A direct technique for the simultaneous determination of 10 drug candidates in plasma by liquid chromatography-atmospheric pressure chemical ionization mass spectrometry interfaced to a Prospekt solid-phase extraction system

Journal of Pharmaceutical and Biomedical Analysis

Volumn 15, Issue 12, 1997, Pages 1893-1901

  McLoughlin, Debra A ^a   Olah, Timothy V ^a   Gilbert, John D ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Animal reduction; Automation; LC MS MS; Multiple analytes; Pharmacokinetic screens; Plasma; Prospekt; Quality control; Solid phase extraction

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; BIOAVAILABILITY; DOG; DRUG BLOOD LEVEL; DRUG DETERMINATION; INTRAVAGINAL DRUG ADMINISTRATION; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; NONHUMAN; ORAL DRUG ADMINISTRATION; PHARMACOKINETICS; PRIORITY JOURNAL; QUALITY CONTROL; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID PHASE EXTRACTION;

ANIMALS; ATMOSPHERIC PRESSURE; AUTOANALYSIS; CHROMATOGRAPHY, LIQUID; DOGS; MALE; MASS SPECTROMETRY; ONLINE SYSTEMS; PHARMACEUTICAL PREPARATIONS; QUALITY CONTROL; REPRODUCIBILITY OF RESULTS;

EID: 0030841892     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(96)02011-0     Document Type: Article

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