Solid dispersion: A strategy for solubility enhancement

International Journal of Pharmacy and Technology

Volumn 3, Issue 2, 2011, Pages 1062-1099

  Verma, Surender ^a   Rawat, Aruna ^a   Kaul, Mahima ^a   Saini, Sapna ^a  

^a KURUKSHETRA UNIVERSITY   (India)

Author keywords

Polymers; Solid dispersion; Solubility; Surfactant

Indexed keywords

CARBOXYMETHYLCELLULOSE; CELLULOSE DERIVATIVE; CYCLODEXTRIN; DISINTEGRATING AGENT; DRUG CARRIER; HYDROXYPROPYLCELLULOSE; HYDROXYPROPYLMETHYLCELLULOSE; KOLLICOAT IR; MACROGOL; POLOXAMER; POLY(METHYL METHACRYLATE); POLYACRYLIC ACID; POLYMER; POVIDONE; SOLVENT; SURFACTANT; UNCLASSIFIED DRUG;

AMORPHOUS STATE; CHEMICAL PROCEDURES; COPRECIPITATION; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; DISSOLUTION TESTING; DROPPING METHOD; DRUG ABSORPTION; DRUG CLASSIFICATION; DRUG FORMULATION; DRUG MIXTURE; DRUG SOLUBILITY; ELECTROSPINNING; EUTECTIC MIXTURE; FUSION METHOD; HOT MELT EXTRUSION; INFRARED SPECTROSCOPY; MATERIAL STATE; PARTICLE SIZE; POROSITY; REVIEW; SCANNING ELECTRON MICROSCOPY; SOLID DISPERSION; SOLUBILITY ENHANCEMENT; SOLVENT EVAPORATION METHOD; SUPERCRITICAL FLUID; WETTABILITY;

EID: 79960149457     PISSN: None     EISSN: 0975766X     Source Type: Journal    
DOI: None     Document Type: Review

References (104)

