Fish immunity and parasite infections: from innate immunity to immunoprophylactic prospects

Veterinary Immunology and Immunopathology

Volumn 126, Issue 3-4, 2008, Pages 171-198

  Alvarez Pellitero, Pilar ^a  

^a CSIC Instituto de Acuicultura de Torre de la Sal IATS   (Spain)

Author keywords

Adaptive immunity; Amoebozoa; Apicomplexa; Cestoda; Ciliophora; Crustacea; Digenea; Dinoflagellata; Diplomonadida; Fish immunity; Gene expression; Inflammation; Innate immunity; Kinetoplastida; Microsporidia; Monogenea; Myxozoa; Nematoda; Parasites; Teleost; Vaccination

Indexed keywords

ACUTE PHASE PROTEIN; ALPHA CHEMOKINE; ANTIBODY; BETA CHEMOKINE; CARBOHYDRATE; COMPLEMENT; CYCLOOXYGENASE 2; IMMUNOGLOBULIN M; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERFERON; INTERLEUKIN 1; INTERLEUKIN 8; LECTIN; LECTIN RECEPTOR; LYSOZYME; PEROXIDASE; POLYPEPTIDE ANTIBIOTIC AGENT; PROTEINASE INHIBITOR; T LYMPHOCYTE RECEPTOR; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR;

ADAPTIVE IMMUNITY; AEROBIC METABOLISM; ANTIBODY PRODUCTION; APOPTOSIS; B LYMPHOCYTE; CESTODE; CILIATE; CRUSTACEA; EOSINOPHIL; FISH; FLAGELLATE; GENE EXPRESSION; IMMUNOPROPHYLAXIS; INFLAMMATION; INNATE IMMUNITY; MAJOR HISTOCOMPATIBILITY COMPLEX; MAST CELL; MOLLUSC; MUCOSAL IMMUNITY; MYXOZOAN SPORE; NEMATODE; NONHUMAN; PARASITE; PARASITOSIS; PHAGOCYTE; PHAGOCYTOSIS; PROTEIN CARBOHYDRATE INTERACTION; REVIEW; T LYMPHOCYTE; TELEOST;

ANIMALS; AQUACULTURE; FISH DISEASES; FISHES; GENE EXPRESSION REGULATION; IMMUNITY, ACTIVE; IMMUNITY, CELLULAR; IMMUNITY, INNATE; IMMUNOTHERAPY; PARASITEMIA;

AMOEBOZOA; APICOMPLEXA; CESTODA; CILIOPHORA; CRUSTACEA; CRYPTOBIA SALMOSITICA; DINOPHYCEAE; DIPLOMONADIDA; ICHTHYOPHTHIRIUS MULTIFILIIS; KINETOPLASTIDA; LEPEOPHTHEIRUS SALMONIS; MAMMALIA; MASTIGOPHORA (FLAGELLATES); MICROSPORIDIA; MONOGENEA; MYXOZOA; NEMATODA; NEOPARAMOEBA; PISCES; SCUTICOCILIATIA; TELEOSTEI;

EID: 56249092734     PISSN: 01652427     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vetimm.2008.07.013     Document Type: Review

References (347)

1. Aaltonen T.M., Valtonen E.T., and Jokinen E.I. Humoral response of roach (Rutilus rutilus) to digenean Rhipidocotyle fennica infection. Parasitology 114 (1997) 285-291
2. Adams M.B., and Nowak B.F. Distribution and structure of lesions in the gills of Atlantic salmon, Salmo salar L., affected with amoebic gill disease. J. Fish Dis. 24 (2001) 535-542
3. Adams M.B., and Nowak B.F. Amoebic gill disease: sequential pathology in cultured Atlantic salmon, Salmo salar L. J. Fish Dis. 26 (2003) 601-614
4. Agius C., and Roberts R.J. Melano-macrophage centres and their role in fish pathology. J. Fish Dis. 26 (2003) 499-509
5. Aiken H.M., Hayward C.J., Crosbie P., Watts M., and Nowak B. Serological evidence of an antibody response in farmed southern bluefin tuna naturally infected with the blood fluke Cardicola fosteri. Fish Shellfish Immunol. 25 (2008) 66-75
6. Akira S., Uematsu S., and Takeuchi O. Pathogen recognition and innate immunity. Cell 124 (2006) 783-801
7. Alexander J.B., and Ingram G.A. Noncellular nonspecific defence mechanisms of fish. Ann. Rev. Fish Dis. 2 (1992) 249-279
8. Alishahi M., and Buchmann K. Temperature-dependent protection against Ichthyophthirius multifiliis following immunisation of rainbow trout using live theronts. Dis. Aquat. Organ. 72 (2006) 269-273
9. Alvarez-Pellitero P. Diseases caused by flagellates. In: Eiras J., Segner H., Wahli T., and Kapoor B.G. (Eds). Fish Diseases vol. 1 (2008), Science Publishers, Enfield, NH, USA 421-515
10. Alvarez-Pellitero P., and Sitjà-Bobadilla A. Cryptosporidium molnari n. sp. (Apicomplexa: Cryptosporidiidae) infecting two marine fish species, Sparus aurata L., and Dicentrarchus labrax L. Int. J. Parasitol. 32 (2002) 1007-1021
11. Alvarez-Pellitero P., Quiroga M.I., Sitjà-Bobadilla A., Rodondo M.J., Palenzuela O., Padrós F., Vázquez S., and Nieto J.M. Cryptosporidium scohpthalmi n. sp. (Apicomplexa: Cryptosporidiidae) from cultured turbot Scophthalmus maximus. Light and electron microscope description and histopathological study. Dis. Aquat. Organ. 62 (2004) 133-145
12. Alvarez-Pellitero P., Palenzuela O., and Sitjà-Bobadilla A. Histopathology and cellular response in Enteromyxum leei (Myxozoa) infections of Diplodus puntazzo (Teleostei). Parasitol. Int. 57 (2008) 110-120
13. Alvarez-Pellitero P., Palenzuela O., Padrós P., Sitjà-Bobadilla A., Riaza A., Silva R., and Arán J. Histophagous scuticociliatids (Ciliophora) parasitizing turbot Scophthalmus maximus: morphology, in vitro culture and virulence. Folia Parasitol. 51 (2004) 177-187
14. Aoki T., and Hirono I. Immune relevant genes of Japanese flounder, Paralichthys olivaceus. Comp. Biochem. Physiol. D 1 (2006) 115-121
15. + leukocytes in fugu (Takifugu rubripes) with antiserum against fugu CD8α. Dev. Comp. Immunol. 32 (2008) 850-858
16. Armstrong P.B., and Quigley J.P. α2-macroglobulin: an evolutionarily conserved arm of the innate immune system. Dev. Comp. Immunol. 23 (1999) 375-390
17. Baoprasertkul P., Peatman E., Abernathy J., and Liu Z. Structural characterisation and expression analysis of Toll-like receptor 2 gene from catfish. Fish Shellfish Immunol. 22 (2007) 418-426
18. Bartholomew J.L. Host resistance to infection by the myxosporean parasite Ceratomyxa shasta: a review. J. Aquat. Anim. Health 10 (1998) 112-120
19. Bartholomew J.L. Parasites, their hosts and why diseases occurs (or doesn't?). Proceedings of the 131st Annual Meeting of the American Fisheries Society. Phoenix, AZ (2001) 1104
20. Bartholomew J.L., Smith C.E., Rohovec J.S., and Fryer J.L. Characterization of a host response to the myxosporean parasite, Ceratomyxa shasta (Noble), by histology, scanning electron microscopy and immunological techniques. J. Fish Dis. 12 (1989) 509-522
21. Bayne C.J., and Gerwick L. The acute phase response and innate immunity of fish. Dev. Comp. Immunol. 25 (2001) 725-743
22. Bei J.-X., Suetake H., Araki K., Yoshiura Y., Lin H.-R., and Suzuki Y. Two interleukin (IL)-15 homologues in fish from two distinct origins. Mol. Immunol. 43 (2006) 860-869
23. Bermúdez R., Vigliano F.A., Marcaccini A., Sitjà-Bobadilla A., Quiroga M.I., and Nieto J.M. Response of Ig-positive cells to Enteromyxum scophthalmi (Myxozoa) experimental infection in turbot, Scophthalmus maximus (L.): a histopathological and immunohistochemical study. Fish Shellfish Immunol. 21 (2006) 501-512
24. Bernard D., Six A., Rigottier-Gois L., Messiaen S., Chilmonczyk S., Quillet E., Boudinot P., and Benmansour A. Phenotypic and functional similarity of gut intraepithelial and systemic T cells in a teleost fish. J. Immunol. 176 (2006) 3942-3949
25. Bienek D.R., Plouffe D.A., Wiegertjes G.F., and Belosevic M. Immunization of goldfish with excretory/secretory molecules of Trypanosoma danilewskyi confers protection against infection. Dev. Comp. Immunol. 26 (2002) 649-657
26. Biering E., Villoing S., Sommerset I., and Christie K.E. Update of viral vaccines for fish. In: Midtlyng P.J. (Ed). Progress in Fish Vaccinology, Developments in Biologicals vol. 121 (2005), Karger, Basel 97-113
27. Bishop G.R., Taylor S.L., Jaso-Friedmann L., and Evans D.L. Mechanisms of nonspecific cytotoxic cell regulation of apoptosis: cytokine-like activity of Fas ligand. Fish Shellfish Immunol. 13 (2002) 47-67
28. + B lymphocytes and macrophages. Immunol. Today 17 (1996) 471-475
29. Boshra H., Li J., and Sunyer J.O. Recent advances on the complement system of teleost fish. Fish Shellfish Immunol. 20 (2006) 239-262
30. Bowden T.J., Cook P., and Rombout J.H.M.W. Development and function of the thymus in teleosts. Fish Shellfish Immunol. 19 (2005) 413-427
31. Bridle A.R., Morrison R.N., and Cupit P.M. Quantitation of immune response gene expression and cellular localisation of interleukin-1β mRNA in Atlantic salmon, Salmo salar L., affected by amoebic gill disease (AGD). Vet. Immunol. Immunopathol. 114 (2006) 121-134
32. Bridle A.R., Morrison R.N., and Nowak B.F. The expression of immune-regulatory genes in rainbow trout, Oncorhynchus mykiss, during amoebic gill disease (AGD). Fish Shellfish Immunol. 20 (2006) 346-364
33. Brown G., Hughes P.J., Michell R.H., Rolink A.G., and Ceredig R. The sequential determination model of hematopoiesis. Trends Immunol. 28 (2007) 442-448
34. Bryant M.S., Lee R.P., Lester R.J.G., and Whittington R.J. Anti-immunoglobulin antisera used in an ELISA to detect antibodies in barramundi Lates calcarifer to Cryptocaryon irritans. Dis. Aquat. Organ. 36 (1999) 21-28
35. Buchmann K. A note on the humoral immune response of infected Anguilla anguilla against the gill monogenean Pseudodactylogyrus bini. Fish Shellfish Immunol. 3 (1993) 397-399
36. Buchmann K. Binding and lethal effect of complement from Oncorhynchus mykiss on Gyrodactylus derjavini (Platyhelminthes: Monogenea). Dis. Aquat. Organ. 32 (1998) 195-200
37. Buchmann K. Immune mechanisms in fish skin against monogeneans-a model. Folia Parasitol. 46 (1999) 1-9
38. Buchmann K. Antiparasitic immune mechanisms in teleost fish: a two-edged sword?. Bull. Eur. Ass. Fish Pathol. 20 (2000) 48-59
39. Buchmann K. Lectins in fish skin: do they play a role in host-monogenean interactions?. J. Helminthol. 75 (2001) 227-231
40. Buchmann K., and Lindenstrøm T. Interactions between monogenean parasites and their fish hosts. Int. J. Parasitol. 32 (2002) 309-319
41. Buchmann K., Lindenstrøm T., and Bresciani J. Defence mechanisms against parasites in fish and the prospect for vaccines. Acta Parasitol. 46 (2001) 71-81
