Inhibition of IGF-1 signalling enhances the apoptotic effect of AS602868, an IKK2 inhibitor, in multiple myeloma cell lines

PLoS ONE

Volumn 6, Issue 7, 2011, Pages

  Tagoug, Ines ^a,b,c   de Chalon, Amélie Sauty ^a,b,c   Dumontet, Charles ^a,b,c  

^a UNIVERSITÉ DE LYON   (France)

^b CENTRE DE RECHERCHE EN CANCÉROLOGIE DE LYON   (France)

^c HCL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 [5 HYDROXY 2 (2 THIENYL) 4 QUINAZOLINYLAMINO] 3 METHYL 2,5 PYRROLEDIONE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MONOCLONAL ANTIBODY; SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR; SOMATOMEDIN C RECEPTOR ANTIBODY; UNCLASSIFIED DRUG; I KAPPA B KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN KINASE INHIBITOR; PYRIMIDINE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DRUG CYTOTOXICITY; DRUG POTENTIATION; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MULTIPLE MYELOMA; MYELOMA CELL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TARGETING; SIGNAL TRANSDUCTION; CELL CYCLE; DRUG ANTAGONISM; DRUG EFFECT; DRUG INTERACTION; GENE EXPRESSION REGULATION; IMMUNOLOGY; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

ANTIBODIES, MONOCLONAL; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; DRUG INTERACTIONS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; I-KAPPA B KINASE; INSULIN-LIKE GROWTH FACTOR I; MEMBRANE POTENTIAL, MITOCHONDRIAL; MULTIPLE MYELOMA; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PROTEIN KINASE INHIBITORS; PROTO-ONCOGENE PROTEINS C-AKT; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRIMIDINES; RECEPTOR, IGF TYPE 1; SIGNAL TRANSDUCTION;

EID: 79960745524     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0022641     Document Type: Article

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