Therapeutic potential of phosphodiesterase inhibitors in parasitic diseases

Handbook of Experimental Pharmacology

Volumn 204, Issue , 2011, Pages 487-510

  Shakur, Yasmin ^a   De Koning, Harry P ^b   Ke, Hengming ^c   Kambayashi, Junichi ^a   Seebeck, Thomas ^d  

^a OTSUKA PHARMACEUTICAL DEVELOPMENT AND COMMERCIALIZATION INC   (United States)

^b UNIVERSITY OF GLASGOW   (United Kingdom)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF BERN   (Switzerland)

Author keywords

Crystal structure; Cyclic AMP; Cyclic nucleotide phosphodiesterase; Kinetoplastid; PDE inhibitor; RNA interference

Indexed keywords

AMPHOTERICIN B LIPID COMPLEX; ANTIMONY DERIVATIVE; BENZNIDAZOLE; BYK 54286; CILOSTAMIDE; DIPYRIDAMOLE; EFLORNITHINE; ETAZOLATE; ISOBUTYLMETHYLXANTHINE; MELARSOPROL; MILTEFOSINE; NIFURTIMOX; PAFURAMIDINE; PAPAVERINE; PAROMOMYCIN; PENTAMIDINE; PHOSPHODIESTERASE INHIBITOR; ROLIPRAM; SURAMIN; UNCLASSIFIED DRUG; ZARDAVERINE; CYCLIC NUCLEOTIDE; PHOSPHODIESTERASE;

AFRICAN TRYPANOSOMIASIS; ANOREXIA; ARTICLE; CATALYSIS; CELL CYCLE ARREST; CHAGAS DISEASE; CRYSTAL STRUCTURE; DRUG ACTIVITY; DRUG EFFICACY; DRUG ERUPTION; DRUG SAFETY; GENETIC VARIABILITY; HOMOZYGOSITY; HUMAN; KINETOPLASTIDA; LEISHMANIASIS; LIFE CYCLE; NAUSEA; NEPHROTOXICITY; NEUROPATHY; NOMENCLATURE; NONHUMAN; PARASITOSIS; PATIENT COMPLIANCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; RNA INTERFERENCE; SEQUENCE HOMOLOGY; SIDE EFFECT; SIGNAL TRANSDUCTION; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; VOMITING; WEIGHT REDUCTION; ANIMAL; CHEMISTRY; CRYSTALLIZATION; ENZYMOLOGY; PHYSIOLOGY; REVIEW; TRYPANOSOMIASIS;

ANIMALS; CRYSTALLIZATION; HUMANS; KINETOPLASTIDA; LEISHMANIASIS; NUCLEOTIDES, CYCLIC; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; SIGNAL TRANSDUCTION; TRYPANOSOMIASIS;

EID: 79960916184     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-642-17969-3_20     Document Type: Article

References (66)