42. Buchmann K., Sigh J., Nielsen C.V., and Dalgaard M. Host responses against the fish parasitizing ciliate Ichthyophthirius multifiliis. Vet. Parasitol. 100 (2001) 105-116
43. Burgess P.J., and Matthews R.A. Cryptocaryon irritans (Ciliophora): acquired protective immunity in the thick-lipped mullet, Chelon labrosus. Fish Shellfish Immunol. 5 (1995) 459-468
44. Cambi A., and Figdor C.G. Levels of complexity in pathogen recognition by C-type lectins. Curr. Opin. Immunol. 17 (2005) 345-351
45. Carroll M.C. The complement system in B cell regulation. Mol. Immunol. 41 (2004) 141-146
46. Cecchini S., Saroglia M., Terova G., and Albanesi F. Detection of antibody response against Amyloodinium ocellatum (Brown, 1931) in serum of naturally infected European sea bass by an enzyme-linked immunosorbent assay (ELISA). Bull. Eur. Ass. Fish Pathol. 21 (2001) 104-108
47. Chang M.X., Nie P., Liu G.Y., Song Y., and Gao Q. Identification of immune genes in grass carp Ctenopharyngodon idella in response to infection of the parasitic copepod Sinergasilus major. Parasitol. Res. 96 (2005) 224-229
48. Chaves-Pozo E., Muñoz P., Lopez-Muñoz A., Pelegrin P., Garcia Ayala A., Mulero V., and Meseguer J. Early innate immune response and redistribution of inflammatory cells in the bony fish gilthead seabream experimentally infected with Vibrio anguillarum. Cell Tissue Res. 320 (2005) 61-68
49. Chen J.S.-C., Wang T.-Y., Tzeng T.-D., Wang C.-Y., and Wang D. Evidence for a positive selection in the TLR9 gene of teleosts. Fish Shellfish Immunol. 24 (2008) 234-242
50. Chilmonczyk S., Monge D., and Kinkelin P. Proliferative kidney disease: cellular aspects of the rainbow trout, Oncorhynchus mykiss (Walbaum), response to parasitic infection. J. Fish Dis. 25 (2002) 217-226
51. Chin A., and Woo P.T.K. Innate cell-mediated immune response and peripheral leukocyte populations in Atlantic salmon, Salmo salar L., to a live Cryptobia salmositica vaccine. Parasitol. Res. 95 (2005) 299-304
52. Chin A., Glebe B.D., and Woo P.T.K. Humoral response and susceptibility of five full-sib families of Atlantic salmon, Salmo salar L., to the haemoflagellate, Cryptobia salmositica. J. Fish Dis. 27 (2004) 471-481
53. Chistiakov D.A., Hellemans B., and Volckaert F.A.M. Review on the immunology of European sea bass Dicentrarchus labrax. Vet. Immunol. Immunopathol. 117 (2007) 1-16
54. Clark T.G., and Dickerson H.W. Antibody-mediated effects on parasite behavior: evidence of a novel mechanism of immunity against a parasitic protist. Parasitol. Today 13 (1997) 477-480
55. Clark T.G., Gao Y., Gaertig J., Wang X., and Cheng G. The I-antigens of Ichthyophthirius multifiliis are GPI-anchored proteins. J. Euk. Microbiol. 48 (2001) 332-337
56. Clem L.W., Bly J.J., Ellsaesser C.F., Lobb C.J., and Miller N.W. Channel catfish is an unconventional model for immunological studies. J. Exp. Zool. Suppl. 4 (1990) 123-125
57. Cobb C.S., Levy M.G., and Noga E.J. Acquired immunity to amyloodiniosis is associated with an antibody response. Dis. Aquat. Organ. 34 (1998) 125-133
58. Cobb C.S., Levy M.G., and Noga E.J. Development of immunity by the tomato clownfish Amphiprion frenatus to the dinoflagellate parasite Amyloodinium ocellatum. J. Aquat. Anim. Health 10 (1998) 259-263
59. Colorni A., Ullal A., Heinisch G., and Noga E.J. Activity of the antimicrobial polypeptide piscidin 2 against fish ectoparasites. J Fish Dis. 31 (2008) 423-432
60. Coscia M.R., and Oreste U. Presence of antibodies specific for proteins of Contracaecum osculatum (Rudolphi, 1908) in plasma of several Antarctic teleosts. Fish Shellfish Immunol. 8 (1998) 295-302
61. Coscia M.R., and Oreste U. Plasma and bile antibodies of the teleost Trematomus bernacchii specific for the nematode Pseudoterranova decipiens. Dis. Aquat. Organ. 41 (2000) 37-42
62. Creagh E.M., and O'Neill L.A.J. TLRs, NLRs and RLRs: a trinity of pathogen sensors that co-operate in innate immunity. Trends Immunol. 27 (2006) 352-357
63. Cuesta A., Esteban M.A., and Meseguer J. Identification of a FasL-like molecule in leucocytes of the teleost fish gilthead seabream (Sparus aurata L.). Dev. Comp. Immunol. 27 (2003) 21-27
64. Cuesta A., Esteban M.A., and Meseguer J. Cloning, distribution and up-regulation of the teleost fish MHC class II alpha suggest a role for granulocytes as antigen-presenting cells. Mol. Immunol. 46 (2006) 1275-1285
65. Cuesta A., Meseguer J., and Esteban M.A. The antimicrobial peptide hepcidin exerts an important role in the innate immunity against bacteria in the bony fish gilthead seabream. Mol. Immunol. 45 (2008) 2333-2342
66. Cuesta A., Muñoz P., Rodríguez A., Salinas I., Sitjà-Bobadilla A., Alvarez-Pellitero P., Esteban M.A., and Meseguer J. Gilthead seabream (Sparus aurata L.) innate defence against the parasite Enteromyxum leei (Myxozoa). Parasitology 132 (2006) 95-104
67. Cuesta A., Salinas I., Rodríguez A., Muñoz P., Sitjà-Bobadilla A., Alvarez-Pellitero P., Meseguer J., and Esteban M.A. Cell-mediated cytotoxicity is the main innate immune mechanism involved in the cellular defence of gilthead seabream (Teleostei: Sparidae) against Enteromyxum leei (Myxozoa). Parasite Immunol. 28 (2006) 657-665
68. Dalmo R.A., Ingebrigtsen K., and Bogwald J. Non-specific defence mechanisms in fish, with particular reference to the reticuloendothelial system (RES). J. Fish Dis. 20 (1997) 241-273
69. Dezfuli B.S., Giari L., and Shinn A.P. The role of rodlet cells in the inflammatory response in Phoxinus phoxinus brains infected with Diplostomum. Fish Shellfish Immunol. 23 (2007) 300-304
70. Dick T.A., and Choudhury A. Cestoidea (Phylum Platyhelminthes). In: Woo P.T.K. (Ed). Fish Diseases and Disorders, vol. 1. Protozoan and Metazoan Infections (1999), CABI Publishing, New York 391-414
71. Dick T.A., and Choudhury A. Phylum nematoda. In: Woo P.T.K. (Ed). Fish Diseases and Disorders, vol. 1. Protozoan and Metazoan Infections (1999), CABI Publishing, New York 415-446
72. Dickerson H.W., and Clark T.G. Immune response of fishes to ciliates. Ann. Rev. Fish Dis. 6 (1996) 107-120
73. Dickerson H.W., and Dawe D.L. Ichthyophthirius multifiliis and Cryptocaryon irritans (Phylum Ciliophora). In: Woo P.T.K. (Ed). Fish Diseases and Disorders, vol. 1. Protozoan and Metazoan Infections (1999), CABI Publishing, New York 181-227
74. Dyková I. Phylum microspora. In: Woo P.T.K. (Ed). Fish Diseases and Disorders, vol. 1, Protozoan and Metazoan Infections (1999), CABI Publishing, New York 149-179
75. Dyková I., and Lom J. Histopathology of Protistan and Myxozoan Infections in Fishes. An Atlas (2007), Academia, Praha 219 pp
76. Dixon B., and Stet R.J.M. The relationship between major histocompatibility receptors and innate immunity in teleost fish. Dev. Comp. Immunol. 25 (2001) 683-699
77. Du Pasquier L. The immune system of invertebrates and vertebrates. Comp. Biochem. Physiol. B 129 (2001) 1-15
78. Ellis R.W. Product development plan for new vaccine technologies. Vaccine 19 (2001) 1559-1566
79. Evans D.L., Leary III J.H., and Jaso-Friedmann L. Nonspecific cytotoxic cells and innate immunity: regulation by programmed cell death. Dev. Comp. Immunol. 25 (2001) 791-805
80. Ewart K.V., Johnson S.C., and Ross N.W. Identification of a pathogen-binding lectin in salmon serum. Comp. Biochem. Physiol. C 123 (1999) 9-15
81. Faliex E., Da Silva C., Simon G., and Sasal P. Dynamic expression of immune response genes in the sea bass, Dicentrarchus labrax experimentally infected with the monogenean Diplectanum aequans. Fish Shellfish Immunol. 24 (2008) 759-767
82. Fast M.D., Muise D.M., Easy R.E., Ross N.W., and Johnson S.C. The effects of Lepeophtheirus salmonis infections on the stress response and immunological status of Atlantic salmon (Salmo salar). Fish Shellfish Immunol. 21 (2006) 228-241
83. Fast M.D., Ross N.W., Muise D.M., and Johnson S.C. Differential gene expression in Atlantic salmon infected with Lepeophtheirus salmonis. J. Aquat. Anim. Health 18 (2006) 116-127
84. Fast M.D., Ross N.W., Mustafa A., Sims D.E., Johnson S.C., Conboy G.A., Speare D.J., Johnson G., and Burka J.F. Susceptibility of rainbow trout Oncorhynchus mykiss, Atlantic salmon Salmo salar and coho salmon Oncorhynchus kisutch to experimental infection with sea lice Lepeophtheirus salmonis. Dis. Aquat. Organ. 52 (2002) 57-68
85. Fearon D.T., and Locksley R.M. The instructive role of innate immunity in the acquired immune response. Science 272 (1996) 50-54
86. Ferguson H.W. Systemic Pathology of Fish, A Text and Atlas of Normal Tissues in Teleosts and their Responses in Disease (2006), Scotian Press, London 367 pp
87. Ferguson H.W., and Ball H.J. Epidemiological aspects of proliferative kidney disease amongst rainbow trout, Salmo gairdneri Richardson in Northern Ireland. J. Fish Dis. 2 (1979) 219-225
88. Findlay V., and Munday B.L. Further studies on acquired resistance to amoebic gill disease (AGD) in Atlantic salmon, Salmo salar L. J. Fish Dis. 21 (1998) 121-125
89. Fischer U., Utke K., Somamoto T., Kollner B., Ototake M., and Nakanishi T. Cytotoxic activities of fish leucocytes. Fish Shellfish Immunol. 20 (2006) 209-226
90. Flajnik M.F., and Du Pasquier L. Evolution of innate and adaptive immunity: can we draw a line?. Trends Immunol. 25 (2004) 640-644
91. Fletcher T.C., White A., and Baldo B.A. Isolation of a phosphorylcholine-containing component from the turbot tapeworm, Bothriocephalus scorpii (Muller) and its reaction with C reactive protein. Parasite Immunol. 2 (1980) 237-248
