An in vitro multistep carcinogenesis model for human cervical cancer

Cancer Research

Volumn 68, Issue 14, 2008, Pages 5699-5705

  Narisawa Saito, Mako ^a   Yoshimatsu, Yuki ^a,b   Ohno, Shin Ichi ^a   Yugawa, Takashi ^a   Egawa, Nagayasu ^a   Fujita, Masatoshi ^a   Hirohashi, Setsuo ^a,b   Kiyono, Tohru ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MYC PROTEIN; PROTEIN E6; PROTEIN E7; PROTEIN HRAS; RAS PROTEIN; UNCLASSIFIED DRUG; EPIDERMAL GROWTH FACTOR RECEPTOR 2; HRAS PROTEIN, HUMAN; PROTEIN P21; TELOMERASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CONTROLLED STUDY; FEMALE; GENE SEQUENCE; HUMAN; HUMAN CELL; IN VITRO STUDY; KERATINOCYTE; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; UTERINE CERVIX CANCER; ANIMAL; BIOLOGICAL MODEL; CANCER TRANSPLANTATION; CELL TRANSFORMATION; CYTOLOGY; GENE EXPRESSION REGULATION; METABOLISM; NUDE MOUSE; PATHOLOGY; TUMOR CELL LINE; UTERINE CERVIX TUMOR;

ANIMALS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KERATINOCYTES; MICE; MICE, NUDE; MODELS, BIOLOGICAL; NEOPLASM TRANSPLANTATION; PROTO-ONCOGENE PROTEINS C-MYC; PROTO-ONCOGENE PROTEINS P21(RAS); RECEPTOR, ERBB-2; TELOMERASE; UTERINE CERVICAL NEOPLASMS;

EID: 48649107699     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-6862     Document Type: Article

References (38)

