cAMP-specific phosphodiesterase TbPDE1 is not essential in Trypanosoma brucei in culture or during midgut infection of tsetse flies

Molecular and Biochemical Parasitology

Volumn 116, Issue 2, 2001, Pages 229-232

  Gong, Ke Wei ^a   Kunz, Stefan ^a   Zoraghi, Roya ^a   Kunz Renggli, Christina ^b   Brun, Reto ^b   Seebeck, Thomas ^a  

^a UNIVERSITY OF BERN   (Switzerland)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

Author keywords

cAMP; cAMP specific phosphodiesterase; Drug target; Genetic knock out; Midgut infection; Tsetse fly

Indexed keywords

CYCLIC AMP; CYCLIC AMP PHOSPHODIESTERASE;

ALLELE; ARTICLE; CULTURE MEDIUM; DIFFERENTIATION; ENZYME ACTIVITY; ENZYME ANALYSIS; GASTROINTESTINAL INFECTION; GENE CONSTRUCT; GENE DELETION; GENE MUTATION; GENETIC TRANSFECTION; GENOME; HOST PARASITE INTERACTION; NONHUMAN; PARASITOSIS; PHENOTYPE; PRIORITY JOURNAL; STRAIN DIFFERENCE; TRYPANOSOMA BRUCEI; TSETSE FLY;

ANIMALS; GENE DELETION; PHOSPHORIC DIESTER HYDROLASES; TRANSFECTION; TRYPANOSOMA BRUCEI BRUCEI; TSETSE FLIES;

EID: 0034890748     PISSN: 01666851     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-6851(01)00315-2     Document Type: Article

References (17)

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15. The PDE1-encoded low-affinity phosphodiesterase in the yeast Saccharomyces cerevisiae has a specific function in controlling agonist-induced cAMP signalling