메뉴 건너뛰기




Volumn 12, Issue 7, 2011, Pages 4465-4476

Epigenetic therapy for breast cancer

Author keywords

Breast cancer; DNA methylation inhibitors; Epigenetic therapy; Histone deacetylation inhibitors

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; 5' FLUORO 2' DEOXYCYTIDINE; APICIDIN; AZACITIDINE; BUTYRIC ACID; CYCLIC HYDROXAMIC ACID CONTAINING PEPTIDE; CYTOTOXIC AGENT; DACINOSTAT; DNA METHYLTRANSFERASE INHIBITOR; DOCETAXEL; ENTINOSTAT; EPIGALLOCATECHIN GALLATE; HISTONE DEACETYLASE INHIBITOR; HYDRALAZINE; MG 98; N PHTHALOYLTRYPTOPHAN; NUCLEOSIDE ANALOG; PACLITAXEL; ROMIDEPSIN; SHORT CHAIN FATTY ACID; TACEDINALINE; TASIDOTIN; TETRAPEPTIDE; TRAPOXIN; TRASTUZUMAB; TRICHOSTATIN A; UNCLASSIFIED DRUG; UNINDEXED DRUG; VALPROIC ACID; VORINOSTAT; ZEBULARINE; ANTINEOPLASTIC AGENT; DNA (CYTOSINE 5) METHYLTRANSFERASE;

EID: 79960815926     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms12074465     Document Type: Review
Times cited : (36)

References (73)
  • 2
  • 4
    • 78650882234 scopus 로고    scopus 로고
    • Present and future evolution of advanced breast cancer therapy
    • Alvarez, R.H. Present and future evolution of advanced breast cancer therapy. Breast Cancer Res. 2010, 12, S1.
    • (2010) Breast Cancer Res , vol.12
    • Alvarez, R.H.1
  • 5
    • 77954726255 scopus 로고    scopus 로고
    • Emerging targeted therapies for breast cancer
    • Alvarez, R.H.; Valero, V.; Hortobagyi, G.N. Emerging targeted therapies for breast cancer. J. Clin. Oncol. 2010, 28, 3366-3379.
    • (2010) J. Clin. Oncol , vol.28 , pp. 3366-3379
    • Alvarez, R.H.1    Valero, V.2    Hortobagyi, G.N.3
  • 6
    • 33947315736 scopus 로고    scopus 로고
    • Cancer epigenomics: DNA methylomes and histone-modification maps
    • Esteller, M. Cancer epigenomics: DNA methylomes and histone-modification maps. Nat. Rev. Genet. 2007, 8, 286-298.
    • (2007) Nat. Rev. Genet , vol.8 , pp. 286-298
    • Esteller, M.1
  • 7
    • 73649107635 scopus 로고    scopus 로고
    • Epigenetics: Molecular mechanisms and implications for disease
    • Handel, A.E.; Ebers, G.C.; Ramagopalan, S.V. Epigenetics: Molecular mechanisms and implications for disease. Trends Mol. Med. 2010, 16, 7-16.
    • (2010) Trends Mol. Med , vol.16 , pp. 7-16
    • Handel, A.E.1    Ebers, G.C.2    Ramagopalan, S.V.3
  • 8
    • 2642531973 scopus 로고    scopus 로고
    • Epigenetics in human disease and prospects for epigenetic therapy
    • Egger, G.; Liang, G.; Aparicio, A.; Jones, P.A. Epigenetics in human disease and prospects for epigenetic therapy. Nature 2004, 429, 457-463.
    • (2004) Nature , vol.429 , pp. 457-463
    • Egger, G.1    Liang, G.2    Aparicio, A.3    Jones, P.A.4
  • 12
  • 13
    • 0033753779 scopus 로고    scopus 로고
    • The DNA methyltransferases of mammals
    • Bestor, T.H. The DNA methyltransferases of mammals. Hum. Mol. Genet. 2000, 9, 2395-2402.
