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Volumn 8, Issue 4, 2010, Pages 224-232

Osteocytes in normal physiology and osteoporosis

Author keywords

Aging; Cell fate; Extracellular matrix; Gene expression; Human disease; Mechanical signal; Mineralization; Mouse genetics; Osteoblast; Osteoclast; PTH; Wnt signaling

Indexed keywords

25 HYDROXYVITAMIN D; ALKALINE PHOSPHATASE; BISPHOSPHONIC ACID DERIVATIVE; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 8 APLHA; COLLAGEN; COLLAGEN TYPE 1; DENTIN MATRIX PROTEIN 1; DICKKOPF 1 PROTEIN; FIBROBLAST GROWTH FACTOR 19; FIBROBLAST GROWTH FACTOR 23; GLYCOSAMINOGLYCAN; HEPARAN SULFATE; MATRIX EXTRACELLULAR PHOSPHOGLYCOPROTEIN; OSTEOCALCIN; OSTEOCLAST DIFFERENTIATION FACTOR; PARATHYROID HORMONE; PERLECAN; PHOSPHATE REGULATING NEUTRAL ENDOPEPTIDASE; PODOPLANIN; PROTEIN ENPP 1; PROTEOGLYCAN; SCLEROSTIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DLX 3; TRANSCRIPTION FACTOR IRX 5; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR TCF 7; TRANSCRIPTION FACTOR VDR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 79960115933     PISSN: 15348644     EISSN: 15590119     Source Type: Journal    
DOI: 10.1007/s12018-010-9076-0     Document Type: Review
Times cited : (6)

References (103)
  • 1
    • 0037709869 scopus 로고    scopus 로고
    • The osteocyte
    • In: Bilezikian JP, Raisz LG, Rodan GA, editors. 2nd ed San Diego: Academic Press
    • Nijweide PJ, Burger EH, Klein-Nulend J. The osteocyte. In: Bilezikian JP, Raisz LG, Rodan GA, editors. Principles of bone biology. 2nd ed. San Diego: Academic Press; 2002. p. 93-107.
    • (2002) Principles of bone biology , pp. 93-107
    • Nijweide, P.J.1    Burger, E.H.2    Klein-Nulend, J.3
  • 2
    • 40849106249 scopus 로고    scopus 로고
    • Osteocytes, mechanosensing and Wnt signaling
    • Bonewald LF, Johnson ML. Osteocytes, mechanosensing and Wnt signaling. Bone. 2008;42:606-15.
    • (2008) Bone , vol.42 , pp. 606-15
    • Bonewald, L.F.1    Johnson, M.L.2
  • 3
    • 50949131016 scopus 로고    scopus 로고
    • The osteocyte lineage
    • Noble BS. The osteocyte lineage. Arch Biochem Biophys. 2008;473:106-11.
    • (2008) Arch Biochem Biophys , vol.473 , pp. 106-11
    • Noble, B.S.1
  • 4
    • 0032895922 scopus 로고    scopus 로고
    • Mechanotransduction in bone-role of the lacuno-canalicular network
    • Burger EH, Klein-Nulend J. Mechanotransduction in bone-role of the lacuno-canalicular network. FASEB J. 1999;13(Suppl): S101-12.
    • (1999) FASEB J. , vol.13 , Issue.SUPPL.
    • Burger, E.H.1    Klein-Nulend, J.2
  • 5
    • 70349885514 scopus 로고    scopus 로고
    • A systems biology approach to the identification and analysis of transcriptional regulatory networks in osteocytes
    • Dean AK, Harris SE, Kalajzic I, Ruan J. A systems biology approach to the identification and analysis of transcriptional regulatory networks in osteocytes. BMC Bioinformatics. 2009;10(Suppl 9):S5.
