메뉴 건너뛰기




Volumn 29, Issue 34, 2011, Pages 5575-5583

Cysteine proteases as potential antigens in antiparasitic DNA vaccines

Author keywords

Cysteine proteases; DNA vaccines; Parasites

Indexed keywords

ANTIPARASITIC AGENT; CANDIDA ANTIGEN; CYSTEINE PROTEINASE; DNA VACCINE;

EID: 79960559864     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2011.05.091     Document Type: Review
Times cited : (7)

References (129)
  • 1
    • 34548304501 scopus 로고    scopus 로고
    • Parasite vaccines: the new generation
    • Crampton A., Vanniasinkam T. Parasite vaccines: the new generation. Infect Genet Evol 2007, 7(5):664-673.
    • (2007) Infect Genet Evol , vol.7 , Issue.5 , pp. 664-673
    • Crampton, A.1    Vanniasinkam, T.2
  • 2
    • 70849110143 scopus 로고    scopus 로고
    • Impact of RTS,S/AS02(A) and RTS. S/AS01(B) on genotypes of P. falciparum in adults participating in a malaria vaccine clinical trial
    • Waitumbi J.N., Anyona S.B., Hunja C.W., Kifude C.M., Polhemus M.E., Walsh D.S., et al. Impact of RTS,S/AS02(A) and RTS. S/AS01(B) on genotypes of P. falciparum in adults participating in a malaria vaccine clinical trial. PLoS One 2009, 4(11):e7849.
    • (2009) PLoS One , vol.4 , Issue.11
    • Waitumbi, J.N.1    Anyona, S.B.2    Hunja, C.W.3    Kifude, C.M.4    Polhemus, M.E.5    Walsh, D.S.6
  • 3
    • 52449104809 scopus 로고    scopus 로고
    • DNA vaccines: ready for prime time?
    • Kutzler M.A., Weiner D.B. DNA vaccines: ready for prime time?. Nat Rev Genet 2008, 9(10):776-788.
    • (2008) Nat Rev Genet , vol.9 , Issue.10 , pp. 776-788
    • Kutzler, M.A.1    Weiner, D.B.2
  • 4
    • 23444450421 scopus 로고    scopus 로고
    • DNA vaccines for aquacultured fish
    • Lorenzen N., LaPatra S.E. DNA vaccines for aquacultured fish. Rev Sci Technol 2005, 24(1):201-213.
    • (2005) Rev Sci Technol , vol.24 , Issue.1 , pp. 201-213
    • Lorenzen, N.1    LaPatra, S.E.2
  • 5
    • 61849159893 scopus 로고    scopus 로고
    • DNA vaccines: developing new strategies to enhance immune responses
    • Abdulhaqq S.A., Weiner D.B. DNA vaccines: developing new strategies to enhance immune responses. Immunol Res 2008, 42(1-3):219-232.
    • (2008) Immunol Res , vol.42 , Issue.1-3 , pp. 219-232
    • Abdulhaqq, S.A.1    Weiner, D.B.2
  • 6
    • 84856121339 scopus 로고    scopus 로고
    • http://www.drugs.com/vet/apex-ihn-can.html.
  • 7
    • 18444409072 scopus 로고    scopus 로고
    • Efficacy of an infectious hematopoietic necrosis (IHN) virus DNA vaccine in Chinook Oncorhynchus tshawytscha and sockeye O. nerka salmon
    • Garver K.A., LaPatra S.E., Kurath G. Efficacy of an infectious hematopoietic necrosis (IHN) virus DNA vaccine in Chinook Oncorhynchus tshawytscha and sockeye O. nerka salmon. Dis Aquat Organ 2005, 64(1):13-22.
    • (2005) Dis Aquat Organ , vol.64 , Issue.1 , pp. 13-22
    • Garver, K.A.1    LaPatra, S.E.2    Kurath, G.3
  • 8
    • 0036178381 scopus 로고    scopus 로고
    • Cysteine proteases of parasitic organisms
    • Sajid M., McKerrow J.H. Cysteine proteases of parasitic organisms. Mol Biochem Parasitol 2002, 120(1):1-21.
    • (2002) Mol Biochem Parasitol , vol.120 , Issue.1 , pp. 1-21
    • Sajid, M.1    McKerrow, J.H.2
  • 10
    • 33748308883 scopus 로고    scopus 로고
    • Targeting proteases: successes, failures and future prospects
    • Turk B. Targeting proteases: successes, failures and future prospects. Nat Rev Drug Discov 2006, 5(9):785-799.
    • (2006) Nat Rev Drug Discov , vol.5 , Issue.9 , pp. 785-799
    • Turk, B.1
  • 11
    • 4544349756 scopus 로고    scopus 로고
    • Differences in substrate specificities between cysteine protease CPB isoforms of Leishmania mexicana are mediated by a few amino acid changes
    • Juliano M.A., Brooks D.R., Selzer P.M., Pandolfo H.L., Judice W.A., Juliano L., et al. Differences in substrate specificities between cysteine protease CPB isoforms of Leishmania mexicana are mediated by a few amino acid changes. Eur J Biochem 2004, 271(18):3704-3714.
    • (2004) Eur J Biochem , vol.271 , Issue.18 , pp. 3704-3714
    • Juliano, M.A.1    Brooks, D.R.2    Selzer, P.M.3    Pandolfo, H.L.4    Judice, W.A.5    Juliano, L.6
  • 12
    • 0345310073 scopus 로고    scopus 로고
    • Revised definition of substrate binding sites of papain-like cysteine proteases
    • Turk D., Guncar G., Podobnik M., Turk B. Revised definition of substrate binding sites of papain-like cysteine proteases. Biol Chem 1998, 379(2):137-147.
    • (1998) Biol Chem , vol.379 , Issue.2 , pp. 137-147
    • Turk, D.1    Guncar, G.2    Podobnik, M.3    Turk, B.4
  • 14
    • 38349025512 scopus 로고    scopus 로고
    • Molecular cloning and functional characterisation of a cathepsin L-like proteinase from the fish kinetoplastid parasite Trypanosoma carassii
    • Ruszczyk A., Forlenza M., Savelkoul H.F., Wiegertjes G.F. Molecular cloning and functional characterisation of a cathepsin L-like proteinase from the fish kinetoplastid parasite Trypanosoma carassii. Fish Shellfish Immunol 2008, 24(2):205-214.
    • (2008) Fish Shellfish Immunol , vol.24 , Issue.2 , pp. 205-214
    • Ruszczyk, A.1    Forlenza, M.2    Savelkoul, H.F.3    Wiegertjes, G.F.4
  • 15
    • 0034930561 scopus 로고    scopus 로고
    • Evolutionary lines of cysteine peptidases
    • Barrett A.J., Rawlings N.D. Evolutionary lines of cysteine peptidases. Biol Chem 2001, 382(5):727-733.
    • (2001) Biol Chem , vol.382 , Issue.5 , pp. 727-733
    • Barrett, A.J.1    Rawlings, N.D.2
  • 17
    • 0035801514 scopus 로고    scopus 로고
    • Lysosomal cysteine proteases: facts and opportunities
    • Turk V., Turk B., Turk D. Lysosomal cysteine proteases: facts and opportunities. EMBO J 2001, 20(17):4629-4633.
    • (2001) EMBO J , vol.20 , Issue.17 , pp. 4629-4633
    • Turk, V.1    Turk, B.2    Turk, D.3
  • 18
    • 0027715975 scopus 로고
    • Fasciola hepatica: a secreted cathepsin L-like proteinase cleaves host immunoglobulin
    • Smith A.M., Dowd A.J., Heffernan M., Robertson C.D., Dalton J.P. Fasciola hepatica: a secreted cathepsin L-like proteinase cleaves host immunoglobulin. Int J Parasitol 1993, 23(8):977-983.
    • (1993) Int J Parasitol , vol.23 , Issue.8 , pp. 977-983
    • Smith, A.M.1    Dowd, A.J.2    Heffernan, M.3    Robertson, C.D.4    Dalton, J.P.5
  • 19
    • 0027491336 scopus 로고
    • Degradation of human IgA by Entamoeba histolytica
    • Kelsall B.L., Ravdin J.I. Degradation of human IgA by Entamoeba histolytica. J Infect Dis 1993, 168(5):1319-1322.
    • (1993) J Infect Dis , vol.168 , Issue.5 , pp. 1319-1322
    • Kelsall, B.L.1    Ravdin, J.I.2
  • 20
    • 0031883488 scopus 로고    scopus 로고
    • The neutral cysteine proteinase of Entamoeba histolytica degrades IgG and prevents its binding
    • Tran V.Q., Herdman D.S., Torian B.E., Reed S.L. The neutral cysteine proteinase of Entamoeba histolytica degrades IgG and prevents its binding. J Infect Dis 1998, 177(2):508-511.
