A protective cocktail vaccine against murine cutaneous leishmaniasis with DNA encoding cysteine proteinases of Leishmania major

Vaccine

Volumn 19, Issue 25-26, 2001, Pages 3369-3375

  Rafati, Sima ^a   Salmanian, Ali Hatef ^a   Taheri, Tahere ^a   Vafa, Manije ^a   Fasel, Nicolas ^b  

^a PASTEUR INSTITUTE OF IRAN   (Iran)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

Cysteine proteinases; DNA vaccine; Leishmania

Indexed keywords

CYSTEINE PROTEINASE; DNA VACCINE; GAMMA INTERFERON; PLASMID DNA; RECOMBINANT VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG EFFICACY; FEMALE; GENE EXPRESSION; IMMUNE RESPONSE; IMMUNIZATION; LEISHMANIA MAJOR; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SKIN LEISHMANIASIS;

ANIMALS; ANTIBODIES, PROTOZOAN; CYSTEINE ENDOPEPTIDASES; FEMALE; GENES, PROTOZOAN; IMMUNOGLOBULIN G; INTERFERON TYPE II; LEISHMANIA MAJOR; LEISHMANIASIS, CUTANEOUS; MICE; MICE, INBRED BALB C; PLASMIDS; PROTOZOAN VACCINES; VACCINES, COMBINED; VACCINES, DNA; VACCINES, SYNTHETIC;

EID: 0035858106     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(01)00081-0     Document Type: Article

References (27)

1. Setting in motion the immune mechanism underlying genetically determined resistance and susceptibility to infection with Leishmania major
2. The regulation of immunity to Leishmania major
3. Leishmania vaccines: Old and new
4. Vaccination against cutaneous leishmaniasis in a murine model. I. Induction of protective immunity with a soluble extract of promastigotes
5. Protection against leishmaniasis by injection of DNA encoding a major surface glycoprotein, gp 63, of L. major
6. Immunostimulatory DNA: Sequence-dependent production of potentially harmful or useful cytokines
7. Bacterial DNA-induced NK cell IFN-γ production is dependent on macrophage secretion of IL-12
8. Pervasive CpG suppression in animal mitochondrial genomes
9. The influence of DNA structure on the in vitro stimulation of murine lymphocytes by natural and synthetic polynucleotide antigens
10. DNA vaccine
11. CpG-containing synthetic oligonucleotides promote B and cytotoxic T cell responses to protein antigen: A new class of vaccine adjuvants
12. CpG oligodeoxynucleotides trigger protective and curative Th1 responses in lethal murine leishmaniasis
13. Genetic immunization with glycoprotein 63 cDNA results in a helper T cell type 1 immune response and protection in a murine model of leishmaniasis
14. Vaccination with DNA encoding the immunodominant LACK parasite antigen confers protective immunity to mice infected with Leishmania major
15. Proteinases of trypanosomes and Leishmania
16. Leishmania major: Comparison of the cathepsin L- and B-like cysteine protease genes with those of other trypanosomatids
17. Parasite cysteine proteinases
18. Identification of Leishmania major cysteine proteinases as targets of the immune response in humans
19. Biochemical analysis and immunogenicity of Leishmania major amastigote fractions in cutaneous leishmaniasis
20. Vaccination of BALB/c mice with Leishmania major amastigote specific cysteine proteinase
21. Mutational analysis of polymeric immunoglobulin receptor/ligand interactions
22. Inhibitory effect of lipopolysaccharide on immune response after DNA immunization is route dependent
23. Immunostimulatory DNA as an adjuvant in vaccination against Leishmania major
24. Immune responses to DNA vaccines
25. Roles of cysteine proteinases of trypanosomes and Leishmania in host-parasite interactions
26. Antigen presentation by Leishmania mexicana-infected macrophages: Activation of helper T cells specific for amastigote cysteine proteinases requires intracellular killing of the parasites
27. Characterization of an antigen from Leishmania amazonensis amastigote able to elicite responses in murine model