    • (2000) Hum. Mol. Genet , vol.9 , pp. 2395-2402
    • Bestor, T.H.1
  • 14
    • 70350234722 scopus 로고    scopus 로고
    • Azacytidine inhibits RNA methylation at DNMT2 target sites in human cancer cell lines
    • Schaefer, M.; Hagemann, S.; Hanna, K.; Lyko, F. Azacytidine inhibits RNA methylation at DNMT2 target sites in human cancer cell lines. Cancer Res. 2009, 69, 8127-8132.
    • (2009) Cancer Res , vol.69 , pp. 8127-8132
    • Schaefer, M.1    Hagemann, S.2    Hanna, K.3    Lyko, F.4
  • 15
    • 79956294973 scopus 로고    scopus 로고
    • DNA methylation and demethylation in mammals
    • Chen, Z.X.; Riggs, A.D. DNA methylation and demethylation in mammals. J. Biol. Chem. 2011, 286, 18347-18353.
    • (2011) J. Biol. Chem , vol.286 , pp. 18347-18353
    • Chen, Z.X.1    Riggs, A.D.2
  • 16
  • 17
    • 55949095127 scopus 로고    scopus 로고
    • Chromatin, cancer and drug therapies
    • Cortez, C.C.; Jones, P.A. Chromatin, cancer and drug therapies. Mutat. Res. 2008, 647, 44-51.
    • (2008) Mutat. Res , vol.647 , pp. 44-51
    • Cortez, C.C.1    Jones, P.A.2
  • 18
    • 33750444968 scopus 로고    scopus 로고
    • Alteration of DNA methylation status in K562 and MCF-7 cancer cell lines by nucleoside analogues
    • Krawczyk, B.; Fabianowska-Majewska, K. Alteration of DNA methylation status in K562 and MCF-7 cancer cell lines by nucleoside analogues. Nucleos. Nucleot. Nucleic Acids 2006, 25, 1029-1032.
    • (2006) Nucleos. Nucleot. Nucleic Acids , vol.25 , pp. 1029-1032
    • Krawczyk, B.1    Fabianowska-Majewska, K.2
  • 19
    • 65249157050 scopus 로고    scopus 로고
    • Epigenetics, DNA methylation, and chromatin modifying drugs
    • Szyf, M. Epigenetics, DNA methylation, and chromatin modifying drugs. Annu. Rev. Pharmacol. Toxicol. 2009, 49, 243-263.
    • (2009) Annu. Rev. Pharmacol. Toxicol , vol.49 , pp. 243-263
    • Szyf, M.1
  • 20
    • 79251557812 scopus 로고    scopus 로고
    • Effects of specific DNMT gene depletion on cancer cell transformation and breast cancer cell invasion; toward selective DNMT inhibitors
    • Chik, F.; Szyf, M. Effects of specific DNMT gene depletion on cancer cell transformation and breast cancer cell invasion; toward selective DNMT inhibitors. Carcinogenesis 2011, 32, 224-232.
    • (2011) Carcinogenesis , vol.32 , pp. 224-232
    • Chik, F.1    Szyf, M.2
  • 21
    • 38049156451 scopus 로고    scopus 로고
    • Neither DNA hypomethylation nor changes in the kinetics of erythroid differentiation explain 5-azacytidine's ability to induce human fetal hemoglobin
    • Mabaera, R.; Greene, M.R.; Richardson, C.A.; Conine, S.J.; Kozul, C.D.; Lowrey, C.H. Neither DNA hypomethylation nor changes in the kinetics of erythroid differentiation explain 5-azacytidine's ability to induce human fetal hemoglobin. Blood 2008, 111, 411-420.
    • (2008) Blood , vol.111 , pp. 411-420
    • Mabaera, R.1    Greene, M.R.2    Richardson, C.A.3    Conine, S.J.4    Kozul, C.D.5    Lowrey, C.H.6
  • 22
    • 0037068379 scopus 로고    scopus 로고
    • 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: Mechanistic studies and their implications for cancer therapy
    • Christman, J.K. 5-Azacytidine and 5-aza-2'-deoxycytidine as inhibitors of DNA methylation: Mechanistic studies and their implications for cancer therapy. Oncogene 2002, 21, 5483-5495.