    • (1998) J Infect Dis , vol.177 , Issue.2 , pp. 508-511
    • Tran, V.Q.1    Herdman, D.S.2    Torian, B.E.3    Reed, S.L.4
  • 21
    • 33750622641 scopus 로고    scopus 로고
    • Protection from murine cysticercosis by immunization with a parasite cysteine protease
    • Baig S., Damian R.T., Morales-Montor J., Ghaleb A., Baghdadi A., White A.C. Protection from murine cysticercosis by immunization with a parasite cysteine protease. Microbes Infect 2006, 8(12-13):2733-2735.
    • (2006) Microbes Infect , vol.8 , Issue.12-13 , pp. 2733-2735
    • Baig, S.1    Damian, R.T.2    Morales-Montor, J.3    Ghaleb, A.4    Baghdadi, A.5    White, A.C.6
  • 22
    • 0027070421 scopus 로고
    • A comparative study of allergenic and potentially allergenic enzymes from Dermatophagoides pteronyssinus, D. farinae and Euroglyphus maynei
    • Stewart G.A., Bird C.H., Krska K.D., Colloff M.J., Thompson P.J. A comparative study of allergenic and potentially allergenic enzymes from Dermatophagoides pteronyssinus, D. farinae and Euroglyphus maynei. Exp Appl Acarol 1992, 16(1-2):165-180.
    • (1992) Exp Appl Acarol , vol.16 , Issue.1-2 , pp. 165-180
    • Stewart, G.A.1    Bird, C.H.2    Krska, K.D.3    Colloff, M.J.4    Thompson, P.J.5
  • 23
    • 0029994048 scopus 로고    scopus 로고
    • Monoclonal antibodies against Dermatophagoides group I allergens as pseudo-cystatins blocking the catalytic site of cysteine proteinases
    • Cambra O., Berrens L. Monoclonal antibodies against Dermatophagoides group I allergens as pseudo-cystatins blocking the catalytic site of cysteine proteinases. Immunol Lett 1996, 50(3):173-177.
    • (1996) Immunol Lett , vol.50 , Issue.3 , pp. 173-177
    • Cambra, O.1    Berrens, L.2
  • 24
    • 0026784425 scopus 로고
    • The secreted and somatic proteinases of the bovine lungworm Dictyocaulus viviparus and their inhibition by antibody from infected and vaccinated animals
    • Britton C., Knox D.P., Canto G.J., Urquhart G.M., Kennedy M.W. The secreted and somatic proteinases of the bovine lungworm Dictyocaulus viviparus and their inhibition by antibody from infected and vaccinated animals. Parasitology 1992, 105(Pt 2):325-333.
    • (1992) Parasitology , vol.105 , Issue.PART 2 , pp. 325-333
    • Britton, C.1    Knox, D.P.2    Canto, G.J.3    Urquhart, G.M.4    Kennedy, M.W.5
  • 25
    • 33847639855 scopus 로고    scopus 로고
    • Differential expression of cysteine proteases in developmental stages of the parasitic ciliate Ichthyophthirius multifiliis
    • Jousson O., Di Bello D., Donadio E., Felicioli A., Pretti C. Differential expression of cysteine proteases in developmental stages of the parasitic ciliate Ichthyophthirius multifiliis. FEMS Microbiol Lett 2007, 269(1):77-84.
    • (2007) FEMS Microbiol Lett , vol.269 , Issue.1 , pp. 77-84
    • Jousson, O.1    Di Bello, D.2    Donadio, E.3    Felicioli, A.4    Pretti, C.5
  • 26
    • 0030720925 scopus 로고    scopus 로고
    • The in vitro inhibition of proteases from Cryptobia salmositica Katz by a monoclonal antibody (MAb-001) against a glycoprotein on the pathogenic haemoflagellate
    • Zuo X., Feng S., Woo P.T.K. The in vitro inhibition of proteases from Cryptobia salmositica Katz by a monoclonal antibody (MAb-001) against a glycoprotein on the pathogenic haemoflagellate. J Fish Dis 1997, 20(6):419-426.
    • (1997) J Fish Dis , vol.20 , Issue.6 , pp. 419-426
    • Zuo, X.1    Feng, S.2    Woo, P.T.K.3
  • 27
    • 0346336793 scopus 로고    scopus 로고
    • Cryptobia (Trypanoplasma) salmositica and salmonid cryptobiosis
    • Woo P.T. Cryptobia (Trypanoplasma) salmositica and salmonid cryptobiosis. J Fish Dis 2003, 26(11-12):627-646.
    • (2003) J Fish Dis , vol.26 , Issue.11-12 , pp. 627-646
    • Woo, P.T.1
  • 30
    • 45749101727 scopus 로고    scopus 로고
    • Induction and effector functions of T(H)17 cells
    • Bettelli E., Korn T., Oukka M., Kuchroo V.K. Induction and effector functions of T(H)17 cells. Nature 2008, 453(7198):1051-1057.
    • (2008) Nature , vol.453 , Issue.7198 , pp. 1051-1057
    • Bettelli, E.1    Korn, T.2    Oukka, M.3    Kuchroo, V.K.4
  • 31
    • 0027134811 scopus 로고
    • Kinetic analysis of antigen-specific immune responses in resistant and susceptible mice during infection with Trypanosoma cruzi
    • Hoft D.F., Lynch R.G., Kirchhoff L.V. Kinetic analysis of antigen-specific immune responses in resistant and susceptible mice during infection with Trypanosoma cruzi. J Immunol 1993, 151(12):7038-7047.
    • (1993) J Immunol , vol.151 , Issue.12 , pp. 7038-7047
    • Hoft, D.F.1    Lynch, R.G.2    Kirchhoff, L.V.3
  • 32
    • 0030992702 scopus 로고    scopus 로고
    • Parasite antigen-induced IFN-gamma and IL-4 production by cells from pathopermissive and pathoresistant strains of mice infected with Trypanosoma cruzi
    • Humphrey J.S., McCormick T.S., Rowland E.C. Parasite antigen-induced IFN-gamma and IL-4 production by cells from pathopermissive and pathoresistant strains of mice infected with Trypanosoma cruzi. J Parasitol 1997, 83(3):533-536.
    • (1997) J Parasitol , vol.83 , Issue.3 , pp. 533-536
    • Humphrey, J.S.1    McCormick, T.S.2    Rowland, E.C.3
  • 33
    • 0035313039 scopus 로고    scopus 로고
    • Antigen-specific Th1 but not Th2 cells provide protection from lethal Trypanosoma cruzi infection in mice
    • Kumar S., Tarleton R.L. Antigen-specific Th1 but not Th2 cells provide protection from lethal Trypanosoma cruzi infection in mice. J Immunol 2001, 166(7):4596-4603.
    • (2001) J Immunol , vol.166 , Issue.7 , pp. 4596-4603
    • Kumar, S.1    Tarleton, R.L.2
  • 34
    • 0036232437 scopus 로고    scopus 로고
    • Cruzipain, a major Trypanosoma cruzi antigen, conditions the host immune response in favor of parasite
    • Giordanengo L., Guinazu N., Stempin C., Fretes R., Cerban F., Gea S. Cruzipain, a major Trypanosoma cruzi antigen, conditions the host immune response in favor of parasite. Eur J Immunol 2002, 32(4):1003-1011.
    • (2002) Eur J Immunol , vol.32 , Issue.4 , pp. 1003-1011
    • Giordanengo, L.1    Guinazu, N.2    Stempin, C.3    Fretes, R.4    Cerban, F.5    Gea, S.6
  • 35
    • 0036718057 scopus 로고    scopus 로고
    • Cruzipain induces both mucosal and systemic protection against Trypanosoma cruzi in mice
    • Schnapp A.R., Eickhoff C.S., Sizemore D., Curtiss R., Hoft D.F. Cruzipain induces both mucosal and systemic protection against Trypanosoma cruzi in mice. Infect Immun 2002, 70(9):5065-5074.
    • (2002) Infect Immun , vol.70 , Issue.9 , pp. 5065-5074
    • Schnapp, A.R.1    Eickhoff, C.S.2    Sizemore, D.3    Curtiss, R.4    Hoft, D.F.5
  • 36
    • 0027528795 scopus 로고
    • Recombinant interleukin 12 cures mice infected with Leishmania major
    • Heinzel F.P., Schoenhaut D.S., Rerko R.M., Rosser L.E., Gately M.K. Recombinant interleukin 12 cures mice infected with Leishmania major. J Exp Med 1993, 177(5):1505-1509.
    • (1993) J Exp Med , vol.177 , Issue.5 , pp. 1505-1509
    • Heinzel, F.P.1    Schoenhaut, D.S.2    Rerko, R.M.3    Rosser, L.E.4    Gately, M.K.5
  • 37
    • 0027309318 scopus 로고
    • Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response
    • Sypek J.P., Chung C.L., Mayor S.E., Subramanyam J.M., Goldman S.J., Sieburth D.S., et al. Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 immune response. J Exp Med 1993, 177(6):1797-1802.
