Prime-boost and recombinant protein vaccination strategies using Sm-p80 protects against Schistosoma mansoni infection in the mouse model to levels previously attainable only by the irradiated cercarial vaccine

Parasitology Research

Volumn 105, Issue 6, 2009, Pages 1767-1777

  Ahmad, Gul ^a   Zhang, Weidong ^a   Torben, Workineh ^a   Haskins, Chad ^a   Diggs, Sue ^a   Noor, Zahid ^a   Le, Loc ^a   Siddiqui, Afzal A ^a  

^a TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN G3; IMMUNOGLOBULIN M; OLIGODEOXYNUCLEOTIDE DERIVATIVE; RECOMBINANT PROTEIN; RECOMBINANT PROTEIN SM P80; UNCLASSIFIED DRUG; VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOMPHALARIA GLABRATA; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG FORMULATION; EGG PRODUCTION; IMMUNOGENICITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS; SCHISTOSOMIASIS MANSONI; SPLEEN CELL; TH1 CELL; TH17 CELL; VACCINATION;

ANIMALS; ANTIBODIES, HELMINTH; ANTIGENS, HELMINTH; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; IMMUNIZATION, SECONDARY; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LEUKOCYTES, MONONUCLEAR; MALE; MICE; MICE, INBRED C57BL; PARASITE EGG COUNT; RECOMBINANT PROTEINS; SCHISTOSOMA MANSONI; SCHISTOSOMIASIS MANSONI; SPLEEN; VACCINES; VACCINES, SYNTHETIC;

ANIMALIA; MUS; SCHISTOSOMA; SCHISTOSOMA MANSONI;

EID: 70350223474     PISSN: 09320113     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00436-009-1646-z     Document Type: Article

References (46)