    • (2009) BMC Bioinformatics , vol.10 , Issue.SUPPL.. 9
    • Dean, A.K.1    Harris, S.E.2    Kalajzic, I.3    Ruan, J.4
  • 7
    • 33644975844 scopus 로고    scopus 로고
    • Buried alive: How osteoblasts become osteocytes
    • DOI 10.1002/dvdy.20603
    • Franz-Odendaal TA, Hall BK, Witten PE. Buried alive: How osteoblasts become osteocytes. Dev Dyn. 2006;235: 176-90. (Pubitemid 46939715)
    • (2006) Developmental Dynamics , vol.235 , Issue.1 , pp. 176-190
    • Franz-Odendaal, T.A.1    Hall, B.K.2    Witten, P.E.3
  • 8
    • 2942750269 scopus 로고    scopus 로고
    • Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene
    • DOI 10.1016/j.bone.2004.03.006, PII S8756328204001097
    • Kalajzic I, Braut A, Guo D, Jiang X, Kronenberg MS, Mina M, Harris MA, Harris SE, Rowe DW. Dentin matrix protein 1 expression during osteoblastic differentiation, generation of an osteocyte GFP-transgene. Bone. 2004;35:74-82. (Pubitemid 38789150)
    • (2004) Bone , vol.35 , Issue.1 , pp. 74-82
    • Kalajzic, I.1    Braut, A.2    Guo, D.3    Jiang, X.4    Kronenberg, M.S.5    Mina, M.6    Harris, M.A.7    Harris, S.E.8    Rowe, D.W.9
  • 9
    • 0029881460 scopus 로고    scopus 로고
    • Characterization and cloning of the E11 antigen, a marker expressed by rat osteoblasts and osteocytes
    • DOI 10.1016/8756-3282(95)00457-2
    • Wetterwald A, Hoffstetter W, Cecchini MG, Lanske B, Wagner C, Fleisch H, Atkinson M. Characterization and cloning of the E11 antigen, a marker expressed by rat osteoblasts and osteocytes. Bone. 1996;18:125-32. (Pubitemid 26092592)
    • (1996) Bone , vol.18 , Issue.2 , pp. 125-132
    • Wetterwald, A.1    Hofstetter, W.2    Cecchini, M.G.3    Lanske, B.4    Wagner, C.5    Fleisch, H.6    Atkinson, M.7
  • 13
    • 57449116084 scopus 로고    scopus 로고
    • Gene expression signatures of a fibroblastoid preosteoblast and cuboidal osteoblast cell model compared to the MLO-Y4 osteocyte cell model
    • Yang W, Harris MA, Heinrich JG, Guo D, Bonewald LF, Harris SE. Gene expression signatures of a fibroblastoid preosteoblast and cuboidal osteoblast cell model compared to the MLO-Y4 osteocyte cell model. Bone. 2009;44:32-45.
    • (2009) Bone , vol.44 , pp. 32-45
    • Yang, W.1    Harris, M.A.2    Heinrich, J.G.3    Guo, D.4    Bonewald, L.F.5    Harris, S.E.6
  • 17
    • 58149137289 scopus 로고    scopus 로고
    • Dlx3 is a crucial regulator of hair follicle differentiation and cycling
    • Hwang J, Mehrani T, Millar SE, Morasso MI. Dlx3 is a crucial regulator of hair follicle differentiation and cycling. Development. 2008;135:3149-59.
    • (2008) Development , vol.135 , pp. 3149-59
    • Hwang, J.1    Mehrani, T.2    Millar, S.E.3    Morasso, M.I.4
  • 18
    • 33744791463 scopus 로고    scopus 로고
    • Wnt signaling: Is the party in the nucleus?
    • DOI 10.1101/gad.1424006
    • Willert K, Jones KA. Wnt signaling: Is the party in the nucleus? Genes Dev. 2006;20:1394-404. (Pubitemid 43830647)
    • (2006) Genes and Development , vol.20 , Issue.11 , pp. 1394-1404
    • Willert, K.1    Jones, K.A.2
  • 26
    • 0025833476 scopus 로고
    • A method to stain decalcified bone without loss of structural detail
    • Schoen FA. A method to stain decalcified bone without loss of structural detail. Biotech Histochem. 1991;66:216-9.
