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Volumn 21, Issue 3, 2007, Pages 720-731

The Trypanosoma brucei cAMP phosphodiesterases TbrPDEB1 and TbrPDEB2: Flagellar enzymes that are essential for parasite virulence

Author keywords

African sleeping sickness; Cytokinesis; Life cycle stages; Paraflagellar rod structure; PDE inhibitor

Indexed keywords

CYCLIC AMP PHOSPHODIESTERASE; MESSENGER RNA; TBRPDEB1 ENZYME; TBRPDEB2 ENZYME; UNCLASSIFIED DRUG;

EID: 33847368239     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.06-6818com     Document Type: Article
Times cited : (124)

References (54)
  • 1
    • 14644435106 scopus 로고    scopus 로고
    • Glucose sensing via the protein kinase A pathway in Schizosaccharomyces pombe
    • Hoffman, C. (2005) Glucose sensing via the protein kinase A pathway in Schizosaccharomyces pombe. Biochem. Soc. Trans. 33, 257-260
    • (2005) Biochem. Soc. Trans , vol.33 , pp. 257-260
    • Hoffman, C.1
  • 2
    • 0037567299 scopus 로고    scopus 로고
    • The signal to move: D. discoideum go orienteering
    • Kimmel, A. R., and Parent, C. A. (2003) The signal to move: D. discoideum go orienteering. Science 300, 1525-1527
    • (2003) Science , vol.300 , pp. 1525-1527
    • Kimmel, A.R.1    Parent, C.A.2
  • 3
    • 33645756342 scopus 로고    scopus 로고
    • Sperm guidance in mammals-an unpaved road to the egg
    • Eisenbach, M., and Giojalas, L. C. (2006) Sperm guidance in mammals-an unpaved road to the egg. Nat. Rev. Mol. Cell Biol. 7, 276-285
    • (2006) Nat. Rev. Mol. Cell Biol , vol.7 , pp. 276-285
    • Eisenbach, M.1    Giojalas, L.C.2
  • 4
    • 0043269271 scopus 로고    scopus 로고
    • Regulation of nitric oxide-sensitive guanylyl cyclase
    • Friebe, A., and Koesling, D. (2003) Regulation of nitric oxide-sensitive guanylyl cyclase. Circ. Res. 93, 96-105
    • (2003) Circ. Res , vol.93 , pp. 96-105
    • Friebe, A.1    Koesling, D.2
  • 5
    • 10344257246 scopus 로고    scopus 로고
    • Bicarbonate stimulated adenylyl cyclases
    • Cann, M. (2004) Bicarbonate stimulated adenylyl cyclases. IUBMB Life 56, 529-534
    • (2004) IUBMB Life , vol.56 , pp. 529-534
    • Cann, M.1
  • 6
    • 0034329385 scopus 로고    scopus 로고
    • Osmotic stress response in Dictyostelium is mediated by cAMP
    • Ott, A., Oehme, F., Keller, H., and Schuster, S. C. (2000) Osmotic stress response in Dictyostelium is mediated by cAMP. EMBO J. 19, 5782-5792
    • (2000) EMBO J , vol.19 , pp. 5782-5792
    • Ott, A.1    Oehme, F.2    Keller, H.3    Schuster, S.C.4
  • 7
    • 0022859343 scopus 로고
    • Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae
    • Sass, P., Field, J., Nikawa, J., Toda, T., and Wigler, M. (1986) Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. U. S. A. 83, 9303-9307
    • (1986) Proc. Natl. Acad. Sci. U. S. A , vol.83 , pp. 9303-9307
    • Sass, P.1    Field, J.2    Nikawa, J.3    Toda, T.4    Wigler, M.5
  • 8
    • 11144231398 scopus 로고    scopus 로고
    • The high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae is the major determinant of cAMP levels in stationary phase: Involvement of different branches of the Ras-cyclic AMP pathway in stress responses