    • (1993) J Exp Med , vol.177 , Issue.6 , pp. 1797-1802
    • Sypek, J.P.1    Chung, C.L.2    Mayor, S.E.3    Subramanyam, J.M.4    Goldman, S.J.5    Sieburth, D.S.6
  • 38
    • 0028049247 scopus 로고
    • The adjuvant effect of interleukin-12 in a vaccine against Leishmania major
    • Afonso L.C., Scharton T.M., Vieira L.Q., Wysocka M., Trinchieri G., Scott P. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 1994, 263(5144):235-237.
    • (1994) Science , vol.263 , Issue.5144 , pp. 235-237
    • Afonso, L.C.1    Scharton, T.M.2    Vieira, L.Q.3    Wysocka, M.4    Trinchieri, G.5    Scott, P.6
  • 39
    • 0026783342 scopus 로고
    • Characterization of a multi-copy gene for a major stage-specific cysteine proteinase of Leishmania mexicana
    • Souza A.E., Waugh S., Coombs G.H., Mottram J.C. Characterization of a multi-copy gene for a major stage-specific cysteine proteinase of Leishmania mexicana. FEBS Lett 1992, 311(2):124-127.
    • (1992) FEBS Lett , vol.311 , Issue.2 , pp. 124-127
    • Souza, A.E.1    Waugh, S.2    Coombs, G.H.3    Mottram, J.C.4
  • 40
    • 0028314784 scopus 로고
    • Null mutants for the lmcpa cysteine proteinase gene in Leishmania mexicana
    • Souza A.E., Bates P.A., Coombs G.H., Mottram J.C. Null mutants for the lmcpa cysteine proteinase gene in Leishmania mexicana. Mol Biochem Parasitol 1994, 63(2):213-220.
    • (1994) Mol Biochem Parasitol , vol.63 , Issue.2 , pp. 213-220
    • Souza, A.E.1    Bates, P.A.2    Coombs, G.H.3    Mottram, J.C.4
  • 41
    • 0029898541 scopus 로고    scopus 로고
    • Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors
    • Mottram J.C., Souza A.E., Hutchison J.E., Carter R., Frame M.J., Coombs G.H. Evidence from disruption of the lmcpb gene array of Leishmania mexicana that cysteine proteinases are virulence factors. Proc Natl Acad Sci U S A 1996, 93(12):6008-6013.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , Issue.12 , pp. 6008-6013
    • Mottram, J.C.1    Souza, A.E.2    Hutchison, J.E.3    Carter, R.4    Frame, M.J.5    Coombs, G.H.6
  • 42
    • 0030745338 scopus 로고    scopus 로고
    • Cathepsin B-like cysteine proteinase-deficient mutants of Leishmania mexicana
    • Bart G., Frame M.J., Carter R., Coombs G.H., Mottram J.C. Cathepsin B-like cysteine proteinase-deficient mutants of Leishmania mexicana. Mol Biochem Parasitol 1997, 88(1-2):53-61.
    • (1997) Mol Biochem Parasitol , vol.88 , Issue.1-2 , pp. 53-61
    • Bart, G.1    Frame, M.J.2    Carter, R.3    Coombs, G.H.4    Mottram, J.C.5
  • 43
    • 4143091399 scopus 로고    scopus 로고
    • Cysteine peptidases as virulence factors of Leishmania
    • Mottram J.C., Coombs G.H., Alexander J. Cysteine peptidases as virulence factors of Leishmania. Curr Opin Microbiol 2004, 7(4):375-381.
    • (2004) Curr Opin Microbiol , vol.7 , Issue.4 , pp. 375-381
    • Mottram, J.C.1    Coombs, G.H.2    Alexander, J.3
  • 44
    • 0038104859 scopus 로고    scopus 로고
    • Expression of multiple CPB genes encoding cysteine proteases is required for Leishmania mexicana virulence in vivo
    • Denise H., McNeil K., Brooks D.R., Alexander J., Coombs G.H., Mottram J.C. Expression of multiple CPB genes encoding cysteine proteases is required for Leishmania mexicana virulence in vivo. Infect Immun 2003, 71(6):3190-3195.
    • (2003) Infect Immun , vol.71 , Issue.6 , pp. 3190-3195
    • Denise, H.1    McNeil, K.2    Brooks, D.R.3    Alexander, J.4    Coombs, G.H.5    Mottram, J.C.6
  • 45
    • 0141955100 scopus 로고    scopus 로고
    • Cysteine protease B of Leishmania mexicana inhibits host Th1 responses and protective immunity
    • Buxbaum L.U., Denise H., Coombs G.H., Alexander J., Mottram J.C., Scott P. Cysteine protease B of Leishmania mexicana inhibits host Th1 responses and protective immunity. J Immunol 2003, 171(7):3711-3717.
    • (2003) J Immunol , vol.171 , Issue.7 , pp. 3711-3717
    • Buxbaum, L.U.1    Denise, H.2    Coombs, G.H.3    Alexander, J.4    Mottram, J.C.5    Scott, P.6
  • 46
    • 0032534577 scopus 로고    scopus 로고
    • Leishmania mexicana cysteine proteinase-deficient mutants have attenuated virulence for mice and potentiate a Th1 response
    • Alexander J., Coombs G.H., Mottram J.C. Leishmania mexicana cysteine proteinase-deficient mutants have attenuated virulence for mice and potentiate a Th1 response. J Immunol 1998, 161(12):6794-6801.
    • (1998) J Immunol , vol.161 , Issue.12 , pp. 6794-6801
    • Alexander, J.1    Coombs, G.H.2    Mottram, J.C.3
  • 47
    • 0033820138 scopus 로고    scopus 로고
    • Analysis of the roles of cysteine proteinases of Leishmania mexicana in the host-parasite interaction
    • Frame M.J., Mottram J.C., Coombs G.H. Analysis of the roles of cysteine proteinases of Leishmania mexicana in the host-parasite interaction. Parasitology 2000, 121(Pt 4):367-377.
    • (2000) Parasitology , vol.121 , Issue.PART 4 , pp. 367-377
    • Frame, M.J.1    Mottram, J.C.2    Coombs, G.H.3
  • 48
    • 33646131385 scopus 로고    scopus 로고
    • Pathogenicity and protective immunogenicity of cysteine proteinase-deficient mutants of Leishmania mexicana in non-murine models
    • Saravia N.G., Escorcia B., Osorio Y., Valderrama L., Brooks D., Arteaga L., et al. Pathogenicity and protective immunogenicity of cysteine proteinase-deficient mutants of Leishmania mexicana in non-murine models. Vaccine 2006, 24(19):4247-4259.
    • (2006) Vaccine , vol.24 , Issue.19 , pp. 4247-4259
    • Saravia, N.G.1    Escorcia, B.2    Osorio, Y.3    Valderrama, L.4    Brooks, D.5    Arteaga, L.6
  • 49
    • 0037442201 scopus 로고    scopus 로고
    • The Leishmania mexicana cysteine protease, CPB2. 8, induces potent Th2 responses
    • Pollock K.G., McNeil K.S., Mottram J.C., Lyons R.E., Brewer J.M., Scott P., et al. The Leishmania mexicana cysteine protease, CPB2. 8, induces potent Th2 responses. J Immunol 2003, 170(4):1746-1753.
    • (2003) J Immunol , vol.170 , Issue.4 , pp. 1746-1753
    • Pollock, K.G.1    McNeil, K.S.2    Mottram, J.C.3    Lyons, R.E.4    Brewer, J.M.5    Scott, P.6
  • 50
    • 4344613395 scopus 로고    scopus 로고
    • Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway
    • Cameron P., McGachy A., Anderson M., Paul A., Coombs G.H., Mottram J.C., et al. Inhibition of lipopolysaccharide-induced macrophage IL-12 production by Leishmania mexicana amastigotes: the role of cysteine peptidases and the NF-kappaB signaling pathway. J Immunol 2004, 173(5):3297-3304.
    • (2004) J Immunol , vol.173 , Issue.5 , pp. 3297-3304
    • Cameron, P.1    McGachy, A.2    Anderson, M.3    Paul, A.4    Coombs, G.H.5    Mottram, J.C.6
  • 51
    • 0029155778 scopus 로고
    • Intracellular Leishmania amazonensis amastigotes internalize and degrade MHC class II molecules of their host cells
    • De Souza Leao S., Lang T., Prina E., Hellio R., Antoine J.C. Intracellular Leishmania amazonensis amastigotes internalize and degrade MHC class II molecules of their host cells. J Cell Sci 1995, 108(Pt 10):3219-3231.