1. Nokhodchi A, Talari R, Valizadeh H and Jalali M B. An Investigation on the Solid Dispersions of Chlordiazepoxide. International Journal of Biomedical Science, 2007, Vol. 3, pp. 211-217.
2. Kumar KV, Kumar A N, Verma PRP, and Rani C. Preparation and in vitro characterization of Valsartan solid dispersion using skimmed milk powder as carrier. International Journal of Pharm tech Research, 2009, Vol.1, pp. 431-437.
3. Aggarwal S, Gupta GD and Chaudhary S. Solid dispersion as an eminent strategic approach in solubility enhancement of poorly soluble drugs. International Journal of Pharmaceutical Sciences and Research, 2010, Vol. 1, pp. 1-13.
4. Mohanachandran PS, Sindhumo PG and Kiran TS. Enhancement of solubility and dissolution rate: an overview. International Journal of Comprehensive Pharmacy, 2010, Vol. 4, pp. 1-10.
5. Vemula VR, LagishettyV and Lingala S. Solubility enhancement techniques. International Journal of Pharmaceutical Sciences Review and Research, 2010, Vol. 5, pp.41-51.
6. Sharma D, Soni M, Kumar S and Gupta GD. Solubility Enhancement -Eminent Role in Poorly Soluble Drugs. Research Journal of Pharmacy and Technology, 2009, Vol. 2, pp. 220-224.
7. Tiwari R, Tiwari G, Srivastava B and Rai AK. Solid Dispersions: An Overview to Modify Bioavailability of Poorly Water Soluble Drugs. International Journal of Pharm tech Research, 2009, Vol. 1, pp.1338-1349.
8. Bock U, Kottke T, Gindorf C and Haltner E. Validation of the Caco-2 cell monolayer system for determining the permeability of drug substances according to the Biopharmaceutics Classification System (BCS), 2003 July. Available from: URL: www.acrossbarriers.de.
9. Vasconcelos TF, Sarmento B and Costa P. Solid dispersion as strategy to improve oral bioavailability of poor water soluble drugs. Drug Discovery Today, 2007, Vol. 12, pp. 1068-1075.
10. Arora SC, Sharma PK et al. Development, characterization and solubility study of solid dispersion of cefixime trihydrate by solvent evaporation method. International Journal of Drug Development & Research, 2010, Vol. 2, pp. 424-430.
11. Ahire BR, Rane BR, Bakliwal SR and Pawar SP. Solubility Enhancement of Poorly Water Soluble Drug by Solid Dispersion Techniques. International Journal of Pharm tech Research, 2010, Vol. 2, pp. 2007-2015.
12. Chaudhari PD et al. Current trends in solid dispersions techniques. pharmainfo.net., 2006, Vol. 4.
13. Arunachalam A, Karthikeyan M. et al. Solid Dispersions: A Review. Current Pharma Research, 2010, Vol. 1, pp. 82-90.
14. Craig DQM. The mechanisms of drug release from solid dispersions in water-soluble polymers. International Journal of Pharmaceutics, 2002, Vol. 231, pp. 131-144.
15. Janssens S and Mooter GVD. Review: physical chemistry of solid dispersions. Journal of Pharmacy and Pharmacology, 2009, Vol. 61, pp. 1571-1586.
16. Liu L and Wang X. Improved Dissolution of Oleanolic Acid with Ternary Solid Dispersions. American Association of Pharmaceutical Scientists, 2007, Vol. 8, pp.E1-E5.
17. Papageorgiou GZ, Bikiaris D et al. Effect of Physical State and Particle Size Distribution on Dissolution Enhancement of Nimodipine/PEG Solid Dispersions Prepared by Melt Mixing and Solvent Evaporation. American Association of Pharmaceutical Scientists, 2006, Vol. 8, pp. E623-E631.
18. Patidar K, Soni M, Sharma KD and Jain KS. Solid Dispersion: Approaches, Technology involved unmet need & Challenges. Drug Invention Today, 2010, Vol. 2, pp. 349-357.
19. Charumanee S, Okonoki S and Sirithunyalug J. Improvement of the Dissolution Rate of Piroxicam by Surface Solid Dispersion. CMU Journal, 2004, Vol. 3, pp. 77-84.
20. Kiran T, Shastri N, Ramakrishna S, and Sadanandam M. Surface solid dispersion of glimepiride for enhancement of dissolution rate. International Journal of Pharm tech Research, 2009, Vol. 1, pp. 822-831.
21. Ghaste R, Dhanyakumar DC, Shah RR, and Ghodke DS. Solid dispersion: an overview. Pharmainfo.net., 2009, Vol. 7.
22. Khan MSA. Solid dispersions: Formulation, characterisation, permeability and genomic evaluation [dissertation]. Aston University, 2010, 40-42.
23. Aleem M A. Solid Dispersion - an Approach to Enhance the Dissolution rate of Aceclofenac [dissertation]. Karnataka, Bangalore, Rajiv Gandhi University of Health Science, 2006, 15.