92. Foott J.S., Harmon R., and Stone R. Effect of water temperature on non-specific immune function and ceratomyxosis in juvenile chinook salmon and steelhead from the Klamath River, Cali. Fish Game 90 (2004) 71-84
93. Forlenza M., Walker P.D., de Vries B.J., Wendelaar Bonga S.E., and Wiegertjes G.F. Transcriptional analysis of the common carp (Cyprinus carpio L.) immune response to the fish louse Argulus japonicus Thiele (Crustacea: Branchuira). Fish Shellfish Immunol. 25 (2008) 76-83
94. Fournier-Betz V., Quentel C., Lamour F., and Le Ven A. Immunocytochemical detection of Ig-positive cells in blood, lymphoid organs and the gut associated lymphoid tissue of the turbot (Scophthalmus maximus). Fish Shellfish Immunol. 10 (2000) 187-202
95. Franch R., Cardazzo B., Antonello J., Castagnaro M., Patarnello T., and Bargelloni L. Full-length sequence and expression analysis of Toll-like receptor 9 in the gilthead seabream (Sparus aurata L.). Gene 378 (2006) 42-51
96. Fritz J.H., Le Bourhis L., Magalhaes J.G., and Philpott D.J. Innate immune recognition at the epithelial barrier drives adaptive immunity: APCs take the back seat. Trends Immunol. 29 (2007) 41-49
97. Fujita T., Matsushita M., and Endo Y. The lectin-complement pathway-its role in innate immunity and evolution. Immunol. Rev. 198 (2004) 185-202
98. Furuta T., Ogawa W., and Wakabayashi H. Humoral immune response of carp Cyprinus carpio to Myxobolus artus (Myxozoa: Myxobolidae) infection. J Fish Biol. 43 (1993) 441-450
99. Gasque Ph. Complement: a unique innate immune sensor for danger signals. Mol. Immunol. 41 (2004) 1089-1098
100. Gazinelli R.T., and Denkers E.Y. Protozoan encounters with Toll-like receptor signaling pathways: implications for host parasitism. Nat. Rev. Immunol. 6 (2006) 895-906
101. Golomazou E., Athanassopoulou F., Karagouni E., Tsagozis P., Tsantilas H., and Vagianou St. Experimental transmission of Enteromyxum leei Diamant, Lom and Dykova, 1994 in sharpsnout sea bream, Diplodus puntazzo C. and the effect on some innate immune parameters. Aquaculture 260 (2006) 44-53
102. Gonzalez S.F., Buchmann K., and Nielsen M.E. Complement expression in common carp (Cyprinus carpio L.) during infection with Ichthyophthirius multifiliis. Dev. Comp. Immunol. 31 (2007) 576-586
103. Gonzalez S.F., Buchmann K., and Nielsen M.E. Ichthyophthirius multifiliis infection induces massive up-regulation of serum amyloid A in carp (Cyprinus carpio). Vet. Immunol. Immunopathol. 115 (2007) 172-178
104. Gonzalez S.F., Buchmann K., and Nielsen M.E. Real-time gene expression analysis in carp (Cyprinus carpio L.) skin: inflammatory responses caused by the ectoparasite Ichthyophthirius multifiliis. Fish Shellfish Immunol. 22 (2007) 641-650
105. González S.F., Chatziandreou N., Nielsen M.E., Li W., Rogers J., Taylor R., Santos Y., and Cossins A. Cutaneous immune responses in the common carp detected using transcript analysis. Mol. Immunol. 44 (2007) 1664-1679
106. Graves S.S., Evans D.L., and Dawe D.L. Antiprotozoal activity of non-specific cytotoxic cells (NCC) from the channel catfish (Ictalurus punctatus). J. Immunol. 134 (1985) 78-85
107. Grayson T.H., Jenkins P.G., Wrathmell A.B., and Harris J.E. Serum responses of salmon louse, Lepeophtheirus salmonis (Kroyer, 1838), in naturally infected salmonids and immunised rainbow trout, Oncorhynchus mykiss (Walbaum), and rabbits. Fish Shellfish Immunol. 1 (1991) 141-155
108. Grayson T.H., John R.J., Wadsworth S., Greaves K., Cox D., Roper J., Wrathmell A.B., Gilpin M.L., and Harris J.E. Immunization of Atlantic salmon against salmon louse: identification of antigens and effects on louse fecundity. J. Fish Biol. 47, Suppl. A (1995) 85-94
109. Griffin B.R., and Davies E.M. Myxosoma cerebralis: detection of circulating antibodies in infected rainbow trout (Salmo gairdneri). J. Fish. Res. Bd Can. 35 (1978) 1186-1190
110. Gross K., Carson J., and Nowak B.F. Presence of anti-Neoparamoeba sp. antibodies in Tasmanian cultured Atlantic salmon, Salmo salar L. J. Fish Dis. 27 (2004) 81-88
111. Gross K.A., Morrison R.N., Butler R., and Nowak B.F. Atlantic salmon, Salmo salar L., previously infected with Neoparamoeba sp. are not resistant to re-infection and have suppressed phagocyte function. J. Fish Dis. 27 (2004) 47-56
112. Grove S., Johansen R., Reitan L.J., and Press C.M. Immune- and enzyme histochemical characterisation of leucocyte populations within lymphoid and mucosal tissues of Atlantic halibut (Hipoglossus hipoglossus). Fish Shellfish Immunol. 20 (2006) 693-708
113. Gudding R., Lillehaug A., and Evensen O. Recent developments in fish vaccinology. Vet. Immunol. Immunopathol. 72 (1999) 203-212
114. Gunimaladevi I., Savan R., and Sakai M. Identification, cloning and characterization of interleukin-17 and its family from zebrafish. Fish Shellfish Immunol. 21 (2006) 393-403
115. Harris P.D., Soleng A., and Bakke T.A. Killing of Gyrodactylus salaris (Platyhelminthes, Monogenea) mediated by host complement. Parasitology 117 (1998) 137-143
116. Håstein T., Gudding R., and Evensen Ø. Bacterial vaccines for fish-an update of the current situation worldwide. In: Midtlyng P.J. (Ed). Progress in Fish Vaccinology, Developments in Biologicals vol. 121 (2005), Karger, Basel 55-74
117. Hawlisch H., and Köhl J. Complement and Toll-like receptors: key regulators of adaptive immune responses. Mol. Immunol. 43 (2006) 13-21
118. Hedrick R.P., Adkinson M.A., and MacConell E. Whirling disease: re-emergence among wild trout. Immunol. Rev. 166 (1998) 365-376
119. Herbert D.R., Holscher C., Mohrs M., Arendse B., Schwegmann A., Radwanska M., Leeto M., Kirsch R., Hall P., Mossmann H., Claussen B., Förster I., and Brombacher F. Alternative macrophage activation is essential for survival during schistosomiasis and downmodulates T helper 1 responses and immunopathology. Immunity 20 (2004) 623-635
120. Holland M.C.H., and Lambris J.D. The complement system in teleosts. Fish Shellfish Immunol. 12 (2002) 399-420
121. Holland J.W., Gould C.R.W., Jones C.S., Noble L.R., and Secombes C.J. The expression of immune-regulatory genes in rainbow trout, Oncorhynchus mykiss, during a natural outbreak of proliferative kidney disease (PKD). Parasitology 126 (2003) S95-S102
122. Holzer A.S., and Schachner O. Myxosporidia and macrophage centres in chub (Leuciscus cephalus)-quantitative interactions focus on Myxobolus cyprini. Parasitology 122 (2001) 55-62
123. Hordvik I., Torvund J., Moore L., and Endresen C. Structure and organization of the T cell receptor alpha chain genes in Atlantic salmon. Mol. Immunol. 41 (2004) 553-559
124. Huising M.O., Stet R.J.M., Savelkoul H.F.J., and Verburg-Van Kemenade B.M.L. The molecular evolution of the interleukin-1 family of cytokines; IL-18 in teleost fish. Dev. Comp. Immunol. 28 (2004) 395-413
125. Huizinga H.W., and Nadakavukaren M.J. Cellular responses of goldfish, Carassius auratus (L.), to metacercariae of Ribeiroia marini (Faust & Hoffman, 1934). J. Fish Dis. 20 (1997) 401-408
126. Hung H.W., Lo C.F., Tseng C.C., and Kou G.H. Antibody response of glass eels, Anguilla japonica Temmninck& Schlegel, to Plesitophora anguillarum Hoshina (Microspora) infection. J. Fish Dis. 20 (1997) 237-239
127. Igawa D., Sakai M., and Savan R. An unexpected discovery of two interferon gamma-like genes along with interleukin (IL)-22 and -26 from teleost: IL-22 and -26 genes have been described for the first time outside mammals. Mol. Immunol. 43 (2006) 999-1009
128. Iglesias R., Paramá A., Alvarez M.F., Leiro J., Aja C., and Sanmartin M.L. In vitro growth requirements for the fish pathogen Philasterides dicentrarchi (Cilophora, Scuticociliatida). Vet. Parasitol. 111 (2003) 19-30
129. Iglesias R., Paramá A., Alvarez M.F., Leiro J., and Ubeira F.M. Philasterides dicentrarchi (Ciliophora: Scuticociliatida) expresses surface immobilization antigens that probably induce protective immune responses in turbot. Parasitology 126 (2003) 125-134
130. Janeway C.A. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol. 54 (1989) 1-13
131. Janeway C.A., and Medzhitov R. Innate immune recognition. Ann. Rev. Immunol. 20 (2002) 197-216
132. James E.R., and Green D.R. Manipulation of apoptosis in the host-parasite interaction. Trends Parasitol. 20 (2004) 280-287
133. Jaso-Friedmann L., Leary III J.H., and Evans D.L. Role of nonspecific cytotoxic cells in the induction of programmed cell death of pathogenic protozoans: participation of the Fas ligand-Fas receptor system. Exp. Parasitol. 96 (2000) 75-88
134. Joerink M., Forlenza M., Ribeiro C.M.S., de Vries B.J., Savelkoul H.F.J., and Wiegertjes G.F. Differential macrophage polarisation during parasitic infections in common carp (Cyprinus carpio L). Fish Shellfish Immunol. 21 (2006) 561-571
135. Joerink M., Savelkoul H.F.J., and Wiegertjes G.F. Evolutionary conservation of alternative activation of macrophages: structural and functional characterization of arginase 1 and 2 in carp (Cyprinus carpio L.). Mol. Immunol. 43 (2006) 1116-1128
136. Jones S.R.M. The occurrence and mechanisms of innate immunity against parasites in fish. Dev. Comp. Immunol. 25 (2001) 841-852
137. Jones S.R., Palmen M., and van Muiswinkel W.B. Effects of inoculum route and dose on the immune response of common carp, Cyprinus carpio to the blood parasite, Trypanoplasma borreli. Vet. Immunol. Immunopathol. 36 (1993) 369-378
138. Jung, S.-J., Kitamura, S.-I., Oh, M.-J., 2004. Parsite vaccine against scuticociliate, Miamiensis avidus. In: Abstracts of the 4th Japan-Korea joint Seminar by Core University Program on Fisheries Sciences (FISCUP). Sapporo, Japan, December 2004, pp. 49.