1. Alonso GD, Schoijet AC, Torres HN, Flawia MM (2006) TcPDE4, a novel membrane-associated cAMP-specific phosphodiesterase from Trypanosoma cruzi. Mol Biochem Parasitol 145:40-49 (Pubitemid 41691853)
2. Alonso GD, Schoijet AC, Torres HN, Flawia MM (2007) TcrPDEA1, a cAMP-specific phosphodiesterase with atypical pharmacological properties from Trypanosoma cruzi. Mol Biochem Parasitol 152:72-79 (Pubitemid 46127525)
3. Alvar J, Aparicio P, Aseffa A, Den BM, Canavate C, Dedet JP, Gradoni L, Ter HR, Lopez-Velez R, Moreno J (2008) The relationship between leishmaniasis and AIDS: the second 10 years. Clin Microbiol Rev 21:334-359, Table (Pubitemid 351555511)
4. Barrett MP, Burchmore RJ, Stich A, Lazzari JO, Frasch AC, Cazzulo JJ, Krishna S (2003) The trypanosomiases. Lancet 362:1469-1480 (Pubitemid 37352887)
5. Bender AT, Beavo JA (2006) Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use. Pharmacol Rev 58:488-520 (Pubitemid 44394910)
6. Berriman M, Ghedin E, Hertz-Fowler C, Blandin G, Renauld H, Bartholomeu DC, Lennard NJ, Caler E, Hamlin NE, Haas B, Bohme U, Hannick L, Aslett MA, Shallom J, Marcello L, Hou L, Wickstead B, Alsmark UC, Arrowsmith C, Atkin RJ, Barron AJ, Bringaud F, Brooks K, Carrington M, Cherevach I, Chillingworth TJ, Churcher C, Clark LN, Corton CH, Cronin A, Davies RM, Doggett J, Djikeng A, Feldblyum T, Field MC, Fraser A, Goodhead I, Hance Z, Harper D, Harris BR, Hauser H, Hostetler J, Ivens A, Jagels K, Johnson D, Johnson J, Jones K, Kerhornou AX, Koo H, Larke N, Landfear S, Larkin C, Leech V, Line A, Lord A, Macleod A, Mooney PJ, Moule S, Martin DM, Morgan GW, Mungall K, Norbertczak H, Ormond D, Pai G, Peacock CS, Peterson J, Quail MA, Rabbinowitsch E, Rajandream MA, Reitter C, Salzberg SL, Sanders M, Schobel S, Sharp S, Simmonds M, Simpson AJ, Tallon L, Turner CM, Tait A, Tivey AR, Van AS, Walker D, Wanless D, Wang S, White B, White O, Whitehead S, Woodward J, Wortman J, Adams MD, Embley TM, Gull K, Ullu E, Barry JD, Fairlamb AH, Opperdoes F, Barrell BG, Donelson JE, Hall N, Fraser CM, Melville SE, El-Sayed NM (2005) The genome of the African trypanosome Trypanosoma brucei. Science 309:416-422 (Pubitemid 40994676)
7. Black S, Seed J (2001) World class parasites: volume 1 the African trypanosomes. Kluwer Academic Publishers, Boston, MA
8. Breidbach T, Ngazoa E, Steverding D (2002) Trypanosoma brucei: in vitro slender-to-stumpy differentiation of culture-adapted, monomorphic bloodstream forms. Exp Parasitol 101: 223-230 (Pubitemid 36269054)
9. Broadhead R, Dawe HR, Farr H, Griffiths S, Hart SR, Portman N, Shaw MK, Ginger ML, Gaskell SJ, McKean PG, Gull K (2006) Flagellar motility is required for the viability of the bloodstream trypanosome. Nature 440:224-227 (Pubitemid 43372101)
10. Brun R, Blum J, Chappuis F, Burri C (2010) Human African trypanosomiasis. Lancet 375(9709): 148-159
11. Butler D (2007) Lost in translation. Nature 449:158-159 (Pubitemid 47402352)
12. Castro JA, de Mecca MM, Bartel LC (2006) Toxic side effects of drugs used to treat Chagas disease (American trypanosomiasis). Hum Exp Toxicol 25:471-479 (Pubitemid 44384589)
13. Chirac P, Torreele E (2006) Global framework on essential health R&D. Lancet 367:1560-1561 (Pubitemid 43674241)
14. Cohen J (2006) Global health. Public-private partnerships proliferate. Science 311:167
