Enhanced specificity of HPV16 E6E7 siRNA by RNA-DNA chimera modification

Cancer Gene Therapy

Volumn 18, Issue 8, 2011, Pages 587-597

  Yamato, K ^a   Egawa, N ^b   Endo, S ^c   Ui Tei, K ^d   Yamada, T ^e   Saigo, K ^d   Hyodo, I ^c   Kiyono, T ^b   Nakagawa, I ^a  

^a TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^b NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^c UNIVERSITY OF TSUKUBA   (Japan)

^d UNIVERSITY OF TOKYO   (Japan)

^e KEIO UNIVERSITY   (Japan)

Author keywords

cervical cancer; HPV16; off target effect; siRNA therapy

Indexed keywords

DOUBLE STRANDED DNA; DOUBLE STRANDED RNA; MESSENGER RNA; PROTEIN E6; PROTEIN E7; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR POU4F1;

ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; CYTOTOXICITY; FEMALE; GENE SILENCING; HELA CELL; HUMAN; HUMAN CELL; HUMAN PAPILLOMAVIRUS TYPE 16; KERATINOCYTE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; UTERINE CERVIX CANCER;

CELL LINE, TUMOR; CHIMERA; DNA, VIRAL; HELA CELLS; HUMAN PAPILLOMAVIRUS 16; HUMANS; ONCOGENE PROTEINS, VIRAL; PAPILLOMAVIRUS E7 PROTEINS; REPRESSOR PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING; RNA, VIRAL; TRANSFECTION;

HUMAN PAPILLOMAVIRUS - 16; HUMAN PAPILLOMAVIRUS TYPE 16;

EID: 79960562542     PISSN: 09291903     EISSN: 14765500     Source Type: Journal    
DOI: 10.1038/cgt.2011.28     Document Type: Article

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