    • (2002) Oncogene , vol.21 , pp. 5483-5495
    • Christman, J.K.1
  • 23
    • 34548598331 scopus 로고    scopus 로고
    • 5-Azacytidine induced methyltransferase-DNA adducts block DNA replication in vivo
    • Kuo, H.K.; Griffith, J.D.; Kreuzer, K.N. 5-Azacytidine induced methyltransferase-DNA adducts block DNA replication in vivo. Cancer Res. 2007, 67, 8248-8254.
    • (2007) Cancer Res , vol.67 , pp. 8248-8254
    • Kuo, H.K.1    Griffith, J.D.2    Kreuzer, K.N.3
  • 24
    • 70350459845 scopus 로고    scopus 로고
    • Three epigenetic drugs up-regulate homeobox gene Rhox5 in cancer cells through overlapping and distinct molecular mechanisms
    • Li, Q.; Bartlett, D.L.; Gorry, M.C.; O'Malley, M.E.; Guo, Z.S. Three epigenetic drugs up-regulate homeobox gene Rhox5 in cancer cells through overlapping and distinct molecular mechanisms. Mol. Pharmacol. 2009, 76, 1072-1081.
    • (2009) Mol. Pharmacol , vol.76 , pp. 1072-1081
    • Li, Q.1    Bartlett, D.L.2    Gorry, M.C.3    O'Malley, M.E.4    Guo, Z.S.5
  • 25
    • 77951236061 scopus 로고    scopus 로고
    • Epigenetic repression of PDZ-LIM domain-containing protein 2: Implications for the biology and treatment of breast cancer
    • Qu, Z.; Fu, J.; Yan, P.; Hu, J.; Cheng, S.Y.; Xiao, G. Epigenetic repression of PDZ-LIM domain-containing protein 2: Implications for the biology and treatment of breast cancer. J. Biol. Chem. 2010, 285, 11786-11792.
    • (2010) J. Biol. Chem , vol.285 , pp. 11786-11792
    • Qu, Z.1    Fu, J.2    Yan, P.3    Hu, J.4    Cheng, S.Y.5    Xiao, G.6
  • 26
    • 33847042352 scopus 로고    scopus 로고
    • Evidence that tumor necrosis factor-related apoptosis-inducing ligand induction by 5-Aza-2'-deoxycytidine sensitizes human breast cancer cells to adriamycin
    • Xu, J.; Zhou, J.Y.; Tainsky, M.A.; Wu, G.S. Evidence that tumor necrosis factor-related apoptosis-inducing ligand induction by 5-Aza-2'-deoxycytidine sensitizes human breast cancer cells to adriamycin. Cancer Res. 2007, 67, 1203-1211.
    • (2007) Cancer Res , vol.67 , pp. 1203-1211
    • Xu, J.1    Zhou, J.Y.2    Tainsky, M.A.3    Wu, G.S.4
  • 27
    • 77955853899 scopus 로고    scopus 로고
    • Demethylating agent 5-aza-2-deoxycytidine enhances susceptibility of breast cancer cells to anticancer agents
    • Mirza, S.; Sharma, G.; Pandya, P.; Ralhan, R. Demethylating agent 5-aza-2-deoxycytidine enhances susceptibility of breast cancer cells to anticancer agents. Mol. Cell Biochem. 2010, 342, 101-109.
    • (2010) Mol. Cell Biochem , vol.342 , pp. 101-109
    • Mirza, S.1    Sharma, G.2    Pandya, P.3    Ralhan, R.4
  • 28
    • 43749124047 scopus 로고    scopus 로고
    • Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU)
    • Beumer, J.H.; Parise, R.A.; Newman, E.M.; Doroshow, J.H.; Synold, T.W.; Lenz, H.J.; Egorin, M.J. Concentrations of the DNA methyltransferase inhibitor 5-fluoro-2'-deoxycytidine (FdCyd) and its cytotoxic metabolites in plasma of patients treated with FdCyd and tetrahydrouridine (THU). Cancer Chemother. Pharmacol. 2008, 62, 363-368.