24. Kumar DS et al. Solubility improvement using solid dispersion; strategy, mechanism and characteristics: responsiveness and prospect way outs. International Research Journal of Pharmacy, 2011, Vol. 2, pp. 55-60.
25. Kamalakkannan V, Puratchikody A, Masilamani K and Senthilnathan B, Solubility enhancement of poorly soluble drugs by solid dispersion technique - A review. Journal of Pharmacy Research, 2010, Vol. 3, pp. 2314-2321.
26. Bandarkar FS, Khattab IS. Lyophilized Gliclazide poloxamer solid dispersions for enhancement of in vitro dissolution and in vivo bioavailability. International Journal of Pharmacy and Pharmaceutical Sciences, 2011, Vol. 3, pp. 122-127.
27. Nagarajan K and Rao MG et al. Formulation and Dissolution Studies of Solid Dispersions of Nifedipine. Indian Journal of Novel Drug Delivery, 2010 Vol. 2, pp. 96-98.
28. Venkatesh DN, Sangeetha S, Samanta MK et al. Dissolution Enhancement of Domperidone Using Water Soluble Carrier by Solid Dispersion Technology. International Journal of Pharmaceutical Sciences and Nanotechnology, 2008, Vol. 1, pp. 221-226.
29. Dhanaraju MD and Thirumurugan G. Dissolution profilling of Nimesulide solid dispersions with polyethylene glycol, talc and their combinations as dispersion carriers. International Journal of Pharm tech Research, 2010, Vol. 2, pp. 480-484.
30. Leuner C and Dressman J. Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm., 2000, Vol. 50, pp. 47-60.
31. ®, in the formulation of solid dispersions of Itraconazole. European Journal of Pharmaceutical Sciences, 2007, Vol. 30, pp. 288-294.
32. Modi A and Tayade P. Enhancement of Dissolution Profile by Solid Dispersion (Kneading) Technique. AAPS Pharm Sci tech., 2006, Vol. 7, pp. E1-E6.
33. Challa R, Ahuja A, Ali J and Khar RK. Cyclodextrins in Drug Delivery: An Updated Review. AAPS Pharm Sci tech., 2005, Vol. 6, pp. E329-E357.
34. Venkatesh DN and Karthick S et al. Studies on the Preparation, Characterization and Solubility of β-Cyclodextrin-Roxythromycin Inclusion Complexes. International Journal of Pharmaceutical Sciences and Nanotechnology, 2009, Vol. 2, pp. 523-530.
35. Rebecca L, Carrier A, Miller LA et al. The utility of cyclodextrins for enhancing oral bioavailability. Journal of Controlled Release, 2007, Vol. 123, pp. 78-99.
36. Patel R and Patel M et al. Formulation strategies for improving drug solubility using solid dispersions. Pharmainfo.net., 2009, Vol. 7.
37. Saharan VA, Kukkar V and Kataria M. Dissolution Enhancement of Drugs Part 2: Effect of Carriers. International Journal of Health Research, 2009, Vol. 2, pp. 207-223.
38. Shrivastava AR, Ursekar B and Kapadia CJ. Design, Optimization, Preparation and Evaluation of Dispersion Granules of Valsartan and Formulation into Tablets. Current Drug Delivery, 2009, Vol. 6, pp. 28-37.
39. Chauhan B, Shimpi S and Paradkar A. Preparation and Characterization of Etoricoxib Solid Dispersions Using Lipid Carriers by Spray Drying Technique. AAPS PharmSci tech., 2005, Vol. 6, pp. E405-E412.
40. Shah TJ, Amin AF, Parikh JR and Parikh RH. Process Optimization and Characterization of Poloxamer Solid Dispersions of a Poorly Water-soluble Drug. AAPS PharmSci tech., 2007, Vol. 8, pp. E1-E7.
41. Saritha A, Shastri N. Preparation, Physico Chemical Characterization of Solid Dispersions of Tenoxicam with Poloxamer. Journal of Pharmaceutical Science and Technology, 2010, Vol. 2, pp. 308-311.
42. Ghebremeskel AN, Vemavarapu C and Lodaya M. Use of surfactants as plasticizers in preparing solid dispersions of poorly soluble API: Selection of polymer-surfactant combinations using solubility parameters and testing the processability. International Journal of Pharmaceutics, 2007, Vol. 328, pp. 119-129.
43. Aly AM, Semreen M, and Qato MK. Superdisintegrants for solid dispersion, to produce rapidly disintegrating Tenoxicam Tablets via Camphor Sublimation. Pharmaceutical Technology. [Serial online] 2005 jan [cited 2011 feb 25]. Available from: URL: www.pharmtech.com.
44. Lewis S, Udupa N et al. Solid dispersions: A review. Pak. J. Pharm. Sci., 2009, Vol. 22, pp. 234-246.