15. Croft SL, Coombs GH (2003) Leishmaniasis-current chemotherapy and recent advances in the search for novel drugs. Trends Parasitol 19:502-508 (Pubitemid 37329659)
16. DAngelo MA, Sanguineti S, Reece JM, Birnbaumer L, Torres HN, Flawia MM (2004) Identification, characterization and subcellular localization of TcPDE1, a novel cAMP-specific phosphodiesterase from Trypanosoma cruzi. Biochem J 378:63-72 (Pubitemid 38299544)
17. De Koning HP (2008) Ever-increasing complexities of diamidine and arsenical crossresistance in African trypanosomes. Trends Parasitol 24:345-349
18. Delespaux V, De Koning HP (2007) Drugs and drug resistance in African trypanosomiasis. Drug Resist Updat 10:30-50 (Pubitemid 46636383)
19. Diaz-Benjumea R, Laxman S, Hinds TR, Beavo JA, Rascon A (2006) Characterization of a novel cAMP-binding, cAMP-specific cyclic nucleotide phosphodiesterase (TcrPDEB1) from Trypanosoma cruzi. Biochem J 399:305-314 (Pubitemid 44570293)
20. Farrell J (2002) World class parasites: volume 4 Leishmania. Kluwer Academic Publishers, Boston
21. Gong KW, Kunz S, Zoraghi R, Kunz RC, Brun R, Seebeck T (2001) cAMP-specific phosphodiesterase TbPDE1 is not essential in Trypanosoma brucei in culture or during midgut infection of tsetse flies. Mol Biochem Parasitol 116:229-232 (Pubitemid 32777832)
22. Gould MK, Vu XL, Seebeck T, De Koning HP (2008) Propidium iodide-based methods for monitoring drug action in the kinetoplastidae: comparison with the Alamar Blue assay. Anal Biochem 382:87-93
23. Huai Q, Liu Y, Francis SH, Corbin JD, Ke H (2004) Crystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivity. J Biol Chem 279:13095-13101 (Pubitemid 38445887)
24. Huang H, Werner C, Weiss LM, Wittner M, Orr GA (2002) Molecular cloning and expression of the catalytic subunit of protein kinase A from Trypanosoma cruzi. Int J Parasitol 32:1107-1115 (Pubitemid 34761904)
25. Huang H, Weiss LM, Nagajyothi F, Tanowitz HB, Wittner M, Orr GA, Bao Y (2006) Molecular cloning and characterization of the protein kinase A regulatory subunit of Trypanosoma cruzi. Mol Biochem Parasitol 149:242-245 (Pubitemid 44279090)
26. Hunger-Glaser I, Seebeck T (1997) Deletion of the genes for the paraflagellar rod protein PFR-A in Trypanosoma brucei is probably lethal. Mol Biochem Parasitol 90:347-351 (Pubitemid 28044404)
27. Ivey FD, Wang L, Demirbas D, Allain C, Hoffman CS (2008) Development of a fission yeastbased high-throughput screen to identify chemical regulators of cAMP phosphodiesterases. J Biomol Screen 13:62-71
28. Johner A, Kunz S, Linder M, Shakur Y, Seebeck T (2006) Cyclic nucleotide specific phosphodiesterases of Leishmania major. BMC Microbiol 6:25
29. Ke H, Wang H (2007) Crystal structures of phosphodiesterases and implications on substrate specificity and inhibitor selectivity. Curr Top Med Chem 7:391-403 (Pubitemid 46358652)
30. Kunz S, Kloeckner T, Essen LO, Seebeck T, Boshart M (2004) TbPDE1, a novel class I phosphodiesterase of Trypanosoma brucei. Eur J Biochem 271:637-647 (Pubitemid 38183638)
31. Kunz S, Oberholzer M, Seebeck T (2005) A FYVE-containing unusual cyclic nucleotide phosphodiesterase from Trypanosoma cruzi. FEBS J 272:6412-6422 (Pubitemid 41815628)
32. Kunz S, Beavo JA, DAngelo MA, Flawia MM, Francis SH, Johner A, Laxman S, Oberholzer M, Rascon A, Shakur Y, Wentzinger L, Zoraghi R, Seebeck T (2006) Cyclic nucleotide specific phosphodiesterases of the kinetoplastida: a unified nomenclature. Mol Biochem Parasitol 145: 133-135 (Pubitemid 41691865)