    • (2008) Cancer Chemother. Pharmacol , vol.62 , pp. 363-368
    • Beumer, J.H.1    Parise, R.A.2    Newman, E.M.3    Doroshow, J.H.4    Synold, T.W.5    Lenz, H.J.6    Egorin, M.J.7
  • 29
    • 22144461094 scopus 로고    scopus 로고
    • Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy
    • Gowher, H.; Jeltsch, A. Mechanism of inhibition of DNA methyltransferases by cytidine analogs in cancer therapy. Cancer Biol. Ther. 2004, 3, 1062-1068.
    • (2004) Cancer Biol. Ther , vol.3 , pp. 1062-1068
    • Gowher, H.1    Jeltsch, A.2
  • 30
    • 0024519539 scopus 로고
    • Exploitation of elevated pyrimidine deaminating enzymes for selective chemotherapy
    • Boothman, D.A.; Briggle, T.V.; Greer, S. Exploitation of elevated pyrimidine deaminating enzymes for selective chemotherapy. Pharmacol. Ther. 1989, 42, 65-88.
    • (1989) Pharmacol. Ther , vol.42 , pp. 65-88
    • Boothman, D.A.1    Briggle, T.V.2    Greer, S.3
  • 32
    • 77950867869 scopus 로고    scopus 로고
    • Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells
    • Billam, M.; Sobolewski, M.D.; Davidson, N.E. Effects of a novel DNA methyltransferase inhibitor zebularine on human breast cancer cells. Breast Cancer Res. Treat. 2010, 120, 581-592.
    • (2010) Breast Cancer Res. Treat , vol.120 , pp. 581-592
    • Billam, M.1    Sobolewski, M.D.2    Davidson, N.E.3
  • 33
    • 27644582534 scopus 로고    scopus 로고
    • Antimitogenic and chemosensitizing effects of the methylation inhibitor zebularine in ovarian cancer
    • Balch, C.; Yan, P.; Craft, T.; Young, S.; Skalnik, D.G.; Huang, T.H.; Nephew, K.P. Antimitogenic and chemosensitizing effects of the methylation inhibitor zebularine in ovarian cancer. Mol. Cancer Ther. 2005, 4, 1505-1514.
    • (2005) Mol. Cancer Ther , vol.4 , pp. 1505-1514
    • Balch, C.1    Yan, P.2    Craft, T.3    Young, S.4    Skalnik, D.G.5    Huang, T.H.6    Nephew, K.P.7
  • 34
    • 27144501839 scopus 로고    scopus 로고
    • In living color: DNA methyltransferase caught in the act
    • Schuebel, K.; Baylin, S. In living color: DNA methyltransferase caught in the act. Nat. Methods 2005, 2, 736-738.
    • (2005) Nat. Methods , vol.2 , pp. 736-738
    • Schuebel, K.1    Baylin, S.2
  • 35
  • 36
    • 0345275879 scopus 로고    scopus 로고
    • Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines
    • Fang, M.Z.; Wang, Y.; Ai, N.; Hou, Z.; Sun, Y.; Lu, H.; Welsh, W.; Yang, C.S. Tea polyphenol (-)-epigallocatechin-3-gallate inhibits DNA methyltransferase and reactivates methylation-silenced genes in cancer cell lines. Cancer Res. 2003, 63, 7563-7570.