    • Park, J. I., Grant, C. M., and Lin, M. C. (2005) The high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae is the major determinant of cAMP levels in stationary phase: involvement of different branches of the Ras-cyclic AMP pathway in stress responses. Biochem. Biophys. Res. Commun. 327, 311-319
    • (2005) Biochem. Biophys. Res. Commun , vol.327 , pp. 311-319
    • Park, J.I.1    Grant, C.M.2    Lin, M.C.3
  • 9
    • 0035117362 scopus 로고    scopus 로고
    • The cyclic AMP/PKA signal pathway is required for initiation of spore germination in Schizosaccharomyces pombe
    • Hatanaka, M., and Shimoda, C. (2001) The cyclic AMP/PKA signal pathway is required for initiation of spore germination in Schizosaccharomyces pombe. Yeast 18, 207-217
    • (2001) Yeast , vol.18 , pp. 207-217
    • Hatanaka, M.1    Shimoda, C.2
  • 10
    • 0034053448 scopus 로고    scopus 로고
    • The cAMP signaling pathway as a therapeutic target in lymphoid malignancies
    • Lerner, A., Kim, D. H., and Lee, R. (2000) The cAMP signaling pathway as a therapeutic target in lymphoid malignancies. Leuk. Lymphoma 37, 39-51
    • (2000) Leuk. Lymphoma , vol.37 , pp. 39-51
    • Lerner, A.1    Kim, D.H.2    Lee, R.3
  • 11
    • 85132522417 scopus 로고    scopus 로고
    • Beavo, J, Francis, S. H, and Houslay, M, eds, CRC Press, Boca Raton, Florida
    • Beavo, J., Francis, S. H., and Houslay, M., eds. (2006) Cyclic nucleotide phosphodiesterases in health and disease. CRC Press, Boca Raton, Florida
    • (2006) Cyclic nucleotide phosphodiesterases in health and disease
  • 12
    • 31844447089 scopus 로고    scopus 로고
    • Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state
    • Rehman, H., Das, J., Knipscheer, P., Wittinghofer, A., and Bos, J. L. (2006) Structure of the cyclic-AMP-responsive exchange factor Epac2 in its auto-inhibited state. Nature 439, 625-628
    • (2006) Nature , vol.439 , pp. 625-628
    • Rehman, H.1    Das, J.2    Knipscheer, P.3    Wittinghofer, A.4    Bos, J.L.5
  • 13
    • 20444385880 scopus 로고    scopus 로고
    • Regulation of cyclic nucleotide-gated channels
    • Bradley, J., Reisert, J., and Frings, S. (2005) Regulation of cyclic nucleotide-gated channels. Curr. Opin. Neurobiol. 15, 343-349
    • (2005) Curr. Opin. Neurobiol , vol.15 , pp. 343-349
    • Bradley, J.1    Reisert, J.2    Frings, S.3
  • 14
    • 14544280656 scopus 로고    scopus 로고
    • The cyanobacterial tandem GAF domains from the cyaB2 adenylyl cyclase signal via both cAMP-binding sites
    • Bruder, S., Linder, J. U., Martinez, S. E., Zheng, N., Beavo, J. A., and Schultz, J. E. (2005) The cyanobacterial tandem GAF domains from the cyaB2 adenylyl cyclase signal via both cAMP-binding sites. Proc. Natl. Acad. Sci. U. S. A. 102, 3088-3092
    • (2005) Proc. Natl. Acad. Sci. U. S. A , vol.102 , pp. 3088-3092
    • Bruder, S.1    Linder, J.U.2    Martinez, S.E.3    Zheng, N.4    Beavo, J.A.5    Schultz, J.E.6
  • 15
    • 15744369740 scopus 로고    scopus 로고
    • Structural and functional features in human PDE5A1 regulatory domain that provide for allosteric cGMP binding, dimerization, and regulation