139. Kaattari S.L., Klemer J.V., and Evans D.A. Teleost antibody structure: simple prototype or elegant alternative?. Bull. Eur. Ass. Fish Pathol. 19 (1999) 245-249
140. Kania P.W., Larsen T.B., Ingerslev H.C., and Buchmann K. Baltic salmon activates immune relevant genes in fin tissue when responding to Gyrodactylus salaris infection. Dis. Aquat. Organ. 76 (2007) 81-85
141. Katzenback B.A., Plouffe D.A., Haddad G., and Belosevic M. Administration of recombinant parasite β-tubulin to goldfish (Carassius auratus L.) confers partial protection against challenge infection with Trypanosoma danilewskyi Laveran and Mesnil 1904. Vet. Parasitol. 151 (2008) 36-45
142. Kelley G.O., Zagmutt-Vergara F.J., Leutenegger Ch.M., Adkinson M.A., Baxa D.V., and Hedrick R.P. Identification of a serine protease gene expressed by Myxobolus cerebralis during development in rainbow trout Oncorhynchus mykiss. Dis. Aquat. Organ. 59 (2004) 235-248
143. Kim K.D., Zhao J., Auh S., Yang X., Du P., Tang H., and Fu Y.-X. Adaptative immune cells temper initial innate response. Nat. Med. 13 (2007) 1248-1252
144. Kim K.H., Hwang Y.J., Cho J.B., and Park S.I. Immunization of cultured juvenile rockfish Sebastes schlegeli against Microcotyle sebastis (Monogenea). Dis. Aquat. Organ. 40 (2000) 29-32
145. Kim J.H., Ogawa K., and Wakabayashi H. Respiratory burst assay of head kidney macrophages of ayu, Plecoglossus altivelis, stimulated whit Glugea plecoglossi (Protozoa: Microspora) spores. J. Parasitol. 84 (1998) 552-556
146. Kim J.H., Ogawa K., and Wakabayashi H. Lectin-reactive components of the microsporidian Glugea plecoglossi and their relation to spore phagocytosis by head kidney macrophages of ayu Plecoglossus altivelis. Dis. Aquat. Organ. 39 (1999) 59-63
147. Kim J.H., Yokohama H., Ogawa K., Takahashi S., and Wakabayashi H. Humoral immune response of ayu, Plecoglossus altivelis to Glugea plecoglossi (Protozoa: Microspora). Fish Pathol. 31 (1996) 215-220
148. Klein N.J. Mannose-binding lectin: do we need it?. Mol. Immunol. 42 (2005) 919-924
149. Knaus M., and El-Matbouli M. Characterisation of carbohydrate-binding sites in developmental stages of Myxobolus cerebralis. Parasit. Res. 97 (2005) 505-514
150. 3. Parasitology 135 (2008) 633-640
151. Kwon S.R., Kim C.S., Chung J.K., Lee H.H., and Kim K.H. Inhibition of chemiluminescent response of olive flounder Paralichthys olivaceus phagocytes by the scuticociliate parasite Uronema marinum. Dis. Aquat. Organ. 52 (2002) 119-122
152. Laing K.J., and Secombes C.J. Chemokines. Dev. Comp. Immunol. 28 (2004) 443-460
153. Lee E.H., and Kim K.H. Can the surface immobilization antigens of Philasterides dicentrarchi (Ciliophora: Scuticociliatida) be used as target antigens to develop vaccines in cultured fish?. Fish Shellfish Immunol. 24 (2008) 142-146
154. Leiro J., Arranz J.A., Iglesias R., Ubeira F.M., and Sanmartin M.L. Effects of the histiophagous ciliate Philasterides dicentrarchi on turbot phagocyte responses. Fish Shellfish Immunol. 17 (2004) 27-39
155. Leiro J., Estevez J., Santamarina M.T., Sanmartin M.L., and Ubeira F.M. Humoral immune response of turbot, Scophthalmus maximus (L.), to antigens from Tetramicra brevifilum Matthews and Matthews, 1980 (Microspora). J. Fish Dis. 16 (1993) 577-584
156. Leiro J., Iglesias R., Parama A., Sanmartin M.L., and Ubeira F.M. Effect of Tetramicra brevifilum (Microspora) infection on respiratory-burst responses of turbot (Scophthalmus maximus L.) phagocytes. Fish Shellfish Immunol. 11 (2001) 639-652
157. Leiro J., Ortega M., Estévez J., Ubeira F.M., and Sanmartín M.L. The role of opsonization by antibody and complement in in vitro phagocytosis of microsporidian parasites by turbot spleen cells. Vet. Immunol. Immunopathol. 51 (1996) 201-210
158. Leulier F., and Lemaitre B. Toll-like receptors-taking and evolutionary approach. Nat. Rev. Genet. 9 (2008) 165-178
159. Li J., Barreda D.R., Zhang Y.-A., Boshra H., Gelman A.E., LaPatra S., Tort L., and Sunyer O. B lymphocytes from early vertebrates have potent phagocytic and microbicidal abilities. Nat. Immunol. 7 (2006) 1116-1124
160. Li J.-H., Shao J.-Z., Xiang L.-X., and Wen Y. Cloning, characterization and expression analysis of pufferfish interleukin-4 cDNA: the first evidence of Th2-type cytokine in fish. Mol. Immunol. 44 (2007) 2078-2086
161. Lin B., Chen S., Cao Z., Lin Y., Mo D., Zhang H., Gu J., Dong M., Liu Z., and Xu A. Acute phase response in zebrafish upon Aeromonas salmonicida and Staphylococcus aureus infection: striking similarities
162. Lin Y., Lin T.L., Wang C.-C., Wang X., Stieger K., Klopfleisch R., and Clark T.G. Variation in primary sequence and tandem repeat copy number among i-antigens of Ichthyophthirius multifiliis. Mol. Biochem. Parasitol. 120 (2002) 93-106
163. Lindenstrøm T., Buchmann K., and Secombes C.J. Gyrodactylus derjavini infection elicits IL-1β expression in rainbow trout skin. Fish Shellfish Immunol. 15 (2003) 107-115
164. Lindenstrøm T., Secombes C.J., and Buchmann K. Expression of immune response genes in rainbow trout skin induced by Gyrodactylus derjavini infections. Vet. Immunol. Immunopathol. 97 (2004) 137-148
165. Lischke A., Klein C., Stierhof Y.D., Hempel M., Mehlert A., Almeida I.C., Ferguson M.A.J., and Overath P. Isolation and characterization of glycosylphosphatidylinositol-anchored, mucin-like surface glycoproteins from bloodstream forms of the freshwater-fish parasite Trypanosoma carassii. Biochem. J. 345 (2000) 693-700
166. Lobb C.J., and Clem L.W. Phylogeny of immunoglobulin structure and function. XI. Secretory immunoglobulin in the cutaneous mucus of the sheepshead. Dev. Comp. Immunol. 5 (1981) 271-282
167. Lom J. Trichodinidae and other ciliates (Phylum Ciliophora). In: Woo P.T.K. (Ed). Fish Diseases and Disorders, vol. 1. Protozoan and Metazoan Infections (1999), CABI Publishing, New York 229-262
168. Lom J., and Dyková I. Protozoan parasites of fish. Developments in Aquaculture and Fisheries Science vol. 26 (1992), Elsevier, Amsterdam 315 pp
169. Lom J., and Dyková I. Myxosporea (Phylum Myxozoa). In: Woo P.T.K. (Ed). Fish Diseases and Disorders, vol. 1. Protozoan and Metazoan Infections (1999), CABI Publishing, New York 97-148
170. López-Castejón G., Sepulcre M.P., Mulero I., Pelegrín P., Meseguer J., and Mulero V. Molecular and functional characterization of gilthead seabream Sparus aurata caspase-1: the first identification of an inflammatory caspase in fish. Mol. Immunol. 45 (2008) 49-57
171. Lorenzen N., and LaPatra S.E. DNA vaccines for aquacultured fish. Rev. Sci. Tech. Off. Int. Epiz. 24 (2005) 201-213
172. Lovy J., Wright G.M., and Speare D.J. Morphological presentation of a dentritic-like cell within the gills of chinook salmon infected with Loma salmonae. Dev. Comp. Immunol. 30 (2006) 259-263
173. Luo X.-C., Xie M.Q., Zhu X.-Q., and Li A.-X. Protective immunity in grouper (Epinephelus coioides) following exposure to or injection with Cryptocaryon irritans. Fish Shellfish Immunol. 22 (2007) 427-432
174. Lutz H.U., Fumia S., Schurtenberger C., and Alaia V. Opinion paper. Stimulation of complement amplification or activation of the alternative pathway of complement. Mol. Immunol. 44 (2007) 3862-3865
175. Magnadóttir B. Innate immunity of fish (overview). Fish Shellfish Immunol. 20 (2006) 137-151
176. Magor B.G., and Magor K.E. Evolution of effectors and receptors of innate immunity. Dev. Comp. Immunol. 25 (2001) 651-682
177. Maier V.H., Schmitt C.N.Z., Gudmunsdottir S., and Gudmunsson G.H. Bacterial DNA indicated as an important inducer of fish cathelicidins. Mol. Immunol. 45 (2008) 2352-2358
178. Manera M., and Dezfuli B.S. Rodlet cells in teleosts: a new insight into their nature and functions. J. Fish Biol. 65 (2004) 597-619
179. Manning M.J., and Nakanishi T. The specific immune system: cellular defenses. In: Iwama G., and Nakanishi T. (Eds). The Fish Immune System. Organism, Pathogen and Environment (1996), Academic Press, San Diego, CA 103-205
180. Marchalonis J.J., Adelman M.K., Schulter S.F., and Ramsland P.A. The antibody repertoire in evolution: chance, selection, and continuity. Dev. Comp. Immunol. 30 (2006) 223-247
181. Martone C.B., Spivak E., Busconi L., Folco E.J.E., and Sanchez J.J. A cysteine protease from myxosporean degrades host myofibrils in vitro. Comp. Biochem. Physiol. B 123 (1999) 267-272
