Glucocorticoids decrease body weight and food intake and inhibit appetite regulatory peptide expression in the hypothalamus of rats

Experimental and Therapeutic Medicine

Volumn 2, Issue 5, 2011, Pages 977-984

  Liu, Xiao Yan ^a   Shi, Jian Hua ^b   Du, Wen Hua ^b   Fan, Yan Ping ^b   Hu, Xiao Lei ^b   Zhang, Chen Chen ^b   Xu, Huan Bai ^b   Miao, Yan Jun ^b   Zhou, Hai Yan ^b   Xiang, Ping ^b   Chen, Feng Ling ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b Department of Endocrinology   (China)

Author keywords

Agouti related protein; Food intake; Glucocorticoids; Neuropeptide Y; Rat; Weight

Indexed keywords

AGOUTI RELATED PROTEIN; COCAINE AND AMPHETAMINE REGULATED TRANSCRIPT PEPTIDE; GLUCOCORTICOID; GLUCOSE; HYDROCORTISONE SODIUM SUCCINATE; LIPID; MESSENGER RNA; NEUROPEPTIDE Y;

ANIMAL EXPERIMENT; ANIMAL MODEL; APPETITE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; FOOD INTAKE; GENE EXPRESSION; GLUCOSE METABOLISM; HYPERINSULINEMIA; HYPOTHALAMUS; LIPID METABOLISM; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; WEIGHT REDUCTION;

EID: 79960209925     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2011.292     Document Type: Article

References (50)