    • Zoraghi, R., Bessay, E. P., Corbin, J. D., and Francis, S. H. (2005) Structural and functional features in human PDE5A1 regulatory domain that provide for allosteric cGMP binding, dimerization, and regulation. J. Biol. Chem. 280, 12051-12063
    • (2005) J. Biol. Chem , vol.280 , pp. 12051-12063
    • Zoraghi, R.1    Bessay, E.P.2    Corbin, J.D.3    Francis, S.H.4
  • 17
    • 0346158373 scopus 로고    scopus 로고
    • The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways
    • Houslay, M. D., and Baillie, G. S. (2003) The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways. Biochem. Soc. Trans. 31, 1186-1190
    • (2003) Biochem. Soc. Trans , vol.31 , pp. 1186-1190
    • Houslay, M.D.1    Baillie, G.S.2
  • 19
    • 33646776455 scopus 로고    scopus 로고
    • A specific pattern of phosphodiesterases controls the cAMP signals generated by different Gs-coupled receptors in adult rat ventricular myocytes
    • Rochais, F., Abi-Gerges, A., Homer, K., Lefebvre, F., Cooper, D. M., Conti, M., Fischmeister, R., and Vandencasteele, G. (2006) A specific pattern of phosphodiesterases controls the cAMP signals generated by different Gs-coupled receptors in adult rat ventricular myocytes. Circ. Res. 98, 1081-1088
    • (2006) Circ. Res , vol.98 , pp. 1081-1088
    • Rochais, F.1    Abi-Gerges, A.2    Homer, K.3    Lefebvre, F.4    Cooper, D.M.5    Conti, M.6    Fischmeister, R.7    Vandencasteele, G.8
  • 20
    • 0347359224 scopus 로고    scopus 로고
    • Localized effects of cAMP mediated by distinct routes of protein kinase A
    • Tasken, K., and Aandahl, E. M. (2004) Localized effects of cAMP mediated by distinct routes of protein kinase A. Physiol. Rev. 84, 137-167
    • (2004) Physiol. Rev , vol.84 , pp. 137-167
    • Tasken, K.1    Aandahl, E.M.2
  • 21
    • 27944502874 scopus 로고    scopus 로고
    • DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling
    • Millar, J. K., Pickard, B. S., Mackie, S., James, R., and Christie, S., et al. (2005) DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science 310, 1187-1191
    • (2005) Science , vol.310 , pp. 1187-1191
    • Millar, J.K.1    Pickard, B.S.2    Mackie, S.3    James, R.4    Christie, S.5
  • 22
    • 0032692936 scopus 로고    scopus 로고
    • Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice
    • Jin, S. L., Richard, F. J., Kuo, W. P., D'Ercole, A. J., and Conti, M. (1999) Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice. Proc. Natl. Acad. Sci. U. S. A. 96, 1998-2003
    • (1999) Proc. Natl. Acad. Sci. U. S. A , vol.96 , pp. 1998-2003
    • Jin, S.L.1    Richard, F.J.2    Kuo, W.P.3    D'Ercole, A.J.4    Conti, M.5
  • 24
    • 33646834266 scopus 로고    scopus 로고
    • Human African trypanosomiasis: Epidemiology and control
    • Fèvre, E. M., Picozzi, K., Welburn, S. C., and Maudlin, I. (2006) Human African trypanosomiasis: epidemiology and control. Adv. Parasitol. 61, 168-221
    • (2006) Adv. Parasitol , vol.61 , pp. 168-221
    • Fèvre, E.M.1    Picozzi, K.2    Welburn, S.C.3    Maudlin, I.4
  • 25
    • 0032029353 scopus 로고    scopus 로고
    • Both IgM and IgG anti-VSG antibodies initiate a cycle of aggregation-disaggregation of bloodstream forms of Trypanosoma brucei without damage to the parasite