182. Matejusová I., Felix B., Sorsa-Leslie T., Gilbey J., Noble L.R., Jones C.S., and Cunningham C.O. Gene expression profiles of some immune relevant genes from skin of susceptible and responding Atlantic salmon (Salmo salar L.) infected with Gyrodactylus salaris (Monogenea) revealed by suppressive subtractive hybridisation. Int. J. Parasitol. 36 (2006) 1175-1183
183. Matsuyama T., Fujiwara A., Nakayasu C., Kamaishi T., Oseko N., Tsutsumi N., Hirono I., and Aoki T. Microarray analyses of gene expression in Japanese flounder Paralichthys olivaceus leucocytes during monogenean parasite Neoheterobothrium hirame infection. Dis. Aquat. Organ. 75 (2007) 79-83
184. Matthews R.A. Ichthyophthirius multifiliis Fouquet and ichthyophthiriosis in freshwater teleost. Adv. Parasitol. 59 (2005) 159-241
185. Mazzanti C., Monni G., and Cognetti-Varriale A.M. Observations on antigenic activity of Pseudodactylogyrus anguillae (Monogenea) on the European eel (Anguilla anguilla). Bull. Eur. Ass. Fish Pathol. 19 (1999) 57-59
186. McGreal E.P., Martinez-Pomares L., and Gordon S. Divergent roles for C-type lectins expressed by cells of the innate immune system. Mol. Immunol. 41 (2004) 1109-1121
187. McGuinness D.H., Dehal P.K., and Pleass R.J. Pattern recognition molecules and innate immunity to parasites. Trends Parasitol. 15 (2003) 312-319
188. Medzhitov J.R. Recognition of microorganisms and activation of the immune response. Nature 449 (2007) 819-826
189. Medzhitov R., and Janeway Jr. C.A. Innate immunity: impact on the adaptive immune response. Curr. Opin. Immunol. 9 (1997) 4-9
190. Medzhitov J.R., and Janeway C.A. Decoding the patterns of self and nonself by the innate immune system. Science 296 (2002) 298-300
191. Meeker N.D., and Trede N.S. Immunology and zebrafish: spawning new models of human disease. Dev. Comp. Immunol. 32 (2008) 745-747
192. Mehta M., and Woo P.T.K. Acquired cell-mediated protection in rainbow trout, Oncorhynchus mykiss, against the haemoflagellate Cryptobia salmositica. Parasit. Res. 88 (2002) 956-962
193. Midtlyng P.J. Vaccination in salmonid aquaculture: a review. Rec. Adv. Mar. Biotechnol. 5 (2000) 227-242
194. Miller N., Wilson M., Bengtén E., Stuge T., Warr G., and Clem W. Functional and molecular characterization of teleost leukocytes. Immunol. Rev. 166 (1998) 187-197
195. Molnár K. Phylum Apicomplexa. In: Woo P.T.K. (Ed). Fish Diseases and Disorders, vol. 1. Protozoan and Metazoan Infections (1999), CABI Publishing, New York 263-287
196. Monni G., and Cognetti-Varriale A.M. Antigenic activity of Diplectanum aequans (Monogenea) in sea bass (Dicentrarchus labrax L.) held under different oxygenation conditions. Bull. Eur. Ass. Fish Pathol. 21 (2001) 241-245
197. Morris D.J., and Adams A. Localization of carbohydrate terminals on Tetracapsuloides bryosalmonae using lectin histochemistry and immunogold electron microscopy. J. Fish Dis. 27 (2004) 37-45
198. Morrison R.N., Koppang E.O., Hordvik I., and Nowak B.F. MHC class II+ cells in the gills of Atlantic salmon (Salmo salar L.) affected by amoebic gill disease. Vet. Immunol. Immunopathol. 109 (2006) 297-303
199. Morrison R.N., Zou J., Secombes C.J., Scapigliati G., Adams M.B., and Nowak B.F. Molecular cloning and expression analysis of tumour necrosis factor-alpha in amoebic gill disease (AGD)-affected Atlantic salmon (Salmo salar L.). Fish Shellfish Immunol. 23 (2007) 1015-1031
200. Mulero I., Sepulcre M.P., Meseguer J., García-Ayala A., and Mulero V. Histamine is stored in mast cells of most evolutionarily advanced fish and regulates the fish inflammatory response. Proc. Natl. Acad. Sci. 104 (2007) 19434-19439
201. Muñoz P., Sitjà-Bobadilla A., and Alvarez-Pellitero P. Cellular and humoral immune response of European sea bass (Dicentrarchus labrax L.) (Teleostei: Serranidae) immunized with Sphaerospora dicentrarchi (Myxosporea: Bivalvulida). Parasitology 120 (2000) 465-477
202. Muñoz P., Alvarez-Pellitero P., and Sitjà-Bobadilla A. Modulation of the in vitro activity of European sea bass (Dicentrarchus labrax L.) phagocytes by the myxosporean parasite Sphaerospora dicentrarchi (Myxosporea: Bivalvulida). Fish Shellfish Immunol. 10 (2000) 57-581
203. Muñoz P., Cuesta A., Athanassopoulou F., Golomazou H., Crespo S., Padrós F., Sitjà-Bobadilla A., Albiñana G., Esteban M.A., Alvarez-Pellitero P., and Meseguer J. Sharpsnout sea bream (Diplodus puntazzo) humoral immune response against the parasite Enteromyxum leei (Myxozoa). Fish Shellfish Immunol. 23 (2007) 636-645
204. Mustafa A., MacWilliams C., Fernandez N., Matchett K., Conboy G.A., and Burka J.F. Effects of sea lice (Lepeophtheirus salmonis Kröyer, 1837) infestation on macrophage functions in Atlantic salmon (Salmo salar L.). Fish Shellfish Immunol. 10 (2000) 47-59
205. Nakane M., Ogawa K., Fujita T., Sameshima M., and Wakabayashi H. Acquired protection of tiger puffer Takifugu rubripes against infection with Heterobothrium okamotoi (Monogenea: Diclidophoridae). Fish Pathol. 40 (2005) 95-101
206. Nakayasu C., Tsutsumi N., Oseko N., and Hasegawa S. Role of cellular response in elimination of the monogenean Neoheterobothrium hirame in Japanese flounder Paralichthys olivaceus. Dis. Aquat. Organ. 64 (2005) 127-134
207. Neumann N.F., Stafford J.L., Barreda D., Ainsworth A.J., and Belosevic M. Antimicrobial mechanisms of fish phagocytes and their role in host defense. Dev. Comp. Immunol. 25 (2001) 807-825
208. Nickol B.B. Phylum Acanthoephala. In: Woo P.T.K. (Ed). Fish Diseases and Disorders, vol. 1. Protozoan and Metazoan Infections (1999), CABI Publishing, New York 447-473
209. Nielsen M.E., and Esteve-Gassent M.D. The eel immune system: present knowledge and the need for research. J. Fish Dis. 29 (2006) 65-78
210. Noël W., Raes G., Ghassabeh G.H., De Baetselier P., and Beschin A. Alternatively activated macrophages during parasite infections. Trends Parasitol. 20 (2004) 126-133
211. Noga E.J., Fan Z., and Silphaduang U. Histone-like proteins from fish are lethal to the parasitic dinoflagellate Amyloodinium ocellatum. Parasitology 123 (2001) 57-65
212. Noga E.J., Fan Z., and Silphaduang U. Host site of activity and cytological effects of histone-like proteins on the parasitic dinoflagellate Amyloodinium ocellatum. Dis. Aquat. Organ. 52 (2002) 207-215
213. Ohno Y., Kawano F., and Hirazawa N. Susceptibility of amberjack (Seriola dumerili), yellowtail (S. quinqueradiata) and Japanese flounder (Paralichthys olivaceus) to Neobenedenia girellae (Monogenea) infection and their acquired protection. Aquaculture 274 (2008) 30-35
214. Onara D.F., Forlenza M., Gonzalez S.F., Rakus K.L., Pilarczyk A., Irnazarow I., and Wiegertjes G.F. Differential transcription of multiple forms of alpha 2-macroglobulin in carp (Cyprinus carpio) infected with parasites. Dev. Comp. Immunol. 32 (2008) 339-347
215. Ordás M.C., Abollo E., Costa M.M., Figueras A., and Novoa B. Molecular cloning and expression analysis of interferon regulatory factor-1 (IRF-1) of turbot and sea bream. Mol. Immunol. 43 (2006) 882-890
216. Overath P., Haag J., Mameza M.G., and Lischke A. Freshwater fish trypanosomes: definition of two types, host control by antibodies and lack of antigenic variation. Parasitology 119 (1999) 591-601
217. Palaksha K.J., Shin G.W., Kim Y.R., and Jung T.S. Evaluation of non-specific immune components from the skin mucus of olive flounder (Paralichthys olivaceus). Fish Shellfish Immunol. 24 (2008) 479-488
218. Paperna I. Digenea (Phylum Plathyhelminthes). In: Woo P.T.K. (Ed). Fish Diseases and Disorders, vol. 1. Protozoan and Metazoan Infections (1999), CABI Publishing, New York 329-389
219. Paramá A., Castro R., Arranz J.A., Sanmartin M.L., Lamas J., and Leiro J. Scuticociliate cysteine proteinases modulate turbot leucocyte functions. Fish Shellfish Immunol. 23 (2007) 945-956
220. Paramá A., Castro R., Lamas J., Sanmartin M.L., Santamarina M.T., and Leiro J. Scuticociliate proteinases may modulate turbot immune response by inducing apoptosis in pronephric leucocytes. Int. J. Parasitol. 37 (2006) 87-95
221. Pasare C., and Medzhitov R. Toll-like receptors: linking innate and adaptative immunity. Microb. Infect. 6 (2004) 1382-1387
222. Paulsen S.M., Sveinbjornsson B., and Robertsen B. Selective staining and disintegration of intestinal eosinophilic granule cells in Atlantic salmon after intraperitoneal injection of the zinc chelator dithizone. J. Fish Biol. 58 (2001) 768-775
