Development, characterization and solubility study of solid dispersion of cefpodoxime proxetil by Solvent Evaporation method

International Journal of ChemTech Research

Volumn 2, Issue 2, 2010, Pages

  Arora, S C ^a   Sharma, P K ^b   Irchhaiya, Raghuveer ^c   Khatkar, Anurag ^a   Singh, Neeraj ^a   Gagoria, Jagbir ^a  

^a RKSD College of Pharmacy   (India)

^b MEERUT INSTITUTE OF ENGINEERING AND TECHNOLOGY   (India)

^c Bundelkand University   (India)

Author keywords

Cefpodoxime proxetil; Solid dispersion; Solvent evaporation method; Urea

Indexed keywords

CEFPODOXIME PROXETIL; SOLVENT; UREA;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG SOLUBILITY; EVAPORATION; INFRARED SPECTROSCOPY; SOLID DRUG DISPERSION; X RAY DIFFRACTION; CONTROLLED STUDY; DRUG RELEASE;

EID: 77954747228     PISSN: None     EISSN: 09744290     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Reynolds, J.E.F., Eds., In; Martindale; The Extra Pharmacopoeia, 29th Edn., The Royal Pharmaceutical Society of Great Britain, London, 1993, 295.
2. Chiou WL, Riegelman S. Pharmaceutical applications of solid dispersion systems. J Pharm Sci. 1971; 60:1281Y1302.
3. Babu GV, Kumar NR, Himasankar K, Seshasayana A, Murthy KV. Nimesulidemodified gum karaya solid mixtures: preparation, characterization and formulation development. Drug Dev Ind Pharm. 2003;29:855Y864.
4. Rogers JA, Anderson AJ. Physical characteristics and dissolution profiles of ketoprofen-urea solid dispersions. Pharm Acta Helv. 1982;57:276Y281.
5. El-Gazayerly ON. Characterization and evaluation of tenoxicam coprecipitates. Drug Dev Ind Pharm. 2000;26:925Y930.
6. Vippagunta SR, Maul KA, Tallavajhala S, Grant DJW. Solid-state characterization of nifedipine solid dispersions. Int J Pharm. 2002; 236:111Y123.
7. Murali Mohan Babu GV, Prasad CHDS, Ramana Murthy KV. Evaluation of modified gum karaya as carrier for the dissolution enhancement of poorly water soluble drug nimodipine. Int J Pharm. 2002;234:1Y17.
8. Okonogi S, Yonemochi E, Oguchi T, Puttipipatkhachorn S, Yamamoto K. Enhanced dissolution of ursodeoxycholic acid from the solid dispersion. Drug Dev Ind Pharm. 1997;23:1115Y1121.
9. Torrado S, Torrado S, Torrado JJ, Cadorniga R. Preparation, dissolution and characterization of albendazole solid dispersions. Int J Pharm. 1996;140:247Y250.
10. Margarit MV, Rodrýguez IC, Cerezo A. Physical characteristics and dissolution kinetics of solid dispersions of ketoprofen and polyethylene glycol 6000. Int J Pharm. 1994; 108:101Y107.
11. Yagi N, Terashima Y, Kenmotsu H, Sekikawa H, Takada M. Dissolution behavior of probucol from solid dispersion systems of probucol-polyvinylpyrrolidone. Chem Pharm Bull (Tokyo). 1996; 44:241Y244.
12. Kushida I, Ichikawa M, Asakawa N. Improvement of dissolution and oral absorption of ER-34122, a poorly water soluble dual 5-lipoxygenase /cyclooxygenase inhibitor with anti-inflammatory activity by preparing solid dispersion. J Pharm Sci. 2002;91:258Y266.
13. Danjo K, Nakata T, Otsuka A. Preparation and dissolution behavior of ethenzamide solid dispersions using various sugars as dispersion carriers. Chem Pharm Bull (Tokyo). 1997; 45:1840Y1844.
14. Arias MJ, Ginés JM, Moyano JR, Pérez-Martínez JI, Rabasco AM. Influence of preparation method of solid dispersions on dissolution rate: study of triammterene-Dmannitol. system. Int J Pharm. 1995;123:25Y31.