    • (1995) J Cell Sci , vol.108 , Issue.PART 10 , pp. 3219-3231
    • De Souza Leao, S.1    Lang, T.2    Prina, E.3    Hellio, R.4    Antoine, J.C.5
  • 52
    • 0035869563 scopus 로고    scopus 로고
    • Successful therapy of lethal murine visceral leishmaniasis with cystatin involves up-regulation of nitric oxide and a favorable T cell response
    • Das L., Datta N., Bandyopadhyay S., Das P.K. Successful therapy of lethal murine visceral leishmaniasis with cystatin involves up-regulation of nitric oxide and a favorable T cell response. J Immunol 2001, 166(6):4020-4028.
    • (2001) J Immunol , vol.166 , Issue.6 , pp. 4020-4028
    • Das, L.1    Datta, N.2    Bandyopadhyay, S.3    Das, P.K.4
  • 53
    • 0033566010 scopus 로고    scopus 로고
    • Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni
    • Hoffmann K.F., James S.L., Cheever A.W., Wynn T.A. Studies with double cytokine-deficient mice reveal that highly polarized Th1- and Th2-type cytokine and antibody responses contribute equally to vaccine-induced immunity to Schistosoma mansoni. J Immunol 1999, 163(2):927-938.
    • (1999) J Immunol , vol.163 , Issue.2 , pp. 927-938
    • Hoffmann, K.F.1    James, S.L.2    Cheever, A.W.3    Wynn, T.A.4
  • 54
    • 0034333080 scopus 로고    scopus 로고
    • Defining a schistosomiasis vaccination strategy - is it really Th1 versus Th2?
    • Wynn T.A., Hoffmann K.F. Defining a schistosomiasis vaccination strategy - is it really Th1 versus Th2?. Parasitol Today 2000, 16(11):497-501.
    • (2000) Parasitol Today , vol.16 , Issue.11 , pp. 497-501
    • Wynn, T.A.1    Hoffmann, K.F.2
  • 55
    • 8944232099 scopus 로고    scopus 로고
    • Calpain is the target antigen of a Th1 clone that transfers protective immunity against Schistosoma mansoni
    • Jankovic D., Aslund L., Oswald I.P., Caspar P., Champion C., Pearce E., et al. Calpain is the target antigen of a Th1 clone that transfers protective immunity against Schistosoma mansoni. J Immunol 1996, 157(2):806-814.
    • (1996) J Immunol , vol.157 , Issue.2 , pp. 806-814
    • Jankovic, D.1    Aslund, L.2    Oswald, I.P.3    Caspar, P.4    Champion, C.5    Pearce, E.6
  • 56
    • 70350223474 scopus 로고    scopus 로고
    • Prime-boost and recombinant protein vaccination strategies using Sm-p80 protects against Schistosoma mansoni infection in the mouse model to levels previously attainable only by the irradiated cercarial vaccine
    • Ahmad G., Zhang W., Torben W., Haskins C., Diggs S., Noor Z., et al. Prime-boost and recombinant protein vaccination strategies using Sm-p80 protects against Schistosoma mansoni infection in the mouse model to levels previously attainable only by the irradiated cercarial vaccine. Parasitol Res 2009.
    • (2009) Parasitol Res
    • Ahmad, G.1    Zhang, W.2    Torben, W.3    Haskins, C.4    Diggs, S.5    Noor, Z.6
  • 57
    • 0034785619 scopus 로고    scopus 로고
    • CD4(+) T cells induced by a DNA vaccine: immunological consequences of epitope-specific lysosomal targeting
    • Rodriguez F., Harkins S., Redwine J.M., de Pereda J.M., Whitton J.L. CD4(+) T cells induced by a DNA vaccine: immunological consequences of epitope-specific lysosomal targeting. J Virol 2001, 75(21):10421-10430.
    • (2001) J Virol , vol.75 , Issue.21 , pp. 10421-10430
    • Rodriguez, F.1    Harkins, S.2    Redwine, J.M.3    de Pereda, J.M.4    Whitton, J.L.5
  • 58
    • 34447505851 scopus 로고    scopus 로고
    • DNA vaccines against protozoan parasites: advances and challenges
    • Dumonteil E. DNA vaccines against protozoan parasites: advances and challenges. J Biomed Biotechnol 2007, 2007(6):90520.
    • (2007) J Biomed Biotechnol , vol.2007 , Issue.6 , pp. 90520
    • Dumonteil, E.1
  • 59
  • 60
    • 0026579897 scopus 로고
    • Genetic immunization is a simple method for eliciting an immune response
    • Tang D.C., DeVit M., Johnston S.A. Genetic immunization is a simple method for eliciting an immune response. Nature 1992, 356(6365):152-154.
    • (1992) Nature , vol.356 , Issue.6365 , pp. 152-154
    • Tang, D.C.1    DeVit, M.2    Johnston, S.A.3
  • 61
    • 0027411456 scopus 로고
    • Heterologous protection against influenza by injection of DNA encoding a viral protein
    • Ulmer J.B., Donnelly J.J., Parker S.E., Rhodes G.H., Felgner P.L., Dwarki V.J., et al. Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 1993, 259(5102):1745-1749.
    • (1993) Science , vol.259 , Issue.5102 , pp. 1745-1749
    • Ulmer, J.B.1    Donnelly, J.J.2    Parker, S.E.3    Rhodes, G.H.4    Felgner, P.L.5    Dwarki, V.J.6
  • 62
    • 33646166860 scopus 로고    scopus 로고
    • Plasmid-mediated growth hormone-releasing hormone efficacy in reducing disease associated with Mycoplasma hyopneumoniae and porcine reproductive and respiratory syndrome virus infection
    • Thacker E.L., Holtkamp D.J., Khan A.S., Brown P.A., Draghia-Akli R. Plasmid-mediated growth hormone-releasing hormone efficacy in reducing disease associated with Mycoplasma hyopneumoniae and porcine reproductive and respiratory syndrome virus infection. J Anim Sci 2006, 84(3):733-742.
    • (2006) J Anim Sci , vol.84 , Issue.3 , pp. 733-742
    • Thacker, E.L.1    Holtkamp, D.J.2    Khan, A.S.3    Brown, P.A.4    Draghia-Akli, R.5
  • 64
    • 0035542678 scopus 로고    scopus 로고
    • Immunity to viral haemorrhagic septicaemia (VHS) following DNA vaccination of rainbow trout at an early life-stage
    • Lorenzen N., Lorenzen E., Einer-Jensen K. Immunity to viral haemorrhagic septicaemia (VHS) following DNA vaccination of rainbow trout at an early life-stage. Fish Shellfish Immunol 2001, 11(7):585-591.
    • (2001) Fish Shellfish Immunol , vol.11 , Issue.7 , pp. 585-591
    • Lorenzen, N.1    Lorenzen, E.2    Einer-Jensen, K.3
  • 65
    • 0034659616 scopus 로고    scopus 로고
    • Nanogram quantities of a DNA vaccine protect rainbow trout fry against heterologous strains of infectious hematopoietic necrosis virus
    • Corbeil S., LaPatra S.E., Anderson E.D., Kurath G. Nanogram quantities of a DNA vaccine protect rainbow trout fry against heterologous strains of infectious hematopoietic necrosis virus. Vaccine 2000, 18(25):2817-2824.
    • (2000) Vaccine , vol.18 , Issue.25 , pp. 2817-2824
    • Corbeil, S.1    LaPatra, S.E.2    Anderson, E.D.3    Kurath, G.4
  • 66
    • 0035984566 scopus 로고    scopus 로고
    • DNA vaccines as a tool for analysing the protective immune response against rhabdoviruses in rainbow trout
    • Lorenzen N., Lorenzen E., Einer-Jensen K., LaPatra S.E. DNA vaccines as a tool for analysing the protective immune response against rhabdoviruses in rainbow trout. Fish Shellfish Immunol 2002, 12(5):439-453.
    • (2002) Fish Shellfish Immunol , vol.12 , Issue.5 , pp. 439-453
    • Lorenzen, N.1    Lorenzen, E.2    Einer-Jensen, K.3    LaPatra, S.E.4
  • 68
    • 78650171049 scopus 로고    scopus 로고
    • Molecular cloning of IgT from Atlantic salmon, and analysis of the relative expression of tau, mu, and delta in different tissues
    • Tadiso T.M., Lie K.K., Hordvik I. Molecular cloning of IgT from Atlantic salmon, and analysis of the relative expression of tau, mu, and delta in different tissues. Vet Immunol Immunopathol 2011, 139(1):17-26.
    • (2011) Vet Immunol Immunopathol , vol.139 , Issue.1 , pp. 17-26
    • Tadiso, T.M.1    Lie, K.K.2    Hordvik, I.3
  • 69
    • 56249092734 scopus 로고    scopus 로고
    • Fish immunity and parasite infections: from innate immunity to immunoprophylactic prospects
    • Alvarez-Pellitero P. Fish immunity and parasite infections: from innate immunity to immunoprophylactic prospects. Vet Immunol Immunopathol 2008, 126(3-4):171-198.