1. Stellar E: The physiology of motivation. 1954. Psychol Rev 101: 301-311, 1994.
2. Bi S, Scott KA, Hyun J, Ladenheim EE and Moran TH: Running wheel activity prevents hyperphagia and obesity in Otsuka Long-Evans Tokushima Fatty rats: role of hypothalamic signaling. Endocrinology 146: 1676-1685, 2005.
3. 2+ signaling via protein kinase A and N-type channel-dependent mechanisms and cross-talk with leptin and orexin. Diabetes 52: 948-956, 2003.
4. Shintani M, Ogawa Y, Ebihara K, Aizawa-Abe M, Miyanaga F, Takaya K, Hayashi T, Inoue G, Hosoda K, Kojima M, Kangawa K and Nakao K: Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway. Diabetes 50: 227-232, 2001.
5. Tebbe JJ, Tebbe CG, Mronga S, Ritter M and Schäfer MK: Central neuropeptide Y receptors are involved in 3rd ventricular ghrelin-induced alteration of colonic transit time in conscious fed rats. BMC Gastroenterol 5: 5, 2005.
6. Hohmann JG, Teklemichael DN, Weinshenker D, Wynick D, Clifton DK and Steiner RA: Obesity and endocrine dysfunction in mice with deletions of both neuropeptide Y and galanin. Mol Cell Biol 24: 2978-2985, 2004.
7. Raposinho PD, Pedrazzini T, White RB, Palmiter RD and Aubert ML: Chronic neuropeptide Y infusion into the lateral ventricle induces sustained feeding and obesity in mice lacking either Npy1r or Npy5r expression. Endocrinology 145: 304-310, 2004.
8. Baran K, Preston E, Wilks D, Cooney GJ, Kraegen EW and Sainsbury A: Chronic central melanocortin-4 receptor antagonism and central neuropeptide-Y infusion in rats produce increased adiposity by divergent pathways. Diabetes 51: 152-158, 2002.
9. Fekete C, Sarkar S, Rand WM, Harney JW, Emerson CH, Bianco AC and Lechan RM: Agouti-related protein (AGRP) has a central inhibitory action on the hypothalamic-pituitary-thyroid (HPT) axis; comparisons between the effect of AGRP and neuropeptide Y on energy homeostasis and the HPT axis. Endocrinology 143: 3846-3853, 2002.
10. Bannon AW, Seda J, Carmouche M, Francis JM, Norman MH, Karbon B and McCaleb ML: Behavioral characterization of neuropeptide Y knockout mice. Brain Res 868: 79-87, 2000.
11. Broberger C, Johansen J, Johansson C, Schalling M and Hökfelt T: The neuropeptide Y/agouti gene-related protein (AGRP) brain circuitry in normal, anorectic, and monosodium glutamate-treated mice. Proc Natl Acad Sci USA 95: 15043-15048, 1998.
12. Hahn TM, Breininger JF, Baskin DG and Schwartz MW: Coexpression of Agrp and NPY in fasting-activated hypothalamic neurons. Nat Neurosci 1: 271-272, 1998.
13. Ollmann MM, Wilson BD, Yang YK, Kerns JA, Chen Y, Gantz I and Barsh GS: Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science 278: 135-138, 1997.
14. Shutter JR, Graham M, Kinsey AC, Scully S, Lüthy R and Stark KL: Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes Dev 11: 593-602, 1997.
15. Tang-Christensen M, Vrang N, Ortmann S, Bidlingmaier M, Horvath TL and Tschöp M: Central administration of ghrelin and agouti-related protein (83-132) increases food intake and decreases spontaneous locomotor activity in rats. Endocrinology 145: 4645-4652, 2004.
16. Marsh DJ, Miura GI, Yagaloff KA, Schwartz MW, Barsh GS and Palmiter RD: Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogues. Brain Res 848: 66-77, 1999.
17. Makimura H, Mizuno TM, Mastaitis JW, Agami R and Mobbs CV: Reducing hypothalamic AGRP by RNA interference increases metabolic rate and decreases body weight without influencing food intake. BMC Neurosci 3: 18, 2002.
18. Small CJ, Kim MS, Stanley SA, Mitchell JR, Murphy K, Morgan DG, Ghatei MA and Bloom SR: Effects of chronic central nervous system administration of agouti-related protein in pair-fed animals. Diabetes 50: 248-254, 2001.
19. Zakrzewska KE, Cusin I, Stricker-Krongrad A, Boss O, Ricquier D, Jeanrenaud B and Rohner-Jeanrenaud F: Induction of obesity and hyperleptinemia by central glucocorticoid infusion in the rat. Diabetes 48: 365-370, 1999.
20. Chen HL and Romsos DR: A single intracerebroventricular injection of dexamethasone elevates food intake and plasma insulin and depresses metabolic rates in adrenalectomized obese (ob/ob) mice. J Nutr 125: 540-545, 1995.
21. De Vos P, Saladin R, Auwerx J and Staels B: Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake. J Biol Chem 270: 15958-15961, 1995.
22. Konno J, Yoshida S, Ina A, Ohmomo H, Shutoh F, Nogami H and Hisano S: Upregulated expression of neuropeptide Y in hypothalamic-pituitary system of rats by chronic dexamethasone administration. Neurosci Res 60: 259-265, 2008.
23. Coll AP, Challis BG, López M, Piper S, Yeo GS and O'Rahilly S: Proopiomelanocortin-deficient mice are hypersensitive to the adverse metabolic effects of glucocorticoids. Diabetes 54: 2269-2276, 2005.
24. Germano CM, de Castro M, Rorato R, Laguna MT, Antunes-Rodrigues J, Elias CF and Elias LL: Time course effects of adrenalectomy and food intake on cocaine- and amphetamine-regulated transcript expression in the hypothalamus. Brain Res 1166: 55-64, 2007.