    • (1991) Biotech Histochem , vol.66 , pp. 216-9
    • Schoen, F.A.1
  • 27
    • 0035130601 scopus 로고    scopus 로고
    • A three-dimensional distribution of osteocyte processes revealed by the combination of confocal laser scanning microscopy and differential interference contrast microscopy
    • DOI 10.1016/S8756-3282(00)00421-X, PII S875632820000421X
    • Kamioka H, Honjo T, Takano-Yamamoto T. A three-dimensional distribution of osteocyte processes revealed by the combination of confocal laser scanning microscopy and differential interference contrast microscopy. Bone. 2001;28:145-9. (Pubitemid 32140970)
    • (2001) Bone , vol.28 , Issue.2 , pp. 145-149
    • Kamioka, H.1    Honjo, T.2    Takano-Yamamoto, T.3
  • 32
    • 0026570593 scopus 로고
    • An electron microscopic study on the presence of proteoglycans in the mineralized matrix of rat and human compact lamellar bone
    • Sauren YM, Mieremet RH, Groot CG, Scherft JP. An electron microscopic study on the presence of proteoglycans in the mineralized matrix of rat and human compact lamellar bone. Anat Rec. 1992;232:36-44.
    • (1992) Anat Rec , vol.232 , pp. 36-44
    • Sauren, Y.M.1    Mieremet, R.H.2    Groot, C.G.3    Scherft, J.P.4
  • 35
    • 0029395299 scopus 로고
    • A case for bone canaliculi as the anatomical site of strain generated potentials
    • Cowin SC, Weinbaum S, Zeng Y. A case for bone canaliculi as the anatomical site of strain generated potentials. J Biomech. 1995;28:1281-97.
    • (1995) J Biomech , vol.28 , pp. 1281-97
    • Cowin, S.C.1    Weinbaum, S.2    Zeng, Y.3
  • 36
    • 0034956917 scopus 로고    scopus 로고
    • Heparan sulfate: Lessons from knockout mice
    • DOI 10.1172/JCI200113561
    • Forsberg E, Kjellen L. Heparan sulfate: Lessons from knockout mice. J Clin Invest. 2001;108:175-80. (Pubitemid 32656239)
    • (2001) Journal of Clinical Investigation , vol.108 , Issue.2 , pp. 175-180
    • Forsberg, E.1    Kjellen, L.2
  • 37
    • 34247610845 scopus 로고    scopus 로고
    • Heparan sulphate proteoglycans fine-tune mammalian physiology
    • DOI 10.1038/nature05817, PII NATURE05817
    • Bishop JR, Schuksz M, Esko JD. Heparan sulphate proteoglycans fine-tune mammalian physiology. Nature. 2007;446:1030-7. (Pubitemid 46676065)
    • (2007) Nature , vol.446 , Issue.7139 , pp. 1030-1037
    • Bishop, J.R.1    Schuksz, M.2    Esko, J.D.3
  • 39
    • 34047097475 scopus 로고    scopus 로고
    • Reduced perlecan in mice results in chondrodysplasia resembling Schwartz-Jampel syndrome
    • DOI 10.1093/hmg/ddl484
    • Rodgers KD, Sasaki T, Aszodi A, Jacenko O. Reduced perlecan in mice results in chondrodysplasia resembling Schwartz-Jampel syndrome. Hum Mol Genet. 2007;16:515-28. (Pubitemid 46522614)
    • (2007) Human Molecular Genetics , vol.16 , Issue.5 , pp. 515-528
    • Rodgers, K.D.1    Sasaki, T.2    Aszodi, A.3    Jacenko, O.4
  • 42
    • 69249231022 scopus 로고    scopus 로고
    • The role of bone in phosphate metabolism
    • Fukumoto S. The role of bone in phosphate metabolism. Mol Cell Endocrinol. 2009;310:63-70.