    • (2008) Vet Immunol Immunopathol , vol.126 , Issue.3-4 , pp. 171-198
    • Alvarez-Pellitero, P.1
  • 70
    • 0000934162 scopus 로고    scopus 로고
    • Immunity to bacteria in fish
    • Ellis A.E. Immunity to bacteria in fish. Fish Shellfish Immunol 1999, 9(4):291-308.
    • (1999) Fish Shellfish Immunol , vol.9 , Issue.4 , pp. 291-308
    • Ellis, A.E.1
  • 71
    • 0035850570 scopus 로고    scopus 로고
    • Host responses against the fish parasitizing ciliate Ichthyophthirius multifiliis
    • Buchmann K., Sigh J., Nielsen C.V., Dalgaard M. Host responses against the fish parasitizing ciliate Ichthyophthirius multifiliis. Vet Parasitol 2001, 100(1-2):105-116.
    • (2001) Vet Parasitol , vol.100 , Issue.1-2 , pp. 105-116
    • Buchmann, K.1    Sigh, J.2    Nielsen, C.V.3    Dalgaard, M.4
  • 72
    • 79952188338 scopus 로고    scopus 로고
    • Cellular and humoral factors involved in the response of rainbow trout gills to Ichthyophthirius multifiliis infections: molecular and immunohistochemical studies
    • Olsen M.M., Kania P.W., Heinecke R.D., Skjoedt K., Rasmussen K.J., Buchmann K. Cellular and humoral factors involved in the response of rainbow trout gills to Ichthyophthirius multifiliis infections: molecular and immunohistochemical studies. Fish Shellfish Immunol 2011, 30(3):859-869.
    • (2011) Fish Shellfish Immunol , vol.30 , Issue.3 , pp. 859-869
    • Olsen, M.M.1    Kania, P.W.2    Heinecke, R.D.3    Skjoedt, K.4    Rasmussen, K.J.5    Buchmann, K.6
  • 73
    • 84856081835 scopus 로고    scopus 로고
    • Experimental evidence for direct in situ binding of IgM and IgT to invading early trophonts of Ichthyophthirius multifiliis (Fouquet) theronts in the gills of rainbow trout Oncorhynchus mykiss (Walbaum). J Fish Dis; in press.
    • Jørgensen LvG, Heinecke RD, Skjoedt K, Rasmussen KJ, Buchmann K. Experimental evidence for direct in situ binding of IgM and IgT to invading early trophonts of Ichthyophthirius multifiliis (Fouquet) theronts in the gills of rainbow trout Oncorhynchus mykiss (Walbaum). J Fish Dis; in press.
    • Jørgensen, L.V.G.1    Heinecke, R.D.2    Skjoedt, K.3    Rasmussen, K.J.4    Buchmann, K.5
  • 74
    • 44749092292 scopus 로고    scopus 로고
    • What happens to the DNA vaccine in fish? A review of current knowledge
    • Tonheim T.C., Bogwald J., Dalmo R.A. What happens to the DNA vaccine in fish? A review of current knowledge. Fish Shellfish Immunol 2008, 25(1-2):1-18.
    • (2008) Fish Shellfish Immunol , vol.25 , Issue.1-2 , pp. 1-18
    • Tonheim, T.C.1    Bogwald, J.2    Dalmo, R.A.3
  • 75
    • 0031079644 scopus 로고    scopus 로고
    • Import of plasmid DNA into the nucleus is sequence specific
    • Dean D.A. Import of plasmid DNA into the nucleus is sequence specific. Exp Cell Res 1997, 230(2):293-302.
    • (1997) Exp Cell Res , vol.230 , Issue.2 , pp. 293-302
    • Dean, D.A.1
  • 76
    • 16344365421 scopus 로고    scopus 로고
    • DNA vaccines: designing strategies against parasitic infections
    • Ivory C., Chadee K. DNA vaccines: designing strategies against parasitic infections. Genet Vaccines Ther 2004, 2(1):17.
    • (2004) Genet Vaccines Ther , vol.2 , Issue.1 , pp. 17
    • Ivory, C.1    Chadee, K.2
  • 77
    • 0037029879 scopus 로고    scopus 로고
    • Muscle specific versus ubiquitous expression of Gag based HIV-1 DNA vaccines: a comparative analysis
    • Bojak A., Hammer D., Wolf H., Wagner R. Muscle specific versus ubiquitous expression of Gag based HIV-1 DNA vaccines: a comparative analysis. Vaccine 2002, 20(15):1975-1979.
    • (2002) Vaccine , vol.20 , Issue.15 , pp. 1975-1979
    • Bojak, A.1    Hammer, D.2    Wolf, H.3    Wagner, R.4
  • 78
    • 0037056040 scopus 로고    scopus 로고
    • Comparative study of immune responses induced after immunization with plasmids encoding the HIV-1 Nef protein under the control of the CMV-IE or the muscle-specific desmin promoter
    • Cazeaux N., Bennasser Y., Vidal P.L., Li Z., Paulin D., Bahraoui E. Comparative study of immune responses induced after immunization with plasmids encoding the HIV-1 Nef protein under the control of the CMV-IE or the muscle-specific desmin promoter. Vaccine 2002, 20(27-28):3322-3331.
    • (2002) Vaccine , vol.20 , Issue.27-28 , pp. 3322-3331
    • Cazeaux, N.1    Bennasser, Y.2    Vidal, P.L.3    Li, Z.4    Paulin, D.5    Bahraoui, E.6
  • 80
    • 57549095591 scopus 로고    scopus 로고
    • In vitro analysis of expression vectors for DNA vaccination of horses: the effect of a Kozak sequence
    • Olafsdottir G., Svansson V., Ingvarsson S., Marti E., Torsteinsdottir S. In vitro analysis of expression vectors for DNA vaccination of horses: the effect of a Kozak sequence. Acta Vet Scand 2008, 50:44.
    • (2008) Acta Vet Scand , vol.50 , pp. 44
    • Olafsdottir, G.1    Svansson, V.2    Ingvarsson, S.3    Marti, E.4    Torsteinsdottir, S.5
  • 81
    • 23944448168 scopus 로고    scopus 로고
    • Optimization of codon usage enhances the immunogenicity of a DNA vaccine encoding mycobacterial antigen Ag85B
    • Ko H.J., Ko S.Y., Kim Y.J., Lee E.G., Cho S.N., Kang C.Y. Optimization of codon usage enhances the immunogenicity of a DNA vaccine encoding mycobacterial antigen Ag85B. Infect Immun 2005, 73(9):5666-5674.
    • (2005) Infect Immun , vol.73 , Issue.9 , pp. 5666-5674
    • Ko, H.J.1    Ko, S.Y.2    Kim, Y.J.3    Lee, E.G.4    Cho, S.N.5    Kang, C.Y.6
  • 82
    • 0037123363 scopus 로고    scopus 로고
    • The use of synthetic genes for the expression of ciliate proteins in heterologous systems
    • Lin Y., Cheng G., Wang X., Clark T.G. The use of synthetic genes for the expression of ciliate proteins in heterologous systems. Gene 2002, 288(1-2):85-94.
    • (2002) Gene , vol.288 , Issue.1-2 , pp. 85-94
    • Lin, Y.1    Cheng, G.2    Wang, X.3    Clark, T.G.4
  • 83
    • 0029813303 scopus 로고    scopus 로고
    • Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are dependent on the route of vector DNA delivery
    • Pertmer T.M., Roberts T.R., Haynes J.R. Influenza virus nucleoprotein-specific immunoglobulin G subclass and cytokine responses elicited by DNA vaccination are dependent on the route of vector DNA delivery. J Virol 1996, 70(9):6119-6125.
    • (1996) J Virol , vol.70 , Issue.9 , pp. 6119-6125
    • Pertmer, T.M.1    Roberts, T.R.2    Haynes, J.R.3
  • 84
    • 0031093543 scopus 로고    scopus 로고
    • Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization
    • Feltquate D.M., Heaney S., Webster R.G., Robinson H.L. Different T helper cell types and antibody isotypes generated by saline and gene gun DNA immunization. J Immunol 1997, 158(5):2278-2284.
    • (1997) J Immunol , vol.158 , Issue.5 , pp. 2278-2284
    • Feltquate, D.M.1    Heaney, S.2    Webster, R.G.3    Robinson, H.L.4
  • 85
    • 0034046182 scopus 로고    scopus 로고
    • DNA vaccines: immunology, application, and optimization*
    • Gurunathan S., Klinman D.M., Seder R.A. DNA vaccines: immunology, application, and optimization*. Annu Rev Immunol 2000, 18:927-974.