223. Pétrilli V., Dostert C., Muruve D.A., and Tschopp J. The inflammasome: a danger sensing complex triggering innate immunity. Curr. Opin. Immunol. 19 (2007) 615-622
224. Pike K.A., and Ratcliffe M.J.H. Cell surface immunoglobulin receptors in B cell development. Semin. Cell Dev. Biol. 14 (2002) 351-358
225. Plouffe D.A., and Belosevic M. Enzyme treatment of Trypanosoma danilewskyi (laveran & Mesnil) increases its susceptibility to lysis by the alternative comp,ement pathway of golffish, Carassius auratus (L.). J. Fish Dis. 27 (2004) 277-285
226. Plouffe D.A., Hanington P.C., Walsh J.G., Wilson E.C., and Belosevic M. Comparison of select innate immune mechanisms of fish and mammals. Xenotransplantation 12 (2005) 266-277
227. Pomport-Castillon C., Gasc C., and Romestand B. IgM levels and specific antibody activity if the flounder (Platichthys flesus L.), following injection of microsporidian spores. Fish Shellfish Immunol. 9 (1999) 153-156
228. Praveen K., Evans D.L., and Jaso-Friedmann L. Constitutive expression of tumor necrosis factor-alpha in cytotoxic cells of teleosts and its role in regulation of cell-mediated cytotoxicity. Mol. Immunol. 43 (2006) 279-291
229. Praveen K., Leary III J.H., Evans D.L., and Jaso-Friedmann L. Molecular cloning of cellular apoptosis susceptibility (CAS) gene in Oreochromis niloticus and its proposed role in regulation of non-specific cytotoxic cell (NCC) functions. Fish Shellfish Immunol. 20 (2006) 647-655
230. Purcell M.K., Smith K.D., Aderem A., Hood L., Winton J.R., and Roach J.C. Conservation of Toll-like receptor signaling pathways in teleost fish. Comp. Biochem. Physiol. D 1 (2006) 77-88
231. Randelli E., Buonocore F., and Scapigliati G. Cell markers and determinants in fish immunology. Fish Shellfish Immunol. 25 (2008) 326-340
232. Raynard R.S., Bricknell I.R., Billingsley P.F., and Nisbet A.J. Development of vaccines against sea lice. Pest Manage. Sci. 58 (2002) 569-575
233. Rebl A., Siegl E., Kollner B., Fischer U., and Seyfert H.-M. Characterization of twin toll-like receptors from rainbow trout (Oncorhynchus mykiss): evolutionary relationship and induced expression by Aeromonas salmonicida salmonicida. Dev. Comp. Immunol. 31 (2007) 499-510
234. Redondo M.J., Palenzuela O., and Alvarez-Pellitero P. Studies on transmission and life cycle of Enteromyxum scophthalmi (Myxozoa), an enteric parasite of turbot Scophthalmus maximus. Folia Parasitol. 51 (2004) 188-198
235. Redondo M.J., Cortadellas N., Palenzuela O., and Alvarez-Pellitero P. Detection of carbohydrate terminals in the enteric parasite Enteromyxum scophthalmi (Myxozoa) and possible interactions with its fish host Psetta maxima. Parasitol. Res. 102 (2008) 1257-1267
236. Reilly P., and Mulcahy M.F. Humoral antibody response in Atlantic salmon (Salmo salar L.) immunized with extracts derived from the ectoparasite caligid copepods, Caligus elongatus (Nordmann,1832) and Lepeopththeirus salmonis (Kroyer, 1838). Fish Shellfish Immunol. 3 (1993) 59-70
237. Reis M.I.R., do Vale A., Pinto C., Nascimento D.S., Costa-Ramos C., Silva D.S.P., Silva M.T., and dos Santos N.M.S. First molecular cloning and characterisation of caspase-9 gene in fish and its involvement in a Gram negative septicaemia. Mol. Immunol. 44 (2007) 1765-1775
238. Reis M.I.R., Nascimiento D.S., Vale A., Silva M.T., and dos Santos N.M.S. Molecular cloning and characterisation of sea bass (Dicentrarchus labrax, L.) caspase-3 gene. Mol. Immunol. 44 (2007) 774-783
239. Reite O.B. Mast cells/eosinophilic granule cells of teleostean fish: a review focusing on staining properties and functional responses. Fish Shellfish Immunol. 8 (1998) 489-513
240. Reite O.B., and Evensen O. Inflammatory cells of teleostean fish: a review focusing on mast cells/eosinophilic granule cells and rodlet cells. Fish Shellfish Immunol. 20 (2006) 192-208
241. Richards D.T., Hoole D., Lewis J.W., Ewens E., and Arme C. Changes in the cellular composition of spleen and pronephros of carp Cyprinus carpio infected with the blood fluke Sanguinicola inermis (Trematoda: Sanguinicolidae). Dis. Aquat. Organ. 19 (1994) 173-179
242. Richards D.T., Hoole D., Lewis J.W., Ewens E., and Arme C. Ultrastructural observations on the cellular response of carp, Cyprinus carpio, to eggs of the blood fluke Sanguinicola inermis Plehn, 1905 (Trematoda: Sanguinicolidae). J. Fish Dis. 17 (1994) 439-446
243. Richards D.T., Hoole D., Lewis J.W., Ewens E., and Arme C. Adherence of carp leucocytes to adults and cercariae of the blood fluke Sanguinicola inermis. J. Helminthol. 70 (1996) 63-67
244. Roach J.C., Glusman G., Rowen L., Kaur A., Purcell M.K., and Smith K.D. The evolution of vertebrate toll-like receptors. Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 9577-9582
245. Roberts M.L., Lewis J.W., Wigertjes G.F., and Hoole D. Interaction between the blood fluke, Sanguinicola inermis and humoral components of the immune response of carp, Cyprinus carpio. Parasitology 131 (2005) 261-271
246. Roberts R.J., Young H., and Milne J.A. Studies on the skin of plaice (Pleuronectes platessa L.). 1. The structure and ultrastructure of normal plaice skin. J. Fish Biol. 4 (1971) 87-98
247. Robertsen B. The interferon system of teleost fish. Fish Shellfish Immunol. 20 (2006) 172-191
248. Rocha B. The extrathymic T-cell differentiation in the murine gut. Immunol. Rev. 215 (2007) 166-177
249. Rocha J.S., and Chiarini-Garcia H. Mast cell heterogeneity between two different species of Hoplias sp. (Characiformes: Erythrinidae): response to fixatives, anatomical distribution, histochemical contents and ultrastructural features. Fish Shellfish Immunol. 22 (2007) 218-229
250. Rodriguez A., Esteban M.A., and Meseguer J. A mannose-receptor is possibly involved in the phagocytosis of Saccharomyces cerevisiae by seabream (Sparus aurata L.) leucocytes. Fish Shellfish Immunol. 14 (2003) 375-388
251. Rogers-Lowery C.L., Dimock Jr. R., and Kuhn R.E. Antibody response of bluegill sunfish during development of acquired resistance against the larvae of the freshwater mussel Utterbackia imbecillis. Dev. Comp. Immunol. 31 (2007) 143-155
252. Rombout J.H.M.W., and Joosten E.P.H.M. Mucosal immunity. In: Pastoret P., Griebel P., Bazin H., and Govaerts A. (Eds). Immunology of Fishes. Handbook of Vertebrate Immunology (1998), Academic Press, London 39-40
253. Rombout J.H.M.W., Huttenhuis H.B.T., Picchietti S., and Scapigliati G. Phylogeny and ontogeny of fish leucocytes. Fish Shellfish Immunol. 19 (2005) 441-445
254. Ronneseth A., Wergeland H.I., and Pettersen E.F. Neutrophils and B-cells in Atlantic cod (Gadus morhua L.). Fish Shellfish Immunol. 23 (2007) 493-503
255. Rubio-Godoy M., Sigh J., Buchmann K., and Tinsley R.C. Immunization of rainbow trout Oncorhynchus mykiss against Discocotyle sagittata (Monogenea). Dis. Aquat. Organ. 55 (2003) 23-30
256. Rubio-Godoy M., Sigh J., Buchmann K., and Tinsley R.C. Antibodies against Discocotyle sagittata (Monogenea) in farmed trout. Dis. Aquat. Organ. 56 (2003) 181-184
257. Rubio-Godoy M., Porter R., and Tinsley R.C. Evidence of complement-mediated killing of Discocotyle sagittata (Platyhelminthes, Monogenea) oncomiracidia. Fish Shellfish Immunol. 17 (2004) 95-103
258. Rucker U., and El-Matbouli M. Sequence analysis of OmNramp α and quantitative expression of Nramp homologues in different trout strains after infection with Myxobolus cerebralis. Dis. Aquat. Organ. 76 (2007) 223-230
259. Russell S., and Lumsden J.S. Function and heterogeneity of fish lectins. Vet. Immunol. Immunopathol. 108 (2005) 111-120
260. Saeij J.P.J., van Muiswinkel W.B., Groeneveld A., and Wiegertjes G.F. Immune modulation by fish kinetoplastid parasites: a role for nitric oxide. Parasitology 124 (2002) 77-86
261. Saeij J.P.J., Stet R.J.M., de Vries B.J., van Muiswinkel W.B., and Wiegertjes G.F. Molecular and functional characterization of carp TNF: a link between TNF polymorphism and trypanotolerance?. Dev. Comp. Immunol. 27 (2003) 29-41
262. Saeij J.P.J., de Vries B.J., and Wiegertjes G.F. The immune response of carp to Trypanoplasma borreli: kinetics of immune gene expression and polyclonal lymphocyte activation. Dev. Comp. Immunol. 27 (2003) 859-874
263. Salaun B., Romero P., and Lebecque S. Toll-like receptors' two edge sword: when immunity meets apoptosis. Eur. J. Immunol. 37 (2007) 3311-3318
264. Sanchez J.G., Speare D.J., Markham R.J.F., and Jones S.R.M. Experimental vaccination of rainbow trout against Loma salmonae using a live low-virulence variant of L. salmonae. J. Fish Biol. 59 (2001) 442-448