45. Karanth H, Shenoy VS and Murthy RR. Industrially Feasible Alternative Approaches in the Manufacture of Solid Dispersions: A Technical Report, AAPS Pharm Sci tech., 2006, Vol. 7, pp. E1-E8.
46. Giri TK, Alexander A and Tripathi DK. Physicochemical Classification and Formulation Development of Solid Dispersion of Poorly Water Soluble Drugs: An Updated Review. International Journal of Pharmaceutical & Biological Archives, 2010, Vol. 1, pp. 309-324.
47. Chokshi R and Zia H. Hot-Melt Extrusion Technique: A Review. Iranian Journal of Pharmaceutical Research, 2004, Vol. 3, pp. 3-16.
48. Singhal S, Lohar VK. et al. Hot Melt Extrusion Technique. Web med central pharmaceutical sciences. [Serial online] 2011 jan [cited 2011 jan 19]. Available from: URL: http://www.webmedcentral.com.
49. Shahroodi AB, Nassab PR and Révész PS. Preparation of a Solid Dispersion by a Dropping Method to Improve the Rate of Dissolution of Meloxicam. Drug Development and Industrial Pharmacy, 2008, Vol. 34, pp. 781-788.
50. McKelvey CA. Solid Dispersions: New Approaches and Technologies in Oral Drug Delivery. Controlled Release Society; Rutgers, NJ. [Serial online] 2009 june [cited 2011 feb 27]. Available from: URL: http://www.njbiomaterials.org.
51. Chen Y, Zhang GGZ and Neilly J. et al. Enhancing the bioavailability of ABT-963 using solid dispersion containing Pluronic F-68. International Journal of Pharmaceutics, 2004, Vol. 286, pp. 69-80.
52. Rao AB, Shivalingam MR, Reddy YVK and Rao S et al. Formulation and Evaluation of Aceclofenac Solid Dispersions for Dissolution Rate Enhancement. International Journal of Pharmaceutical Sciences and Drug Research, 2010, Vol. 2, pp. 146-150.
53. Sachan NK, Pushkar S, Solanki SS and Bhatere DS. Enhancement of solubility of Acyclovir by Solid Dispersion and Inclusion Complexation methods. World Applied Sciences journal, 2010, Vol. 11, pp. 857-864.
54. Jagdale SC, Kuchekar BS, Chabukswar AR, Musale VP and Jadhao MA. Preparation and in vitro evaluation of Allopurinol-Gelucire 50/13 solid dispersions. International Journal of Advances in Pharmaceutical Sciences, 2010, Vol. 1, pp. 60-67.
55. Bobe KR, Subrahmanya CR, Suresh S, Gaikwad DT, Patil M D et al. Formulation and Evaluation of Solid Dispersion of Atorvatstatin with various carriers. International Journal of Comprehensive Pharmacy, 2011, Vol. 1, pp. 1-6.
56. Hamidia HA, Edwardsa AA, Mohammadb MA et al. To enhance dissolution rate of poorly water-soluble drugs: Glucosamine hydrochloride as a potential carrier in solid dispersion formulations. Colloids and Surfaces B: Biointerfaces., 2010, Vol. 76, pp. 170-178.
57. Arora SC, Sharma PK, Irchhaiya R, Khatkar R et al. Development, characterization and solubility study of solid dispersion of Cefixime trihydrate by solvent evaporation method. International Journal of Drug Development & Research, 2010, Vol. 2, pp. 424-430.
58. Kumar P, Kumar S, Kumar A and Chander M. Physicochemical Characterization of Solid Dispersions of Cefdinir with PVP K-30 and PEG 4000. International Journal of Pharmaceutical Sciences and Nanotechnology, 2010, Vol. 3, pp. 948-956.
59. Arora AC, Sharma RK, Irchhaiya RK and Khatkar A. Development, Characterization and Solubility Study of Solid Dispersion of Cefpodoxime Proxetil by Solvent Evaporation Method. International Journal of Chem tech Research, 2010, Vol. 2, pp. 1156-1162.
60. Arora SC, Sharma PK, Irchhaiya R, Khatkar A et al. Development, Characterization and solubility study of Solid Dispersions of Cefuroxime Axetil by the Solvent Evaporation Method. Journal of Advanced Pharmaceutical Technology & Research, 2010, Vol. 1, pp. 326-329.
61. Punitha S, Karthikeyan D, Devi P and Vedha Hari BN. Enhancement of Solubility and Dissolution of Celecoxib by Solid Dispersion Technique. Journal of Pharmaceutical Science and Technology, 2009, Vol. 1, pp. 63-68.
62. Nagabhushanam MV. Formulation studies on Solid Dispersions of Celecoxib in superdisintegrants alone and with PVP. Rasayan J. Chem., 2009, Vol. 2, pp.691-698.
63. Nokhodchi A, Talari R, Valizadeh H and Jalali MB. An Investigation on the Solid Dispersions of Chlordiazepoxide. International Journal of Biomedical Science, 2007, Vol. 3, pp. 211-217.
