Solubility enhancement of lovastatin by modified locust bean gum using solid dispersion techniques

AAPS PharmSciTech

Volumn 9, Issue 4, 2008, Pages 1262-1269

  Patel, Manjil ^a   Tekade, Avinash ^a   Gattani, Surendra ^a   Surana, Sanjay ^a  

^a R C PATEL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH   (India)

Author keywords

Dissolution enhancement; Locust bean gum; Lovastatin; Modified locust bean gum; Solid dispersions

Indexed keywords

DRUG CARRIER; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LOCUS BEAN GUM; MEVINOLIN; POLYMER; UNCLASSIFIED DRUG; ALGAROBA; GALACTAN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MANNAN; PLANT GUM;

ANGLE OF REPOSE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DISSOLUTION; DRUG SOLUBILITY; ENZYME INHIBITION; EVAPORATION; HEATING; MALE; MODIFIED SOLVENT EVAPORATION; NONHUMAN; RAT; SCANNING ELECTRON MICROSCOPY; SOLID DISPERSION TECHNIQUE; TABLET COMPRESSION; TABLET PROPERTY; TABLET SWELLING; VISCOSITY; X RAY DIFFRACTION; CHEMISTRY; INFRARED SPECTROPHOTOMETRY; INFRARED SPECTROSCOPY; KINETICS; SOLUBILITY;

CALORIMETRY, DIFFERENTIAL SCANNING; GALACTANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; KINETICS; LOVASTATIN; MANNANS; MICROSCOPY, ELECTRON, SCANNING; PLANT GUMS; SOLUBILITY; SPECTROPHOTOMETRY, INFRARED; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; VISCOSITY; X-RAY DIFFRACTION;

EID: 63649143585     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-008-9171-4     Document Type: Article

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