    • (2000) Annu Rev Immunol , vol.18 , pp. 927-974
    • Gurunathan, S.1    Klinman, D.M.2    Seder, R.A.3
  • 86
    • 2942605891 scopus 로고    scopus 로고
    • Antibody responses to Brugia malayi antigens induced by DNA vaccination
    • Li B.W., Rush A., Zhang S.R., Curtis K.C., Weil G.J. Antibody responses to Brugia malayi antigens induced by DNA vaccination. Filaria J 2004, 3(1):1.
    • (2004) Filaria J , vol.3 , Issue.1 , pp. 1
    • Li, B.W.1    Rush, A.2    Zhang, S.R.3    Curtis, K.C.4    Weil, G.J.5
  • 87
    • 0033587314 scopus 로고    scopus 로고
    • Immune responses and protection obtained by oral immunization with rotavirus VP4 and VP7 DNA vaccines encapsulated in microparticles
    • Herrmann J.E., Chen S.C., Jones D.H., Tinsley-Bown A., Fynan E.F., Greenberg H.B., et al. Immune responses and protection obtained by oral immunization with rotavirus VP4 and VP7 DNA vaccines encapsulated in microparticles. Virology 1999, 259(1):148-153.
    • (1999) Virology , vol.259 , Issue.1 , pp. 148-153
    • Herrmann, J.E.1    Chen, S.C.2    Jones, D.H.3    Tinsley-Bown, A.4    Fynan, E.F.5    Greenberg, H.B.6
  • 88
    • 3142530535 scopus 로고    scopus 로고
    • Immunogenicity in mice of a cationic microparticle-adsorbed plasmid DNA encoding Japanese encephalitis virus envelope protein
    • Kaur R., Rauthan M., Vrati S. Immunogenicity in mice of a cationic microparticle-adsorbed plasmid DNA encoding Japanese encephalitis virus envelope protein. Vaccine 2004, 22(21-22):2776-2782.
    • (2004) Vaccine , vol.22 , Issue.21-22 , pp. 2776-2782
    • Kaur, R.1    Rauthan, M.2    Vrati, S.3
  • 89
    • 0032863158 scopus 로고    scopus 로고
    • Protective immunization against melanoma by gp100 DNA-HVJ-liposome vaccine
    • Zhou W.Z., Kaneda Y., Huang S., Morishita R., Hoon D. Protective immunization against melanoma by gp100 DNA-HVJ-liposome vaccine. Gene Ther 1999, 6(10):1768-1773.
    • (1999) Gene Ther , vol.6 , Issue.10 , pp. 1768-1773
    • Zhou, W.Z.1    Kaneda, Y.2    Huang, S.3    Morishita, R.4    Hoon, D.5
  • 90
    • 34547914816 scopus 로고    scopus 로고
    • Strong cellular and humoral immune responses induced by transcutaneous immunization with HBsAg DNA-cationic deformable liposome complex
    • Wang J., Hu J.H., Li F.Q., Liu G.Z., Zhu Q.G., Liu J.Y., et al. Strong cellular and humoral immune responses induced by transcutaneous immunization with HBsAg DNA-cationic deformable liposome complex. Exp Dermatol 2007, 16(9):724-729.
    • (2007) Exp Dermatol , vol.16 , Issue.9 , pp. 724-729
    • Wang, J.1    Hu, J.H.2    Li, F.Q.3    Liu, G.Z.4    Zhu, Q.G.5    Liu, J.Y.6
  • 91
    • 9644278103 scopus 로고    scopus 로고
    • Intranasal immunization with liposome-encapsulated plasmid DNA encoding influenza virus hemagglutinin elicits mucosal, cellular and humoral immune responses
    • Wang D., Christopher M.E., Nagata L.P., Zabielski M.A., Li H., Wong J.P., et al. Intranasal immunization with liposome-encapsulated plasmid DNA encoding influenza virus hemagglutinin elicits mucosal, cellular and humoral immune responses. J Clin Virol 2004, 31(Suppl 1):S99-106.
    • (2004) J Clin Virol , vol.31 , Issue.SUPPL. 1
    • Wang, D.1    Christopher, M.E.2    Nagata, L.P.3    Zabielski, M.A.4    Li, H.5    Wong, J.P.6
  • 92
    • 28844459086 scopus 로고    scopus 로고
    • Enhancement of immunity by a DNA melanoma vaccine against TRP2 with CCL21 as an adjuvant
    • Yamano T., Kaneda Y., Huang S., Hiramatsu S.H., Hoon D.S.B. Enhancement of immunity by a DNA melanoma vaccine against TRP2 with CCL21 as an adjuvant. Mol Ther 2006, 13(1):194-202.
    • (2006) Mol Ther , vol.13 , Issue.1 , pp. 194-202
    • Yamano, T.1    Kaneda, Y.2    Huang, S.3    Hiramatsu, S.H.4    Hoon, D.S.B.5
  • 93
    • 0033766645 scopus 로고    scopus 로고
    • Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination
    • Barouch D.H., Santra S., Schmitz J.E., Kuroda M.J., Fu T.M., Wagner W., et al. Control of viremia and prevention of clinical AIDS in rhesus monkeys by cytokine-augmented DNA vaccination. Science 2000, 290(5491):486-492.
    • (2000) Science , vol.290 , Issue.5491 , pp. 486-492
    • Barouch, D.H.1    Santra, S.2    Schmitz, J.E.3    Kuroda, M.J.4    Fu, T.M.5    Wagner, W.6
  • 94
    • 0031568095 scopus 로고    scopus 로고
    • In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen
    • Kim J.J., Ayyavoo V., Bagarazzi M.L., Chattergoon M.A., Dang K., Wang B., et al. In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen. J Immunol 1997, 158(2):816-826.
    • (1997) J Immunol , vol.158 , Issue.2 , pp. 816-826
    • Kim, J.J.1    Ayyavoo, V.2    Bagarazzi, M.L.3    Chattergoon, M.A.4    Dang, K.5    Wang, B.6
  • 95
    • 24744463560 scopus 로고    scopus 로고
    • Activation of innate immunity, inflammation, and potentiation of DNA vaccination through mammalian expression of the TLR5 agonist flagellin
    • Applequist S.E., Rollman E., Wareing M.D., Liden M., Rozell B., Hinkula J., et al. Activation of innate immunity, inflammation, and potentiation of DNA vaccination through mammalian expression of the TLR5 agonist flagellin. J Immunol 2005, 175(6):3882-3891.
    • (2005) J Immunol , vol.175 , Issue.6 , pp. 3882-3891
    • Applequist, S.E.1    Rollman, E.2    Wareing, M.D.3    Liden, M.4    Rozell, B.5    Hinkula, J.6
  • 96
    • 69349101739 scopus 로고    scopus 로고
    • Enhancement of the priming efficacy of DNA vaccines encoding dendritic cell-targeted antigens by synergistic toll-like receptor ligands
    • Grossmann C., Tenbusch M., Nchinda G., Temchura V., Nabi G., Stone G.W., et al. Enhancement of the priming efficacy of DNA vaccines encoding dendritic cell-targeted antigens by synergistic toll-like receptor ligands. BMC Immunol 2009, 10:43.
    • (2009) BMC Immunol , vol.10 , pp. 43
    • Grossmann, C.1    Tenbusch, M.2    Nchinda, G.3    Temchura, V.4    Nabi, G.5    Stone, G.W.6
  • 97
    • 78650301390 scopus 로고    scopus 로고
    • Effects of particle size on toll-like receptor 9-mediated cytokine profiles
    • Chen H.C., Sun B., Tran K.K., Shen H. Effects of particle size on toll-like receptor 9-mediated cytokine profiles. Biomaterials 2011, 32(6):1731-1737.
    • (2011) Biomaterials , vol.32 , Issue.6 , pp. 1731-1737
    • Chen, H.C.1    Sun, B.2    Tran, K.K.3    Shen, H.4
  • 98
    • 32944464648 scopus 로고    scopus 로고
    • Pathogen recognition and innate immunity
    • Akira S., Uematsu S., Takeuchi O. Pathogen recognition and innate immunity. Cell 2006, 124(4):783-801.
    • (2006) Cell , vol.124 , Issue.4 , pp. 783-801
    • Akira, S.1    Uematsu, S.2    Takeuchi, O.3
  • 99
    • 42049083555 scopus 로고    scopus 로고
    • T cell responses generated by HIV vaccines in clinical trials
    • De Rosa S.D., McElrath M.J. T cell responses generated by HIV vaccines in clinical trials. Curr Opin HIV AIDS 2008, 3(3):375-379.
    • (2008) Curr Opin HIV AIDS , vol.3 , Issue.3 , pp. 375-379
    • De Rosa, S.D.1    McElrath, M.J.2
  • 100
    • 33845412550 scopus 로고    scopus 로고
    • Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 DNA candidate vaccine
    • Graham B.S., Koup R.A., Roederer M., Bailer R.T., Enama M.E., Moodie Z., et al. Phase 1 safety and immunogenicity evaluation of a multiclade HIV-1 DNA candidate vaccine. J Infect Dis 2006, 194(12):1650-1660.
