Development of New Insulin-like Growth Factor-1 Receptor Kinase Inhibitors Using Catechol Mimics

Journal of Biological Chemistry

Volumn 278, Issue 42, 2003, Pages 40442-40454

  Blum, Galia ^a   Gazit, Aviv ^a   Levitzki, Alexander ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELLS; TUMORS;

BIOISOSTERE INHIBITORS;

ENZYMES;

2 CYANO 3',4'DIHYDROXYACETOPHENONE; AG 532; BIOISOSTERE INHIBITOR; CATECHOL; PROTEIN KINASE B; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; SOMATOMEDIN C RECEPTOR; SOMATOMEDIN C RECEPTOR RECEPTOR KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; AUTOPHOSPHORYLATION; BREAST CANCER; CELL CULTURE; CELL FREE SYSTEM; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; IC 50; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN ANALYSIS; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; ANIMALS; BINDING, COMPETITIVE; CATECHOLS; CELL LINE, TUMOR; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MODELS, CHEMICAL; NIH 3T3 CELLS; OXYGEN; PHOSPHORYLATION; RECEPTOR, IGF TYPE 1; RECEPTOR, INSULIN; SIGNAL TRANSDUCTION; TIME FACTORS; TYRPHOSTINS;

ANIMALIA;

EID: 0142103667     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M305490200     Document Type: Article

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