1. zur Hausen H. Papillomaviruses and cancer: from basic studies to clinical application. Nat Rev Cancer 2002;2:342-50.
2. Klaes R, Woerner SM, Ridder R, et al. Detection of highrisk cervical intraepithelial neoplasia and cervical cancer by amplification of transcripts derived from integrated papillomavirus oncogenes. Cancer Res 1999;59:6132-6.
3. Baseman JG, Koutsky LA. The epidemiology of human papillomavirus infections. J Clin Virol 2005;32 Suppl 1:S16-24.
4. Bertelsen BI, Steine SJ, Sandvei R, Molven A, Laerum OD. Molecular analysis of the PI3K-AKT pathway in uterine cervical neoplasia: frequent PIK3CA amplification and AKT phosphorylation. Int J Cancer 2006;118:1877-83.
5. Zhang A, Maner S, Betz R, et al. Genetic alterations in cervical carcinomas: frequent low-level amplifications of oncogenes are associated with human papillomavirus infection. Int J Cancer 2002;101:427-33.
6. Imoto I, Tsuda H, Hirasawa A, et al. Expression of cIAP1, a target for 11q22 amplification, correlates with resistance of cervical cancers to radiotherapy. Cancer Res 2002;62:4860-6.
7. Alonio L, VPicconi MA, Dalbert D, et al. Ha-ras oncogene mutation associated to progression of papillomavirus induced lesions of uterine cervix. J Clin Virol 2003;27:263-9.
8. Cheung TH, Lo KW, Yim SF, et al. Epigenetic and genetic alternation of PTEN in cervical neoplasm. Gynecol Oncol 2004;93:621-7.
9. Soh LT, Heng D, Lee IW, Ho TH, Hui KM. The relevance of oncogenes as prognostic markers in cervical cancer. Int J Gynecol Cancer 2002;12:465-74.
10. Manavi M, Hudelist G, Fink-Retter A, et al. Gene profiling in Pap-cell smears of high-risk human papillomavirus-positive squamous cervical carcinoma. Gynecol Oncol 2007;105:418-26.
11. Shai A, Brake T, Somoza C, Lambert PF. The human papillomavirus E6 oncogene dysregulates the cell cycle and contributes to cervical carcinogenesis through two independent activities. Cancer Res 2007;67:1626-35.
12. Narisawa-Saito M, Handa K, Yugawa T, et al. HPV16 E6-mediated stabilization of ErbB2 in neoplastic transformation of human cervical keratinocytes. Oncogene 2007;26:2988-96.
13. Kim SH, Nakagawa H, Navaraj A, et al. Tumorigenic conversion of primary human esophageal epithelial cells using oncogene combinations in the absence of exogenous Ras. Cancer Res 2006;66:10415-24.
14. Mizumoto Y, Kyo S, Ohno S, et al. Creation of tumorigenic human endometrial epithelial cells with intact chromosomes by introducing defined genetic elements. Oncogene 2006;25:5673-82.
15. Takeda Y, Mori T, Imabayashi H, et al. Can the life span of human marrow stromal cells be prolonged by bmi-1, E6, E7, and/or telomerase without affecting cardiomyogenic differentiation? J Gene Med 2004;6:833-45.
16. Yugawa T, Handa K, Narisawa-Saito M, et al. Regulation of Notch1 gene expression by p53 in epithelial cells. Mol Cell Biol 2007;27:3732-42.
17. Ueno T, Sasaki K, Yoshida S, et al. Molecular mechanisms of hyperplasia induction by human papillomavirus E7. Oncogene 2006;25:4155-64.
18. Sato H, Takino T, Okada Y, et al. A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature 1994;370:61-5.
19. Haga K, Ohno S, Yugawa T, et al. Efficient immortalization of primary human cells by p16INK4a-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT. Cancer Sci 2007;98:147-54.
20. Miyashita M, Smith MW, Willey JC, et al. Effects of serum, transforming growth factor type β, or 12-O-tetradecanoyl-phorbol-13-acetate on ionized cytosolic calcium concentration in normal and transformed human bronchial epithelial cells. Cancer Res 1989;49:63-7.
21. Okawa T, Michaylira CZ, Kalabis J, et al. The functional interplay between EGFR overexpression, hTERT activation, and p53 mutation in esophageal epithelial cells with activation of stromal fibroblasts induces tumor development, invasion, and differentiation. Genes Dev 2007;21:2788-803.
22. Schlegel R, Phelps WC, Zhang YL, Barbosa M. Quantitative keratinocyte assay detects two biological activities of human papillomavirus DNA and identifies viral types associated with cervical carcinoma. EMBO J 1988;7:3181-7.
23. Sherman L, Itzhaki H, Jackman A, et al. Inhibition of serum- and calcium-induced terminal differentiation of human keratinocytes by HPV 16 E6: study of the association with p53degradation, inhibition of p53 transactivation, and binding to E6BP. Virology 2002;292:309-20.
24. Uren A, Fallen S, Yuan H, et al. Activation of the canonical Wnt pathway during genital keratinocyte transformation: a model for cervical cancer progression. Cancer Res 2005;65:6199-206.
25. Zhao JJ, Gjoerup OV, Subramanian RR, et al. Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase. Cancer Cell 2003;3:483-95.
26. Wang J, Xie LY, Allan S, Beach D, Hannon GJ. Myc activates telomerase. Genes Dev 1998;12:1769-74.
27. O'Brien CA, Pollett A, Gallinger S, Dick JE. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature 2007;445:106-10.
28. Wang JC, Doedens M, Dick JE. Primitive human hematopoietic cells are enriched in cord blood compared with adult bone marrow or mobilized peripheral blood as measured by the quantitative in vivo SCID-repopulating cell assay. Blood 1997;89:3919-24.
29. Dokianakis DN, Papaefthimiou M, Tsiveleka A, Spandidos DA. High prevalence of HPV18 in correlation with ras gene mutations and clinicopathological parameters in cervical cancer studied from stained cytological smears. Oncol Rep 1999;6:1327-31.
30. Pochylski T, Kwasniewska A. Absence of point mutation in codons 12 and 13of K-RAS oncogene in HPV-associated high grade dysplasia and squamous cell cervical carcinoma. Eur J Obstet Gynecol Reprod Biol 2003;111:68-73.
31. O'Leary JJ, Landers RJ, Silva I, et al. Molecular analysis of ras oncogenes in CIN III and in stage I and II invasive squamous cell carcinoma of the uterine cervix. J Clin Pathol 1998;51:576-82.
32. Land H, Parada LF, Weinberg RA. Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 1983;304:596-602.
33. Al Moustafa AE, Foulkes WD, Benlimame N, et al. E6/E7 proteins of HPV type 16 and ErbB-2 cooperate to induce neoplastic transformation of primary normal oral epithelial cells. Oncogene 2004;23:350-8.
34. Hahn WC, Dessain SK, Brooks MW, et al. Enumeration of the simian virus 40 early region elements necessary for human cell transformation. Mol Cell Biol 2002;22:2111-23.
35. Sears R, Nuckolls F, Haura E, et al. Multiple Ras-dependent phosphorylation pathways regulate Myc protein stability. Genes Dev 2000;14:2501-14.
36. Watnick RS, Cheng YN, Rangarajan A, Ince TA, Weinberg RA. Ras modulates Myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis. Cancer Cell 2003;3:219-31.
37. Pinion SB, Kennedy JH, Miller RW, MacLean AB. Oncogene expression in cervical intraepithelial neoplasia and invasive cancer of cervix. Lancet 1991;337:819-20.
38. Berger KL, Barriga F, Lace MJ, et al. Cervical keratinocytes containing stably replicating extrachromosomal HPV-16 are refractory to transformation by oncogenic H-Ras. Virology 2006;356:68-78.