    • (2009) Mol Cell Endocrinol , vol.310 , pp. 63-70
    • Fukumoto, S.1
  • 43
    • 37249057821 scopus 로고    scopus 로고
    • Osteocytes as dynamic multifunctional cells
    • DOI 10.1196/annals.1402.018, Skeletal Biology and Medicine, Part A: Aspects of Bone Morphogenesis and Remodeling
    • Bonewald LF. Osteocytes as dynamic multifunctional cells. Ann NY Acad Sci. 2007;1116:281-90. (Pubitemid 350274320)
    • (2007) Annals of the New York Academy of Sciences , vol.1116 , pp. 281-290
    • Bonewald, L.F.1
  • 46
    • 42049084378 scopus 로고    scopus 로고
    • Actions and mode of actions of FGF19 subfamily members
    • DOI 10.1507/endocrj.KR07E-002
    • Fukumoto S. Actions and mode of actions of FGF19 subfamily members. Endocr J. 2008;55:23-31. (Pubitemid 351520176)
    • (2008) Endocrine Journal , vol.55 , Issue.1 , pp. 23-31
    • Fukumoto, S.1
  • 48
    • 0033763097 scopus 로고    scopus 로고
    • Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23
    • ADHR-Consortium
    • ADHR-Consortium. Autosomal dominant hypophosphataemic rickets is associated with mutations in FGF23. Nat Genet. 2000;26:345-8.
    • (2000) Nat Genet , vol.26 , pp. 345-8
  • 52
    • 33746341155 scopus 로고    scopus 로고
    • Hypervitaminosis D and premature aging: lessons learned from Fgf23 and Klotho mutant mice
    • DOI 10.1016/j.molmed.2006.05.002, PII S1471491406000943
    • Razzaque MS, Lanske B. Hypervitaminosis D and premature aging: Lessons learned from Fgf23 and Klotho mutant mice. Trends Mol Med. 2006;12:298-305. (Pubitemid 44110001)
    • (2006) Trends in Molecular Medicine , vol.12 , Issue.7 , pp. 298-305
    • Razzaque, M.S.1    Lanske, B.2
  • 54
    • 0032867706 scopus 로고    scopus 로고
    • Genetic causes of rickets
    • DOI 10.1097/00008480-199908000-00012
    • Miller WL, Portale AA. Genetic causes of rickets. Curr Opin Pediatr. 1999;11:333-9. (Pubitemid 29406507)
    • (1999) Current Opinion in Pediatrics , vol.11 , Issue.4 , pp. 333-339
    • Miller, W.L.1    Portale, A.A.2
  • 55
    • 0034235036 scopus 로고    scopus 로고
    • MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia
    • DOI 10.1006/geno.2000.6235
    • Rowe PS, de Zoysa PA, Dong R, Wang HR, White KE, Econs MJ, Oudet CL. MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia. Genomics. 2000;67:54-68. (Pubitemid 30471121)
    • (2000) Genomics , vol.67 , Issue.1 , pp. 54-68
    • Rowe, P.S.N.1    De Zoysa, P.A.2    Dong, R.3    Wang, H.R.4    White, K.E.5    Econs, M.J.6    Oudet, C.L.7
  • 56
    • 0034680755 scopus 로고    scopus 로고
    • Identification of osteoblast/osteocyte factor 45 (OF45), a bone-specific cDNA encoding an RGD-containing protein that is highly expressed in osteoblasts and osteocytes
    • Petersen DN, Tkalcevic GT, Mansolf AL, Rivera-Gonzalez R, Brown TA. Identification of osteoblast/osteocyte factor 45 (OF45), a bone-specific cDNA encoding an RGD-containing protein that is highly expressed in osteoblasts and osteocytes. J Biol Chem. 2000;275:36172-80.
