Interleukin-6 with its soluble receptor enhances the expression of insulin-like growth factor-I in osteoblasts

Endocrinology

Volumn 138, Issue 12, 1997, Pages 5248-5255

  Franchimont, Nathalie ^a   Gangji, Valerie ^a   Durant, Deena ^a   Canalis, Ernesto ^a,b  

^a SAINT FRANCIS HOSPITAL AND MEDICAL CENTER   (United States)

^b UNIVERSITY OF CONNECTICUT SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 6; SOMATOMEDIN C;

ARTICLE; BONE REMODELING; CALVARIA; GENETIC TRANSCRIPTION; IMMUNOREACTIVITY; MITOGENICITY; NONHUMAN; OSTEOBLAST; OSTEOCLAST; OSTEOLYSIS; PRIORITY JOURNAL; RECEPTOR UPREGULATION; TRANSCRIPTION REGULATION;

EID: 0030664646     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.138.12.5559     Document Type: Article

References (53)

1. Manolagas SC, Jilka RL 1995 Mechanisms of disease: bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med 332:305-311
2. Jilka RL, Hangoc G, Girasole G, Passen G, Williams DC, Abrams JS, Boyce B, Broxmeyer H, Manolagas SC 1992 Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science 257:88-91
3. Horowitz MC 1993 Cytokines and estrogen in bone: anti-osteoporotic effects. Science 260:626-627
4. Girasole G, Jilka RL, Passen G, Boswell S, Boder G, Williams DC, Manolagas SC 1992 17β-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens. J Clin Invest 89:883-891
5. Pacifici R 1996 Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis. J Bone Miner Res 11:1043-1051
6. Bellido T, Jilka RL, Boyce BF, Girasole G, Broxmeyer H, Dairymple SA, Murray R, Manolagas SC 1995 Regulation of interleukin-6, osteoclastogenesis, and bone mass by androgens. The role of the androgen receptor. J Clin Invest 95:2886-2895
7. De La Mata J, Uy HL, Guise TA, Story B, Boyce BF, Mundy GR, Roodman GD 1995 Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivo. J Clin Invest 95:2846-2852
8. Tamura T, Udagawa N, Takahashi N, Miyaura C, Tanaka S, Yamada Y, Koishihara Y, Ohsugi Y, Kumaki K, Taga T, Kishimoto T, Suda T 1993 Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. Proc Natl Acad Sci USA 90:11924-11928
9. Kishimoto T, Akira S, Taga T 1992 Interleukin-6 and its receptor: a paradigm for cytokines. Science 258:593-597
10. Rose-John S, Ehlers M, Grötzinger J, Müllberg J 1995 The soluble interleukin-6 receptor. Ann NY Acad Sci 762:207-221
11. Ikeda U, Ikeda M, Oohara T, Oguchi A, Kamitani T, Tsuruya Y, Kano S 1991 Interleukin 6 stimulates growth of vascular smooth muscle cells in a PDGF-dependent manner. Am J Physiol 260:H1713-H1717
12. Fang MA, Hahn TJ 1991 Effects of interleukin-6 on cellular function in UMR-106-01 Osteoblastlike cells. J Bone Miner Res 6:133-139
13. Lorenzo J, Kalinowski J, McKinstry M, Cassarino D, Harrison J, Gronowicz G, Clark S, Lichtler A 1996 Targeted overexpression of interleukin-6 in osteoblasts of transgenic mice produces a phenotype of hypercellularity and disorganized bone. J Bone Miner Res 11[Suppl]: S101
14. Delany AM, Pash JM, Canalis E 1994 Cellular and clinical perspectives on skeletal insulin-like growth factor. J Cell Biochem 55:328-333
15. Canalis E, McCarthy T, Centrella M 1988 Isolation and characterization of insulin-like growth factor I (Somatomedin-C) from cultures of fetal rat calvariae. Endocrinology 122:22-27
16. Frolik CA, Ellis LF, Williams DC 1988 Isolation and characterization of insulin-like growth factor II from human bone. Biochem Biophys Res Commun 151:1011-1018
17. Mohan S, Jennings JC, Linkhart TA, Baylink DJ 1988 Primary structure of human skeletal growth factor: homology with human insulin-like growth factor II. Biochim Biophys Acta 966:44-45
18. Hock JM, Centrella M, Canalis E 1988 Insulin-like growth factor I has independent effects on bone matrix formation and cell replication. Endocrinology 122:254-260
19. Canalis E, Pash J, Gabbitas B, Rydziel S, Varghese S 1993 Growth factors regulate the synthesis of insulin-like growth factor-I in bone cell cultures. Endocrinology 133:33-38
20. Canalis E, Centrella M, McCarthy TL 1991 Regulation of insulin-like growth factor II production in bone cultures. Endocrinology 129:2457-2462
21. Gabbitas B, Pash J, Canalis E 1994 Regulation of insulin-like growth factor II synthesis in bone cell cultures by skeletal growth factors. Endocrinology 135:284-289
22. Bellido T, Stahl N, Farruggella TJ, Borba V, Yancopoulos GD, Manolagas SC 1996 Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells. J Clin Invest 97:431-437
23. Jay PR, Centrella M, Lorenzo J, Bruce AG, Horowitz MC 1996 Oncostatin-M: A new bone active cytokine that activates osteoblasts and inhibits bone resorption. Endocrinology 137:1151-1158
24. McCarthy TL, Centrella M, Canalis E 1988 Further biochemical and molecular characterization of primary rat parietal bone cell cultures. J Bone Miner Res 3:401-408
25. Chomczynski P, Sacchi N 1987 Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