1. G Ahmad W Torben W Zhang M Wyatt AA Siddiqui 2009 Sm-p80-based DNA vaccine formulation induces potent protective immunity against Schistosoma mansoni Parasite Immunol 31 156 161 10.1111/j.1365-3024.2008.01091.x 1:CAS:528:DC%2BD1MXjs1WhtL8%3D 19222788
2. G Ahmad W Zhang W Torben RT Damian RF Wolf GL White M Chavez-Suarez RC Kennedy AA Siddiqui 2009 Protective and antifecundity effects of Sm-p80-based DNA vaccine formulation against Schistosoma mansoni in a nonhuman primate model Vaccine 27 2830 2837 10.1016/j.vaccine.2009.02.096 1:CAS:528: DC%2BD1MXkslOhsbs%3D 19366570
3. NR Bergquist LR Leonardo GF Mitchell 2005 Vaccine-linked chemotherapy: can schistosomiasis control benefit from an integrated approach? Trends Parasitol 21 112 117 10.1016/j.pt.2005.01.001 1:CAS:528:DC%2BD2MXhslChu74%3D 15734657 (Pubitemid 40269774)
4. R Bergquist J Utzinger DP McManus 2008 Trick or treat: the role of vaccines in integrated schistosomiasis control PLoS Negl Trop Dis 2 e244 10.1371/journal.pntd.0000244 18575619 (Pubitemid 352002887)
5. E Bettelli T Korn M Oukka VK Kuchroo 2008 Induction and effector functions of T(H)17 cells Nature 453 1051 1057 10.1038/nature07036 1:CAS:528:DC%2BD1cXntlGjtbo%3D 18563156 (Pubitemid 351871737)
6. K Brandt S Bulfone-Paus DC Foster R Ruckert 2003 Interleukin-21 inhibits dendritic cell activation and maturation Blood 102 4090 4098 10.1182/blood-2003-03-0669 1:CAS:528:DC%2BD3sXpsFals78%3D 12893770 (Pubitemid 37486993)
7. AA Da'dara DA Harn 2005 DNA vaccines against tropical parasitic diseases Expert Rev Vaccines 4 575 589 10.1586/14760584.4.4.575 16117713 (Pubitemid 41297303)
8. AA Da'dara N Lautsch T Dudek V Novitsky TH Lee M Essex DA Harn 2006 Helminth infection suppresses T-cell immune response to HIV-DNA-based vaccine in mice Vaccine 24 5211 5219 10.1016/j.vaccine.2006.03.078 16675073 (Pubitemid 43818187)
9. T El-Khoby N Galal A Fenwick R Barakat A El-Hawey Z Nooman M Habib F bdel-Wahab NS Gabr HM Hammam MH Hussein NN Mikhail BL Cline GT Strickland 2000 The epidemiology of schistosomiasis in Egypt: summary findings in nine governorates Am J Trop Med Hyg 62 88 99 1:STN:280:DC%2BD3c3ntFKisQ%3D%3D 10813505
10. LM Ganley-Leal J Guarner CW Todd AA 'Dara GL Freeman Jr AE Boyer DA Harn WE Secor 2005 Comparison of Schistosoma mansoni irradiated cercariae and Sm23 DNA vaccines Parasite Immunol 27 341 349 10.1111/j.1365-3024.2005.00785.x 1:CAS:528:DC%2BD2MXhtFeksb7O 16149992 (Pubitemid 41360829)
11. I Godinez T Haneda M Raffatellu MD George TA Paixao HG Rolan RL Santos S Dandekar RM Tsolis AJ Baumler 2008 T cells help to amplify inflammatory responses induced by Salmonella enterica serotype Typhimurium in the intestinal mucosa Infect Immun 76 2008 2017 10.1128/IAI.01691-07 1:CAS:528: DC%2BD1cXltlektbs%3D 18347048 (Pubitemid 351656133)
12. P Hagan O Sharaf 2003 Schistosomiasis vaccines Expert Opin Biol Ther 3 1271 1278 10.1517/14712598.3.8.1271 1:CAS:528:DC%2BD3sXptlelsL4%3D 14640953 (Pubitemid 38004698)
13. JP Hewitson PA Hamblin AP Mountford 2005 Immunity induced by the radiation-attenuated schistosome vaccine Parasite Immunol 27 271 280 10.1111/j.1365-3024.2005.00764.x 1:CAS:528:DC%2BD2MXhtFars7vJ 16138848 (Pubitemid 41344619)
14. S Hota-Mitchell AA Siddiqui GA Dekaban J Smith C Tognon RB Podesta 1997 Protection against Schistosoma mansoni infection with a recombinant baculovirus-expressed subunit of calpain Vaccine 15 1631 1640 10.1016/S0264-410X(97)00081-9 1:CAS:528:DyaK2sXntleisbw%3D 9364694 (Pubitemid 27445743)
15. S Hota-Mitchell MW Clarke RB Podesta GA Dekaban 1999 Recombinant vaccinia viruses and gene gun vectors expressing the large subunit of Schistosoma mansoni calpain used in a murine immunization-challenge model Vaccine 17 1338 1354 10.1016/S0264-410X(98)00391-0 1:CAS:528:DyaK1MXitlCitbw%3D 10195769 (Pubitemid 29138800)
16. PJ Hotez DH Molyneux A Fenwick J Kumaresan SE Sachs JD Sachs L Savioli 2007 Control of neglected tropical diseases N Engl J Med 357 1018 1027 10.1056/NEJMra064142 1:CAS:528:DC%2BD2sXhtVegsb%2FM 17804846 (Pubitemid 47367081)