    • (2006) J Infect Dis , vol.194 , Issue.12 , pp. 1650-1660
    • Graham, B.S.1    Koup, R.A.2    Roederer, M.3    Bailer, R.T.4    Enama, M.E.5    Moodie, Z.6
  • 101
    • 0032973140 scopus 로고    scopus 로고
    • HIV-1 DNA vaccines
    • Fomsgaard A. HIV-1 DNA vaccines. Immunol Lett 1999, 65(1-2):127-131.
    • (1999) Immunol Lett , vol.65 , Issue.1-2 , pp. 127-131
    • Fomsgaard, A.1
  • 103
    • 0037095578 scopus 로고    scopus 로고
    • Influenza DNA vaccines
    • Ulmer J.B. Influenza DNA vaccines. Vaccine 2002, 20(Suppl. 2):S74-S76.
    • (2002) Vaccine , vol.20 , Issue.SUPPL. 2
    • Ulmer, J.B.1
  • 104
    • 41049092088 scopus 로고    scopus 로고
    • A DNA vaccine against tuberculosis based on the 65kDa heat-shock protein differentially activates human macrophages and dendritic cells
    • Franco L.H., Wowk P.F., Silva C.L., Trombone A.P., Coelho-Castelo A.A., Oliver C., et al. A DNA vaccine against tuberculosis based on the 65kDa heat-shock protein differentially activates human macrophages and dendritic cells. Genet Vaccines Ther 2008, 6:3.
    • (2008) Genet Vaccines Ther , vol.6 , pp. 3
    • Franco, L.H.1    Wowk, P.F.2    Silva, C.L.3    Trombone, A.P.4    Coelho-Castelo, A.A.5    Oliver, C.6
  • 105
    • 32844455083 scopus 로고    scopus 로고
    • DNA vaccines for therapy of tuberculosis: where are we now?
    • Lowrie D.B. DNA vaccines for therapy of tuberculosis: where are we now?. Vaccine 2006, 24(12):1983-1989.
    • (2006) Vaccine , vol.24 , Issue.12 , pp. 1983-1989
    • Lowrie, D.B.1
  • 106
    • 48849115460 scopus 로고    scopus 로고
    • Persistence of Entamoeba histolytica infection in CBA mice owes to intestinal IL-4 production and inhibition of protective IFN-gamma
    • Guo X., Stroup S.E., Houpt E.R. Persistence of Entamoeba histolytica infection in CBA mice owes to intestinal IL-4 production and inhibition of protective IFN-gamma. Mucosal Immunol 2008, 1(2):139-146.
    • (2008) Mucosal Immunol , vol.1 , Issue.2 , pp. 139-146
    • Guo, X.1    Stroup, S.E.2    Houpt, E.R.3
  • 107
    • 3142547281 scopus 로고    scopus 로고
    • Cysteine proteinase activity is required for survival of the parasite in experimental acute amoebic liver abscesses in hamsters
    • Olivos-Garcia A., Tello E., Nequiz-Avendano M., Gonzalez-Canto A., Lopez-Vancell R., Garcia de Leon M.C., et al. Cysteine proteinase activity is required for survival of the parasite in experimental acute amoebic liver abscesses in hamsters. Parasitology 2004, 129(Pt 1):19-25.
    • (2004) Parasitology , vol.129 , Issue.PART 1 , pp. 19-25
    • Olivos-Garcia, A.1    Tello, E.2    Nequiz-Avendano, M.3    Gonzalez-Canto, A.4    Lopez-Vancell, R.5    Garcia de Leon, M.C.6
  • 108
    • 67349241691 scopus 로고    scopus 로고
    • A pcDNA-Ehcpadh vaccine against Entamoeba histolytica elicits a protective Th1-like response in hamster liver
    • Martinez M.B., Rodriguez M.A., Garcia-Rivera G., Sanchez T., Hernandez-Pando R., Aguilar D., et al. A pcDNA-Ehcpadh vaccine against Entamoeba histolytica elicits a protective Th1-like response in hamster liver. Vaccine 2009, 27(31):4176-4186.
    • (2009) Vaccine , vol.27 , Issue.31 , pp. 4176-4186
    • Martinez, M.B.1    Rodriguez, M.A.2    Garcia-Rivera, G.3    Sanchez, T.4    Hernandez-Pando, R.5    Aguilar, D.6
  • 109
    • 2342461107 scopus 로고    scopus 로고
    • Immunization with the hybrid protein vaccine, consisting of Leishmania major cysteine proteinases Type I (CPB) and Type II (CPA), partially protects against leishmaniasis
    • Zadeh-Vakili A., Taheri T., Taslimi Y., Doustdari F., Salmanian A.H., Rafati S. Immunization with the hybrid protein vaccine, consisting of Leishmania major cysteine proteinases Type I (CPB) and Type II (CPA), partially protects against leishmaniasis. Vaccine 2004, 22(15-16):1930-1940.
    • (2004) Vaccine , vol.22 , Issue.15-16 , pp. 1930-1940
    • Zadeh-Vakili, A.1    Taheri, T.2    Taslimi, Y.3    Doustdari, F.4    Salmanian, A.H.5    Rafati, S.6
  • 110
    • 0035858106 scopus 로고    scopus 로고
    • A protective cocktail vaccine against murine cutaneous leishmaniasis with DNA encoding cysteine proteinases of Leishmania major
    • Rafati S., Salmanian A.H., Taheri T., Vafa M., Fasel N. A protective cocktail vaccine against murine cutaneous leishmaniasis with DNA encoding cysteine proteinases of Leishmania major. Vaccine 2001, 19(25-26):3369-3375.
    • (2001) Vaccine , vol.19 , Issue.25-26 , pp. 3369-3375
    • Rafati, S.1    Salmanian, A.H.2    Taheri, T.3    Vafa, M.4    Fasel, N.5
  • 111
    • 0037035854 scopus 로고    scopus 로고
    • Recombinant cysteine proteinases-based vaccines against Leishmania major in BALB/c mice: the partial protection relies on interferon gamma producing CD8(+) T lymphocyte activation
    • Rafati S., Kariminia A., Seyde-Eslami S., Narimani M., Taheri T., Lebbatard M. Recombinant cysteine proteinases-based vaccines against Leishmania major in BALB/c mice: the partial protection relies on interferon gamma producing CD8(+) T lymphocyte activation. Vaccine 2002, 20(19-20):2439-2447.
    • (2002) Vaccine , vol.20 , Issue.19-20 , pp. 2439-2447
    • Rafati, S.1    Kariminia, A.2    Seyde-Eslami, S.3    Narimani, M.4    Taheri, T.5    Lebbatard, M.6
  • 112
    • 0037449085 scopus 로고    scopus 로고
    • DNA vaccines induce partial protection against Leishmania mexicana
    • Dumonteil E., Maria Jesus R.S., Javier E.O., Maria del Rosario G.M. DNA vaccines induce partial protection against Leishmania mexicana. Vaccine 2003, 21(17-18):2161-2168.
    • (2003) Vaccine , vol.21 , Issue.17-18 , pp. 2161-2168
    • Dumonteil, E.1    Maria Jesus, R.S.2    Javier, E.O.3    Maria del Rosario, G.M.4
  • 113
    • 21044441505 scopus 로고    scopus 로고
    • Protective vaccination against experimental canine visceral leishmaniasis using a combination of DNA and protein immunization with cysteine proteinases type I and II of L. infantum
    • Rafati S., Nakhaee A., Taheri T., Taslimi Y., Darabi H., Eravani D., et al. Protective vaccination against experimental canine visceral leishmaniasis using a combination of DNA and protein immunization with cysteine proteinases type I and II of L. infantum. Vaccine 2005, 23(28):3716-3725.
    • (2005) Vaccine , vol.23 , Issue.28 , pp. 3716-3725
    • Rafati, S.1    Nakhaee, A.2    Taheri, T.3    Taslimi, Y.4    Darabi, H.5    Eravani, D.6
  • 114
    • 32844459122 scopus 로고    scopus 로고
    • Prime-boost vaccination using cysteine proteinases type I and II of Leishmania infantum confers protective immunity in murine visceral leishmaniasis
    • Rafati S., Zahedifard F., Nazgouee F. Prime-boost vaccination using cysteine proteinases type I and II of Leishmania infantum confers protective immunity in murine visceral leishmaniasis. Vaccine 2006, 24(12):2169-2175.
    • (2006) Vaccine , vol.24 , Issue.12 , pp. 2169-2175
    • Rafati, S.1    Zahedifard, F.2    Nazgouee, F.3
  • 115
    • 36749085459 scopus 로고    scopus 로고
    • Towards a metalloprotease-DNA vaccine against piscine cryptobiosis caused by Cryptobia salmositica
    • Tan C.W., Jesudhasan P., Woo P.T. Towards a metalloprotease-DNA vaccine against piscine cryptobiosis caused by Cryptobia salmositica. Parasitol Res 2008, 102(2):265-275.