25. Devenport L, Knehans A, Sundstrom A and Thomas T: Cortico-sterone's dual metabolic actions. Life Sci 45: 1389-1396, 1989.
26. Makimura H, Mizuno TM, Isoda F, Beasley J, Silverstein JH and Mobbs CV: Role of glucocorticoids in mediating effects of fasting and diabetes on hypothalamic gene expression. BMC Physiol 3: 5, 2003.
27. Drazen DL, Wortman MD, Schwartz MW, Clegg DJ, van Dijk G, Woods SC and Seeley RJ: Adrenalectomy alters the sensitivity of the central nervous system melanocortin system. Diabetes 52: 2928-2934, 2003.
28. Balkan B, Koylu E, Pogun S and Kuhar MJ: Effects of adrenalectomy on CART expression in the rat arcuate nucleus. Synapse 50: 14-19, 2003.
29. Vrang N, Larsen PJ, Tang-Christensen M, Larsen LK and Kristensen P: Hypothalamic cocaine-amphetamine regulated transcript (CART) is regulated by glucocorticoids. Brain Res 965: 45-50, 2003.
30. Vicentic A, Dominguez G, Hunter RG, Philpot K, Wilson M and Kuhar MJ: Cocaine- and amphetamine-regulated transcript peptide levels in blood exhibit a diurnal rhythm: regulation by glucocorticoids. Endocrinology 145: 4119-4124, 2004.
31. Wittmann G, Liposits Z, Lechan RM and Fekete C: Origin of cocaine- and amphetamine-regulated transcript-containing axons innervating hypophysiotropic corticotropin-releasing hormone-synthesizing neurons in the rat. Endocrinology 146: 2985-2991, 2005.
32. Hunter RG, Bellani R, Bloss E, Costa A, Romeo RD and McEwen BS: Regulation of CART mRNA by stress and corticosteroids in the hippocampus and amygdala. Brain Res 1152: 234-240, 2007.
33. Misaki N, Higuchi H, Yamagata K and Miki N: Identification of glucocorticoid responsive elements (GREs) at far upstream of rat NPY gene. Neurochem Int 21: 185-189, 1992.
34. Cintra A, Fuxe K, Solfrini V, Agnati LF, Tinner B, Wikström AC, Staines W, Okret S and Gustafsson JA: Central peptidergic neurons as targets for glucocorticoid action. Evidence for the presence of glucocorticoid receptor immunoreactivity in various types of classes of peptidergic neurons. J Steroid Biochem Mol Biol 40: 93-103, 1991.
35. Härfstrand A, Cintra A, Fuxe K, Aronsson M, Wikström AC, Okret S, Gustafsson JA and Agnati LF: Regional differences in glucocorticoid receptor immunoreactivity among neuropeptide Y immunoreactive neurons of the rat brain. Acta Physiol Scand 135: 3-9, 1989.
36. Burdakov D, Luckman SM and Verkhratsky A: Glucose-sensing neurons of the hypothalamus. Philos Trans R Soc Lond B Biol Sci 360: 2227-2235, 2005.
37. Claret M, Smith MA, Batterham RL, et al: AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons. J Clin Invest 117: 2325-2336, 2007.
38. Parton LE, Ye CP, Coppari R, et al: Glucose sensing by POMC neurons regulates glucose homeostasis and is impaired in obesity. Nature 449: 228-232, 2007.
39. Arumugam R, Fleenor D and Freemark M: Lactogenic and somatogenic hormones regulate the expression of neuropeptide Y and cocaine- and amphetamine-regulated transcript in rat insulinoma (INS-1) cells: interactions with glucose and glucocorticoids. Endocrinology 148: 258-267, 2007.
40. Singh BS, Westfall TC and Devaskar SU: Maternal diabetes-induced hyperglycemia and acute intracerebral hyperinsulinism suppress fetal brain neuropeptide Y concentrations. Endocrinology 138: 963-969, 1997.
41. Baura GD, Foster DM, Porte D Jr, Kahn SE, Bergman RN, Cobelli C and Schwartz MW: Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. A mechanism for regulated insulin delivery to the brain. J Clin Invest 92: 1824-1830, 1993.
42. Chavez M, Seeley RJ and Woods SC: A comparison between effects of intraventricular insulin and intraperitoneal lithium chloride on three measures sensitive to emetic agents. Behav Neurosci 109: 547-550, 1995.
43. Sipols AJ, Baskin DG and Schwartz MW: Effect of intracerebroventricular insulin infusion on diabetic hyperphagia and hypothalamic neuropeptide gene expression. Diabetes 44: 147-151, 1995.
44. Schwartz MW, Seeley RJ, Campfield LA, Burn P and Baskin DG: Identification of targets of leptin action in rat hypothalamus. J Clin Invest 98: 1101-1106, 1996.
45. Baskin DG, Wilcox BJ, Figlewicz DP and Dorsa DM: Insulin and insulin-like growth factors in the CNS. Trends Neurosci 11: 107-111, 1988.
46. Sahu A, Sninsky CA, Phelps CP, Dube MG, Kalra PS and Kalra SP: Neuropeptide Y release from the paraventricular nucleus increases in association with hyperphagia in streptozotocin-induced diabetic rats. Endocrinology 131: 2979-2985, 1992.
47. Schwartz MW, Baskin DG, Bukowski TR, et al: Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ob mice. Diabetes 45: 531-535, 1996.
48. Baskin DG, Breininger JF and Schwartz MW: Leptin receptor mRNA identifies a subpopulation of neuropeptide Y neurons activated by fasting in rat hypothalamus. Diabetes 48: 828-833, 1999.
49. Cheung CC, Clifton DK and Steiner RA: Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 138: 4489-4492, 1997.
50. Ma X, Zubcevic L and Ashcroft FM: Glucose regulates the effects of leptin on hypothalamic POMC neurons. Proc Natl Acad Sci USA 105: 9811-9816, 2008.