265. Sanmartín M.L., Paramá A., Castro R., Cabaleiro S., Leiro J., Lamas J., and Barja J.L. Vaccination of turbot, Psetta maxima (L.), against the protozoan parasite Philasterides dicentrarchi: effects on antibody production and protection. J. Fish Dis. 31 (2008) 135-140
266. Saurab S., and Sahoo P.K. Lysozyme: an important defence molecule of fish innate immune system. Aquacult. Res. 39 (2008) 233-239
267. Schaumburg F., Hippe D., Vutova P., and Luder C.G.K. Pro- and anti-apoptotic activities of protozoan parasites. Parasitology 132 (2006) S69-S85
268. Scharsack J.P., Steinhagen D., Kleczka C., Schmidt J.O., Korting W., Leibold W., and Schuberth H.J. Head kidney neutrophils of carp (Cyprinus carpio L.) are functionally modulated by the haemoflagellate Trypanoplasma borreli. Fish Shellfish Immunol. 14 (2003) 389-403
269. Scharsack J.P., Steinhagen D., Kleczka C., Schmidt J.O., Korting W., Leibold W., and Schuberth H.J. The haemoflagellate Trypanoplasma borreli induces the production of nitric oxide, which is associated with modulation of carp (Cyprinus carpio L.) leucocyte functions. Fish Shellfish Immunol. 14 (2003) 207-222
270. Scharsack J.P., Steinhagen D., Körting W., Wagner B., Leibold W., and Schuberth H.J. Some immune parameters in carp Cyprinus carpio susceptible and resistant to the haemoflagellate Trypanoplasma borreli. Dis. Aquat. Organ. 60 (2004) 41-48
271. Secombes C.J. The nonspecific immune system: cellular defenses. In: Iwama G., and Nakanishi T. (Eds). The Fish Immune System. Organism, Pathogen and Environment (1996), Academic Press, San Diego, CA 63-101
272. Secombes C.J., and Chappell L.H. Fish immune responses to experimental and natural infection with helminth parasites. Ann. Rev. Fish Dis. 6 (1996) 167-177
273. Secombes C.J., Bird S., Cunningham C., and Zou J. Interleukin-1 in fish. Fish Shellfish Immunol. 9 (1999) 335-343
274. Secombes C.J., Wang T., Hong S., Peddie S., Crampe M., Laing K., Cunningham C., and Zou J. Cytokines and innate immunity of fish. Dev. Comp. Immunol. 25 (2001) 713-723
275. Secombes C.J., Zou J., Laing K., Daniels G.D., and Cunningham C. Cytokine genes in fish. Aquaculture 172 (1999) 93-102
276. Sepulcre M.P., Pelegrin P., Mulero V., and Meseguer J. Characterisation of gilthead seabream acidophilic granulocytes by a monoclonal antibody unequivocally points to their involvement in fish phagocytic response. Cell Tissue Res. 308 (2002) 97-102
277. Sepulcre M.P., López-Castejón G., Meseguer J., and Mulero V. The activation of gilthead sea bream professional phagocytes by different PAMPs underlines the behavioural diversity of the main innate immune cells of bony fish. Mol. Immunol. 44 (2007) 2009-2016
278. Severin V.I.C., and El-Matbouli M. Relative quantification of immune-regulatory genes in two rainbow trout strains, Oncorhynchus mykiss, after exposure to Myxobolus cerebralis, the causative agent of whirling disease. Parasitol. Res. 101 (2007) 1019-1027
279. Shao L., Serrano D., and Mayer L. The role of epithelial cells in immune regulation in the gut. Semin. Immunol. 13 (2001) 163-175
280. Sharp G.J.E., Pike A.W., and Secombes C.J. The immune response of wild rainbow trout, Salmo gairdneri Richardson, to naturally acquired plerocercoid infections of Diphyllobothrium dendriticum (Nitzsch, 1824) and D. ditremum (Creplin, 1925). J. Fish Biol. 35 (1989) 781-794
281. Sharp G.J.E., Pike A.W., and Secombes C.J. Rainbow trout [Oncorhynchus mykiss (Walbaum, 1792)] leucocyte interactions with metacestode stages of Diphyllobothrium dendriticum (Nitzsch, 1824) (Cestoda, Pseudophyllidea). Fish Shellfish Immunol. 1 (1991) 195-211
282. Shaw R.W., Kent M.L., and Adamson M.L. Phagocytosis of Loma salmonae (Microsporidia) spores in Atlantic salmon (Salmo salar), a resistant host, and chinook salmon (Oncorhynchus tshawytscha), a susceptible host. Fish Shellfish Immunol. 11 (2001) 91-100
283. Shen L., Stuge T.B., Evenhuis J.P., Bengten E., Wilson M., Chinchar V.G., Clem L.W., and Miller N.W. Channel catfish NK-like cells are armed with IgM via a putative FcμR. Dev. Comp. Immunol. 27 (2003) 699-714
284. Sigh J., and Buchmann K. Comparison of immobilization assays and enzyme-linked immunosorbent assays for detection of rainbow trout antibody-titres against Ichthyphthirius multifiliis Fouquet, 1876. J. Fish Dis. 24 (2001) 49-51
285. Sigh J., Lindenstrom T., and Buchmann K. Expression of pro-inflammatory cytokines in rainbow trout (Oncorhynchus mykiss) during an infection with Ichthyophthirius multifiliis. Fish Shellfish Immunol. 17 (2004) 75-86
286. Sigh J., Lindenstrom T., and Buchmann K. The parasitic ciliate Ichthyophthirius multifiliis induces expression of immune relevant genes in rainbow trout, Oncorhynchus mykiss (Walbaum). J. Fish Dis. 27 (2004) 409-417
287. Silphaduang U., and Noga E.J. Peptide antibiotics in mast cells of fish. Nature 414 (2001) 268-269
288. Silphaduang U., Colorni A., and Noga E.J. Evidence for widespread distribution of piscidin antimicrobial peptides in teleost fish. Dis. Aquat. Organ. 72 (2006) 241-252
289. Sitjà-Bobadilla A. Living off a fish: a trade-off between parasites and the immune system. Fish Shellfish Immunol. 25 (2008) 358-372
290. Sitjà-Bobadilla A., Palenzuela O., Riaza A., Macías M.A., and Alvarez-Pellitero P. Protective acquired immunity to Enteromyxum scophthalmi (Myxozoa) is related to specific antibodies in Psetta maxima (L.) (Teleostei). Scand. J. Immunol. 66 (2007) 26-34
291. Sitjà-Bobadilla A., Palenzuela O., and Alvarez-Pellitero P. Immune response of turbot, Psetta maxima (L.) (Pisces: Teleostei), to formalin-killed scuticociliates (Ciliophora) and adjuvanted formulations. Fish Shellfish Immunol. 24 (2008) 1-10
292. Sitjà-Bobadilla A., Calduch-Giner J., Saera-Vila A., Palenzuela O., Alvarez-Pellitero P., and Pérez-Sánchez J. Chronic exposure to the parasite Enteromyxum leei (Myxozoa: Myxosporea) modulates the immune response and the expression of growth, redox and immune relevant genes in gilthead sea bream, Sparus aurata L. Fish Shellfish Immunol. 24 (2008) 610-619
293. Sitjà-Bobadilla A., Redondo M.J., Bermudez R., Palenzuela O., Fereiro I., Riaza A., Quiroga I., Nieto J.M., and Alvarez-Pellitero P. Innate and adaptive immune responses of turbot, Scophthalmus maximus (L.), following experimental infection with Enteromyxum scophthalmi (Myxosporea: Myzozoa). Fish Shellfish Immunol. 21 (2006) 485-500
294. Sitjà-Bobadilla A., Redondo M.J., Macias M.A., Ferreiro I., Riaza A., and Alvarez-Pellitero P. Development of immunohistochemistry and enzyme-linked immunosorbent assays for the detection of circulating antibodies against Enteromyxum scophthalmi (Myxozoa) in turbot (Scophthalmus maximus L.). Fish Shellfish Immunol. 17 (2004) 335-345
295. Smith S.A., Levy M.G., and Noga E.J. Development of an enzyme-linked immunosorbent assay (ELISA) for the detection of antibody to the parasitic dinoflagellate Amyloodinium ocellatum in Oreochromis aureus. Vet. Parasitol. 42 (1992) 145-155
296. Smith S.A., Levy M.G., and Noga E.J. Detection of anti-Amyloodinium ocellatum antibody from cultured hybrid striped bass (Morone saxatilis × M. chrysops) during an epizootic of amyloodiniosis. J. Aquat. Anim. Health 6 (1994) 79-81
297. Solem S.T., and Stenvik J. Antibody repertoire development in teleosts-a review with emphasis on salmonids and Gadus morhua L. Dev. Comp. Immunol. 30 (2006) 57-76
298. Sommerset I., Krossøy B., Biering E., and Frost P. Vaccines for fish in aquaculture. Exp. Rev. Vac. 4 (2005) 89-101
299. Speare D.J., Markhan J.F., and Guselle N.J. Development of an effective whole-spore vaccine to protect against microsporidial gill disease in rainbow trout (Oncorhynchus mykiss) by using a low-virulence strain of Loma salmonae. Clin. Vac. Immunol. 14 (2007) 1652-1654
300. Stakauskas R., Schuberth H.J., Leibold W., and Steinhagen D. Modulation of carp (Cyprinus carpio) neutrophil functions during an infection with the haemoparasite Trypanoplasma borreli. Fish Shellfish Immunol. 23 (2007) 446-458
301. Steinhagen D., and Hespe K. Carp occidiosis: activity of phagocytic cells from common carp infected with Goussia carpelli. Dis. Aquat. Organ. 31 (1997) 155-159
302. Sterud E., Poppe T.T., and Borno G. Intracellular infection with Spironucleus barkhanus (Diplomonadida: Hexamitidae) in farmed Artic char Salvelinus alpinus. Dis. Aquat. Organ. 56 (2003) 155-161
