Effects of neuropeptide Y deficiency on hypothalamic agouti-related protein expression and responsiveness to melanocortin analogues

Brain Research

Volumn 848, Issue 1-2, 1999, Pages 66-77

  Marsh, Donald J ^a   Miura, Grant I ^a   Yagaloff, Keith A ^b   Schwartz, Michael W ^a   Barsh, Gregory S ^c   D Palmiter, Richard ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Hoffman La Roche Department of Metabolic Diseases   (United States)

^c STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Agouti related protein (AgRP); Feeding behavior; Hypothalamus; MC4R deficient mice; Melanocortin 4 receptor (MC4R); Neuropeptide Y (NPY); NPY deficient mice

Indexed keywords

MELANOCORTIN RECEPTOR; MESSENGER RNA; NEUROPEPTIDE; NEUROPEPTIDE Y; PEPTIDE YY; PROOPIOMELANOCORTIN; PROTEIN;

AGONIST; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; FEEDING BEHAVIOR; GENE EXPRESSION; HYPOTHALAMUS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION;

ALPHA-MSH; ANIMALS; HYPOTHALAMUS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MELANOCYTE-STIMULATING HORMONES; MICE; MICE, KNOCKOUT; NEURONS; NEUROPEPTIDE Y; PROTEINS; RECEPTORS, CORTICOTROPIN; RECEPTORS, MELANOCORTIN; RNA, MESSENGER;

EID: 0033429342     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(99)01962-9     Document Type: Article

References (41)