64. Hui Xu D, Wang S et al. Dissolution and absorption researches of Curcumin in Solid Dispersion with the polymer PVP. Asian Journal of Pharmacokinetics and Pharmacodynamics, 2006, Vol. 6, pp. 343-349.
65. Pignatello R, Ferro M and Puglisi G. Preparation of Solid Dispersions of Nonsteroidal Anti-inflammatory Drugs with Acrylic Polymers and Studies on Mechanisms of Drug-Polymer Interactions. AAPS Pharm Sci tech., 2002, Vol. 3, pp. 1-11.
66. Karavas E, Georgarakis E, Sigalas MP et al. Investigation of the release mechanism of a sparingly water-soluble drug from solid dispersions in hydrophilic carriers based on physical state of drug, particle size distribution and drug-polymer interactions. European Journal of Pharmaceutics and Biopharmaceutics, 2007, Vol. 66, pp. 334-347.
67. Won DH, Kim MS, Lee S, Park JS and Hwang SJ. Improved physicochemical characteristics of Felodipine solid dispersion particles by supercritical anti-solvent precipitation process. International Journal of Pharmaceutics, 2005, Vol. 301, pp. 199-208.
68. Patel T, Patel LD, Patel T, Makwana S and Patel T. Enhancement of dissolution of Fenofibrate by Solid dispersion Technique. Int. J. Res. Pharm. Sci., 2010, Vol. 1, pp. 127-132.
69. Patel RP, Patel DJ, Bhimani DB and Patel JK. Physicochemical Characterization and Dissolution Study of Solid Dispersions of Furosemide with Polyethylene Glycol 6000 and Polyvinylpyrrolidone K30. Dissolution Technologies, 2008, pp. 17-25.
70. Shavi GV, Kumar AR, Usha YN et al. Enhanced dissolution and bioavailability of gliclazide using solid dispersion techniques. International Journal of Drug Delivery, 2010, Vol. 2, pp. 49-57.
71. Tiwari G, Tiwari R, Srivastava B and Rai AK. Development and optimization of multi-unit solid dispersion systems of poorly water soluble drug. Research J. Pharm. and Tech., 2008, Vol. 1, pp. 444-449.
72. Dehghan MHG, Saifee M and Hanwate RM. Comparative Dissolution Study of Glipizide by Solid Dispersion Technique. Journal of Pharmaceutical Science and Technology, 2010, Vol. 2, pp. 293-297.
73. Dabbagh MA and Taghipour B. Investigation of Solid Dispersion Technique in Improvement of Physicochemical Characteristics of Ibuprofen Powder. Iranian Journal of Pharmaceutical Sciences, 2007, Vol. 3, pp. 69-76.
74. Najmuddin M, Khan T, Mohsin AA, Shelar SS and Patel V. Enhancement of dissolution rate of Ketoconazole by solid dispersion technique. International Journal of Pharmacy and Pharmaceutical Sciences, 2010, Vol. 2, pp. 132-136.
75. Matsunaga N, Nakamura K, Yamamoto A et al. Improvement by solid dispersion of the bioavailability of KRN633, a selective inhibitor of VEGF receptor-2 tyrosine kinase, and identification of its potential therapeutic window. Molecular Cancer Therapeutics. [Serial online] 2006 [cited 2011 jan 29]. Availabla from: URL: 10.1158/1535-7163.MCT-05-0202.
76. Patel M, Tekade A et al. Solubility Enhancement of Lovastatin by Modified Locust Bean Gum Using Solid Dispersion Techniques. AAPS Pharm Sci tech., 2008, Vol. 9, pp. 1262-1269.
77. Pathak D, Dahiya S and Pathak K. Solid dispersion of Meloxicam: Factorially designed dosage form for geriatric population. Acta Pharm., 2008, Vol. 58, pp. 99-110.
78. Prasobh GR, Mohammed SAS et al. Solid Dispersion of Nabumetone in Ethyl Cellulose an Approach to Enhance the Solubility and Dissolution Rate. Hygeia., 2009, Vol. 1, pp. 33-35.
79. Rao MG. Suneetha R et al. Preparation and Evaluation of solid dispersion of Naproxen. International Journal of Pharmaceutical Sciences, 2005, Vol. 67, pp. 26-29.
80. Rathinaraj BS, Choudhury PK et al. Studies on dissolution behaviour of sustained release solid dispersions of nimodipine. International Journal of Pharmaceutical Sciences Review and Research, 2010, Vol. 3, pp. 77-82.
81. Okonogi S and Puttipipatkhachorn S. Dissolution Improvement of High Drug-loaded Solid Dispersion. AAPS Pharm Sci tech., 2006, Vol. 7, pp. E1-E6.
82. Liu L and Wang X. Improved Dissolution of Oleanolic Acid with Ternary Solid Dispersions. AAPS Pharm Sci tech., 2007, Vol. 8, pp. E1-E5.
83. Mirza S, Miroshnyk I et al. Enhanced Dissolution and Oral Bioavailability of Piroxicam Formulations: Modulating Effect of Phospholipids. Pharmaceutics., 2010, Vol. 2, pp. 339-350.