    • (2003) Cancer Res , vol.63 , pp. 7563-7570
    • Fang, M.Z.1    Wang, Y.2    Ai, N.3    Hou, Z.4    Sun, Y.5    Lu, H.6    Welsh, W.7    Yang, C.S.8
  • 37
    • 2542520785 scopus 로고    scopus 로고
    • Green tea polyphenols and cancer chemoprevention: Multiple mechanisms and endpoints for phase II trials
    • Moyers, S.B.; Kumar, N.B. Green tea polyphenols and cancer chemoprevention: Multiple mechanisms and endpoints for phase II trials. Nutr. Rev. 2004, 62, 204-211.
    • (2004) Nutr. Rev , vol.62 , pp. 204-211
    • Moyers, S.B.1    Kumar, N.B.2
  • 41
    • 12444297637 scopus 로고    scopus 로고
    • Phase I and pharmacologic study of the human DNA methyltransferase antisense oligodeoxynucleotide MG98 given as a 21-day continuous infusion every 4 weeks
    • Davis, A.J.; Gelmon, K.A.; Siu, L.L.; Moore, M.J.; Britten, C.D.; Mistry, N.; Klamut, H.; D'Aloisio, S.; MacLean, M.; Wainman, N., et al. Phase I and pharmacologic study of the human DNA methyltransferase antisense oligodeoxynucleotide MG98 given as a 21-day continuous infusion every 4 weeks. Invest. New Drugs 2003, 21, 85-97.
    • (2003) Invest. New Drugs , vol.21 , pp. 85-97
    • Davis, A.J.1    Gelmon, K.A.2    Siu, L.L.3    Moore, M.J.4    Britten, C.D.5    Mistry, N.6    Klamut, H.7    D'aloisio, S.8    Maclean, M.9    Wainman, N.10
  • 45
    • 49249116407 scopus 로고    scopus 로고
    • A work in progress: The clinical development of histone deacetylase inhibitors
    • Marsoni, S.; Damia, G.; Camboni, G. A work in progress: The clinical development of histone deacetylase inhibitors. Epigenetics 2008, 3, 164-171.
    • (2008) Epigenetics , vol.3 , pp. 164-171
    • Marsoni, S.1    Damia, G.2    Camboni, G.3
  • 46
    • 79960806528 scopus 로고    scopus 로고
    • Histone modification and its application in therapy for hematologic malignancies
    • (in Chinese)
    • Fang, M.H.; Ji, X.M. Histone modification and its application in therapy for hematologic malignancies. Zhongguo Shi Yan Xue Ye Xue Za Zhi 2009, 17, 816-820 (in Chinese).
    • (2009) Zhongguo Shi Yan Xue Ye Xue Za Zhi , vol.17 , pp. 816-820
    • Fang, M.H.1    Ji, X.M.2
  • 47
    • 78650575875 scopus 로고    scopus 로고
    • Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents
    • Namdar, M.; Perez, G.; Ngo, L.; Marks, P.A. Selective inhibition of histone deacetylase 6 (HDAC6) induces DNA damage and sensitizes transformed cells to anticancer agents. Proc. Natl. Acad. Sci. USA 2010, 107, 20003-20008.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 20003-20008
    • Namdar, M.1    Perez, G.2    Ngo, L.3    Marks, P.A.4
  • 48
    • 0017886958 scopus 로고
    • Sodium butyrate inhibits histone deacetylation in cultured cells
    • Candido, E.P.; Reeves, R.; Davie, J.R. Sodium butyrate inhibits histone deacetylation in cultured cells. Cell 1978, 14, 105-113.
    • (1978) Cell , vol.14 , pp. 105-113
    • Candido, E.P.1    Reeves, R.2    Davie, J.R.3
  • 49
    • 67649659846 scopus 로고    scopus 로고
    • The combination effect of sodium butyrate and 5-Aza-2'-deoxycytidine on radiosensitivity in RKO colorectal cancer and MCF-7 breast cancer cell lines
    • Cho, H.J.; Kim, S.Y.; Kim, K.H.; Kang, W.K.; Kim, J.I.; Oh, S.T.; Kim, J.S.; An, C.H. The combination effect of sodium butyrate and 5-Aza-2'-deoxycytidine on radiosensitivity in RKO colorectal cancer and MCF-7 breast cancer cell lines. World J. Surg. Oncol. 2009, 7, 49:1-49:7.