    • O'Beirne, C., Lowry, C. M., and Voorheis, H. P. (1998) Both IgM and IgG anti-VSG antibodies initiate a cycle of aggregation-disaggregation of bloodstream forms of Trypanosoma brucei without damage to the parasite. Mol. Biochem. Parasitol. 91, 165-193
    • (1998) Mol. Biochem. Parasitol , vol.91 , pp. 165-193
    • O'Beirne, C.1    Lowry, C.M.2    Voorheis, H.P.3
  • 26
    • 0030696101 scopus 로고    scopus 로고
    • Differentiation of African trypanosomes is controlled by a density sensing mechanism which signals cell cycle arrest via the cAMP pathway
    • Vassella, E., Reuner, B., Yutzy, B., and Boshart, M. (1997) Differentiation of African trypanosomes is controlled by a density sensing mechanism which signals cell cycle arrest via the cAMP pathway. J. Cell Sci. 110, 2661-2671
    • (1997) J. Cell Sci , vol.110 , pp. 2661-2671
    • Vassella, E.1    Reuner, B.2    Yutzy, B.3    Boshart, M.4
  • 27
    • 0842322479 scopus 로고    scopus 로고
    • cAMP signalling in the kinetoplastid protozoa
    • Seebeck, T., Schaub, R., and Johner, A. (2004) cAMP signalling in the kinetoplastid protozoa. Current. Mol. Med. 4, 585-599
    • (2004) Current. Mol. Med , vol.4 , pp. 585-599
    • Seebeck, T.1    Schaub, R.2    Johner, A.3
  • 28
    • 0035946414 scopus 로고    scopus 로고
    • The VSG expression sites of Trypanosoma brucei: Multipurpose tools for the adaptation of the parasite to mammalian hosts
    • Pays, E., Lips, S., Nolan, D., Vanhamme, L., and Perez-Morga, D. (2001) The VSG expression sites of Trypanosoma brucei: multipurpose tools for the adaptation of the parasite to mammalian hosts. Mol. Biochem. Parasitol. 114, 1-16
    • (2001) Mol. Biochem. Parasitol , vol.114 , pp. 1-16
    • Pays, E.1    Lips, S.2    Nolan, D.3    Vanhamme, L.4    Perez-Morga, D.5
  • 29
    • 25444512182 scopus 로고    scopus 로고
    • Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and
    • Parsons, M., Worthey, E. A., Ward, P. N., and Mottram, J. C. (2005) Comparative analysis of the kinomes of three pathogenic trypanosomatids: Leishmania major, Trypanosoma brucei and. Trypanosoma cruzi. BMC Genomics 6, 127
    • (2005) Trypanosoma cruzi. BMC Genomics , vol.6 , pp. 127
    • Parsons, M.1    Worthey, E.A.2    Ward, P.N.3    Mottram, J.C.4
  • 30
    • 0035213903 scopus 로고    scopus 로고
    • The regulatory subunit of a cGMP regulated protein kinase A of Trypanosoma brucei
    • Shalaby, T., Liniger, M., and Seebeck, T. (2001) The regulatory subunit of a cGMP regulated protein kinase A of Trypanosoma brucei. Eur. J. Biochem. 268, 6197-6206
    • (2001) Eur. J. Biochem , vol.268 , pp. 6197-6206
    • Shalaby, T.1    Liniger, M.2    Seebeck, T.3
  • 31
    • 0028802726 scopus 로고
    • Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms
    • Beavo, J. A. (1995) Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms. Physiol. Rev. 75, 725-748
    • (1995) Physiol. Rev , vol.75 , pp. 725-748
    • Beavo, J.A.1
  • 34
    • 0037007032 scopus 로고    scopus 로고
    • The cAMP-specific phosphodiesterase TbPDE2C is an essential enzyme in bloodstream form Trypanosoma brucei