33. Kunz S, Luginbuehl E, Seebeck T (2009a) Gene conversion transfers the GAF-A domain of phosphodiesterase TbrPDEB1 to one allele of TbrPDEB2 of Trypanosoma brucei. PLoS Negl Trop Dis 3:e455
34. Kunz S, Minca M, Luginbuehl E, Bregy P, Seebeck T (2009b) Cyclic nucleotide signaling in the kinetoplastids. Handbook of cell signaling. Academic Press, New York, NY, pp 1543-1547
35. Kutateladze TG (2007) Mechanistic similarities in docking of the FYVE and PX domains to phosphatidylinositol 3-phosphate containing membranes. Prog Lipid Res 46:315-327 (Pubitemid 47483946)
36. Laxman S, Beavo JA (2007) Cyclic nucleotide signaling mechanisms in trypanosomes: Possible targets for therapeutic agents. Molecular Interventions 7:203-215 (Pubitemid 47437267)
37. Laxman S, Rascon A, Beavo JA (2005) Trypanosome cyclic nucleotide phosphodiesterase 2B binds cAMP through its GAF-A domain. J Biol Chem 280:3771-3779 (Pubitemid 40223846)
38. Laxman S, Riechers A, Sadilek M, Schwede F, Beavo JA (2006) Hydrolysis products of cAMP analogs cause transformation of Trypanosoma brucei from slender to stumpy-like forms. Proc Natl Acad Sci USA 103:19194-19199 (Pubitemid 350002849)
39. Luscher A, Nerima B, Maser P (2006) Combined contribution of TbAT1 and TbMRPA to drug resistance in Trypanosoma brucei. Mol Biochem Parasitol 150:364-366 (Pubitemid 44691943)
40. Ma P, Wera S, van DP, Thevelein JM (1999) The PDE1-encoded low-affinity phosphodiesterase in the yeast Saccharomyces cerevisiae has a specific function in controlling agonist-induced cAMP signaling. Mol Biol Cell 10:91-104 (Pubitemid 29156929)
41. Mancini PE, Patton CL (1981) Cyclic 30, 50-adenosine monophosphate levels during the developmental cycle of Trypanosoma brucei brucei in the rat. Mol Biochem Parasitol 3:19-31
42. McKean PG (2003) Coordination of cell cycle and cytokinesis in Trypanosoma brucei. Curr Opin Microbiol 6:600-607 (Pubitemid 38020057)
43. Nett IR, Martin DM, Miranda-Saavedra D, Lamont D, Barber JD, Mehlert A, Ferguson MA (2009) The phosphoproteome of bloodstream form Trypanosoma brucei, causative agent of African sleeping sickness. Mol Cell Proteomics 8:1527-1538
44. Oberholzer M, Marti G, Baresic M, Kunz S, Hemphill A, Seebeck T (2007) The Trypanosoma brucei cAMP phosphodiesterases TbrPDEB1 and TbrPDEB2: flagellar enzymes that are essential for parasite virulence. FASEB J 21:720-731 (Pubitemid 46348248)
45. Olliaro PL, Guerin PJ, Gerstl S, Haaskjold AA, Rottingen JA, Sundar S (2005) Treatment options for visceral leishmaniasis: a systematic review of clinical studies done in India, 1980-2004. Lancet Infect Dis 5:763-774 (Pubitemid 41688981)
46. Paine M, Wang M, Boykin D, Wilson W, De Koning H, Olson C, Polig G, Burri C, Brun R, Murilla G, Thuita JK, Barrett M, Tidwell R (2010) Diamidines for human African trypanosomiasis. Curr Opin Invest Drugs In Press
47. Priotto G, Kasparian S, Mutombo W, Ngouama D, Ghorashian S, Arnold U, Ghabri S, Baudin E, Buard V, Kazadi-Kyanza S, Ilunga M, Mutangala W, Pohlig G, Schmid C, Karunakara U, Torreele E, Kande V (2009) Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial. Lancet 374:56-64