17. D Jankovic L Aslund IP Oswald P Caspar C Champion E Pearce JE Coligan M Strand A Sher SL James 1996 Calpain is the target antigen of a Th1 clone that transfers protective immunity against Schistosoma mansoni J Immunol 157 806 814 1:CAS:528:DyaK28XktVymsbk%3D 8752932
18. D Jankovic TA Wynn MC Kullberg S Hieny P Caspar S James AW Cheever A Sher 1999 Optimal vaccination against Schistosoma mansoni requires the induction of both B cell- and IFN-gamma-dependent effector mechanisms J Immunol 162 345 351 1:CAS:528:DyaK1MXjt1Olsg%3D%3D 9886405
19. C Kishimoto H Kawamata S Sakai H Shinohara H Ochiai 2001 Enhanced production of macrophage inflammatory protein 2 (MIP-2) by in vitro and in vivo infections with encephalomyocarditis virus and modulation of myocarditis with an antibody against MIP-2 J Virol 75 1294 1300 10.1128/JVI.75.3.1294-1300.2001 1:CAS:528:DC%2BD3MXkvVCrsA%3D%3D 11152502 (Pubitemid 32094688)
20. BR Lauwerys N Garot JC Renauld FA Houssiau 2000 Cytokine production and killer activity of NK/T-NK cells derived with IL-2, IL-15, or the combination of IL-12 and IL-18 J Immunol 165 1847 1853 1:CAS:528:DC%2BD3cXls1Kmsro%3D 10925263
21. M Lebens JB Sun C Czerkinsky J Holmgren 2004 Current status and future prospects for a vaccine against schistosomiasis Expert Rev Vaccines 3 315 328 10.1586/14760584.3.3.315 1:CAS:528:DC%2BD2cXksV2gur4%3D 15176948 (Pubitemid 38796869)
22. DP McManus A Loukas 2008 Current status of vaccines for schistosomiasis Clin Microbiol Rev 21 225 242 10.1128/CMR.00046-07 1:CAS:528: DC%2BD1cXitlGrtb8%3D 18202444 (Pubitemid 351160017)
23. P Minard DA Dean RH Jacobson WE Vannier KD Murrell 1978 Immunization of mice with cobalt-60 irradiated Schistosoma mansoni cercariae Am J Trop Med Hyg 27 76 86 1:STN:280:DyaE1c7itFKjtg%3D%3D 626284
24. RA Montgomery MJ Dallman 1991 Analysis of cytokine gene expression during fetal thymic ontogeny using the polymerase chain reaction J Immunol 147 554 560 1:CAS:528:DyaK3MXlsFahtL0%3D 1649220
25. N Ohta T Kumagai H Maruyama A Yoshida Y He R Zhang 2004 Research on calpain of Schistosoma japonicum as a vaccine candidate Parasitol Int 53 175 181 10.1016/j.parint.2004.01.007 1:CAS:528:DC%2BD2cXjtVCnsLs%3D 15081949 (Pubitemid 38479892)
26. F Ren X Zhan G Martens J Lee D Center SK Hanson H Kornfeld 2005 Pro-IL-16 regulation in activated murine CD4+ lymphocytes J Immunol 174 2738 2745 1:CAS:528:DC%2BD2MXhsFeqs7s%3D 15728482
27. L Shen C Zhang T Wang S Brooks RJ Ford YC Lin-Lee A Kasianowicz V Kumar L Martin P Liang J Cowell JL Ambrus Jr 2006 Development of autoimmunity in IL-14alpha-transgenic mice J Immunol 177 5676 5686 1:CAS:528: DC%2BD28XhtVans7%2FJ 17015757
28. A Sher S Hieny SL James R Asofsky 1982 Mechanisms of protective immunity against Schistosoma mansoni infection in mice vaccinated with irradiated cercariae. II. Analysis of immunity in hosts deficient in T lymphocytes, B lymphocytes, or complement J Immunol 128 1880 1884 1:STN:280: DyaL387ktlOgsw%3D%3D 6801124
29. AA Siddiqui Y Zhou RB Podesta SR Karcz CE Tognon GH Strejan GA Dekaban MW Clarke 1993 Characterization of Ca(2+)-dependent neutral protease (calpain) from human blood flukes, Schistosoma mansoni Biochim Biophys Acta 1181 37 44 1:CAS:528:DyaK3sXktVelsrw%3D 8457603
30. AA Siddiqui T Phillips H Charest RB Podesta ML Quinlin JR Pinkston JD Lloyd M Paz RM Villalovos J Pompa 2003 Induction of protective immunity against Schistosoma mansoni via DNA priming and boosting with the large subunit of calpain (Sm-p80): adjuvant effects of granulocyte-macrophage colony-stimulating factor and interleukin-4 Infect Immun 71 3844 3851 10.1128/IAI.71.7.3844-3851. 2003 1:CAS:528:DC%2BD3sXms1Wjt7c%3D 12819068 (Pubitemid 36753707)
31. AA Siddiqui T Phillips H Charest RB Podesta ML Quinlin JR Pinkston JD Lloyd J Pompa RM Villalovos M Paz 2003 Enhancement of Sm-p80 (large subunit of calpain) induced protective immunity against Schistosoma mansoni through co-delivery of interleukin-2 and interleukin-12 in a DNA vaccine formulation Vaccine 20 21 2882 2889 10.1016/S0264-410X(03)00159-2 (Pubitemid 36703200)