26. Murphy LJ, Bell GI, Duchworth ML, Friesen HG 1987 Identification, characterization and regulation of rat cDNA which encodes insulin-like growth factor-1. Endocrinology 121:684-691
27. Stempien NM, Fong, NM, Rall LB, Bell GI 1986 Sequence of a placental cDNA encoding the mouse insulin-like growth factor II precursor. DNA 5:357-361
28. Feinberg AP, Vogelstein B 1984 A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 137:266-267
29. Lipson KE, Baserga R 1989 Transcriptional activity of the human thymidine kinase gene determined by a method using the polymerase chain reaction and an intron-specific probe. Proc Natl Acad Sci USA 86:9774-9777
30. Buttice G, Kurkinen M 1993 A polyomavirus enhancer A-binding protein-3 site and Ets-2 protein have a major role in the 12-0-tetradecanolyphorbol-13-acetate response of the human stromelysin gene. J Biol Chem 268:7196-7204
31. Hall LJ, Kajimoto Y, Bichell D, Kim S-W, James PL, Counts D, Nixon LJ, Tobin G, Rotwein P 1992 Functional analysis of the rat insulin-like growth factor I gene and identification of an IGF-I gene promoter. DNA Cell Biol 11:301-313
32. Centrella M, McCarthy TL, Canalis E 1991 Glucocorticoid regulation of transforming growth factor β1 activity and binding in osteoblast-enriched cultures from fetal rat bone. Mol Cell Biol 11:4490-4496
33. Sokal RR, Rohlf FJ 1981 Biometry, ed 2. WH Freeman, San Francisco
34. Zandomeni R, Bunick D, Ackerman S, Mittleman B, Weinmann R 1983 Mechanism of action of DRB. Effect on specific in vitro initiation of transcription. J Mol Biol 167:561-574
35. Delany AM, Canalis E 1995 Transcriptional repression of insulin-like growth factor I by glucocorticoids in rat bone cells. Endocrinology 136:4776-4781
36. 2 in osteoblast cells. Endocrinology 136:33-38
37. Udagawa N, Takahashi N, Katagiri T, Tamura T, Wada S, Findlay DM, Martin TJ, Hirota H, Taga T, Kishimoto T, Suda T 1995 Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors. J Exp Med 182:1461-1468
38. Narazaki M, Yasukawa K, Saito T, Ohsugi Y, Fukui H, Koishihara Y, Yancopoulos GD, Taga T, Kishimoto T 1993 Soluble forms of interleukin-6 signal-transducing receptor component gp130 in human serum possessing a potential to inhibit signals through membrane-anchored gp130. Blood 82:1120-1126
39. Klein B, Zhang X-G, Lu Z-Y, Bataille R 1995 Interleukin-6 in human multiple myeloma. Blood 85:863-872
40. De Benedetti F, Alonzi T, Moretta A, Lazzaro D, Costa P, Poli V, Martini A, Ciliberto G, Fattori E 1997 Interleukin 6 causes growth impairment in transgenic mice through a decrease in insulin-like growth factor-I. J Clin Invest 99:643-650
41. Adamo ML, Ben-Hur H, Roberts Jr CT, LeRoith D 1991 Regulation of start site usage in the leader exons of the rat insulin-like growth factor-I gene by development, fasting and diabetes. Mol Endocrinol 5:1677-1686
42. McCarthy TL, Centrella M, Canalis E 1989 Parathyroid hormone enhances the transcript and polypeptide levels of insulin-like growth factor I in osteoblast-enriched cultures from fetal rat bone. Endocrinology 124:1247-1253
43. Slootweg MC, Most WW, van Beek E, Schot LPC, Papapoulos SE, Löwik CWGM 1992 Osteoclast formation together with interleukin-6 production in mouse long bones is increased by insulin-like growth factor-I. J Endocrinol 132:433-438
44. Swolin D, Ohlsson C 1996 Growth hormone increases interleukin-6 produced by human osteoblast-like cells. J Clin Endocrinol Metab 81:4329-4333
45. Canalis E, Lian J 1988 Effects of bone associated growth factors on DNA, collagen and osteocalcin synthesis in cultured fetal rat calvariae. Bone 9:243-246
46. Motoyama T, Hotta T, Watanabe H, Kumanishi T, Ichikawa T, Sekiguchi M 1993 Differential production of interleukin 6 in human osteosarcoma cells and the possible effects on neoplastic bone metabolism. Virchows Arch [B] 63:277-281
47. Li YP, Stashenko P 1992 Proinflammatory cytokines tumor necrosis factor-alpha and IL-6, but not IL-1, down-regulate the osteocalcin gene promoter. J Immunol 148:788-794
48. Hughes FJ, Howells GL 1993 Interleukin-6 inhibits bone formation in vitro. Bone Miner 21:21-28
49. Rechler MM 1993 Insulin-like growth factor binding proteins. Vitam Horm 47:1-114
50. Okazaki R, Riggs BL, Conover CA 1994 Glucocorticoid regulation of insulin-like growth factor binding protein expression in normal human osteoblast-like cells. Endocrinology 134:126-132
51. 2, growth hormone, and the insulin-like growth factors. J Cell Physiol 160:163-175
52. Andress DL, Loop SM, Zapf J, Kiefer MC 1993 Carboxy-truncated insulin-like growth factor binding protein-5 stimulates mitogenesis in osteoblast-like cells. Biochem Biophys Res Commun 195:25-30
53. Franchimont N, Durant D, Canalis E 1997 Interleukin-6 and its soluble receptor regulate the expression of insulin-like growth factor binding protein-5 in osteoblast cultures. Endocrinology 138:3380-3386