48. Rangel-Aldao R, Triana F, Comach G, Abate T, Fernandez V, Mahon-Pratt D (1988) Intracellular signaling transduction in the differentiation of Trypanosoma cruzi: role of cAMP. Arch Biol Med Exp (Santiago) 21:403-408 (Pubitemid 19131814)
49. Rascon A, Soderling SH, Schaefer JB, Beavo JA (2002) Cloning and characterization of a cAMPspecific phosphodiesterase (TbPDE2B) from Trypanosoma brucei. Proc Natl Acad Sci USA 99:4714-4719 (Pubitemid 34286050)
50. Reed SL, Fierer AS, Goddard DR, Colmerauer ME, Davis CE (1985) Effect of theophylline on differentiation of Trypanosoma brucei. Infect Immun 49:844-847 (Pubitemid 15021557)
51. Seebeck T, Schaub R, Johner A (2004) cAMP signalling in the kinetoplastid protozoa. Curr Mol Med 4:585-599 (Pubitemid 39172365)
52. Shalaby T, Liniger M, Seebeck T (2001) The regulatory subunit of a cGMP-regulated protein kinase A of Trypanosoma brucei. Eur J Biochem 268:6197-6206 (Pubitemid 33132040)
53. Siman-Tov MM, Aly R, Shapira M, Jaffe CL (1996) Cloning from Leishmania major of a developmentally regulated gene, c-lpk2, for the catalytic subunit of the cAMP-dependent protein kinase. Mol Biochem Parasitol 77:201-215
54. Strickler JE, Patton CL (1975) Adenosine 30, 50-monophosphate in reproducing and differentiated trypanosomes. Science 190:1110-1112
55. Stuart K, Brun R, Croft S, Fairlamb A, Gurtler RE, McKerrow J, Reed S, Tarleton R (2008) Kinetoplastids: related protozoan pathogens, different diseases. J Clin Invest 118:1301-1310 (Pubitemid 351500422)
56. Tyler K, Miles M (2002) World class parasites: volume 7 American trypanosomiasis. Kluwer Academic Publishers, Boston
57. Urbina JA (2010) Specific chemotherapy of Chagas disease: relevance, current limitations and new approaches. Acta Trop 115(1-2):55-68
58. Vassella E, Reuner B, Yutzy B, Boshart M (1997) Differentiation of African trypanosomes is controlled by a density sensing mechanism which signals cell cycle arrest via the cAMP pathway. J Cell Sci 110(Pt 21):2661-2671 (Pubitemid 27499424)
59. Walter RD (1974) 30:50-cyclic-AMP phosphodiesterase from Trypanosoma gambiense. Hoppe Seylers Z Physiol Chem 355:1443-1450
60. Walter RD, Buse E, Ebert F (1978) Effect of cyclic AMP on transformation and proliferation of leishmania cells. Tropenmed Parasitol 29:439-442
61. Wang H, Liu Y, Huai Q, Cai J, Zoraghi R, Francis SH, Corbin JD, Robinson H, Xin Z, Lin G, Ke H (2006) Multiple conformations of phosphodiesterase-5: implications for enzyme function and drug development. J Biol Chem 281:21469-21479 (Pubitemid 44115485)
62. Wang H, Yan Z, Geng J, Kunz S, Seebeck T, Ke H (2007) Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors. Mol Microbiol 66:1029-1038 (Pubitemid 350050428)
63. Wang H, Yan Z, Yang S, Cai J, Robinson H, Ke H (2008) Kinetic and structural studies of phosphodiesterase-8A and implication on the inhibitor selectivity. Biochemistry 47:12760-12768
64. Weatherly DB, Boehlke C, Tarleton RL (2009) Chromosome level assembly of the hybrid Trypanosoma cruzi genome. BMC Genomics 10:255
65. Zoraghi R, Seebeck T (2002) The cAMP-specific phosphodiesterase TbPDE2C is an essential enzyme in bloodstream form Trypanosoma brucei. Proc Natl Acad Sci USA 99:4343-4348 (Pubitemid 34285987)
66. Zoraghi R, Kunz S, Gong K, Seebeck T (2001) Characterization of TbPDE2A, a novel cyclic nucleotide-specific phosphodiesterase from the protozoan parasite Trypanosoma brucei. J Biol Chem 276:11559-11566