32. AA Siddiqui JR Pinkston ML Quinlin V Kavikondala KA Rewers-Felkins T Phillips J Pompa 2005 Characterization of protective immunity induced against Schistosoma mansoni via DNA priming with the large subunit of calpain (Sm-p80) in the presence of genetic adjuvants Parasite 12 3 8 1:STN:280: DC%2BD2M7psFSrsg%3D%3D 15828575
33. AA Siddiqui JR Pinkston ML Quinlin Q Saeed GL White MH Shearer RC Kennedy 2005 Characterization of the immune response to DNA vaccination strategies for schistosomiasis candidate antigen, Sm-p80 in the baboon Vaccine 23 1451 1456 10.1016/j.vaccine.2004.09.018 1:CAS:528:DC%2BD2MXmslGmtg%3D%3D 15670880 (Pubitemid 40164704)
34. AA Siddiqui G Ahmad RT Damian RC Kennedy 2008 Experimental vaccines in animal models for schistosomiasis Parasitol Res 102 825 833 10.1007/s00436-008- 0887-6 18259777
35. EE Silva MW Clarke RB Podesta 1993 Characterization of a C3 receptor on the envelope of Schistosoma mansoni J Immunol 151 7057 7066 1:CAS:528: DyaK2cXnsFWhtw%3D%3D 8258710
36. JK Smith AA Siddiqui LA Modica R Dykes C Simmons J Schmidt GA Krishnaswamy SL Berk 1999 Interferon-alpha upregulates gene expression of aquaporin-5 in human parotid glands J Interferon Cytokine Res 19 929 935 10.1089/107999099313479 1:CAS:528:DyaK1MXlsFCrt7Y%3D 10476940 (Pubitemid 29406649)
37. P Steinmann J Keiser R Bos M Tanner J Utzinger 2006 Schistosomiasis and water resources development: systematic review, meta-analysis, and estimates of people at risk Lancet Infect Dis 6 411 425 10.1016/S1473-3099(06)70521-7 16790382 (Pubitemid 43949139)
38. Tallima H, Salah M, Guirguis FR, El RR (2009) Transforming growth factor-beta and Th17 responses in resistance to primary murine schistosomiasis mansoni. Cytokine (in press)
39. J Utzinger J Keiser X Shuhua M Tanner BH Singer 2003 Combination chemotherapy of schistosomiasis in laboratory studies and clinical trials Antimicrob Agents Chemother 47 1487 1495 10.1128/AAC.47.5.1487-1495.2003 1:CAS:528:DC%2BD3sXjslGhtrc%3D 12709312 (Pubitemid 36548527)
40. MJ van der Werf SJ de Vlas S Brooker CW Looman NJ Nagelkerke JD Habbema D Engels 2003 Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa Acta Trop 86 125 139 10.1016/S0001-706X(03) 00029-9 12745133 (Pubitemid 36561364)
41. MS Wilson MM Mentink-Kane JT Pesce TR Ramalingam R Thompson TA Wynn 2007 Immunopathology of schistosomiasis Immunol Cell Biol 85 148 154 10.1038/sj.icb.7100014 1:CAS:528:DC%2BD2sXisFynt7o%3D 17160074 (Pubitemid 46398720)
42. RA Wilson JA Langermans GJ Van Dam RA Vervenne SL Hall WC Borges GP Dillon AW Thomas PS Coulson 2008 Elimination of Schistosoma mansoni adult worms by rhesus macaques: basis for a therapeutic vaccine? PLoS Negl Trop Dis 2 e290 10.1371/journal.pntd.0000290 18820739
43. M Yoshida T Kezuka JW Streilein 2000 Participation of pigment epithelium of iris and ciliary body in ocular immune privilege. 2. Generation of TGF-beta-producing regulatory T cells Invest Ophthalmol Vis Sci 41 3862 3870 1:STN:280:DC%2BD3M%2FisFSnsg%3D%3D 11053287 (Pubitemid 30816173)
44. BW Young RB Podesta 1986 Complement and 5-HT increase phosphatidylcholine incorporation into the outer bilayers of Schistosoma mansoni J Parasitol 72 802 803 10.2307/3281488 1:CAS:528:DyaL2sXitFWhu78%3D 3806337 (Pubitemid 17000673)
45. R Zhang A Yoshida T Kumagai H Kawaguchi H Maruyama T Suzuki M Itoh M El-Malky N Ohta 2001 Vaccination with calpain induces a Th1-biased protective immune response against Schistosoma japonicum Infect Immun 69 386 391 10.1128/IAI.69.1.386-391.2001 1:CAS:528:DC%2BD3MXitValug%3D%3D 11119528 (Pubitemid 32038336)
46. Y Zhou RB Podesta 1989 Effects of serotonin (5HT) and complement C3 on the synthesis of the surface membrane precursors of adult Schistosoma mansoni J Parasitol 75 333 343 10.2307/3282583 1:CAS:528:DyaL1MXkvFGitbk%3D 2542507 (Pubitemid 19150519)