1. Allen Y.S., Adrian T.E., Allen J.M., Tatemoto K., Crow T.J., Bloom S.R., Polak J.M. Neuropeptide Y distribution in the rat brain. Science. 221:1983;877-879.
2. Baskin D.G., Norwood B.J., Schwartz M.W., Koerker D.J. Estradiol inhibits the increase of hypothalamic neuropeptide Y messenger ribonucleic acid expression induced by weight loss in ovariectomized rats. Endocrinology. 136:1995;5547-5554.
3. Beck B., Jhanwar-Uniyal M., Burlet A., Chapleur-Chateau M., Leibowitz S.F., Burlet C. Rapid and localized alterations of neuropeptide Y in discrete hypothalamic nuclei with feeding status. Brain Res. 528:1990;245-249.
4. Brady L.S., Smith M.A., Gold P.W., Herkenham M. Altered expression of hypothalamic neuropeptide mRNAs in food-restricted and food-deprived rats. Neuroendocrinology. 52:1990;441-447.
5. Broberger C., Johansen J., Johansson C., Schalling M., Hokfelt T. The neuropeptideY/agouti gene-related protein (AGRP) brain circuitry in nornal, anorectic, and monosodium glutamate-treated mice. Proc. Nat. Acad. Sci. USA. 95:1998;15043-15048.
6. Chronwall B.M., DiMaggio D.A., Massari V.J., Pickel V.M., Ruggiero D.A., O'Donohue T.L. The anatomy of neuropeptide-Y-containing neurons in the rat brain. Neuroscience. 15:1985;1159-1181.
7. Clark J.T., Kalra P.S., Crowley W.R., Kalra S.P. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats. Endocrinology. 115:1984;427-429.
8. W.F. Colmers, C. Wahlestedt, The biology of neuropeptide Y and related peptides, Humana Press, Totowa, New Jersey, 1993.
9. Dumont Y., Martel J.C., Fournier A., St. Pierre S., Quirion R. Neuropeptide Y and neuropeptide Y receptor subtypes in brain and peripheral tissues. Prog. Neurobiol. 38:1992;125-167.
10. Erickson J.C., Clegg K.E., Palmiter R.D. Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature. 381:1996;415-418.
11. Fan W., Boston B.A., Kesterson R.A., Hruby V.J., Cone R.D. Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature. 385:1997;165-168.
12. Fong T.M., Mao C., MacNeil T., Kalyani R., Smith T., Weinberg D., Tota M.R., Van der Ploeg L.H.T. ART (protein product of agouti-related transcript) as an antagonist of MC-3 and MC-4 receptors. Biochem. Biophys. Res. Commun. 237:1997;629-631.
13. K.B.J. Franklin, G. Paxinos, The mouse brain in stereotaxic coordinates, Academic Press, San Diego, California, 1997.
14. Gerald C., Walker M.W., Criscione L., Gustafson E.L., Batzl-Hartmann C., Smith K.E., Vaysse P., Durkin M.M., Laz T.M., Linemeyer D.L., Schaffhauser A.O., Whitebread S., Hofbauer K.G., Taber R.I., Branchek T.A., Weinshank R.L. A receptor subtype involved in neuropeptide-Y-induced food intake. Nature. 382:1996;1768-1771.
15. Graham M., Shutter J.R., Sarmiento U., Sarosi I., Stark K.L. Overexpression of Agrt leads to obesity in transgenic mice. Nat. Genet. 17:1997;273-274.
16. Hahn T., Breininger J., Baskin D., Schwartz M. Coexpression of AgRP and NPY in fasting-activated hypothalamic neurons. Nat. Neurosci. 1:1998;271-272.
17. Haskell-Luevano C., Chen P., Li C., Chang K., Smith M.S., Cameron J.L., Cone R.D. Characterization of the neuroanatomical distribution of agouti-related protein immunoreactivity in the rhesus monkey and the rat. Endocrinology. 140:1999;1408-1415.
18. S.H.C. Hendry, Organization of neuropeptide Y neurons in the mammalian central nervous system, in: W.F. Colmers, C. Wahlestedt (Eds.), The biology of neuropeptide Y and related peptides, Humana Press, Totowa, New Jersey, 1993, pp. 65-135.
19. Hollopeter G., Erickson J.C., Seeley R.J., Marsh D.J., Palmiter R.D. Response of neuropeptide Y-deficient mice to feeding effectors. Regul. Pept. 75 76:1998;383-389.
20. Huszar D., Lynch C.A., Fairchild-Huntress V., Dunmore J.H., Fang Q., Berkermeier L.R., Gu W., Kesterson R.A., Boston B.A., Cone R.D., Smith F.J., Campfield L.A., Burn P., Lee F. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell. 88:1997;131-141.
21. Kalra S.P. Appetite and body weight regulation: Is it all in the brain? Neuron. 19:1997;227-230.
22. Kalra S.P., Dube M.G., Sahu A., Phelps C., Kalra P.S. Neuropeptide Y secretion increases in the paraventricular nucleus in association with increased appetite for food. Proc. Natl. Acad. Sci. USA. 38:1991;10931-10935.
23. Krude H., Biebermann H., Luck W., Horn R., Brabant G., Gruters A. Severe early-onset obesity, adrenal insufficiency and red hair pigmentation caused by POMC mutations in humans. Nat. Genet. 19:1998;155-157.
24. Lu D., Willard D., Patel I.R., Kadwell S., Overton L., Kost T., Luther M., Chen W., Woychik R.P., Wilkison W.O., Cone R.D. Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature. 371:1994;799-802.
25. Manne J., Argeson A.C., Siracusa L.D. Mechanisms for the pleiotropic effects of the agouti gene. Proc. Natl. Acad. Sci. USA. 92:1995;4721-4724.
26. Marsh D.J., Hollopeter G., Huszar D., Laufer R., Yagaloff K.A., Fisher S.L., Burn P., Palmiter R.D. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat. Genet. 21:1999;119-122.
27. Mountjoy K.G., Mortrud M.T., Low M.J., Simerly R.B., Cone R.D. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol. Endo. 8:1994;1298-1308.
28. Ollmann M.M., Wilson B.D., Yang Y.K., Kerns J.A., Chen Y., Gantz I., Barsh G.S. Antagonism of central melanocortin receptors in vitro and in vivo by agouti-related protein. Science. 278:1997;135-138.
29. Palmiter R.D., Erickson J.C., Hollopeter G., Baraban S.C., Schwartz M.W. Life without neuropeptide Y. Recent Prog. Horm. Res. 53:1998;163-199.
30. Rossi M., Kim M.S., Morgan D.G.A., Small C.J., Edwards C.M.B., Sunter D., Abusnana S., Goldstone A.P., Russell S.H., Stanley S.A., Smith D.M., Yagaloff K., Ghatei M.A., Bloom S.R. A C-terminal fragment of agouti-related protein increases feeding and antagonizes the effect of α-melanocyte stimulating hormone in vivo. Endocrinology. 139:1998;4428-4431.
31. Sahu A., Kalra P.S., Kalra S.P. Food deprivation and ingestion induce reciprocal changes in neuropeptide Y concentrations in the paraventricular nucleus. Peptides. 9:1988;83-86.
32. Sanacora G., Kershaw M., Finkelstein J.A., White J.D. Increased hypothalamic content of preproneuropeptide Y messenger ribonucleic acid in genetically obese Zucker rats and its regulation by food deprivation. Endocrinology. 127:1990;730-737.
33. Schwartz M.W., Sipols A.J., Marks J.L., Sanacora G., White J.D., Scheurink A., Kahn S.E., Baskin D.G., Woods S.C., Figlewicz D.P., Porte D. Jr. Inhibition of hypothalamic neuropeptide Y gene expression by insulin. Endocrinology. 130:1992;3608-3616.
34. Shutter J.R., Graham M., Kinsey A.C., Scully S., Luthy R., Stark K.L. Hypothalamic expression of ART, a novel gene related to agouti, is up-regulated in obese and diabetic mutant mice. Genes Dev. 11:1997;593-602.
35. Stanley B.G., Leibowitz S.F. Neuropeptide Y injected into the paraventicular hypothalamus: A powerful stimulant of feeding behavior. Proc. Natl Acad. Sci. USA. 82:1985;3940-3943.
36. Stanley B.G., Leibowitz S.F. Neuropeptide Y: Stimulation of feeding and drinking by injection into the paraventricular nucleus. Life Sci. 35:1984;2635-2642.
37. Stephens T.W. Life without neuropeptide Y. Nature. 381:1996;377-378.
38. Tomaszuk A., Simpson C., Williams G. Neuropeptide Y, the hypothalamus and the regulation of energy homeostasis. Horm. Res. 46:1996;53-58.
39. Vaisse C., Clement K., Guy-Grand B., Froguel P. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nat. Genet. 20:1998;113-114.
40. Wilson B.D., Didier B., Kaelin C.B., Ollmann M.M., Gantz I., Watson S.J., Barsh G.S. Physiological and anatomical circuitry between agouti-related protein and leptin signaling. Endocrinology. 140:1999;2387-2397.
41. Yeo G.S.H., Farooqi I.S., Aminian S., Halsall D.J., Stanhope R.G., O'Rahilly S. A frameshift mutation in MC4R associated with dominantly inherited human obesity. Nat. Genet. 20:1998;111-112.