    • (2000) J Biol Chem , vol.275 , pp. 36172-80
    • Petersen, D.N.1    Tkalcevic, G.T.2    Mansolf, A.L.3    Rivera-Gonzalez, R.4    Brown, T.A.5
  • 58
    • 0037237957 scopus 로고    scopus 로고
    • Six genes expressed in bones and teeth encode the current members of the SIBLING family of proteins
    • Fisher LW, Fedarko NS. Six genes expressed in bones and teeth encode the current members of the SIBLING family of proteins. Connect Tissue Res. 2003;44(Suppl 1):33-40. (Pubitemid 36395419)
    • (2003) Connective Tissue Research , vol.44 , Issue.SUPPL. 1 , pp. 33-40
    • Fisher, L.W.1    Fedarko, N.S.2
  • 60
    • 39749187284 scopus 로고    scopus 로고
    • Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): Multifunctional proteins in cancer
    • DOI 10.1038/nrc2345, PII NRC2345
    • Bellahcene A, Castronovo V, Ogbureke KU, Fisher LW, Fedarko NS. Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): Multifunctional proteins in cancer. Nat Rev Cancer. 2008;8:212-26. (Pubitemid 351301854)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.3 , pp. 212-226
    • Bellahcene, A.1    Castronovo, V.2    Ogbureke, K.U.E.3    Fisher, L.W.4    Fedarko, N.S.5
  • 62
    • 76049105171 scopus 로고    scopus 로고
    • Loss-of-function ENPP1 mutations cause both generalized arterial calcification of infancy and autosomal-recessive hypophosphatemic rickets
    • Lorenz-Depiereux B, Schnabel D, Tiosano D, Hausler G, Strom TM. Loss-of-function ENPP1 mutations cause both generalized arterial calcification of infancy and autosomal-recessive hypophosphatemic rickets. Am J Hum Genet. 2010;86:267-72.
    • (2010) Am J Hum Genet. , vol.86 , pp. 267-72
    • Lorenz-Depiereux, B.1    Schnabel, D.2    Tiosano, D.3    Hausler, G.4    Strom, T.M.5
  • 64
    • 1642313676 scopus 로고    scopus 로고
    • Concerted Regulation of Inorganic Pyrophosphate and Osteopontin by Akp2, Enpp1, and Ank: An Integrated Model of the Pathogenesis of Mineralization Disorders
    • Harmey D, Hessle L, Narisawa S, Johnson KA, Terkeltaub R, Millan JL. Concerted regulation of inorganic pyrophosphate and osteopontin by akp2, enpp1, and ank: An integrated model of the pathogenesis of mineralization disorders. Am J Pathol. 2004;164:1199-209. (Pubitemid 38387787)
    • (2004) American Journal of Pathology , vol.164 , Issue.4 , pp. 1199-1209
    • Harmey, D.1    Hessle, L.2    Narisawa, S.3    Johnson, K.A.4    Terkeltaub, R.5    Millan, J.L.6
  • 66
    • 0031859977 scopus 로고    scopus 로고
    • Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine
    • DOI 10.1038/956
    • Okawa A, Nakamura I, Goto S, Moriya H, Nakamura Y, Ikegawa S. Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nat Genet. 1998;19:271-3. (Pubitemid 28309341)
    • (1998) Nature Genetics , vol.19 , Issue.3 , pp. 271-273
    • Okawa, A.1    Nakamura, I.2    Goto, S.3    Moriya, H.4    Nakamura, Y.5    Ikegawa, S.6
  • 68
    • 9644303231 scopus 로고    scopus 로고
    • Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice
    • DOI 10.1016/j.matbio.2004.09.007, PII S0945053X04001155
    • Sitara D, Razzaque MS, Hesse M, Yoganathan S, Taguchi T, Erben RG, Juppner H, Lanske B. Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice. Matrix Biol. 2004;23:421-32. (Pubitemid 39576657)
    • (2004) Matrix Biology , vol.23 , Issue.7 , pp. 421-432
    • Sitara, D.1    Razzaque, M.S.2    Hesse, M.3    Yoganathan, S.4    Taguchi, T.5    Erben, R.G.6    Juppner, H.7    Lanske, B.8
  • 70
    • 33644514312 scopus 로고    scopus 로고
    • Teriparatide [human PTH(1-34)]: 2.5 years of experience on the use and safety of the drug for the treatment of osteoporosis
    • Tashjian AH Jr, Gagel RF. Teriparatide [human PTH(1-34)]: 2.5 years of experience on the use and safety of the drug for the treatment of osteoporosis. J Bone Miner Res. 2006;21:354-65.