84. Leonardi D, Barrera MG, Lamas MC, and Salomón1 CJ. Development of Prednisone: Polyethylene Glycol 6000 Fast-Release Tablets From Solid Dispersions: Solid-State Characterization, Dissolution Behavior, and Formulation Parameters. AAPS Pharm Sci tech., 2007, Vol. 8, pp. E1-E8.
85. Ulla MR, Gangadharappa HV and Rathod N. Solubility and dissolution improvement of Rofecoxib using Solid dispesion technique. Pak. J. Pharm. Sci., 2008, Vol. 21, pp. 350-355.
86. Yamashita K, Nakate T, Okimoto K et al. Establishment of new preparation method for solid dispersion formulation of tacrolimus. International Journal of Pharmaceutics, 2003, Vol. 267, pp. 79-91.
87. Kothawade SN, Kadam NR, Aragade PD and Baheti DG. Formulation and characterization of Telmisatan Solid Dispersions. International Journal of Pharm Tech Research, 2010, Vol. 2, pp. 341-347.
88. Prasad KA, Narayanan N and Rajalakshmi G. Preparation and Evaluation of Solid dispersion of Terbinafine hydrochloride. International Journal of Pharmaceutical Sciences Review and Research, 2010, Vol. 3, pp. 130-134.
89. Kollidon®SR. AAPS Pharm Sci tech., 2009, Vol. 10,pp. 27-33.
90. Madhavi BR, Devi NKD and Rani AP. Preparation and characterization of Zafirlukast- β-cyclodextrin complexes using Solid dispersion techniques. International Journal of Pharmaceutical Sciences Review and Research, 2010, Vol. 4, pp. 88-93.
91. Waghmare A, Pore Y and Kuchekar B. Development and Characterization of Zaleplon Solid Dispersion Systems: A Technical Note. AAPS Pharm Sci tech., 2008, Vol. 9, pp. 536-543.
92. Aejaz A, Azmail K, Sanaullah S and Mohsin AA. Studies on Aceclofenac Solid dispersion in corporated gels: development, characterization and in vitro evaluation. International Journal of Pharmacy and Pharmaceutical Sciences, 2010, Vol. 2, pp. 111-115.
93. Castro SG, Bruni SS et al. Improved Albendazole Dissolution Rate in Pluronic 188 Solid Dispersions. AAPS Pharm Sci tech., 2010, Vol. 2, pp. 1518-1525.
94. Badryl ME, Fetih G and Fathy M. Improvement of solubility and dissolution rate of Indomethacin by Solid dispersions in gelucire 50/13 and PEG 4000. Saudi Pharmaceutical Journal, 2009, Vol. 17, pp. 219-230.
95. Guanhao Y, Wang S et al. Development and optimization of solid dispersion containing pellets of itraconazole prepared by high shear pelletization. International Journal of Pharmaceutics, 2007, Vol. 337, pp. 80-87.
96. Gorajana A, Rajendran A et al. Preperation and in vitro evaluation of solid dispersions of Nimodipine using PEG 4000 and PVP k30. Journal of Pharmaceutical Research and Health Care, 2010, Vol. 2, pp. 163-169.
97. Akiladevi D and Basak S. Dissolution enhancement of Paracetamol by solid dispersion technique. Journal of Pharmacy Research, 2010, Vol. 3, pp. 2846-2849.
98. Chaud MV, Tamascia P et al. Solid dispersions with hydrogenated castor oil increase solubility, dissolution rate and intestinal absorption of praziquantel. Brazillian Journal of Pharmaceutical Sciences, 2010, Vol. 46, pp. 473-481.
99. Shah TJ, Amin AF et al. Process Optimization and Characterization of Poloxamer Solid Dispersions of a Poorly Water-soluble Drug. AAPS Pharm Sci tech., 2007, Vol. 8, pp. E1-E7.
100. Mandal D, Ojha PK et al. Effect of Carriers on Solid Dispersions of Simvastatin (Sim): Physico-Chemical Characterizations and Dissolution Studies. Scholars Research Library, 2010, Vol. 2, pp. 47-56.
101. Vyas V, Sancheti P et al. Physicochemical characterization of solid dispersion systems of Tadalafil with poloxamer 407. Acta Pharm., 2009, vol. 59, pp. 453-461.
102. Saritha A and Shastri N. Preparation, Physico Chemical Characterization of Solid Dispersions of Tenoxicam with Poloxamer. Journal of Pharmaceutical Science and Technology, 2010, Vol. 2, pp. 308-311.
103. Kumar N, Jain AK, Akhilesh, et al. Development, Characterization and Solubility Study of Solid Dispersion of Terbinafine Hydrochloride. International Journal of Pharmaceutical Sciences and Nanotechnology, 2008, vol.1, pp. 171-176.
104. Patel MM and Patel DM. Fast dissolving Valdecoxib tablets containing Solid dispersion of Valdecoxib. Indian Journal of Pharmaceutical Sciences, 2006, Vol. 68, pp. 222-226.