    • (2008) Parasitol Res , vol.102 , Issue.2 , pp. 265-275
    • Tan, C.W.1    Jesudhasan, P.2    Woo, P.T.3
  • 116
    • 34147117996 scopus 로고    scopus 로고
    • Falcipain-1, a Plasmodium falciparum cysteine protease with vaccine potential
    • Kumar A., Kumar K., Korde R., Puri S.K., Malhotra P., Singh Chauhan V. Falcipain-1, a Plasmodium falciparum cysteine protease with vaccine potential. Infect Immun 2007, 75(4):2026-2034.
    • (2007) Infect Immun , vol.75 , Issue.4 , pp. 2026-2034
    • Kumar, A.1    Kumar, K.2    Korde, R.3    Puri, S.K.4    Malhotra, P.5    Singh Chauhan, V.6
  • 117
    • 0029807053 scopus 로고    scopus 로고
    • Induction of protective immunity in cattle against infection with Fasciola hepatica by vaccination with cathepsin L proteinases and with hemoglobin
    • Dalton J.P., McGonigle S., Rolph T.P., Andrews S.J. Induction of protective immunity in cattle against infection with Fasciola hepatica by vaccination with cathepsin L proteinases and with hemoglobin. Infect Immun 1996, 64(12):5066-5074.
    • (1996) Infect Immun , vol.64 , Issue.12 , pp. 5066-5074
    • Dalton, J.P.1    McGonigle, S.2    Rolph, T.P.3    Andrews, S.J.4
  • 118
    • 1942477617 scopus 로고    scopus 로고
    • Identification of a novel Fasciola hepatica cathepsin L protease containing protective epitopes within the propeptide
    • Harmsen M.M., Cornelissen J.B., Buijs H.E., Boersma W.J., Jeurissen S.H., van Milligen F.J. Identification of a novel Fasciola hepatica cathepsin L protease containing protective epitopes within the propeptide. Int J Parasitol 2004, 34(6):675-682.
    • (2004) Int J Parasitol , vol.34 , Issue.6 , pp. 675-682
    • Harmsen, M.M.1    Cornelissen, J.B.2    Buijs, H.E.3    Boersma, W.J.4    Jeurissen, S.H.5    van Milligen, F.J.6
  • 119
    • 33344467062 scopus 로고    scopus 로고
    • Vaccination with DNA encoding cysteine proteinase confers protective immune response to rats infected with Clonorchis sinensis
    • Lee J.S., Kim I.S., Sohn W.M., Lee J., Yong T.S. Vaccination with DNA encoding cysteine proteinase confers protective immune response to rats infected with Clonorchis sinensis. Vaccine 2006, 24(13):2358-2366.
    • (2006) Vaccine , vol.24 , Issue.13 , pp. 2358-2366
    • Lee, J.S.1    Kim, I.S.2    Sohn, W.M.3    Lee, J.4    Yong, T.S.5
  • 120
    • 0035851378 scopus 로고    scopus 로고
    • DNA vaccination with asparaginyl endopeptidase (Sm32) from the parasite Schistosoma mansoni: anti-fecundity effect induced in mice
    • Chlichlia K., Bahgat M., Ruppel A., Schirrmacher V. DNA vaccination with asparaginyl endopeptidase (Sm32) from the parasite Schistosoma mansoni: anti-fecundity effect induced in mice. Vaccine 2001, 20(3-4):439-447.
    • (2001) Vaccine , vol.20 , Issue.3-4 , pp. 439-447
    • Chlichlia, K.1    Bahgat, M.2    Ruppel, A.3    Schirrmacher, V.4
  • 121
    • 0038310628 scopus 로고    scopus 로고
    • Induction of protective immunity against Schistosoma mansoni via DNA priming and boosting with the large subunit of calpain (Sm-p80): adjuvant effects of granulocyte-macrophage colony-stimulating factor and interleukin-4
    • Siddiqui A.A., Phillips T., Charest H., Podesta R.B., Quinlin M.L., Pinkston J.R., et al. Induction of protective immunity against Schistosoma mansoni via DNA priming and boosting with the large subunit of calpain (Sm-p80): adjuvant effects of granulocyte-macrophage colony-stimulating factor and interleukin-4. Infect Immun 2003, 71(7):3844-3851.
    • (2003) Infect Immun , vol.71 , Issue.7 , pp. 3844-3851
    • Siddiqui, A.A.1    Phillips, T.2    Charest, H.3    Podesta, R.B.4    Quinlin, M.L.5    Pinkston, J.R.6
  • 122
    • 0030873953 scopus 로고    scopus 로고
    • Protection against Schistosoma mansoni infection with a recombinant baculovirus-expressed subunit of calpain
    • Hota-Mitchell S., Siddiqui A.A., Dekaban G.A., Smith J., Tognon C., Podesta R.B. Protection against Schistosoma mansoni infection with a recombinant baculovirus-expressed subunit of calpain. Vaccine 1997, 15(15):1631-1640.
    • (1997) Vaccine , vol.15 , Issue.15 , pp. 1631-1640
    • Hota-Mitchell, S.1    Siddiqui, A.A.2    Dekaban, G.A.3    Smith, J.4    Tognon, C.5    Podesta, R.B.6
  • 123
    • 60349094458 scopus 로고    scopus 로고
    • Sm-p80-based DNA vaccine formulation induces potent protective immunity against Schistosoma mansoni
    • Ahmad G., Torben W., Zhang W., Wyatt M., Siddiqui A.A. Sm-p80-based DNA vaccine formulation induces potent protective immunity against Schistosoma mansoni. Parasite Immunol 2009, 31(3):156-161.
    • (2009) Parasite Immunol , vol.31 , Issue.3 , pp. 156-161
    • Ahmad, G.1    Torben, W.2    Zhang, W.3    Wyatt, M.4    Siddiqui, A.A.5
  • 124
    • 64449084477 scopus 로고    scopus 로고
    • Protective and antifecundity effects of Sm-p80-based DNA vaccine formulation against Schistosoma mansoni in a nonhuman primate model
    • Ahmad G., Zhang W., Torben W., Damian R.T., Wolf R.F., White G.L., et al. Protective and antifecundity effects of Sm-p80-based DNA vaccine formulation against Schistosoma mansoni in a nonhuman primate model. Vaccine 2009, 27(21):2830-2837.
    • (2009) Vaccine , vol.27 , Issue.21 , pp. 2830-2837
    • Ahmad, G.1    Zhang, W.2    Torben, W.3    Damian, R.T.4    Wolf, R.F.5    White, G.L.6
  • 125
    • 0032835839 scopus 로고    scopus 로고
    • Molecular cloning and characterization of gut-derived cysteine proteinases associated with a host protective extract from Haemonchus contortus
    • Skuce P.J., Redmond D.L., Liddell S., Stewart E.M., Newlands G.F., Smith W.D., et al. Molecular cloning and characterization of gut-derived cysteine proteinases associated with a host protective extract from Haemonchus contortus. Parasitology 1999, 119(Pt 4):405-412.
    • (1999) Parasitology , vol.119 , Issue.PART 4 , pp. 405-412
    • Skuce, P.J.1    Redmond, D.L.2    Liddell, S.3    Stewart, E.M.4    Newlands, G.F.5    Smith, W.D.6
  • 126
    • 34548425052 scopus 로고    scopus 로고
    • Vaccination of goats against Haemonchus contortus with a recombinant cysteine protease
    • Muleke C.I., Yan R., Sun Y., Zhao G., Xu L., Li X. Vaccination of goats against Haemonchus contortus with a recombinant cysteine protease. Small Ruminant Res 2007, 73:95-102.
    • (2007) Small Ruminant Res , vol.73 , pp. 95-102
    • Muleke, C.I.1    Yan, R.2    Sun, Y.3    Zhao, G.4    Xu, L.5    Li, X.6
  • 127
    • 0242364218 scopus 로고    scopus 로고
    • Fish immune system. A crossroads between innate and adaptive responses
    • Tort L., Balasch J.C., Mackenzie S. Fish immune system. A crossroads between innate and adaptive responses. Inmunología 2003, 22:277-286.
    • (2003) Inmunología , vol.22 , pp. 277-286
    • Tort, L.1    Balasch, J.C.2    Mackenzie, S.3
  • 128
    • 47849103448 scopus 로고    scopus 로고
    • Zebrafish: an in vivo model for the study of neurological diseases
    • Best J.D., Alderton W.K. Zebrafish: an in vivo model for the study of neurological diseases. Neuropsychiatr Dis Treat 2008, 4(3):567-576.
    • (2008) Neuropsychiatr Dis Treat , vol.4 , Issue.3 , pp. 567-576
    • Best, J.D.1    Alderton, W.K.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.