Effect of physical state and particle size distribution on dissolution enhancement of nimodipine/PEG solid dispersions prepared by melt mixing and solvent evaporation

AAPS Journal

Volumn 8, Issue 4, 2006, Pages

  Papageorgiou, George Z ^a   Bikiaris, Dimitrios ^a   Karavas, Evagelos ^b   Politis, Stavros ^b   Docoslis, Aristides ^c   Park, Yong ^c   Stergiou, Anagnostis ^a   Georgarakis, Emmanouel ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

^b Pharmaceutical Industry   (Greece)

^c QUEEN S UNIVERSITY   (Canada)

Author keywords

Nimodipine; Polymorphism; Raman; Solid dipersion

Indexed keywords

MACROGOL 4000; NIMODIPINE; SOLVENT; MACROGOL DERIVATIVE;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL PROCEDURES; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG FORMULATION; DRUG MIXTURE; DRUG PURITY; DRUG RELEASE; DRUG SOLUBILITY; DRUG STRUCTURE; EVAPORATION; INTERMETHOD COMPARISON; MELTING POINT; PARTICLE SIZE; PHYSICAL CHEMISTRY; PHYSICAL PARAMETERS; RACEMIC MIXTURE; RAMAN SPECTROMETRY; SCANNING ELECTRON MICROSCOPY; X RAY DIFFRACTION; CHEMISTRY; METHODOLOGY; SOLUBILITY;

DRUG COMPOUNDING; NIMODIPINE; PARTICLE SIZE; POLYETHYLENE GLYCOLS; SOLUBILITY; SOLVENTS;

EID: 33947601234     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/aapsj080471     Document Type: Article

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