    • (2009) World J. Surg. Oncol , vol.7 , Issue.49
    • Cho, H.J.1    Kim, S.Y.2    Kim, K.H.3    Kang, W.K.4    Kim, J.I.5    Oh, S.T.6    Kim, J.S.7    An, C.H.8
  • 51
    • 55949105764 scopus 로고    scopus 로고
    • Epigenetic reprogramming of breast cancer cells by valproic acid occurs regardless of estrogen receptor status
    • Travaglini, L.; Vian, L.; Billi, M.; Grignani, F.; Nervi, C. Epigenetic reprogramming of breast cancer cells by valproic acid occurs regardless of estrogen receptor status. Int. J. Biochem. Cell. Biol. 2009, 41, 225-234.
    • (2009) Int. J. Biochem. Cell. Biol , vol.41 , pp. 225-234
    • Travaglini, L.1    Vian, L.2    Billi, M.3    Grignani, F.4    Nervi, C.5
  • 52
    • 77956627130 scopus 로고    scopus 로고
    • Trichostatin A enhances acetylation as well as protein stability of ERα through induction of p300 protein
    • Kim, S.H.; Kang, H.J.; Na, H.; Lee, M.O. Trichostatin A enhances acetylation as well as protein stability of ERα through induction of p300 protein. Breast Cancer Res. 2010, 12, R22.
    • (2010) Breast Cancer Res , vol.12
    • Kim, S.H.1    Kang, H.J.2    Na, H.3    Lee, M.O.4
  • 53
    • 77957784810 scopus 로고    scopus 로고
    • Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells
    • Li, Y.; Yuan, Y.Y.; Meeran, S.M.; Tollefsbol, T.O. Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells. Mol. Cancer 2010, 9, 274.
    • (2010) Mol. Cancer , vol.9 , pp. 274
    • Li, Y.1    Yuan, Y.Y.2    Meeran, S.M.3    Tollefsbol, T.O.4
  • 54
    • 36849037857 scopus 로고    scopus 로고
    • Epigenetic regulation as a new target for breast cancer therapy
    • Stearns, V.; Zhou, Q.; Davidson, N.E. Epigenetic regulation as a new target for breast cancer therapy. Cancer Invest. 2007, 25, 659-665.
    • (2007) Cancer Invest , vol.25 , pp. 659-665
    • Stearns, V.1    Zhou, Q.2    Davidson, N.E.3
  • 55
    • 24744434639 scopus 로고    scopus 로고
    • Induction of polyploidy by histone deacetylase inhibitor: A pathway for antitumor effects
    • Xu, W.S.; Perez, G.; Ngo, L.; Gui, C.Y.; Marks, P.A. Induction of polyploidy by histone deacetylase inhibitor: A pathway for antitumor effects. Cancer Res. 2005, 65, 7832-7839.
    • (2005) Cancer Res , vol.65 , pp. 7832-7839
    • Xu, W.S.1    Perez, G.2    Ngo, L.3    Gui, C.Y.4    Marks, P.A.5
  • 57
    • 0027378351 scopus 로고
    • Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase
    • Kijima, M.; Yoshida, M.; Sugita, K.; Horinouchi, S.; Beppu, T. Trapoxin, an antitumor cyclic tetrapeptide, is an irreversible inhibitor of mammalian histone deacetylase. J. Biol. Chem. 1993, 268, 22429-22435.
    • (1993) J. Biol. Chem , vol.268 , pp. 22429-22435
    • Kijima, M.1    Yoshida, M.2    Sugita, K.3    Horinouchi, S.4    Beppu, T.5
  • 58
    • 11844278521 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors
    • Monneret, C. Histone deacetylase inhibitors. Eur. J. Med. Chem. 2005, 40, 1-13.
