Glucose-induced preproinsulin gene expression is inhibited by the free fatty acid palmitate

Endocrinology

Volumn 140, Issue 9, 1999, Pages 4005-4014

  Ritz Laser, Beate ^a   Meda, Paolo ^a   Constant, Isabel ^a   Klages, Natacha ^a   Charollais, Anne ^a   Morales, Anne ^a   Magnan, Christophe ^b   Ktorza, Alain ^b   Philippe, Jacques ^a  

^a UNIVERSITY OF GENEVA MEDICAL SCHOOL   (Switzerland)

^b CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; GLUCOSE; MESSENGER RNA; PALMITIC ACID; PREPROINSULIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENE INDUCTION; HORMONAL REGULATION; HORMONE DETERMINATION; HORMONE SYNTHESIS; INSULIN RELEASE; NONHUMAN; PRIORITY JOURNAL; RAT; RNA ANALYSIS;

EID: 0033304970     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.140.9.6953     Document Type: Article

References (49)

1. Nutrient regulation of insulin gene expression
2. Long-term exposure of rat pancreatic islets inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle
3. Impaired β-cell function with chronic hyperglycemia: 'Overworked β-cell hypothesis'
4. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
5. Obesity and NIDDM: The retrograde concept
6. The glucose-fatty acid cycle: Its role in insulin insensitivity and the metabolic disturbances in diabetes mellitus
7. Mechanism of free fatty acid-induced insulin resistance in humans
8. Free fafty acid as a link in the regulation of hepatic glucose output by peripheral insulin
9. Induction of hepatic glucose-6-phosphatase gene expression by lipid infusion
10. β-Cell hypersensitivity to glucose following 24-h exposure of rat islets to fatty acids
11. Molecular or pharmcologic pertubation of the link between glucose and lipid metabolism is without effect on glucose-stimulated insulin secretion: A re-evaluation of the long-chain acyl-CoA hypothesis
12. Fatty acids rapidly induce the carnitine palmitoyltransferase I gene in the pancreatic β-cell line INS-1
13. Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic β-cell line INS-1
14. B-Cell size influences glucose-stimulated insulin secretion
15. Establishment of a pancreatic β cell line that retains glucose-inducible secretion: Special reference to expression of glucose transporter isoforms
16. α Cell-specific expression of the glucagon gene is conferred to the glucagon gene promoter element by the interactions of DNA-binding proteins
17. Functional analysis of a cAMP responsive element of the rat insulin I gene
18. CAT expression vectors for analysis of eukaryotic promoters and enhancers
19. Insulin regulation of the glucagon gene is mediated by an insulin-responsive DNA element
20. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
21. Cloning, sequencing, and expression of a cDNA encoding rat liver carnitine palmitoyl-transferase I. Direct evidence that a single polypeptide is involved in inhibitor interaction and catalytic function
22. The structure and evolution of the two nonallelic rat preproinsulin genes
23. 2+ and insulin release in an insulin-secreting cell line
24. Pancreatic β-cells in obesity
25. Pancreatic beta cell line MIN6 exhibits characteristics of glucose metabolism and glucose-stimulated insulin secretion similar to those of normal islets
26. Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. I. Effects of glucose and cyclic AMP on the transcription of insulin mRNA
27. Control of insulin gene expression in pancreatic beta-cells and in an insulin-producing cell line, RIN-5F cells. II. Regulation of insulin mRNA stability
28. Regulation of insulin mRNA splicing by glucose
29. The insulinotropic potency of fatty acids is influenced profoundly by their chain length and degree of saturation
30. Fatty acids decrease IDX-1 expression in rat pancreatic islets and reduce GLUT2, glucokinase, insulin, and somatostatin levels
31. Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion
32. Are the β-cell signaling molecules malonyl-CoA and cystolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?
33. Chronic exposure to free fatty acid reduces pancreatic β cell insulin content by increasing basal insulin secretion that is not compensated for by a corresponding increase in proinsulin biosynthesis translation
34. Dietary polyunsaturated fatty acid regulation of gene transcription
35. Fatty acid-responsive control of RNA stability
36. Differential expression of rat insulin I and II messenger ribonucleic acid after prolonged exposure of islet β-cells to elevated glucose levels
37. Glucose modulates the binding of an islet-specific factor to a conserved sequence within the rat I and human insulin gene promoters
38. Glucose modulates the binding activity of the β-cell transcription factor IUF1 in a phosporylation-dependent manner
39. Specific inhibition of mitochondrial fatty acid oxidation by 2-bromopalmitate and its coenzyme A and carnitine esters
40. The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis
41. Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein β and transactivator islet duodenum homeobox-1 in rat pancreatic β-cells during the development of diabetes mellitus
42. Hypolipidemic drugs, polyunsaturated acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ
43. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ
44. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
45. Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-α, -β, and γ in the adult rat
46. Fatty acyl-CoA thioesters are ligands of hepatic nuclear factor-4α
47. Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat
48. β-Cell function in normal rats made chronically hyperleptinemic by adenovirus-leptin gene therapy