    • Zoraghi, R., and Seebeck, T. (2002) The cAMP-specific phosphodiesterase TbPDE2C is an essential enzyme in bloodstream form Trypanosoma brucei. Proc. Natl. Acad. Sci. U. S. A. 99, 4343-4348
    • (2002) Proc. Natl. Acad. Sci. U. S. A , vol.99 , pp. 4343-4348
    • Zoraghi, R.1    Seebeck, T.2
  • 35
    • 0037007021 scopus 로고    scopus 로고
    • Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei
    • Rascon, A., Soderling, S. H., Schaefer, J. B., and Beavo, J. A. (2002) Cloning and characterization of a cAMP-specific phosphodiesterase (TbPDE2B) from Trypanosoma brucei. Proc. Natl. Acad. Sci. U. S. A. 99, 4714-4719
    • (2002) Proc. Natl. Acad. Sci. U. S. A , vol.99 , pp. 4714-4719
    • Rascon, A.1    Soderling, S.H.2    Schaefer, J.B.3    Beavo, J.A.4
  • 36
    • 1542374655 scopus 로고    scopus 로고
    • Identification, characterization and subcellular localization of TcPDE1, a novel cAMP-specific phosphodiesterase from Trypanosoma cruzi
    • D'Angelo, M. A., Sanguineti, S., Reece, J. M., Birnbaumer, J., Torres, H. N., and Flawia, M. M. (2004) Identification, characterization and subcellular localization of TcPDE1, a novel cAMP-specific phosphodiesterase from Trypanosoma cruzi. Biochem. J. 378, 63-72
    • (2004) Biochem. J , vol.378 , pp. 63-72
    • D'Angelo, M.A.1    Sanguineti, S.2    Reece, J.M.3    Birnbaumer, J.4    Torres, H.N.5    Flawia, M.M.6
  • 37
    • 33645558859 scopus 로고    scopus 로고
    • Cyclic nucleotide specific phosphodiesterases of Leishmania major
    • Johner, A., Kunz, S., Linder, M., Shakur, Y., and Seebeck, T. (2006) Cyclic nucleotide specific phosphodiesterases of Leishmania major. BMC Microbiol. 8;6, 25
    • (2006) BMC Microbiol , vol.8 , Issue.6 , pp. 25
    • Johner, A.1    Kunz, S.2    Linder, M.3    Shakur, Y.4    Seebeck, T.5
  • 38
    • 33750005401 scopus 로고    scopus 로고
    • Characterization of a novel cAMP-binding, cAMP-specific cyclic nucleotide phosphodiesterase (TcrPDEB1) from Trypanosoma cruzi
    • Diaz-Benjoumena, R., Laxman, S., Hinds, T. R., Beavo, J. A., and Rascon, A. (2006) Characterization of a novel cAMP-binding, cAMP-specific cyclic nucleotide phosphodiesterase (TcrPDEB1) from Trypanosoma cruzi. Biochem. J. 399, 305-314
    • (2006) Biochem. J , vol.399 , pp. 305-314
    • Diaz-Benjoumena, R.1    Laxman, S.2    Hinds, T.R.3    Beavo, J.A.4    Rascon, A.5
  • 39
    • 18644376713 scopus 로고    scopus 로고
    • The next generation of phosphodiesterase inhibitors: Structural clues to ligand and substrate selectivity of phosphodiesterases
    • Manallack, D. T., Hughes, R. A., and Thompson, P. E. (2005) The next generation of phosphodiesterase inhibitors: structural clues to ligand and substrate selectivity of phosphodiesterases. J. Med. Chem. 48, 3449-3462
    • (2005) J. Med. Chem , vol.48 , pp. 3449-3462
    • Manallack, D.T.1    Hughes, R.A.2    Thompson, P.E.3
  • 40
    • 13544249975 scopus 로고    scopus 로고
    • Trypanosome cyclic nucleotide phosphodiesterase 2B binds cAMP through its GAF-A domain
    • Laxman, S., Rascon, A., and Beavo, J. A. (2005) Trypanosome cyclic nucleotide phosphodiesterase 2B binds cAMP through its GAF-A domain. J. Biol. Chem. 280, 3771-3779