    • (2005) Eur. J. Med. Chem , vol.40 , pp. 1-13
    • Monneret, C.1
  • 59
    • 33845231988 scopus 로고    scopus 로고
    • Systemic co-administration of depsipeptide selectively targets transfection enhancement to specific tissues and cell types
    • Liu, Y.; Liggitt, D.; Fong, S.; Debs, R.J. Systemic co-administration of depsipeptide selectively targets transfection enhancement to specific tissues and cell types. Gene Ther. 2006, 13, 1724-1730.
    • (2006) Gene Ther , vol.13 , pp. 1724-1730
    • Liu, Y.1    Liggitt, D.2    Fong, S.3    Debs, R.J.4
  • 61
    • 34248592567 scopus 로고    scopus 로고
    • Mechanism of action of the microtubule-targeted antimitotic depsipeptide tasidotin (formerly ILX651) and its major metabolite tasidotin C-carboxylate
    • Ray, A.; Okouneva, T.; Manna, T.; Miller, H.P.; Schmid, S.; Arthaud, L.; Luduena, R.; Jordan, M.A.; Wilson, L. Mechanism of action of the microtubule-targeted antimitotic depsipeptide tasidotin (formerly ILX651) and its major metabolite tasidotin C-carboxylate. Cancer Res. 2007, 67, 3767-3776.
    • (2007) Cancer Res , vol.67 , pp. 3767-3776
    • Ray, A.1    Okouneva, T.2    Manna, T.3    Miller, H.P.4    Schmid, S.5    Arthaud, L.6    Luduena, R.7    Jordan, M.A.8    Wilson, L.9
  • 62
    • 0035793107 scopus 로고    scopus 로고
    • Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin
    • Furumai, R.; Komatsu, Y.; Nishino, N.; Khochbin, S.; Yoshida, M.; Horinouchi, S. Potent histone deacetylase inhibitors built from trichostatin A and cyclic tetrapeptide antibiotics including trapoxin. Proc. Natl. Acad. Sci. USA 2001, 98, 87-92.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 87-92
    • Furumai, R.1    Komatsu, Y.2    Nishino, N.3    Khochbin, S.4    Yoshida, M.5    Horinouchi, S.6
  • 63
    • 40949162039 scopus 로고    scopus 로고
    • Modulation of cell cycles and apoptosis by apicidin in estrogen receptor (ER)-positive and-negative human breast cancer cells
    • Im, J.Y.; Park, H.; Kang, K.W.; Choi, W.S.; Kim, H.S. Modulation of cell cycles and apoptosis by apicidin in estrogen receptor (ER)-positive and-negative human breast cancer cells. Chem. Biol. Interact. 2008, 172, 235-244.
    • (2008) Chem. Biol. Interact , vol.172 , pp. 235-244
    • Im, J.Y.1    Park, H.2    Kang, K.W.3    Choi, W.S.4    Kim, H.S.5
  • 64
    • 40249087077 scopus 로고    scopus 로고
    • Effects of apicidin, a histone deacetylase inhibitor, on the regulation of apoptosis in H-ras-transformed breast epithelial cells
    • Park, H.; Im, J.Y.; Kim, J.; Choi, W.S.; Kim, H.S. Effects of apicidin, a histone deacetylase inhibitor, on the regulation of apoptosis in H-ras-transformed breast epithelial cells. Int. J. Mol. Med. 2008, 21, 325-333.
    • (2008) Int. J. Mol. Med , vol.21 , pp. 325-333
    • Park, H.1    Im, J.Y.2    Kim, J.3    Choi, W.S.4    Kim, H.S.5
  • 65
    • 79960824568 scopus 로고    scopus 로고
    • Apicidin suppresses transcription of 17β-hydroxysteroid dehydrogenase type 1 in endometrial adenocarcinoma cells
    • Keles, E.; Lianeri, M.; Jagodziński, P.P. Apicidin suppresses transcription of 17β-hydroxysteroid dehydrogenase type 1 in endometrial adenocarcinoma cells. Mol. Biol. Rep. 2011, 38, 3355-3360.