303. Sveinbjornsson B., Olsen R., and Paulsen S. Immunocytochemical localization of lysozyme in intestinal eosinophilic granule cells (EGCs) of Atlantic salmon, Salmo salar L. J. Fish Dis. 19 (1996) 349-355
304. Swennes A.G., Findly R.C., and Dickerson H.W. Cross-immunity and antibody responses to different immobilisation serotypes of Ichthyophthirius multifiliis. Fish Shellfish Immunol. 22 (2007) 589-597
305. Swennes A.G., Noe J.G., Findly R.C., and Dickerson H.W. Differences in virulence between two serotypes of Ichthyophthirius multifiliis. Dis. Aquat. Organ. 69 (2006) 227-232
306. Takano T., Kondo H., Hirono I., Saito-Taki T., Endo M., and Aoki T. Identification and characterization of a myeloid differentiation factor 88 (MyD88) cDNA and gene in Japanese flounder, Paralichthys olivaceus. Dev. Comp. Immunol. 30 (2006) 807-816
307. Takano T., Kondo H., Hirono I., Endo M., Saito-Taki T., and Aoki T. Molecular cloning and characterization of Toll-like receptor 9 in Japanese flounder, Paralichthys olivaceus. Mol. Immunol. 44 (2007) 1855-1863
308. Taylor I.S., Adam B., Veverkova M., Tatner M.F., Low C., Secombes C., and Birkbeck T.H. T-cell antigen receptor genes in turbot (Scophthalmus maximus L.). Fish Shellfish Immunol. 18 (2005) 445-448
309. Thorarinsson R., and Powell D.B. Effects of disease risk, vaccine efficacy, and market price on the economics of fish vaccination. Aquaculture 256 (2006) 42-49
310. Tonheim T.C., Bøgwald J., and Dalmo R.A. What happens to the DNA vaccines in fish?-a review of the current knowledge. Fish Shellfish Immunol. 25 (2008) 1-18
311. Trede N.S., Langenau D.M., Traver D., Look A.T.:, and Zon L.I. The use of zebrafish to understand immunity. Immunity 20 (2004) 367-379
312. Tsoi S., Park K.C., Kay H.H., O'Brien T.J., Podor E., Sun G., Douglas S.E., Brown L.L., and Johnson S.C. Identification of a transcript encoding a soluble form of toll-like receptor 5 (TLR5) in Atlantic salmon during Aeromonas salmonicida infection. Vet. Immunol. Immunopathol. 109 (2006) 183-187
313. Tsutsui S., Tasumi S., Suetake H., and Suzuki Y. Lectins homologous to those monocotyledonous plants in the skin mucus and intestine of pufferfish, Fugu rubripes. J. Biol. Chem. 23 (2003) 20882-20889
314. Tsutsui Sh., Tasumi S., Suetake H., Kikuchi K., and Suzuki Y. Demonstration of the mucosal lectins in the epithelial cells of internal and external body surface tissues in pufferfish (Fugu rubripes). Dev. Comp. Immunol. 29 (2004) 243-253
315. Turner M.W. The role of mannose-binding lectin in health and disease. Mol. Immunol. 40 (2003) 423-429
316. Vigliano F.A., Bermúdez R., Quiroga M.I., and Nieto J.M. Evidence for melano-macrophage centres of teleost as evolutionary precursors of germinal centres of higher vertebrates: an inmunohistochemical study. Fish Shellfish Immunol. 21 (2006) 467-471
317. Vigliano F.A., Bermúdez R., Nieto J.M., and Quiroga M.I. Development of rodlet cells in the gut of turbot (Psetta maxima L.): relationship between their morphology and S100 protein immunoreactivity. Fish Shellfish Immunol. (2008) 10.1016/j.fsi.2008.02.016
318. Vincent B.N., Morrison R.N., and Nowak B.F. Amoebic gill disease (AGD)-affected Atlantic salmon, Salmo salar L., are resistant to subsequent AGD challenge. J. Fish Dis. 29 (2006) 549-559
319. Wang G., Kim J.-H., Sameshima M., and Ogawa K. Detection of antibodies against the monogenean Hetrobothirum okamotoi in tiger puffer by ELISA. Fish Pathol. 32 (1997) 179-180
320. Wang Q., Wang Y., Xu P., and Liu Z. NK-lysin of channel catfish: gene triplication, sequence variation, and expression analysis. Mol. Immunol. 43 (2006) 1676-1686
321. Watts M., Munday B.L., and Burke C.M. Immune responses of teleost fish. Aust. Vet. J. 79 (2001) 570-574
322. Weaver C.T., Hatton R.D., Mangan P.R., and Harrington L.E. IL-17 family cytokines and the expanding diversity of effector T cell lineages. Annu. Rev. Immunol. 25 (2007) 821-852
323. Whyte S.K. The innate immune response in finfish: a review of current knowledge. Fish Shellfish Immunol. 23 (2007) 1127-1151
324. Whyte S.K., Chappell L.H., and Secombes C.J. Cytotoxic reactions of rainbow trout, Salmo garidneri Richardson, macrophages for larvae of the eye fluke Diplostomum spathaceum (Digenea). J. Fish Biol. 35 (1989) 333-345
325. Whyte S.K., Chappell L.H., and Secombes C.J. Protection of rainbow
326. Wiegertjes G.F., Groeneveld A., and van Muiswinkel W.B. Genetic variation in susceptibility to Trypanoplasma borreli infection in common carp (Cyprinus carpio L.). Vet. Immunol. Immunopathol. 47 (1995) 153-161
327. Wiegertjes G.F., Forlenza M., Joerink M., and Scharsack J.P. Parasite infections revisited. Dev. Comp. Immunol. 29 (2005) 749-758
328. Winton J.R. Molecular approaches to fish vaccines. J. Appl. Ichthyol. 14 (1998) 153-158
329. Woo P.T.K. Immunological responses of fishes to parasitic organisms. Ann. Rev. Fish Dis. 2 (1992) 339-366
330. Woo P.T.K. Protective immune response of fish to parasitic flagellates. Ann. Rev. Fish Dis. 6 (1996) 121-131
331. Woo P.T.K. Cryptobiosis and its control in North American fishes. Int. J. Parasitol. 31 (2001) 566-574
332. Woo P.T.K. Cryptobia (Trypanoplasma) salmositica and salmonid cryptobiosis. J. Fish Dis. 26 (2003) 627-646
333. Woo P.T.K., and Poynton S.L. Diplomonadida, Kinetoplastida and Amoebida (Phylum Sarcomastigophora). In: Woo P.T.K. (Ed). Fish Diseases and Disorders, vol. 1. Protozoan and Metazoan Infections (1999), CABI Publishing, New York 27-96
334. Wynne J.W., Cook M.T., Nowak B.F., and Elliot N.G. Major histocompatibility polymorphism associated with resistance towards amoebic gill disease in Atlantic salmon (Salmo salar L.). Fish Shellfish Immunol. 22 (2007) 707-717
335. Xu D.-H., Klesius P.H., and Shoemaker C.A. Effect of lectins on the invasion of Ichthyophthirius theront to channel catfish tissue. Dis. Aquat. Organ. 45 (2001) 115-120
336. Xu D.-H., Klesius P.H., and Shelby R.A. Immune responses and host protection of channel catfish, Ictalurus punctatus (Rafinesque), against Ichthyophthirius multifiliis after immunization with live theronts and sonicated trophonts. J. Fish Dis. 27 (2004) 135-141
337. Xu D.-H., Klesius P.H., and Schoemaker C.A. Cutaneous antibodies from channel catfish, Ictalurus punctatus (Rafinesque), immune to Ichthyophthirius multifiliis (Ich) may induce apoptosis of Ich theronts. J. Fish Dis. 28 (2005) 213-220
338. Xu D.-H., Klesius P.H., and Panangala V.S. Induced cross-protection in channel catfish, Ictalurus punctatus (Rafinesque), against different immobilization serotypes of Ichthyophthirius multifiliis. J. Fish Dis. 29 (2006) 131-138
339. Xu D.-H., Klesius P.H., and Shoemaker C.A. Apoptosis in Ichthyophthirius multifiliis is associated with expression of the Fas receptor of theronts. J. Fish Dis. 29 (2006) 225-232
340. Xu D.-H., Klesius P.H., and Shoemaker C.A. Protective immunity of Nile tilapia against Ichthyophthirius multifiliis post immunization with live theronts and sonicated trophonts. Fish Shellfish Immunol. 25 (2008) 124-127
341. Yambot A.V., and Song Y.-L. Immunization of grouper, Epinephelus coioides, confers protection against a protozoan parasite, Cryptocaryon irritans. Aquaculture 260 (2006) 1-9
342. Young N.D., Cooper G.A., Nowak B.F., Koop B.F., and Morrison R.N. Coordinated down-regulation of the antigen processing machinery in the gills of amoebic gill disease-affected Atlantic salmon (Salmo salar L.). Mol. Immunol. 45 (2008) 2581-2597
343. Young N.D., Crosbie P.B.B., Adams M.B., Nowak B.F., and Morrison R.N. Neoparamoeba perurans n. sp., an agent of amoebic gill disease of Atlantic salmon (Salmo salar). Int. J. Parasitol. 37 (2007) 1469-1481
344. Zapata A., and Amemiya C.T. Phylogeny of lower vertebrates and their immunological structures. Origin and evolution of the vertebrate immune system. Curr. Top. Microbiol. Immunol. 248 (2000) 67-107
345. Zapata A., Diez B., Cejalvo T., Gutierrez-de Frias C., and Cortes A. Ontogeny of the immune system of fish. Fish Shellfish Immunol. 20 (2006) 126-136
346. Zasloff M. Antimicrobial peptides of multicellular organisms. Nature 415 (2002) 389-395
347. Zhang J.Y., Wu Y.S., Wu H.B., Wang J.G., Li A.H., and Li M. Humoral immune responses of the grouper Epinephelus akaara against the microsporidium Glugea epinephelusis. Dis. Aquat. Organ. 64 (2005) 121-126