Crystal Structures of Phosphodiesterases 4 and 5 in Complex with Inhibitor 3-Isobutyl-1-methylxanthine Suggest a Conformation Determinant of Inhibitor Selectivity

Journal of Biological Chemistry

Volumn 279, Issue 13, 2004, Pages 13095-13101

  Huai, Qing ^a   Liu, Yudong ^a   Francis, Sharron H ^b   Corbin, Jackie D ^b   Ke, Hengming ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALYST SELECTIVITY; CELLS; CRYSTAL STRUCTURE; ENZYME INHIBITION;

PHOSPHODIESTERASES (PDE);

ENZYMES;

CYCLIC NUCLEOTIDE PHOSPHODIESTERASE; ENZYME INHIBITOR; ION CHANNEL; ISOBUTYLMETHYLXANTHINE; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE V; SILDENAFIL; TADALAFIL; VARDENAFIL;

ARTICLE; CATALYSIS; COMPLEX FORMATION; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME STRUCTURE; ERECTILE DYSFUNCTION; GLYCOGENOLYSIS; NEUROTRANSMITTER RELEASE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FOLDING; SECOND MESSENGER; SMOOTH MUSCLE CONTRACTION;

1-METHYL-3-ISOBUTYLXANTHINE; 3',5'-CYCLIC-GMP PHOSPHODIESTERASE; 3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; AMINO ACID SEQUENCE; BINDING SITES; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYCLIC AMP; CYCLIC GMP; ENZYME INHIBITORS; ESCHERICHIA COLI; HUMANS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PHOSPHODIESTERASE INHIBITORS; PHOSPHORIC DIESTER HYDROLASES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 1842581748     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M311556200     Document Type: Article

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