    • (2005) J. Biol. Chem , vol.280 , pp. 3771-3779
    • Laxman, S.1    Rascon, A.2    Beavo, J.A.3
  • 41
    • 0037144411 scopus 로고    scopus 로고
    • A novel calcium-stimulated adenylyl cyclase from Trypanosoma cruzi which interacts with the structural flagellar protein paraflagellar rod
    • D'Angelo, M. A., Montagna, A. E., Sanguineti, S., Torres, H. N., and Flawia, M. M. (2002) A novel calcium-stimulated adenylyl cyclase from Trypanosoma cruzi which interacts with the structural flagellar protein paraflagellar rod. J. Biol. Chem. 277, 35025-35034
    • (2002) J. Biol. Chem , vol.277 , pp. 35025-35034
    • D'Angelo, M.A.1    Montagna, A.E.2    Sanguineti, S.3    Torres, H.N.4    Flawia, M.M.5
  • 42
    • 0024451447 scopus 로고
    • The major component of the paraflagellar rod of Trypanosoma brucei is a helical protein that is encoded by two identical, tandemly linked genes
    • Schlaeppi, K., Deflorin, J., and Seebeck, T. (1989) The major component of the paraflagellar rod of Trypanosoma brucei is a helical protein that is encoded by two identical, tandemly linked genes. J. Cell Biol. 109, 1695-1709
    • (1989) J. Cell Biol , vol.109 , pp. 1695-1709
    • Schlaeppi, K.1    Deflorin, J.2    Seebeck, T.3
  • 43
    • 0037031944 scopus 로고    scopus 로고
    • Mitochondrial substrate level phosphorylation is essential for growth of procyclic Trypanosoma brucei
    • Bochud-Allemann, N., and Schneider, A. (2002) Mitochondrial substrate level phosphorylation is essential for growth of procyclic Trypanosoma brucei. J. Biol. Chem. 277, 32849-32854
    • (2002) J. Biol. Chem , vol.277 , pp. 32849-32854
    • Bochud-Allemann, N.1    Schneider, A.2
  • 44
    • 0033525524 scopus 로고    scopus 로고
    • A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei
    • Wirtz, E., Leal, S., Ochatt, C., and Cross, G. A. M. (1999) A tightly regulated inducible expression system for conditional gene knock-outs and dominant-negative genetics in Trypanosoma brucei. Mol. Biochem. Parasitol. 99, 89-101
    • (1999) Mol. Biochem. Parasitol , vol.99 , pp. 89-101
    • Wirtz, E.1    Leal, S.2    Ochatt, C.3    Cross, G.A.M.4
  • 45
    • 0018601361 scopus 로고
    • Cultivation and in vitro cloning or procyclic culture forms of Trypanosoma brucei in a semi-defined medium. Short communication
    • Brun, R., and Schoenenberger, M. (1979) Cultivation and in vitro cloning or procyclic culture forms of Trypanosoma brucei in a semi-defined medium. Short communication. Acta Trop. 36, 289-292
    • (1979) Acta Trop , vol.36 , pp. 289-292
    • Brun, R.1    Schoenenberger, M.2
  • 46
    • 0028988032 scopus 로고
    • A novel cultivation technique for long-term maintenance of bloodstream form trypanosomes in vitro
    • Hesse, F., Selzer, P. M., Muehlstadt, K., and Duszenko, M. (1995) A novel cultivation technique for long-term maintenance of bloodstream form trypanosomes in vitro. Mol. Biochem. Parasitol. 70, 157-166
    • (1995) Mol. Biochem. Parasitol , vol.70 , pp. 157-166
    • Hesse, F.1    Selzer, P.M.2    Muehlstadt, K.3    Duszenko, M.4
  • 47
    • 28044439662 scopus 로고    scopus 로고
    • A vector series for rapid PCR-mediated C-terminal in situ tagging of Trypanosoma brucei genes