    • (2006) J Bone Miner Res , vol.21 , pp. 354-65
    • Tashjian Jr., A.H.1    Gagel, R.F.2
  • 71
    • 77951624097 scopus 로고    scopus 로고
    • Update in new anabolic therapies for osteoporosis
    • Canalis E. Update in new anabolic therapies for osteoporosis. J Clin Endocrinol Metab. 2010;95:1496-504.
    • (2010) J Clin Endocrinol Metab. , vol.95 , pp. 1496-504
    • Canalis, E.1
  • 74
    • 26844521277 scopus 로고    scopus 로고
    • Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: A novel mechanism for hormonal control of osteoblastogenesis
    • DOI 10.1210/en.2005-0239
    • Bellido T, Ali AA, Gubrij I, Plotkin LI, Fu Q, O'Brien CA, Manolagas SC, Jilka RL. Chronic elevation of parathyroid hormone in mice reduces expression of sclerostin by osteocytes: A novel mechanism for hormonal control of osteoblastogenesis. Endocrinology. 2005;146:4577-83. (Pubitemid 41446595)
    • (2005) Endocrinology , vol.146 , Issue.11 , pp. 4577-4583
    • Bellido, T.1    Ali, A.A.2    Gubrij, I.3    Plotkin, L.I.4    Fu, Q.5    O'Brien, C.A.6    Manolagas, S.C.7    Jilka, R.L.8
  • 75
    • 21844467220 scopus 로고    scopus 로고
    • SOST is a target gene for PTH in bone
    • DOI 10.1016/j.bone.2005.03.018, PII S8756328205001171
    • Keller H, Kneissel M. SOST is a target gene for PTH in bone. Bone. 2005;37:148-58. (Pubitemid 40962421)
    • (2005) Bone , vol.37 , Issue.2 , pp. 148-158
    • Keller, H.1    Kneissel, M.2
  • 82
    • 0037073707 scopus 로고    scopus 로고
    • Parathyroid hormone stimulates receptor activator of NFB ligand and inhibits osteoprotegerin expression via protein kinase a activation of cAMP-response element-binding protein
    • DOI 10.1074/jbc.M208494200
    • Fu Q, Jilka RL, Manolagas SC, O'Brien CA. Parathyroid hormone stimulates receptor activator of NFkappa B ligand and inhibits osteoprotegerin expression via protein kinase A activation of cAMP-response element-binding protein. J Biol Chem. 2002;277:48868-75. (Pubitemid 35470855)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.50 , pp. 48868-48875
    • Fu, Q.1    Jilka, R.L.2    Manolagas, S.C.3    O'Brien, C.A.4
  • 83
    • 0036708157 scopus 로고    scopus 로고
    • Cyclic adenosine monophosphate/ protein kinase A mediates parathyroid hormone/parathyroid hormone-related protein receptor regulation of osteoclastogenesis and expression of RANKL and osteoprotegerin mRNAs by marrow stromal cells
    • Kondo H, Guo J, Bringhurst FR. Cyclic adenosine monophosphate/ protein kinase A mediates parathyroid hormone/parathyroid hormone-related protein receptor regulation of osteoclastogenesis and expression of RANKL and osteoprotegerin mRNAs by marrow stromal cells. J Bone Miner Res. 2002;17:1667-79.