    • (2011) Mol. Biol. Rep , vol.38 , pp. 3355-3360
    • Keles, E.1    Lianeri, M.2    Jagodziński, P.P.3
  • 67
    • 1642576220 scopus 로고    scopus 로고
    • Enhanced radiation-induced cell killing and prolongation of gammaH2AX foci expression by the histone deacetylase inhibitor MS-275
    • Camphausen, K.; Burgan, W.; Cerra, M.; Oswald, K.A.; Trepel, J.B.; Lee, M.J.; Tofilon, P.J. Enhanced radiation-induced cell killing and prolongation of gammaH2AX foci expression by the histone deacetylase inhibitor MS-275. Cancer Res. 2004, 64, 316-321.
    • (2004) Cancer Res , vol.64 , pp. 316-321
    • Camphausen, K.1    Burgan, W.2    Cerra, M.3    Oswald, K.A.4    Trepel, J.B.5    Lee, M.J.6    Tofilon, P.J.7
  • 68
    • 78650443648 scopus 로고    scopus 로고
    • MS-275 sensitizes TRAIL-resistant breast cancer cells, inhibits angiogenesis and metastasis, and reverses epithelial-mesenchymal transition in vivo
    • Srivastava, R.K.; Kurzrock, R.; Shankar, S. MS-275 sensitizes TRAIL-resistant breast cancer cells, inhibits angiogenesis and metastasis, and reverses epithelial-mesenchymal transition in vivo. Mol. Cancer Ther. 2010, 9, 3254-3266.
    • (2010) Mol. Cancer Ther , vol.9 , pp. 3254-3266
    • Srivastava, R.K.1    Kurzrock, R.2    Shankar, S.3
  • 69
    • 53049107304 scopus 로고    scopus 로고
    • Sp1-mediated TRAIL induction in chemosensitization
    • Xu, J.; Zhou, J.Y.; Wei, W.Z.; Philipsen, S.; Wu, G.S. Sp1-mediated TRAIL induction in chemosensitization. Cancer Res. 2008, 68, 6718-6726.
    • (2008) Cancer Res , vol.68 , pp. 6718-6726
    • Xu, J.1    Zhou, J.Y.2    Wei, W.Z.3    Philipsen, S.4    Wu, G.S.5
  • 70
    • 0034058081 scopus 로고    scopus 로고
    • Pharmacokinetics and cerebrospinal fluid penetration of CI-994 (N-acetyldinaline) in the nonhuman primate
    • Riva, L.; Blaney, S.M.; Dauser, R.; Nuchtern, J.G.; Durfee, J.; McGuffey, L.; Berg, S.L. Pharmacokinetics and cerebrospinal fluid penetration of CI-994 (N-acetyldinaline) in the nonhuman primate. Clin. Cancer Res. 2000, 6, 994-997.
    • (2000) Clin. Cancer Res , vol.6 , pp. 994-997
    • Riva, L.1    Blaney, S.M.2    Dauser, R.3    Nuchtern, J.G.4    Durfee, J.5    McGuffey, L.6    Berg, S.L.7
  • 71
    • 34447301799 scopus 로고    scopus 로고
    • New agents for treatment of advanced transitional cell carcinoma
    • Perabo, F.G.; Müller, S.C. New agents for treatment of advanced transitional cell carcinoma. Annu. Oncol. 2007, 18, 835-843.
    • (2007) Annu. Oncol , vol.18 , pp. 835-843
    • Perabo, F.G.1    Müller, S.C.2
  • 72
    • 77957937450 scopus 로고    scopus 로고
    • Epigenetic modifications as therapeutic targets
    • Kelly, T.K.; De, Carvalho, D.D.; Jones, P.A. Epigenetic modifications as therapeutic targets. Nat. Biotechnol. 2010, 28, 1069-1078.
    • (2010) Nat. Biotechnol , vol.28 , pp. 1069-1078
    • Kelly, T.K.1    de Carvalho, D.D.2    Jones, P.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.