Interrogation of the protein-protein interactions between human BRCA2 BRC repeats and RAD51 reveals atomistic determinants of affinity

PLoS Computational Biology

Volumn 7, Issue 7, 2011, Pages

  Cole, Daniel J ^a   Rajendra, Eeson ^b   Roberts Thomson, Meredith ^c   Hardwick, Bryn ^b,c   McKenzie, Grahame J ^b,c   Payne, Mike C ^a   Venkitaraman, Ashok R ^b,c   Skylaris, Chris Kriton ^d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c HUTCHISON MRC RESEARCH CENTRE   (United Kingdom)

^d UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BEHAVIORAL RESEARCH; BINDING ENERGY; CALCULATIONS; CHEMICAL ANALYSIS; DISEASES; FREE ENERGY; MAMMALS; PROTEINS; QUANTUM THEORY;

ATOMISTICS; BINDING FREE ENERGY; BREAST CANCER; CELLULAR PROCESS; DNA RECOMBINATION; ERROR-FREE REPAIR; PEPTIDE MOTIFS; PROTEIN-PROTEIN INTERACTIONS; RECOMBINASES; SEQUENCE VARIATIONS;

CRYSTAL STRUCTURE;

ALANINE; BRCA2 PROTEIN; RAD51 PROTEIN; SERINE;

ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; FLUORESCENCE POLARIZATION IMMUNOASSAY; MOLECULAR DYNAMICS; MUTAGENESIS; OLIGOMERIZATION; PROTEIN ANALYSIS; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; QUANTITATIVE ANALYSIS; QUANTUM MECHANICS; THERMODYNAMICS; AMINO ACID SEQUENCE; CHEMICAL STRUCTURE; CHEMISTRY; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MUTATION; PHYSIOLOGY; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; SEQUENCE ALIGNMENT;

MAMMALIA;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BRCA2 PROTEIN; FLUORESCENCE POLARIZATION IMMUNOASSAY; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN INTERACTION MAPPING; PROTEIN STABILITY; RAD51 RECOMBINASE; REPETITIVE SEQUENCES, AMINO ACID; SEQUENCE ALIGNMENT; THERMODYNAMICS;

EID: 79960959128     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.1002096     Document Type: Article

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