Cassette dosing for pharmacokinetic screening in drug discovery: Comparison of clearance, volume of distribution, half-life, mean residence time, and oral bioavailability obtained by cassette and discrete dosing in rats

Journal of Pharmaceutical Sciences

Volumn 100, Issue 9, 2011, Pages 3862-3874

  Nagilla, Rakesh ^a   Nord, Melanie ^a   Mcatee, Jeff J ^a   Jolivette, Larry J ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Cassette dosing; Clearance; Drug discovery; Half life; Liquid chromatography tandem mass spectrometry; N in one dosing; Oral bioavailability; Pharmacokinetics; Volume of distribution at steady state

Indexed keywords

2 HYDROXYPROPYL BETA CYCLODEXTRIN; ULTRASONIC SURGICAL ASPIRATOR; UNCLASSIFIED DRUG;

AREA UNDER THE CURVE; ARTICLE; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DEVELOPMENT; DRUG DISTRIBUTION; DRUG DOSE; DRUG ELIMINATION; DRUG HALF LIFE; FEMALE; MALE; NONHUMAN; PHARMACOKINETICS; RAT;

EID: 79960130501     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.22525     Document Type: Article

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