 1989;257:H1327-H1333.
9. Tesfamariam B, Brown ML, Deykin D, et al. Elevated glucose promotes generation of endothelium-derived vasoconstrictor prostanoids in rabbit aorta. J Clin Invest. 1990;85:929-932.
10. Adachi T, Weisbrod RM, Pimentel D, et al. S-glutathiolation by peroxynitrite activates SERCA during arterial relaxation by nitric oxide. A mechanism targeted by oxidants in vascular disease. Nat Med. 2004;10:1200-1207.
11. Bolotina VM, Najibi S, Palacino JJ, et al. Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle cells. Nature. 1994;368:850-853.
12. 2+ influx. Circ Res. 1999;84:210-219.