    • (2002) J Bone Miner Res , vol.17 , pp. 1667-79
    • Kondo, H.1    Guo, J.2    Bringhurst, F.R.3
  • 84
    • 0036317417 scopus 로고    scopus 로고
    • Regulation of receptor activator of nuclear factor-B ligand and osteoprotegerin mRNA expression by parathyroid hormone is predominantly mediated by the protein kinase a pathway in murine bone marrow cultures
    • DOI 10.1016/S8756-3282(02)00804-9, PII S8756328202008049
    • Lee SK, Lorenzo JA. Regulation of receptor activator of nuclear factor-kappa B ligand and osteoprotegerin mRNA expression by parathyroid hormone is predominantly mediated by the protein kinase a pathway in murine bone marrow cultures. Bone. 2002;31:252-9. (Pubitemid 34754455)
    • (2002) Bone , vol.31 , Issue.1 , pp. 252-259
    • Lee, S.-K.1    Lorenzo, J.A.2
  • 85
    • 77955301116 scopus 로고    scopus 로고
    • Osteocyte remodeling of the perilacunar and pericanalicular matrix
    • Qing H, Bonewald LF. Osteocyte remodeling of the perilacunar and pericanalicular matrix. Int J Oral Sci. 2009;1:59-65.
    • (2009) Int J Oral Sci , vol.1 , pp. 59-65
    • Qing, H.1    Bonewald, L.F.2
  • 86
    • 57449116758 scopus 로고    scopus 로고
    • Do osteocytes contribute to bone mineral homeostasis? Osteocytic osteolysis revisited
    • Teti A, Zallone A. Do osteocytes contribute to bone mineral homeostasis? Osteocytic osteolysis revisited. Bone. 2009;44: 11-6.
    • (2009) Bone , vol.44 , pp. 11-6
    • Teti, A.1    Zallone, A.2
  • 87
    • 0017417514 scopus 로고
    • A laboratory model demonstrating osteocyte-osteoblast control of plasma calcium concentrations. Table model for plasma calcium control
    • Talmage RV, Grubb SA. A laboratory model demonstrating osteocyte-osteoblast control of plasma calcium concentrations. Table model for plasma calcium control. Clin Orthop Relat Res. 1977;122:299-306.
    • (1977) Clin Orthop Relat Res , vol.122 , pp. 299-306
    • Talmage, R.V.1    Grubb, S.A.2
  • 89
    • 8744256394 scopus 로고    scopus 로고
    • Osteocytic osteolysis observed in rats to which parathyroid hormone was continuously administered
    • DOI 10.1007/s00774-004-0519-x
    • Tazawa K, Hoshi K, Kawamoto S, Tanaka M, Ejiri S, Ozawa H. Osteocytic osteolysis observed in rats to which parathyroid hormone was continuously administered. J Bone Miner Metab. 2004;22:524-9. (Pubitemid 39517871)
    • (2004) Journal of Bone and Mineral Metabolism , vol.22 , Issue.6 , pp. 524-529
    • Tazawa, K.1    Hoshi, K.2    Kawamoto, S.3    Tanaka, M.4    Ejiri, S.5    Ozawa, H.6
  • 91
    • 0033981552 scopus 로고    scopus 로고
    • Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo
    • Verborgt O, Gibson GJ, Schaffler MB. Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo. J Bone Miner Res. 2000;15:60-7. (Pubitemid 30026933)
    • (2000) Journal of Bone and Mineral Research , vol.15 , Issue.1 , pp. 60-67
    • Verborgt, O.1    Gibson, G.J.2    Schaffler, M.B.3
  • 92
    • 34249657953 scopus 로고    scopus 로고
    • Targeted Ablation of Osteocytes Induces Osteoporosis with Defective Mechanotransduction
    • DOI 10.1016/j.cmet.2007.05.001, PII S1550413107001283
    • Tatsumi S, Ishii K, Amizuka N, Li M, Kobayashi T, Kohno K, Ito M, Takeshita S, Ikeda K. Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Cell Metab. 2007;5:464-75. (Pubitemid 46825494)
    • (2007) Cell Metabolism , vol.5 , Issue.6 , pp. 464-475
    • Tatsumi, S.1    Ishii, K.2    Amizuka, N.3    Li, M.4    Kobayashi, T.5    Kohno, K.6    Ito, M.7    Takeshita, S.8    Ikeda, K.9
  • 93
    • 33745845537 scopus 로고    scopus 로고