    • Oberholzer, M., Morand, S., Kunz, S., and Seebeck, T. (2006) A vector series for rapid PCR-mediated C-terminal in situ tagging of Trypanosoma brucei genes. Mol. Biochem. Parasitol. 145, 117-120
    • (2006) Mol. Biochem. Parasitol , vol.145 , pp. 117-120
    • Oberholzer, M.1    Morand, S.2    Kunz, S.3    Seebeck, T.4
  • 48
    • 0023110716 scopus 로고
    • Subpellicular and flagellar microtubules of Trypanosoma brucei brucei contain the same alpha-tubulin isoforms
    • Schneider, A., Sherwin, T., Sasse, R., Russell, D. G., Gull, K., and Seebeck, T. (1987) Subpellicular and flagellar microtubules of Trypanosoma brucei brucei contain the same alpha-tubulin isoforms. J. Cell Biol. 104, 431-438
    • (1987) J. Cell Biol , vol.104 , pp. 431-438
    • Schneider, A.1    Sherwin, T.2    Sasse, R.3    Russell, D.G.4    Gull, K.5    Seebeck, T.6
  • 49
    • 0033215138 scopus 로고    scopus 로고
    • Unravelling the kinetoplastid paraflagellar rod
    • Maga, J. A., and LeBowitz, J. H. (1999) Unravelling the kinetoplastid paraflagellar rod. Trends. Cell Biol. 9, 409-413
    • (1999) Trends. Cell Biol , vol.9 , pp. 409-413
    • Maga, J.A.1    LeBowitz, J.H.2
  • 50
    • 0032724638 scopus 로고    scopus 로고
    • The cytoskeleton of trypanosomatid parasites
    • Gull, K. (1999) The cytoskeleton of trypanosomatid parasites. Annu. Rev. Microbiol. 53, 629-655
    • (1999) Annu. Rev. Microbiol , vol.53 , pp. 629-655
    • Gull, K.1
  • 51
    • 0033785520 scopus 로고    scopus 로고
    • Flagellum ontogeny in trypanosomes studied via an inherited and regulated RNA interference system
    • Bastin, P., Ellis, K., Kohl, L., and Gull, K. (2000) Flagellum ontogeny in trypanosomes studied via an inherited and regulated RNA interference system. J. Cell Sci. 113, 3321-3328
    • (2000) J. Cell Sci , vol.113 , pp. 3321-3328
    • Bastin, P.1    Ellis, K.2    Kohl, L.3    Gull, K.4
  • 52
    • 0032693564 scopus 로고    scopus 로고
    • Protein transport and flagellum assembly dynamics revealed by analysis of the paralysed trypanosome mutant snl-1
    • Bastin, P., Pullen, T. J., Sherwin, T., and Gull, K. (1999) Protein transport and flagellum assembly dynamics revealed by analysis of the paralysed trypanosome mutant snl-1. J. Cell Sci. 112, 3769-3777
    • (1999) J. Cell Sci , vol.112 , pp. 3769-3777
    • Bastin, P.1    Pullen, T.J.2    Sherwin, T.3    Gull, K.4
  • 54
    • 0026558281 scopus 로고
    • A gene from the variant surface glycoprotein expression site encodes one of several transmembrane adenylate cyclases located on the flagellum of Trypanosoma brucei
    • Paindavoine, P., Rolin, S., Van Assel, S., Geuskens, M., Jauniaux, J. C., Dinsart, C., Huet, G., and Pays, E. (1992) A gene from the variant surface glycoprotein expression site encodes one of several transmembrane adenylate cyclases located on the flagellum of Trypanosoma brucei. Mol. Cell Biol. 12, 1218-1225
    • (1992) Mol. Cell Biol , vol.12 , pp. 1218-1225
    • Paindavoine, P.1    Rolin, S.2    Van Assel, S.3    Geuskens, M.4    Jauniaux, J.C.5    Dinsart, C.6    Huet, G.7    Pays, E.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.