The neutral cysteine proteinase of Entamoeba histolytica degrades IgG and prevents its binding

Journal of Infectious Diseases

Volumn 177, Issue 2, 1998, Pages 508-511

  Tran, Vinh Q ^a,c   Herdman, D Scott ^a   Torian, Bruce E ^a   Reed, Sharon L ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UCSD MEDICAL CENTER   (United States)

^c ROSS UNIVERSITY SCHOOL OF MEDICINE   (Dominica)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE PROTEINASE; HUMAN IMMUNOGLOBULIN; IMMUNOGLOBULIN G; MONOCLONAL ANTIBODY;

AMINO ACID SEQUENCE; ARTICLE; ENTAMOEBA HISTOLYTICA; ENZYME ACTIVITY; ENZYME ANALYSIS; HUMAN; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; TROPHOZOITE;

EID: 0031883488     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/517388     Document Type: Article

References (15)

1. Clark CB, Diamond LS. Ribosomal RNA genes of "pathogenic" and "nonpathogenic" Entamoeba histolytica are distinct. Mol Biochem Parasitol 1991;49:297-302.
2. Keene WE, Pettit MG, Allen S, McKerrow JH. The major neutral proteinase of Entamoeba histolytica. J Exp Med 1986;163:536-49.
3. Reed SL, Ember JA, Herdman DS, DiScipio RG, Hugli TE, Gigli I. The extracellular neutral cysteine proteinase of Entamoeba histolytica degrades anaphylatoxins C3a and C5a. J Immunol 1995;155:266-74.
4. Kelsall BL, Ravdin JI. Degradation of human immunoglobulin A by Entamoeba histolytica. J Infect Dis 1993;168:1319-22.
5. Jackson TFHG, Gathiram V, Simjee AE. Seroepidemiological study of antibody responses to the zymodemes of Entamoeba histolytica. Lancet 1985;2:716-9.
6. Reed SL, Flores BM, Batzer MA, et al. Molecular and cellular characterization of the 29-kDa peripheral membrane protein of Entamoeba histolytica: differentiation between pathogenic and nonpathogenic isolates. Infect Immun 1992;60:542-9.
7. Cieslak PR, Virgin HW, Stanley SL. A severe combined immunodeficient (SCID) mouse model for infection with Entamoeba histolytica. J Exp Med 1992;176:1605-9.
8. Reed SL, Bouvier J, Pollack AS, et al. Cloning of a virulence factor of Entamoeba histolytica: pathogenic strains possess a unique cysteine proteinase gene. J Clin Invest 1993;91:1532-40.
9. Calderon J, Munoz M, Acosta HM. Surface redistribution and release of antibody-induced caps in Entamoebae. J Exp Med 1980;151:184-93.
10. Plaut AG. The IgA1 proteases of pathogenic bacteria. Annu Rev Microbiol 1983;37:603-22.
11. Bontempi E, Cazzulo JJ. Digestion of human immunoglobulin G by the major cysteine proteinase (cruzipain) from Trypanosoma cruzi. FEMS Microbiol Lett 1990;70:337-42.
12. Auriault C, Ouaissi MA, Torpier G, Eisen H, Capron A. Proteolytic cleavage of IgG bound to the Fc receptor of Schistosoma mansoni schistosomula. Parasite Immunol 1981;3:33-44.
13. Carmona C, Dowd AJ, Smith AM, Dalton JP. Cathepsin L proteinase secreted by Fasciola hepatica in vitro prevents antibody-mediated eosinophil attachment to newly excysted juveniles. Mol Biochem Parasitol 1993;62:9-18.
14. Provenzano D, Alderete JF. Analysis of human immunoglobulin-degrading cysteine proteinases of Trichomonas vaginalis. Infect Immun 1995;63:3388-95.
15. Talbot JA, Nielsen K, Corbeil LB. Cleavage of proteins of reproductive secretions by extracellular proteinases of Tritrichomonas foetus. Can J Microbiol 1991;37:384-90.