    • Microdamage: A cell transducing mechanism based on ruptured osteocyte processes
    • DOI 10.1016/j.jbiomech.2005.06.006, PII S0021929005002721
    • Hazenberg JG, Freeley M, Foran E, Lee TC, Taylor D. Microdamage: A cell transducing mechanism based on ruptured osteocyte processes. J Biomech. 2006;39:2096-103. (Pubitemid 44038721)
    • (2006) Journal of Biomechanics , vol.39 , Issue.11 , pp. 2096-2103
    • Hazenberg, J.G.1    Freeley, M.2    Foran, E.3    Lee, T.C.4    Taylor, D.5
  • 96
    • 0034010683 scopus 로고    scopus 로고
    • Decline in osteocyte lacunar density in human cortical bone is associated with accumulation of microcracks with age
    • DOI 10.1016/S8756-3282(00)00236-2, PII S8756328200002362
    • Vashishth D, Verborgt O, Divine G, Schaffler MB, Fyhrie DP. Decline in osteocyte lacunar density in human cortical bone is associated with accumulation of microcracks with age. Bone. 2000;26:375-80. (Pubitemid 30136128)
    • (2000) Bone , vol.26 , Issue.4 , pp. 375-380
    • Vashishth, D.1    Verborgt, O.2    Divine, G.3    Schaffler, M.B.4    Fyhrie, D.P.5
  • 97
    • 0041475992 scopus 로고    scopus 로고
    • Reduced iliac cancellous osteocyte density in patients with osteoporotic vertebral fracture
    • DOI 10.1359/jbmr.2003.18.9.1657
    • Qiu S, Rao DS, Palnitkar S, Parfitt AM. Reduced iliac cancellous osteocyte density in patients with osteoporotic vertebral fracture. J Bone Miner Res. 2003;18:1657-63. (Pubitemid 37022924)
    • (2003) Journal of Bone and Mineral Research , vol.18 , Issue.9 , pp. 1657-1663
    • Qiu, S.1    Rao, D.S.2    Palnitkar, S.3    Parfitt, A.M.4
  • 98
    • 0036020416 scopus 로고    scopus 로고
    • Age and distance from the surface but not menopause reduce osteocyte density in human cancellous bone
    • DOI 10.1016/S8756-3282(02)00819-0, PII S8756328202008190
    • Qiu S, Rao DS, Palnitkar S, Parfitt AM. Age and distance from the surface but not menopause reduce osteocyte density in human cancellous bone. Bone. 2002;31:313-8. (Pubitemid 34822826)
    • (2002) Bone , vol.31 , Issue.2 , pp. 313-318
    • Qiu, S.1    Rao, D.S.2    Palnitkar, S.3    Parfitt, A.M.4
  • 101
    • 0032528180 scopus 로고    scopus 로고
    • Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts end osteocytes by glucocorticoids potential mechanisms of their deleterious effects on bone
    • Weinstein RS, Jilka RL, Parfitt AM, Manolagas SC. Inhibition of osteoblastogenesis and promotion of apoptosis of osteoblasts and osteocytes by glucocorticoids. Potential mechanisms of their deleterious effects on bone. J Clin Invest. 1998;102:274-82. (Pubitemid 28335186)
    • (1998) Journal of Clinical Investigation , vol.102 , Issue.2 , pp. 274-282
    • Weinstein, R.S.1    Jilka, R.L.2    Michael Parfitt, A.3    Manolagas, S.C.4
  • 102
    • 14844283132 scopus 로고    scopus 로고
    • Bisphosphonates and estrogens inhibit osteocyte apoptosis via distinct molecular mechanisms downstream of extracellular signal-regulated kinase activation
    • DOI 10.1074/jbc.M412817200
    • Plotkin LI, Aguirre JI, Kousteni S, Manolagas SC, Bellido T. Bisphosphonates and estrogens inhibit osteocyte apoptosis via distinct molecular mechanisms downstream of extracellular signal-regulated kinase activation. J Biol Chem. 2005;280: 7317-25. (Pubitemid 40341290)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.8 , pp. 7317-7325
    • Plotkin, L.I.1    Aguirre, J.I.2    Kousteni, S.3    Manolagas, S.C.4    Bellido, T.5


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